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Heme Oxygenase-1/Carbon Monoxide: From Basic Science to Therapeutic Applications
Abstract
The heme oxygenases, which consist of constitutive and inducible isozymes (HO-1, HO-2), catalyze the rate-limiting step in the metabolic conversion of heme to the bile pigments (i.e., biliverdin and bilirubin) and thus constitute a major intracellular source of iron and carbon monoxide (CO). In recent years, endogenously produced CO has been shown to possess intriguing signaling properties affecting numerous critical cellular functions including but not limited to inflammation, cellular proliferation, and apoptotic cell death. The era of gaseous molecules in biomedical research and human diseases initiated with the discovery that the endothelial cell-derived relaxing factor was identical to the gaseous molecule nitric oxide (NO). The discovery that endogenously produced gaseous molecules such as NO and now CO can impart potent physiological and biological effector functions truly represented a paradigm shift and unraveled new avenues of intense investigations. This review covers the molecular and biochemical characterization of HOs, with a discussion on the mechanisms of signal transduction and gene regulation that mediate the induction of HO-1 by environmental stress. Furthermore, the current understanding of the functional significance of HO shall be discussed from the perspective of each of the metabolic by-products, with a special emphasis on CO. Finally, this presentation aspires to lay a foundation for potential future clinical applications of these systems.
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Song, R., Mahidhara, R. S., Liu, F., Ning, W., Otterbein, L. E., & Choi, A. M. K. (2002) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.4851 · Cited by 127
Self-citationRetractedRegulation of IL-1β-induced GM-CSF production in human airway smooth muscle cells by carbon monoxide
Song, R., Ning, W., Liu, F., Ameredes, B. T., Calhoun, W. J., Otterbein, L. E., & Choi, A. M. K. (2003) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00212.2002 · Cited by 42
Self-citationRetractedFree radicals in biology and medicine
(1991) · General Pharmacology: The Vascular System · doi:10.1016/0306-3623(91)90478-o · Cited by 17,178
Nitric oxide: physiology, pathophysiology, and pharmacology.
Moncada, S., Palmer, R. M., & Higgs, E. A. (1991) · Pharmacological Reviews · doi:10.1016/s0031-6997(25)06663-3 · Cited by 15,525
(2000) · New England Journal of Medicine · doi:10.1056/nejm200005043421801 · Cited by 12,941
Furchgott, R. F., & Zawadzki, J. V. (1980) · Nature · doi:10.1038/288373a0 · Cited by 12,064
The Carbon Monoxide-binding Pigment of Liver Microsomes
Omura, T., & Sato, R. (1964) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(20)82244-3 · Cited by 11,781
Hershko, A., & Ciechanover, A. (1998) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.67.1.425 · Cited by 8,840
Meister, A., & Anderson, M. E. (1983) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.52.070183.003431 · Cited by 5,680
The phosphoinositide 3-kinase pathway
Cantley, L. C. (2002) · Science · doi:10.1126/science.296.5573.1655 · Cited by 5,621
Jaakkola, P., Mole, D. R., Tian, Y.-M., Wilson, M. I., Gielbert, J., Gaskell, S. J., Kriegsheim, A. V., Hebestreit, H. F., Mukherji, M., Schofield, C. J., et al. (2001) · Science · doi:10.1126/science.1059796 · Cited by 5,535
Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxide.
Ignarro, L. J., Buga, G. M., Wood, K. S., Byrns, R. E., & Chaudhuri, G. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.24.9265 · Cited by 5,074
HIFα Targeted for VHL-Mediated Destruction by Proline Hydroxylation: Implications for O 2 Sensing
Ivan, M., Kondo, K., Yang, H., Kim, W., Valiando, J., Ohh, M., Salic, A., Asara, J. M., Lane, W. S., & Kaelin Jr., W. G. (2001) · Science · doi:10.1126/science.1059817 · Cited by 4,735
Dougherty, T. J., Gomer, C. J., Henderson, B. W., Jori, G., Kessel, D., Korbelik, M., Moan, J., & Peng, Q. (1998) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/90.12.889 · Cited by 4,716
The Merck Index: An Encyclopedia of Chemicals, Drugs, and Biologicals
(1990) · Annals of Internal Medicine · doi:10.7326/0003-4819-113-6-487_2 · Cited by 4,500
Gomer, C. J. (1988) · Cited by 4,169
Itoh, K., Chiba, T., Takahashi, S., Ishii, T., Igarashi, K., Katoh, Y., Oyake, T., Hayashi, N., Satoh, K., Hatayama, I., et al. (1997) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1997.6943 · Cited by 3,999
Schreck, R., Rieber, P., & Baeuerle, P. A. (1991) · The EMBO Journal · doi:10.1002/j.1460-2075.1991.tb07761.x · Cited by 3,816
Effect of a protective-ventilation strategy on mortality in the acute respiratory distress syndrome.
