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Cited by 2,307

The DOI matches its Crossref record; 716 of the 716 references it cites were found in a registry or an index.

Heme Oxygenase-1/Carbon Monoxide: From Basic Science to Therapeutic Applications

Ryter, Stefan W., Alam, Jawed, Choi, Augustine M. K.·2006·Physiological Reviews
DOI 10.1152/physrev.00011.2005
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Abstract

The heme oxygenases, which consist of constitutive and inducible isozymes (HO-1, HO-2), catalyze the rate-limiting step in the metabolic conversion of heme to the bile pigments (i.e., biliverdin and bilirubin) and thus constitute a major intracellular source of iron and carbon monoxide (CO). In recent years, endogenously produced CO has been shown to possess intriguing signaling properties affecting numerous critical cellular functions including but not limited to inflammation, cellular proliferation, and apoptotic cell death. The era of gaseous molecules in biomedical research and human diseases initiated with the discovery that the endothelial cell-derived relaxing factor was identical to the gaseous molecule nitric oxide (NO). The discovery that endogenously produced gaseous molecules such as NO and now CO can impart potent physiological and biological effector functions truly represented a paradigm shift and unraveled new avenues of intense investigations. This review covers the molecular and biochemical characterization of HOs, with a discussion on the mechanisms of signal transduction and gene regulation that mediate the induction of HO-1 by environmental stress. Furthermore, the current understanding of the functional significance of HO shall be discussed from the perspective of each of the metabolic by-products, with a special emphasis on CO. Finally, this presentation aspires to lay a foundation for potential future clinical applications of these systems.

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Crossref · 10.1152/physrev.00011.2005

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Citations

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Metadata

Authors
Ryter, S. W., Alam, J., & Choi, A. M. K.
Venue
Physiological Reviews
Publisher
American Physiological Society
Published
2006-04
Volume
86
Issue
2
Pages
583-650
ISSN
  • 0031-9333 (ISSN-L)
  • 1522-1210
DOI
10.1152/physrev.00011.2005
OpenAlex
W2005904261
Cited by
2,307
References
716
FWCI
6.74
Type
journal article
Language
en
Open access
closed

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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