Long-term space flight simulation reveals infradian rhythmicity in human Na(+) balance
Open accessAbstract
The steady-state concept of Na(+) homeostasis, based on short-term investigations of responses to high salt intake, maintains that dietary Na(+) is rapidly eliminated into urine, thereby achieving constant total-body Na(+) and water content. We introduced the reverse experimental approach by fixing salt intake of men participating in space flight simulations at 12 g, 9 g, and 6 g/day for months and tested for the predicted constancy in urinary excretion and total-body Na(+) content. At constant salt intake, daily Na(+) excretion exhibited aldosterone-dependent, weekly (circaseptan) rhythms, resulting in periodic Na(+) storage. Changes in total-body Na(+) (±200-400 mmol) exhibited longer infradian rhythm periods (about monthly and longer period lengths) without parallel changes in body weight and extracellular water and were directly related to urinary aldosterone excretion and inversely to urinary cortisol, suggesting rhythmic hormonal control. Our findings define rhythmic Na(+) excretory and retention patterns independent of blood pressure or body water, which occur independent of salt intake.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Primates including humans possess hormonal cycles with monthly periodicity.
“primates including humans clearly possess hormonal cycles with monthly periodicity”
From An Overview of Monthly Rhythms and Clocks (2017) · cites this paper as [89]
Hormonal cycles are not limited to females, but can occur in males as well.
“Recent data from human males who were kept isolated in a highly controlled environment indicates that such hormonal cycles are not limited to females, but can occur in males as well (89)”
From An Overview of Monthly Rhythms and Clocks (2017) · cites this paper as [89]
Cites
Organization for physiological homeostasis
Cannon, W. B. (1929) · Physiological Reviews · doi:10.1152/physrev.1929.9.3.399 · Cited by 1,844 · see citing works
Machnik, A., Neuhofer, W., Jantsch, J., Dahlmann, A., Tammela, T., Machura, K., Park, J.-K., Beck, F.-X., Müller, D. N., Derer, W., et al. (2009) · Nature Medicine · doi:10.1038/nm.1960 · Cited by 953 · see citing works
Aschoff, J. (1965) · Science · doi:10.1126/science.148.3676.1427 · Cited by 752 · see citing works
Circadian Systems: Entrainment
Pittendrigh, C. S. (1981) · Springer eBooks · doi:10.1007/978-1-4615-6552-9_7 · Cited by 556 · see citing works
Doi, M., Takahashi, Y., Komatsu, R., Yamazaki, F., Yamada, H., Haraguchi, S., Emoto, N., Okuno, Y., Tsujimoto, G., Kanematsu, A., et al. (2010) · Nature Medicine · doi:10.1038/nm.2061 · Cited by 431 · see citing works
Age as a determinant of renal sodium conservation in normal man.
Kirkendall, A. M., Connor, W. E., Abboud, F. M., Rastogi, S., Anderson, T. A., & Fry, M. M. (1976) · PubMed · Cited by 429 · see citing works
GUYTON, A. C., COLEMAN, T. G., COWLEY, A. W., MANNING, R. D., NORMAN, R. A., & FERGUSON, J. D. (1974) · Circulation Research · doi:10.1161/01.res.35.2.159 · Cited by 298 · see citing works
High dietary sodium chloride consumption may not induce body fluid retention in humans
Heer, M., Baisch, F., Kropp, J., Gerzer, R., & Drummer, C. (2000) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.2000.278.4.f585 · Cited by 285 · see citing works
23 Na Magnetic Resonance Imaging of Tissue Sodium
Kopp, C., Linz, P. R., Wachsmuth, L., Dahlmann, A., Horbach, T., Schöfl, C., Renz, W., Santoro, D., Niendorf, T., Müller, D. N., et al. (2011) · Hypertension · doi:10.1161/hypertensionaha.111.183517 · Cited by 265 · see citing works
Osmotically inactive skin Na + storage in rats
Titze, J. M., Lang, R., Ilies, C., Schwind, K. H., Kirsch, K. A., Dietsch, P., Luft, F. C., & Hilgers, K. F. (2003) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00200.2003 · Cited by 252 · see citing works
Smith, H. W. (1953) · ETHZ Thomas Mann Archiv · doi:10.24448/ethz-1890 · Cited by 242 · see citing works
THE REGULATION OF ALDOSTERONE SECRETION IN MAN: THE ROLE OF FLUID VOLUME 1
Bartter, F. C., Liddle, G. W., Duncan, L. E., Barber, J. K., & Delea, C. S. (1956) · Journal of Clinical Investigation · doi:10.1172/jci103386 · Cited by 233 · see citing works
Machnik, A., Dahlmann, A., Kopp, C., Goss, J., Wagner, H., van Rooijen, N., Eckardt, K., Müller, D. N., Park, J.-K., Luft, F. C., et al. (2010) · Hypertension · doi:10.1161/hypertensionaha.109.143339 · Cited by 203 · see citing works
Franz Halberg, A., Engeli, M., Hamburger, C., & Hillman, D. (1965) · European Journal of Endocrinology · doi:10.1530/acta.0.050s0005 · Cited by 169 · see citing works
Strauss, M. B. (1958) · A M A Archives of Internal Medicine · doi:10.1001/archinte.1958.00260210013003 · Cited by 161 · see citing works
Estimating dietary sodium intake in individuals receiving a randomly fluctuating intake.