Amato, M. B. P., Barbas, C. S. V., Medeiros, D. M., Magaldi, R. B., Schettino, G. P., Lorenzi-Filho, G., Kairalla, R. A., Deheinzelin, D., Munoz, C., Oliveira, R., et al. (1998) · New England Journal of Medicine · doi:10.1056/nejm199802053380602 · Cited by 3,654
Itoh, K., Wakabayashi, N., Katoh, Y., Ishii, T., Igarashi, K., Engel, J. D., & Yamamoto, M. (1999) · Genes & Development · doi:10.1101/gad.13.1.76 · Cited by 3,634
Kyriakis, J. M., & Avruch, J. (2001) · Physiological Reviews · doi:10.1152/physrev.2001.81.2.807 · Cited by 3,382
Casarett and Doull's Toxicology: The Basic Science of Poisons
(1992) · Annals of Internal Medicine · doi:10.7326/0003-4819-117-5-448_2 · Cited by 3,302
Baeuerle, P. A., & Baltimore, D. (1996) · Cell · doi:10.1016/s0092-8674(00)81318-5 · Cited by 3,001
Bilirubin Is an Antioxidant of Possible Physiological Importance
Stocker, R., Yamamoto, Y., McDonagh, A. F., Glazer, A. N., & Ames, B. N. (1987) · Science · doi:10.1126/science.3029864 · Cited by 2,948
Budavari, S. (1998) · Royal Society of Chemistry eBooks · Cited by 2,741
Interleukin-6 and the acute phase response
Heinrich, P. C., Castell, J. V., & Andus, T. (1990) · Biochemical Journal · doi:10.1042/bj2650621 · Cited by 2,734
Hemoglobin and myoglobin in their reactions with ligands
Antonini, E., & Brunori, M. (1971) · Medical Entomology and Zoology · Cited by 2,671
A MAP Kinase Targeted by Endotoxin and Hyperosmolarity in Mammalian Cells
Han, J., Lee, J.-D., Bibbs, L., & Ulevitch, R. J. (1994) · Science · doi:10.1126/science.7914033 · Cited by 2,646
THE HEME OXYGENASE SYSTEM:A Regulator of Second Messenger Gases
Maines, M. D. (1997) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.37.1.517 · Cited by 2,505
Raingeaud, J., Gupta, S., Rogers, J. S., Dickens, M., Han, J., Ulevitch, R. J., & Davis, R. J. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.13.7420 · Cited by 2,241
Kobayashi, A., Kang, M.-I., Okawa, H., Ohtsuji, M., Zenke, Y., Chiba, T., Igarashi, K., & Yamamoto, M. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.16.7130-7139.2004 · Cited by 2,224
Carbon monoxide has anti-inflammatory effects involving the mitogen-activated protein kinase pathway
Otterbein, L. E., Bach, F. H., Alam, J., Soares, M., Tao Lu, H., Wysk, M., Davis, R. J., Flavell, R. A., & Choi, A. M. K. (2000) · Nature Medicine · doi:10.1038/74680 · Cited by 2,153
Self-citationThe reaction of NO with superoxide
Huie, R. E., & Padmaja, S. (1993) · Free Radical Research Communications · doi:10.3109/10715769309145868 · Cited by 2,121
Dinkova-Kostova, A. T., Holtzclaw, W. D., Cole, R. N., Itoh, K., Wakabayashi, N., Katoh, Y., Yamamoto, M., & Talalay, P. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.172398899 · Cited by 1,947
Toll-like Receptor-4 Mediates Lipopolysaccharide-induced Signal Transduction
Chow, J. C., Young, D. W., Golenbock, D. T., Christ, W. J., & Gusovsky, F. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.16.10689 · Cited by 1,924
Regulation of Mammalian O 2 Homeostasis by Hypoxia-Inducible Factor 1
Semenza, G. L. (1999) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.15.1.551 · Cited by 1,914
The enzymatic conversion of heme to bilirubin by microsomal heme oxygenase.
Tenhunen, R., Marver, H. S., & Schmid, R. (1968) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.61.2.748 · Cited by 1,803
Hamer, D. H. (1986) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.55.070186.004405 · Cited by 1,800
Sorokin, S. P. (1983) · Histology · doi:10.1007/978-1-349-06859-3_23 · Cited by 1,782
Nrf2–Keap1 defines a physiologically important stress response mechanism
Motohashi, H., & Yamamoto, M. (2004) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2004.09.003 · Cited by 1,725
Heme oxygenase: Function, multiplicity, regulatory mechanisms, and clinical applications
Maines, M. D. (1988) · The FASEB Journal · doi:10.1096/fasebj.2.10.3290025 · Cited by 1,707
Wink, D. A., & Mitchell, J. B. (1998) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(98)00092-6 · Cited by 1,606
Carbon Monoxide: a Putative Neural Messenger
Verma, A., Hirsch, D. J., Glatt, C. E., Ronnett, G. V., & Snyder, S. H. (1993) · Science · doi:10.1126/science.7678352 · Cited by 1,563
Independent Human MAP-Kinase Signal Transduction Pathways Defined by MEK and MKK Isoforms
Dérijard, B., Raingeaud, J., Barrett, T., Wu, I.-H., Han, J., Ulevitch, R. J., & Davis, R. J. (1995) · Science · doi:10.1126/science.7839144 · Cited by 1,555
Tenhunen, R., Marver, H. S., & Schmid, R. (1969) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)63477-5 · Cited by 1,357
FERRITIN: STRUCTURE, GENE REGULATION, AND CELLULAR FUNCTION IN ANIMALS, PLANTS, AND MICROORGANISMS
Theil, E. C. (1987) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.56.070187.001445 · Cited by 1,350
Tremblay, L., Valenza, F., Ribeiro, S. P., Li, J., & Slutsky, A. S. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119259 · Cited by 1,330
Yan, S. D., Schmidt, A. M., Anderson, G. M., Zhang, J., Brett, J., Zou, Y. S., Pinsky, D., & Stern, D. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)36966-1 · Cited by 1,306
Reduced stress defense in heme oxygenase 1-deficient cells
Poss, K. D., & Tonegawa, S. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.20.10925 · Cited by 1,291
Nrf2, a Cap'n'Collar Transcription Factor, Regulates Induction of the Heme Oxygenase-1 Gene
Alam, J., Stewart, D., Touchard, C., Boinapally, S., Choi, A. M. K., & Cook, J. L. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.37.26071 · Cited by 1,285
Self-citationRaingeaud, J., Whitmarsh, A. J., Barrett, T., Dérijard, B., & Davis, R. J. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.3.1247 · Cited by 1,278
Keyse, S. M., & Tyrrell, R. M. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.1.99 · Cited by 1,264
Oxidative stress causes enhanced endothelial cell injury in human heme oxygenase-1 deficiency
Yachie, A., Niida, Y., Wada, T., Igarashi, N., Kaneda, H., Toma, T., Ohta, K., Kasahara, Y., & Koizumi, S. (1999) · Journal of Clinical Investigation · doi:10.1172/jci4165 · Cited by 1,255
Keap1 Is a Redox-Regulated Substrate Adaptor Protein for a Cul3-Dependent Ubiquitin Ligase Complex
Zhang, D. D., Lo, S.-C., Cross, J. V., Templeton, D. J., & Hannink, M. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.24.10941-10953.2004 · Cited by 1,254
Ignarro, L. J., Byrns, R. E., Buga, G. M., & Wood, K. S. (1987) · Circulation Research · doi:10.1161/01.res.61.6.866 · Cited by 1,179
Oxygen sensing and molecular adaptation to hypoxia
Bunn, H. F., & Poyton, R. O. (1996) · Physiological Reviews · doi:10.1152/physrev.1996.76.3.839 · Cited by 1,172
McMahon, M., Itoh, K., Yamamoto, M., & Hayes, J. D. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m300931200 · Cited by 1,141
Choi, A. M., & Alam, J. (1996) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/ajrcmb.15.1.8679227 · Cited by 1,126
Self-citationFerritin: a cytoprotective antioxidant strategem of endothelium.
