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Heme Oxygenase-1/Carbon Monoxide: From Basic Science to Therapeutic Applications
Abstract
The heme oxygenases, which consist of constitutive and inducible isozymes (HO-1, HO-2), catalyze the rate-limiting step in the metabolic conversion of heme to the bile pigments (i.e., biliverdin and bilirubin) and thus constitute a major intracellular source of iron and carbon monoxide (CO). In recent years, endogenously produced CO has been shown to possess intriguing signaling properties affecting numerous critical cellular functions including but not limited to inflammation, cellular proliferation, and apoptotic cell death. The era of gaseous molecules in biomedical research and human diseases initiated with the discovery that the endothelial cell-derived relaxing factor was identical to the gaseous molecule nitric oxide (NO). The discovery that endogenously produced gaseous molecules such as NO and now CO can impart potent physiological and biological effector functions truly represented a paradigm shift and unraveled new avenues of intense investigations. This review covers the molecular and biochemical characterization of HOs, with a discussion on the mechanisms of signal transduction and gene regulation that mediate the induction of HO-1 by environmental stress. Furthermore, the current understanding of the functional significance of HO shall be discussed from the perspective of each of the metabolic by-products, with a special emphasis on CO. Finally, this presentation aspires to lay a foundation for potential future clinical applications of these systems.
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Ryter, S. W., & Tyrrell, R. M. (2000) · Current Protocols in Toxicology · doi:10.1002/0471140856.tx0906s05 · Cited by 5
Self-citationPathogenesis of Alzheimer's disease and the role of heme oxygenase: new perspectives and hypothesis.
Celec, P., & Príhodová, M. (2003) · PubMed · Cited by 3
Regulation of Heme Oxygenase-1 Gene Transcription Via the Stress-Response Element
Stewart, D., Cook, J. L., & Alam, J. (2002) · Springer eBooks · doi:10.1007/978-1-4615-0741-3_33 · Cited by 2
Self-citation
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Bhattacharyya, A., Chattopadhyay, R., Mitra, S., & Crowe, S. E. (2014) · Physiological Reviews · doi:10.1152/physrev.00040.2012 · Cited by 2,484
The therapeutic potential of carbon monoxide
Motterlini, R., & Otterbein, L. E. (2010) · Nature Reviews Drug Discovery · doi:10.1038/nrd3228 · Cited by 1,638
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Haas, K. L., & Franz, K. J. (2009) · Chemical Reviews · doi:10.1021/cr900134a · Cited by 984
Carbon monoxide intoxication: An updated review
Prockop, L. D., & Chichkova, R. I. (2007) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2007.06.037 · Cited by 730
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Metadata
- Authors
- Ryter, S. W., Alam, J., & Choi, A. M. K.
- Venue
- Physiological Reviews
- Publisher
- American Physiological Society
- Published
- 2006-04
- Volume
- 86
- Issue
- 2
- Pages
- 583-650
- ISSN
- 0031-9333 (ISSN-L)
- 1522-1210
- OpenAlex
- W2005904261
- Cited by
- 2,307
- References
- 716
- FWCI
- 6.74
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