Luft, F. C., Fineberg, N. S., & Sloan, R. S. (1982) · Hypertension · doi:10.1161/01.hyp.4.6.805 · Cited by 160 · see citing works
Sealey, J. E., Bühler, F. R., Laragh, J. H., Manning, E. L., & Brunner, H. R. (1972) · Circulation Research · doi:10.1161/01.res.31.3.367 · Cited by 141 · see citing works
Reduced osmotically inactive Na storage capacity and hypertension in the Dahl model
Titze, J. M., Krause, H., Hecht, H., Dietsch, P., Rittweger, J., Lang, R., Kirsch, K. A., & Hilgers, K. F. (2002) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00323.2001 · Cited by 131 · see citing works
Internal sodium balance in DOCA-salt rats: a body composition study
Titze, J. M., Bauer, K. H., Schafflhuber, M., Dietsch, P., Lang, R., Schwind, K. H., Luft, F. C., Eckardt, K., & Hilgers, K. F. (2005) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00096.2005 · Cited by 128 · see citing works
Lehrbuch der Physiologie des Menschen
Höber, R. (1934) · Springer eBooks · doi:10.1007/978-3-642-91709-7 · Cited by 121 · see citing works
Set point for sodium homeostasis: Surfeit, deficit, and their implications
Hollenberg, N. K. (1980) · Kidney International · doi:10.1038/ki.1980.50 · Cited by 92 · see citing works
A Method for the Detection and Quantification of Impaired Sodium Excretion
D, E. B. M., Plauth, W. H., & Morrow, A. G. (1965) · Circulation · doi:10.1161/01.cir.32.2.223 · Cited by 79 · see citing works
Carey, R. M. (1978) · Circulation Research · doi:10.1161/01.res.43.1.19 · Cited by 76 · see citing works
Leaf, A., Couter, W. T., Lutchansky, M., & Reimer, A. (1949) · Journal of Clinical Investigation · doi:10.1172/jci102139 · Cited by 72 · see citing works
Ziomber, A., Machnik, A., Dahlmann, A., Dietsch, P., Beck, F.-X., Wagner, H., Hilgers, K. F., Luft, F. C., Eckardt, K., & Titze, J. M. (2008) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00531.2007 · Cited by 72 · see citing works
Andersen, K. K., Hartman, D., Peppard, T., Hermann, D. J., Ess, P. J. V., Lefkowitz, M. P., & Trapani, A. J. (2012) · Journal of Clinical Hypertension · doi:10.1111/j.1751-7176.2012.00667.x · Cited by 70 · see citing works
Brown, W. J., Brown, F. K., & Krishan, I. (1971) · Circulation · doi:10.1161/01.cir.43.4.508 · Cited by 61 · see citing works
Sodium homeostasis: Steady states without a set point
Bonventre, J. V., & Leaf, A. (1982) · Kidney International · doi:10.1038/ki.1982.113 · Cited by 45 · see citing works
Schweiger, H., Berger, S., Kretschmer, H., Mörler, H., HALBERG, E., Sothern, R. B., & Franz Halberg, A. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.22.8619 · Cited by 40 · see citing works
Lienhard, D., Lauterburg, M., Escher, G., Frey, F. J., & Frey, B. M. (2012) · PLoS ONE · doi:10.1371/journal.pone.0037898 · Cited by 29 · see citing works
Circaseptan rhythm in sodium and potassium excretion in salt-sensitive and salt-resistant Dahl rats.