Balla, G., Jacob, H. S., Balla, J., Rosenberg, M., Nath, K., Apple, F., Eaton, J. W., & Vercellotti, G. M. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)37165-0 · Cited by 1,097
Biliverdin reductase: A major physiologic cytoprotectant
Barañano, D. E., Rao, M., Ferris, C. D., & Snyder, S. H. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.252626999 · Cited by 1,088
Sounding the Alarm: Protein Kinase Cascades Activated by Stress and Inflammation
Kyriakis, J. M., & Avruch, J. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.40.24313 · Cited by 1,084
BALOGUN, E., HOQUE, M., GONG, P., KILLEEN, E., GREEN, C. J., FORESTI, R., ALAM, J., & MOTTERLINI, R. (2003) · Biochemical Journal · doi:10.1042/bj20021619 · Cited by 1,036
Self-citationThe glucose-regulated proteins: stress induction and clinical applications
Lee, A. S. (2001) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(01)01908-9 · Cited by 1,032
Heme oxygenase-1 mediates the anti-inflammatory effect of interleukin-10 in mice
Lee, T.-S., & Chau, L.-Y. (2002) · Nature Medicine · doi:10.1038/nm0302-240 · Cited by 1,019
Heme oxygenase 1 is required for mammalian iron reutilization
Poss, K. D., & Tonegawa, S. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.20.10919 · Cited by 1,016
Role of Akt Signaling in Vascular Homeostasis and Angiogenesis
Shiojima, I., & Walsh, K. (2002) · Circulation Research · doi:10.1161/01.res.0000022200.71892.9f · Cited by 1,012
Oxidation of toxic and carcinogenic chemicals by human cytochrome P-450 enzymes
Guengerich, F. P., & Shimada, T. (1991) · Chemical Research in Toxicology · doi:10.1021/tx00022a001 · Cited by 1,000
Carbon Monoxide-Releasing Molecules: Characterization of Biochemical and Vascular Activities
Motterlini, R., Clark, J. E., Foresti, R., Sarathchandra, P., Mann, B. E., & Green, C. J. (2002) · Circulation Research · doi:10.1161/hh0202.104530 · Cited by 998
Wakabayashi, N., Dinkova-Kostova, A. T., Holtzclaw, W. D., Kang, M.-I., Kobayashi, A., Yamamoto, M., Kensler, T. W., & Talalay, P. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0307301101 · Cited by 986
Cullinan, S. B., Gordan, J. D., Jin, J., Harper, J. W., & Diehl, J. A. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.19.8477-8486.2004 · Cited by 986
Carbon Monoxide Generated by Heme Oxygenase 1 Suppresses Endothelial Cell Apoptosis
Brouard, S., Otterbein, L. E., Anrather, J., Tobiasch, E., Bach, F. H., Choi, A. M. K., & Soares, M. P. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.192.7.1015 · Cited by 984
Self-citationItoh, K., Tong, K. I., & Yamamoto, M. (2004) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2004.02.075 · Cited by 864
Motterlini, R., Foresti, R., Bassi, R., & Green, C. J. (2000) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(00)00294-x · Cited by 846
Mccoubrey, W. K., Huang, T. J., & Maines, M. D. (1997) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1997.00725.x · Cited by 823
The heme synthesis and degradation pathways: role in oxidant sensitivity
Ryter, S. W., & Tyrrell, R. M. (2000) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(99)00223-3 · Cited by 820
Self-citationItoh, K., Wakabayashi, N., Katoh, Y., Ishii, T., O'Connor, T., & Yamamoto, M. (2003) · Genes to Cells · doi:10.1046/j.1365-2443.2003.00640.x · Cited by 816
Protein phosphatases and the regulation of mitogen-activated protein kinase signalling
Keyse, S. M. (2000) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(99)00075-7 · Cited by 807
Craig, E. A., & Schlesinger, M. J. (1985) · Critical Reviews in Biochemistry · doi:10.3109/10409238509085135 · Cited by 801
Lee, P. J., Jiang, B.-H., Chin, B. Y., Iyer, N. V., Alam, J., Semenza, G. L., & Choi, A. K. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.9.5375 · Cited by 782
Self-citationESTEBAN, A., ANZUETO, A., ALÍA, I., GORDO, F., APEZTEGUÍA, C., PÁLIZAS, F., CIDE, D., GOLDWASER, R., SOTO, L., BUGEDO, G., et al. (2000) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.161.5.9902018 · Cited by 780
Antioxidant activity of albumin-bound bilirubin.