Uezono, K., Sackett-Lundeen, L. L., Kawasaki, T., Omae, T., & Haus, E. L. (1987) · PubMed · Cited by 12 · see citing works
Flagged first, then by citations
2 of the 33 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Evidence for Health Decision Making — Beyond Randomized, Controlled Trials
Frieden, T. R. (2017) · New England Journal of Medicine · doi:10.1056/nejmra1614394 · Cited by 770 · see citing works
Salt Reduction to Prevent Hypertension and Cardiovascular Disease
He, F. J., Tan, M., Ma, Y., & MacGregor, G. A. (2020) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2019.11.055 · Cited by 589 · see citing works
Mente, A., O'Donnell, M., Rangarajan, S., Dagenais, G., Lear, S., McQueen, M., Diaz, R., Avezum, A., Lopez-Jaramillo, P., Lanas, F., et al. (2016) · The Lancet · doi:10.1016/s0140-6736(16)30467-6 · Cited by 483 · see citing works
Salt Sensitivity of Blood Pressure: A Scientific Statement From the American Heart Association
Elijovich, F., Weinberger, M. H., Anderson, C. A. M., Appel, L. J., Bursztyn, M., Cook, N. R., Dart, R. A., Newton-Cheh, C. H., Sacks, F. M., & Laffer, C. L. (2016) · Hypertension · doi:10.1161/hyp.0000000000000047 · Cited by 482 · see citing works
Role of “Western Diet” in Inflammatory Autoimmune Diseases
Manzel, A., Müller, D. N., Hafler, D. A., Erdman, S. E., Linker, R. A., & Kleinewietfeld, M. (2013) · Current Allergy and Asthma Reports · doi:10.1007/s11882-013-0404-6 · Cited by 451 · see citing works
Immune cells control skin lymphatic electrolyte homeostasis and blood pressure
Wiig, H., Schröder, A., Neuhofer, W., Jantsch, J., Kopp, C., Karlsen, T. V., Boschmann, M., Goss, J., Bry, M., Rakova, N., et al. (2013) · Journal of Clinical Investigation · doi:10.1172/jci60113 · Cited by 402 · see citing works
Karoly, P. J., Rao, V. R., Gregg, N. M., Worrell, G. A., Bernard, C., Cook, M. J., & Baud, M. O. (2021) · Nature Reviews Neurology · doi:10.1038/s41582-021-00464-1 · Cited by 266 · see citing works
Rossier, B. C., Baker, M. E., & Studer, R. A. (2015) · Physiological Reviews · doi:10.1152/physrev.00011.2014 · Cited by 269 · see citing works
Freedman, L. S., Commins, J. M., Moler, J. E., Willett, W. C., Tinker, L. F., Subar, A. F., Spiegelman, D. L., Rhodes, D., Potischman, N. A., Neuhouser, M. L., et al. (2015) · American Journal of Epidemiology · doi:10.1093/aje/kwu325 · Cited by 262 · see citing works
Sodium Intake and All-Cause Mortality Over 20 Years in the Trials of Hypertension Prevention
Cook, N. R., Appel, L. J., & Whelton, P. K. (2016) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2016.07.745 · Cited by 228 · see citing works
Circadian rhythms and the kidney
Firsov, D., & Bonny, O. (2018) · Nature Reviews Nephrology · doi:10.1038/s41581-018-0048-9 · Cited by 217 · see citing works
Dietary Sodium and Cardiovascular Disease Risk — Measurement Matters
Cogswell, M. E., Mugavero, K., Bowman, B. A., & Frieden, T. R. (2016) · New England Journal of Medicine · doi:10.1056/nejmsb1607161 · Cited by 211 · see citing works
Agreement Between 24-Hour Salt Ingestion and Sodium Excretion in a Controlled Environment
Lerchl, K., Rakova, N., Dahlmann, A., Rauh, M., Goller, U., Basner, M., Dinges, D. F., Beck, L., Agureev, A., Larina, I., et al. (2015) · Hypertension · doi:10.1161/hypertensionaha.115.05851 · Cited by 198 · see citing works
Sodium Intake and Cardiovascular Health
O’Donnell, M., Mente, A., & Yusuf, S. (2015) · Circulation Research · doi:10.1161/circresaha.116.303771 · Cited by 208 · see citing works
Dietary reference values for sodium
EFSA Panel on Nutrition, N. F. A. F. A. (., Turck, D., Castenmiller, J. J. M., Henauw, S. D., Hirsch‐Ernst, K. I., Kearney, J., Knutsen, H. K., Maciuk, A., Mangelsdorf, I., McArdle, H. J., et al. (2019) · EFSA Journal · doi:10.2903/j.efsa.2019.5778 · Cited by 206 · see citing works
Skin Sodium Concentration Correlates with Left Ventricular Hypertrophy in CKD
Schneider, M. P., Raff, U., Kopp, C., Scheppach, J. B., Toncar, S., Wanner, C., Schlieper, G., Saritas, T., Floege, J., Schmid, M., et al. (2017) · Journal of the American Society of Nephrology · doi:10.1681/asn.2016060662 · Cited by 195 · see citing works