Stocker, R., Glazer, A. N., & Ames, B. N. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.16.5918 · Cited by 766
Maines, M. D., Trakshel, G. M., & Kutty, R. K. (1986) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)42488-4 · Cited by 759
Hyperoxia increases oxygen radical production in rat lungs and lung mitochondria.
Freeman, B. A., & Crapo, J. D. (1981) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)68544-3 · Cited by 758
THE PROTEIN KINASE C FAMILY: HETEROGENEITY AND ITS IMPLICATIONS
Kikkawa, U., Kishimoto, A., & Nishizuka, Y. (1989) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.58.070189.000335 · Cited by 743
Smooth muscle cell-derived carbon monoxide is a regulator of vascular cGMP.
Morita, T., Perrella, M. A., Lee, M. E., & Kourembanas, S. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.5.1475 · Cited by 707
The molecular mechanisms of the metabolism and transport of iron in normal and neoplastic cells
Richardson, D. R., & Ponka, P. (1997) · Biochimica et Biophysica Acta (BBA) - Reviews on Biomembranes · doi:10.1016/s0304-4157(96)00014-7 · Cited by 704
Martin, D., Rojo, A. I., Salinas, M., Diaz, R., Gallardo, G., Alam, J., de Galarreta, C. M. R., & Cuadrado, A. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m309660200 · Cited by 700
Self-citationDoré, S., Takahashi, M., Ferris, C. D., Hester, L. D., Guastella, D., & Snyder, S. H. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.5.2445 · Cited by 699
Cardioprotective Actions by a Water-Soluble Carbon Monoxide–Releasing Molecule
Clark, J. E., Naughton, P., Shurey, S., Green, C. J., Johnson, T. R., Mann, B. E., Foresti, R., & Motterlini, R. (2003) · Circulation Research · doi:10.1161/01.res.0000084381.86567.08 · Cited by 673
Oyake, T., Itoh, K., Motohashi, H., Hayashi, N., Hoshino, H., Nishizawa, M., Yamamoto, M., & Igarashi, K. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.11.6083 · Cited by 656
I RON R EGULATORY P ROTEINS AND THE M OLECULAR C ONTROL OF M AMMALIAN I RON M ETABOLISM
Eisenstein, R. S. (2000) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.20.1.627 · Cited by 653
PULMONARY OXYGEN TOXICITY: A REVIEW
Clark, J. M., & Lambertsen, C. J. (1971) · Pharmacological Reviews · doi:10.1016/s0031-6997(25)06887-5 · Cited by 649
Stone, J. R., & Marletta, M. A. (1994) · Biochemistry · doi:10.1021/bi00184a036 · Cited by 647
Hemoprotein Bach1 regulates enhancer availability of heme oxygenase‐1 gene
Sun, J., Hoshino, H., Takaku, K., Nakajima, O., Muto, A., Suzuki, H., Tashiro, S., Takahashi, S., Shibahara, S., Alam, J., et al. (2002) · The EMBO Journal · doi:10.1093/emboj/cdf516 · Cited by 637
Self-citationInduction of heme oxygenase: a general response to oxidant stress in cultured mammalian cells.
Applegate, L. A., Lüscher, P., & Tyrrell, R. M. (1991) · PubMed · Cited by 629
Hepatology. A Textbook of Liver Disease
(1990) · Annals of Internal Medicine · doi:10.7326/0003-4819-113-3-259_2 · Cited by 621
Expression of heme oxygenase-1 can determine cardiac xenograft survival
Soares, M. P., Lin, Y., Anrather, J., Csizmadia, E., Takigami, K., Sato, K., Grey, S. T., Colvin, R. B., Choi, A. M., Poss, K. D., et al. (1998) · Nature Medicine · doi:10.1038/2063 · Cited by 612
Self-citationCowan, K. J., & Storey, K. B. (2003) · Journal of Experimental Biology · doi:10.1242/jeb.00220 · Cited by 593
Balla, J., Jacob, H. S., Balla, G., Nath, K., Eaton, J. W., & Vercellotti, G. M. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.20.9285 · Cited by 591
Yamada, N., Yamaya, M., Okinaga, S., Nakayama, K., Sekizawa, K., Shibahara, S., & Sasaki, H. (2000) · The American Journal of Human Genetics · doi:10.1086/302729 · Cited by 568
Venugopal, R., & Jaiswal, A. K. (1998) · Oncogene · doi:10.1038/sj.onc.1202237 · Cited by 564
PRINCIPLES AND PRACTICE OF MECHANICAL VENTILATION
Tobin, M. J. (1996) · Shock · doi:10.1097/00024382-199601000-00018 · Cited by 562
LEVONEN, A.-L., LANDAR, A., RAMACHANDRAN, A., CEASER, E. K., DICKINSON, D. A., ZANONI, G., MORROW, J. D., & DARLEY-USMAR, V. M. (2004) · Biochemical Journal · doi:10.1042/bj20031049 · Cited by 560
Stress protein systems of mammalian cells
Subjeck, J. R., & Shyy, T. T. (1986) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1986.250.1.c1 · Cited by 557
Wegenka, U. M., Buschmann, J., Lütticken, C., Heinrich, P. C., & Horn, F. (1993) · Molecular and Cellular Biology · doi:10.1128/mcb.13.1.276 · Cited by 552
Interleukin-10 Signaling Blocks Inhibitor of κB Kinase Activity and Nuclear Factor κB DNA Binding
Schottelius, A. J. G., Mayo, M. W., Sartor, R. B., & Baldwin, A. S. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.45.31868 · Cited by 532
Ogawa, K. (2001) · The EMBO Journal · doi:10.1093/emboj/20.11.2835 · Cited by 528
Otterbein, L. E., Zuckerbraun, B. S., Haga, M., Liu, F., Song, R., Usheva, A., Stachulak, C., Bodyak, N., Smith, R. N., Csizmadia, E., et al. (2003) · Nature Medicine · doi:10.1038/nm817 · Cited by 526
Self-citationHeme oxygenase-1 protects against vascular constriction and proliferation
Duckers, H. J., Boehm, M., True, A. L., Yet, S.-F., San, H., Park, J. L., Clinton Webb, R., Lee, M.-E., Nabel, G. J., & Nabel, E. G. (2001) · Nature Medicine · doi:10.1038/89068 · Cited by 525
Katoh, Y., Itoh, K., Yoshida, E., Miyagishi, M., Fukamizu, A., & Yamamoto, M. (2001) · Genes to Cells · doi:10.1046/j.1365-2443.2001.00469.x · Cited by 520
Heme oxygenase 1 mediates an adaptive response to oxidative stress in human skin fibroblasts.
Vile, G. F., Basu-Modak, S., Waltner, C., & Tyrrell, R. M. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.7.2607 · Cited by 517
Current Protocols in Toxicology
(2001) · John Wiley & Sons, Inc. eBooks · doi:10.1002/0471140856 · Cited by 513
Haem oxygenase-1 prevents cell death by regulating cellular iron
Ferris, C. D., Jaffrey, S. R., Sawa, A., Takahashi, M., Brady, S. D., Barrow, R. K., Tysoe, S. A., Wolosker, H., Barañano, D. E., Doré, S., et al. (1999) · Nature Cell Biology · doi:10.1038/11072 · Cited by 509
Neuzil, J., & Stocker, R. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)89449-8 · Cited by 508
CHIUMELLO, D., PRISTINE, G., & SLUTSKY, A. S. (1999) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.160.1.9803046 · Cited by 505
Heme oxygenase/carbon monoxide signaling pathways: Regulation and functional significance
Ryter, S. W., Otterbein, L. E., Morse, D., & Choi, A. M. K. (2002) · Molecular and Cellular Biochemistry · doi:10.1023/a:1015957026924 · Cited by 497
Self-citationTranscriptional regulation by the MAP kinase signaling cascades
Yang, S.-H., Sharrocks, A. D., & Whitmarsh, A. J. (2003) · Gene · doi:10.1016/s0378-1119(03)00816-3 · Cited by 494
Otterbein, L. E., Kolls, J. K., Mantell, L. L., Cook, J. L., Alam, J., & Choi, A. M. K. (1999) · Journal of Clinical Investigation · doi:10.1172/jci5342 · Cited by 492
Self-citationThe role of PI3K in immune cells
Koyasu, S. (2003) · Nature Immunology · doi:10.1038/ni0403-313 · Cited by 487
Grasso, S., Mascia, L., Del Turco, M., Malacarne, P., Giunta, F., Brochard, L., Slutsky, A. S., & Marco Ranieri, V. (2002) · Anesthesiology · doi:10.1097/00000542-200204000-00005 · Cited by 482
Association of low serum concentration of bilirubin with increased risk of coronary artery disease
Schwertner, H. A., Jackson, W. G., & Tolan, G. (1994) · Clinical Chemistry · doi:10.1093/clinchem/40.1.18 · Cited by 474
Amersi, F., Buelow, R., Kato, H., Ke, B., Coito, A. J., Shen, X.-D., Zhao, D., Zaky, J., Melinek, J., Lassman, C. R., et al. (1999) · Journal of Clinical Investigation · doi:10.1172/jci7903 · Cited by 474
Self-citationIdentification of Activating Transcription Factor 4 (ATF4) as an Nrf2-interacting Protein
He, C. H., Gong, P., Hu, B., Stewart, D., Choi, M. E., Choi, A. M. K., & Alam, J. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m101198200 · Cited by 473
Self-citationActivation of c-Jun N-terminal kinase in bacterial lipopolysaccharide-stimulated macrophages.
Hambleton, J., Weinstein, S. L., Lem, L., & DeFranco, A. L. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.7.2774 · Cited by 470
Furchgott, R. F., & Jothianandan, D. (1991) · Journal of Vascular Research · doi:10.1159/000158843 · Cited by 469
Zhuo, M., Small, S. A., Kandel, E. R., & Hawkins, R. D. (1993) · Science · doi:10.1126/science.8100368 · Cited by 467
Soares, M. P., Seldon, M. P., Gregoire, I. P., Vassilevskaia, T., Berberat, P. O., Yu, J., Tsui, T.-Y., & Bach, F. H. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.172.6.3553 · Cited by 465
Stewart, D., Killeen, E., Naquin, R., Alam, S., & Alam, J. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m209195200 · Cited by 463
Self-citationSato, K., Balla, J., Otterbein, L., Smith, R. N., Brouard, S., Lin, Y., Csizmadia, E., Sevigny, J., Robson, S. C., Vercellotti, G., et al. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.166.6.4185 · Cited by 461
Self-citationHemoxygenase-2 Is an Oxygen Sensor for a Calcium-Sensitive Potassium Channel
Williams, S. E. J., Wootton, P., Mason, H. S., Bould, J., Iles, D. E., Riccardi, D., Peers, C., & Kemp, P. J. (2004) · Science · doi:10.1126/science.1105010 · Cited by 458
Hosenpud, J. D., Bennett, L. E., Keck, B. M., Boucek, M. M., & Novick, R. J. (2000) · The Journal of Heart and Lung Transplantation · doi:10.1016/s1053-2498(00)00138-8 · Cited by 457
Cloning and expression of cDNA for rat heme oxygenase.
Shibahara, S., Müller, R., Taguchi, H., & Yoshida, T. (1985) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.82.23.7865 · Cited by 452
Carbon monoxide provides protection against hyperoxic lung injury
Otterbein, L. E., Mantell, L. L., & Choi, A. M. K. (1999) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.1999.276.4.l688 · Cited by 436
Self-citationNPAS2: A Gas-Responsive Transcription Factor
Dioum, E. M., Rutter, J., Tuckerman, J. R., Gonzalez, G., Gilles-Gonzalez, M.-A., & McKnight, S. L. (2002) · Science · doi:10.1126/science.1078456 · Cited by 432
Does carbon monoxide have a physiological function?
Marks, G. S., Brien, J. F., Nakatsu, K., & McLaughlin, B. E. (1991) · Trends in Pharmacological Sciences · doi:10.1016/0165-6147(91)90544-3 · Cited by 425
Heme oxygenase-1 is associated with the neurofibrillary pathology of Alzheimer's disease.
Smith, M. A., Kutty, R. K., Richey, P. L., Yan, S. D., Stern, D., Chader, G. J., Wiggert, B. O., Petersen, R. B., & Perry, G. L. (1994) · PubMed · Cited by 424
Reversal of HO‐1 related cytoprotection with increased expression is due to reactive iron
Suttner, D. M., & Dennery, P. A. (1999) · The FASEB Journal · doi:10.1096/fasebj.13.13.1800 · Cited by 424
The laws of combination of hæmoglobin with carbon monoxide and oxygen
Douglas, C. G., Haldane, J. B. S., & Haldane, J. B. S. (1912) · The Journal of Physiology · doi:10.1113/jphysiol.1912.sp001517 · Cited by 424
Evolution of bronchoalveolar cell populations in the adult respiratory distress syndrome.
Steinberg, K. P., Milberg, J. A., Martin, T. R., Maunder, R. J., Cockrill, B. A., & Hudson, L. D. (1994) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.150.1.8025736 · Cited by 423
Yet, S.-F., Tian, R., Layne, M. D., Wang, Z. Y., Maemura, K., Solovyeva, M., Ith, B., Melo, L. G., Zhang, L., Ingwall, J. S., et al. (2001) · Circulation Research · doi:10.1161/hh1401.093314 · Cited by 420
Obliterative bronchiolitis after lung and heart-lung transplantation
Bando, K., Paradis, I. L., Similo, S., Konishi, H., Komatsu, K., Zullo, T. G., Yousem, S. A., Close, J. M., Zeevi, A., Duquesnoy, R. J., et al. (1995) · The Journal of Thoracic and Cardiovascular Surgery · doi:10.1016/s0022-5223(05)80003-0 · Cited by 418
Transcriptional control of rat heme oxygenase by heat shock.
Shibahara, S., Müller, R. M., & Taguchi, H. (1987) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)45138-1 · Cited by 412
Hypoxia induces severe right ventricular dilatation and infarction in heme oxygenase-1 null mice
Yet, S.-F., Perrella, M. A., Layne, M. D., Hsieh, C.-M., Maemura, K., Kobzik, L., Wiesel, P., Christou, H., Kourembanas, S., & Lee, M.-E. (1999) · Journal of Clinical Investigation · doi:10.1172/jci6163 · Cited by 410
Mechanism of Heme Oxygenase-1 Gene Activation by Cadmium in MCF-7 Mammary Epithelial Cells
Alam, J., Wicks, C., Stewart, D., Gong, P., Touchard, C., Otterbein, S., Choi, A. M. K., Burow, M. E., & Tou, J.-S. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m004729200 · Cited by 407
Self-citationVile, G. F., & Tyrrell, R. M. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)82386-9 · Cited by 406
Lavrovsky, Y., Schwartzman, M. L., Levere, R. D., Kappas, A., & Abraham, N. G. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.13.5987 · Cited by 403
Zakhary, R., Gaine, S. P., Dinerman, J. L., Ruat, M., Flavahan, N. A., & Snyder, S. H. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.2.795 · Cited by 401
Cytochrome and cytochrome oxidase
Keilin, D., Hartree, E. F., & Hartree, E. F. (1939) · Proceedings of the Royal Society of London. Series B - Biological Sciences · doi:10.1098/rspb.1939.0016 · Cited by 400
Fujita, T., Toda, K., Karimova, A., Yan, S.-F., Naka, Y., Yet, S.-F., & Pinsky, D. J. (2001) · Nature Medicine · doi:10.1038/87929 · Cited by 398
The reaction of NO· with O2·− and HO2·−: A pulse radiolysis study
Goldstein, S., & Czapski, G. (1995) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(95)00034-u · Cited by 398
Ishii, T., Itoh, K., Ruiz, E., Leake, D. S., Unoki, H., Yamamoto, M., & Mann, G. E. (2004) · Circulation Research · doi:10.1161/01.res.0000119171.44657.45 · Cited by 398
The enzymatic catabolism of hemoglobin: stimulation of microsomal heme oxygenase by hemin.
Tenhunen, R., Marver, H. S., & Schmid, R. (1970) · PubMed · Cited by 392
Carbon monoxide in biology and medicine
Ryter, S. W., & Otterbein, L. E. (2004) · BioEssays · doi:10.1002/bies.20005 · Cited by 392
Self-citationHeme oxygenase-1-derived bilirubin ameliorates postischemic myocardial dysfunction
Clark, J. E., Foresti, R., Sarathchandra, P., Kaur, H., Green, C. J., & Motterlini, R. (2000) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.2000.278.2.h643 · Cited by 392
Sawle, P., Foresti, R., Mann, B. E., Johnson, T. R., Green, C. J., & Motterlini, R. (2005) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0706241 · Cited by 391
CORM‐A1: a new pharmacologically active carbon monoxide‐releasing molecule
Motterlini, R., Sawle, P., Bains, S., Hammad, J., Alberto, R., Foresti, R., & Green, C. J. (2005) · The FASEB Journal · doi:10.1096/fj.04-2169fje · Cited by 385
Suppression of Inflammatory Cytokine Production by Carbon Monoxide Involves the JNK Pathway and AP-1
Morse, D., Pischke, S. E., Zhou, Z., Davis, R. J., Flavell, R. A., Loop, T., Otterbein, S. L., Otterbein, L. E., & Choi, A. M. K. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m302942200 · Cited by 373
Self-citationMinamino, T., Christou, H., Hsieh, C.-M., Liu, Y., Dhawan, V., Abraham, N. G., Perrella, M. A., Mitsialis, S. A., & Kourembanas, S. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.161272598 · Cited by 366
The Endothelial Nitric-oxide Synthase-Caveolin Regulatory Cycle
Feron, O., Saldana, F., Michel, J. B., & Michel, T. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.6.3125 · Cited by 361
Expression of heme oxygenase‐1 in the senescent and alzheimer‐diseased brain
Schipper, H. M., Cissé, S., & Stopa, E. G. (1995) · Annals of Neurology · doi:10.1002/ana.410370609 · Cited by 356
Sensitizing soluble guanylyl cyclase to become a highly CO-sensitive enzyme.
Friebe, A., Schultz, G., & Koesling, D. (1996) · The EMBO Journal · doi:10.1002/j.1460-2075.1996.tb01078.x · Cited by 352
Morita, T., & Kourembanas, S. (1995) · Journal of Clinical Investigation · doi:10.1172/jci118334 · Cited by 350
Dandekar, T., Stripecke, R., Gray, N. K., Goossen, B., Constable, A., Johansson, H. E., & Hentze, M. W. (1991) · The EMBO Journal · doi:10.1002/j.1460-2075.1991.tb07716.x · Cited by 348
Electromagnetic Properties of Hemoproteins
Yonetani, T., Yamamoto, H., Erman, J. E., Leigh, J. S., & Reed, G. H. (1972) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)45449-5 · Cited by 344
Yu, R., Chen, C., Mo, Y.-Y., Hebbar, V., Owuor, E. D., Tan, T.-H., & Kong, A.-N. T. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m004037200 · Cited by 340
Hyperventilation Induces Release of Cytokines from Perfused Mouse Lung
von BETHMANN, A. N., BRASCH, F., NÜSING, R., VOGT, K., VOLK, H. D., MÜLLER, K.-M., WENDEL, A., & UHLIG, S. (1998) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.157.1.9608052 · Cited by 340
Casey, J. L., Koeller, D. M., Ramin, V. C., Klausner, R. D., & Harford, J. B. (1989) · The EMBO Journal · doi:10.1002/j.1460-2075.1989.tb08544.x · Cited by 338
Metals as Regulators of Heme Metabolism
Maines, M. D., & Kappas, A. (1977) · Science · doi:10.1126/science.337492 · Cited by 336
Laminar Flow Induction of Antioxidant Response Element-mediated Genes in Endothelial Cells
Chen, X.-L., Varner, S. E., Rao, A. S., Grey, J. Y., Thomas, S., Cook, C. K., Wasserman, M. A., Medford, R. M., Jaiswal, A. K., & Kunsch, C. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m203161200 · Cited by 333
Carbon Monoxide Controls the Proliferation of Hypoxic Vascular Smooth Muscle Cells
Morita, T., Mitsialis, S. A., Koike, H., Liu, Y., & Kourembanas, S. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.52.32804 · Cited by 332
Carbon monoxide‐induced vasorelaxation and the underlying mechanisms
Wang, R., Wang, Z., & Wu, L. (1997) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0701222 · Cited by 331
Juan, S.-H., Lee, T.-S., Tseng, K.-W., Liou, J.-Y., Shyue, S.-K., Wu, K. K., & Chau, L.-Y. (2001) · Circulation · doi:10.1161/hc3801.095663 · Cited by 331
Durante, W., Kroll, M. H., Christodoulides, N., Peyton, K. J., & Schafer, A. I. (1997) · Circulation Research · doi:10.1161/01.res.80.4.557 · Cited by 329
Nakaso, K., Yano, H., Fukuhara, Y., Takeshima, T., Wada-Isoe, K., & Nakashima, K. (2003) · FEBS Letters · doi:10.1016/s0014-5793(03)00517-9 · Cited by 326
Caffeic Acid Phenethyl Ester and Curcumin: A Novel Class of Heme Oxygenase-1 Inducers
Scapagnini, G., Foresti, R., Calabrese, V., Stella, A. M. G., Green, C. J., & Motterlini, R. (2002) · Molecular Pharmacology · doi:10.1016/s0026-895x(24)12118-9 · Cited by 323
Muramoto, T., Kohchi, T., Yokota, A., Hwang, I., & Goodman, H. M. (1999) · The Plant Cell · doi:10.1105/tpc.11.3.335 · Cited by 323
Induction of Haem Oxygenase as a Defence Against Oxidative Stress
Stocker, R. (1990) · Free Radical Research Communications · doi:10.3109/10715769009148577 · Cited by 322
Motterlini, R., Foresti, R., Intaglietta, M., & Winslow, R. M. (1996) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1996.270.1.h107 · Cited by 317
Human heme oxygenase cDNA and induction of its mRNA by hemin
YOSHIDA, T., BIRO, P., COHEN, T., MÜLLER, R. M., & SHIBAHARA, S. (1988) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1988.tb13811.x · Cited by 317
Numazawa, S., Ishikawa, M., Yoshida, A., Tanaka, S., & Yoshida, T. (2003) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00043.2003 · Cited by 317
Transcriptional Regulation of the Heme Oxygenase-1 Gene Via the Stress Response Element Pathway
Alam, J., & Cook, J. (2003) · Current Pharmaceutical Design · doi:10.2174/1381612033453730 · Cited by 315
Self-citationChen, Y.-H., Lin, S.-J., Lin, M.-W., Tsai, H.-L., Kuo, S.-S., Chen, J.-W., Charng, M.-J., Wu, T.-C., Chen, L.-C., Ding, P., et al. (2002) · Human Genetics · doi:10.1007/s00439-002-0769-4 · Cited by 314
Clark, J., Foresti, R., Green, C. J., & Motterlini, R. (2000) · Biochemical Journal · doi:10.1042/0264-6021:3480615 · Cited by 313
Regulation of ferritin and heme oxygenase synthesis in rat fibroblasts by different forms of iron.
Eisenstein, R. S., Garcia-Mayol, D., Pettingell, W., & Munro, H. N. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.3.688 · Cited by 308
Heme Oxygenase: Recent Advances in Understanding Its Regulation and Role
Elbirt, K. K., & Bonkovsky, H. L. (1999) · Proceedings of the Association of American Physicians · doi:10.1111/paa.1999.111.5.438 · Cited by 308
Brouard, S., Berberat, P. O., Tobiasch, E., Seldon, M. P., Bach, F. H., & Soares, M. P. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m108317200 · Cited by 306
Crystal structure of human heme oxygenase-1.
Poulos, T. L., Schuller, D. J., Wilks, A., & de Montellano, P. R. O. (1999) · Nature Structural Biology · doi:10.1038/12319 · Cited by 303
Vasoactive properties of CORM‐3, a novel water‐soluble carbon monoxide‐releasing molecule
Foresti, R., Hammad, J., Clark, J. E., Johnson, T. R., Mann, B. E., Friebe, A., Green, C. J., & Motterlini, R. (2004) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0705825 · Cited by 303
Horvath, I., Donnelly, L. E., Kiss, A., Paredi, P., Kharitonov, S. A., & Barnes, P. J. (1998) · Thorax · doi:10.1136/thx.53.8.668 · Cited by 302
Gene regulation of heme oxygenase-1 as a therapeutic target
Immenschuh, S., & Ramadori, G. (2000) · Biochemical Pharmacology · doi:10.1016/s0006-2952(00)00443-3 · Cited by 301
Purification and characterization of biliverdin reductase from rat liver.
Kutty, R. K., & Maines, M. D. (1981) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)69552-9 · Cited by 300
Llesuy, S. F., & Tomaro, M. L. (1994) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/0167-4889(94)90067-1 · Cited by 297
Heme Oxygenase-1 Inhibits Atherosclerotic Lesion Formation in LDL-Receptor Knockout Mice
Ishikawa, K., Sugawara, D., Wang, X.-P., Suzuki, K., Itabe, H., Maruyama, Y., & Lusis, A. J. (2001) · Circulation Research · doi:10.1161/01.res.88.5.506 · Cited by 295
Foresti, R., Clark, J. E., Green, C. J., & Motterlini, R. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.29.18411 · Cited by 294
Heme oxygenase-1 inhibits TNF-α-induced apoptosis in cultured fibroblasts
Petrache, I., Otterbein, L. E., Alam, J., Wiegand, G. W., & Choi, A. M. K. (2000) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.2000.278.2.l312 · Cited by 293
Self-citationJuo, P., Kuo, C. J., Reynolds, S. E., Konz, R. F., Raingeaud, J., Davis, R. J., Biemann, H.-P., & Blenis, J. (1997) · Molecular and Cellular Biology · doi:10.1128/mcb.17.1.24 · Cited by 290
Zhang, X., Shan, P., Otterbein, L. E., Alam, J., Flavell, R. A., Davis, R. J., Choi, A. M. K., & Lee, P. J. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m208419200 · Cited by 288
Self-citationEvidence suggesting that the two forms of heme oxygenase are products of different genes.
Cruse, I., & Maines, M. D. (1988) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)69078-7 · Cited by 286
Risk factors for the development of obliterative bronchiolitis after lung transplantation.
Girgis, R. E., Tu, I., Berry, G. J., Reichenspurner, H. C., Valentine, V. G., Conte, J. V., Ting, A., Johnstone, I., Miller, J. L., Robbins, R. C., et al. (1996) · PubMed · Cited by 283
IsdG and IsdI, Heme-degrading Enzymes in the Cytoplasm of Staphylococcus aureus
Skaar, E. P., Gaspar, A. H., & Schneewind, O. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m307952200 · Cited by 282
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Motterlini, R., & Otterbein, L. E. (2010) · Nature Reviews Drug Discovery · doi:10.1038/nrd3228 · Cited by 1,638
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Metadata
- Authors
- Ryter, S. W., Alam, J., & Choi, A. M. K.
- Venue
- Physiological Reviews
- Publisher
- American Physiological Society
- Published
- 2006-04
- Volume
- 86
- Issue
- 2
- Pages
- 583-650
- ISSN
- 0031-9333 (ISSN-L)
- 1522-1210
- OpenAlex
- W2005904261
- Cited by
- 2,307
- References
- 716
- FWCI
- 6.74
- Type
- journal article
- Language
- en
- Open access
- closed
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