Self-citationSalt and cardiovascular disease: insufficient evidence to recommend low sodium intake
O'Donnell, M. J., Mente, A., Alderman, M. H., Brady, A. J. B., Díaz, R., Gupta, R., López-Jaramillo, P. A., Luft, F. C., Lüscher, T. F., Mancia, G., et al. (2020) · European Heart Journal · doi:10.1093/eurheartj/ehaa586 · Cited by 195 · see citing works
Yi, B., Titze, J. M., Рыкова, М. П., Feuerecker, M., Vassilieva, G. Y., Ничипорук, И. А., Schelling, G., Morukov, B. V., & Choukèr, A. (2014) · Translational research · doi:10.1016/j.trsl.2014.11.007 · Cited by 167 · see citing works
Effects of isolation and confinement on humans-implications for manned space explorations
Pagel, J. I., & Choukèr, A. (2016) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00928.2015 · Cited by 162 · see citing works
Leyvraz, M., Chatelan, A., da Costa, B. R., Taffé, P., Paradis, G., Bovet, P., Bochud, M., & Chioléro, A. (2018) · International Journal of Epidemiology · doi:10.1093/ije/dyy121 · Cited by 161 · see citing works
Sodium Intake and Chronic Kidney Disease
Borrelli, S., Provenzano, M., Gagliardi, I., Michael, A., Liberti, M., Nicola, L. D., Conte, G., Garofalo, C., & Andreucci, M. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21134744 · Cited by 164 · see citing works
The inextricable role of the kidney in hypertension
Coffman, T. M. (2014) · Journal of Clinical Investigation · doi:10.1172/jci72274 · Cited by 155 · see citing works
Increased salt consumption induces body water conservation and decreases fluid intake
Rakova, N., Kitada, K., Lerchl, K., Dahlmann, A., Birukov, A., Daub, S., Kopp, C., Pedchenko, T., Zhang, Y., Beck, L., et al. (2017) · Journal of Clinical Investigation · doi:10.1172/jci88530 · Cited by 157 · see citing works
Sodium in the microenvironment regulates immune responses and tissue homeostasis
Müller, D. N., Wilck, N., Haase, S., Kleinewietfeld, M., & Linker, R. A. (2019) · Nature Reviews Immunology · doi:10.1038/s41577-018-0113-4 · Cited by 149 · see citing works
Titze, J. M., Dahlmann, A., Lerchl, K., Kopp, C., Rakova, N., Schröder, A., & Luft, F. C. (2013) · Kidney International · doi:10.1038/ki.2013.367 · Cited by 148 · see citing works
Use of Urine Biomarkers to Assess Sodium Intake: Challenges and Opportunities
Cogswell, M. E., Maalouf, J., Elliott, P., Loria, C. M., Patel, S., & Bowman, B. A. (2015) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-071714-034322 · Cited by 140 · see citing works
Wiig, H., Luft, F. C., & Titze, J. M. (2017) · Acta Physiologica · doi:10.1111/apha.13006 · Cited by 144 · see citing works
Campbell, N. R. C., He, F. J., Tan, M., Cappuccio, F. P., Neal, B. C., Woodward, M., Cogswell, M. E., McLean, R. M., Arcand, J., MacGregor, G. A., et al. (2019) · Journal of Clinical Hypertension · doi:10.1111/jch.13551 · Cited by 136 · see citing works
Sodium balance is not just a renal affair
Titze, J. (2014) · Current Opinion in Nephrology and Hypertension · doi:10.1097/01.mnh.0000441151.55320.c3 · Cited by 130 · see citing works
Epithelial sodium channel (ENaC) and the control of blood pressure
Rossier, B. C. (2013) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2013.11.010 · Cited by 127 · see citing works
The role of sodium in modulating immune cell function
Wilck, N., Balogh, A., Markó, L., Bartolomaeus, H., & Müller, D. N. (2019) · Nature Reviews Nephrology · doi:10.1038/s41581-019-0167-y · Cited by 124 · see citing works
Morris, R. C., Schmidlin, O., Sebastian, A., Tanaka, M., & Kurtz, T. W. (2016) · Circulation · doi:10.1161/circulationaha.115.017923 · Cited by 123 · see citing works
An Overview of Monthly Rhythms and Clocks
Raible, F., Takekata, H., & Tessmar-Raible, K. (2017) · Frontiers in Neurology · doi:10.3389/fneur.2017.00189 · Cited by 121 · see citing works
Salt Sensitivity: Causes, Consequences, and Recent Advances
Bailey, M. A., & Dhaun, N. (2023) · Hypertension · doi:10.1161/hypertensionaha.123.17959 · Cited by 121 · see citing works
Insights into Salt Handling and Blood Pressure
Ellison, D. H., & Welling, P. (2021) · New England Journal of Medicine · doi:10.1056/nejmra2030212 · Cited by 113 · see citing works
Iwahori, T., Miura, K., & Ueshima, H. (2017) · Nutrients · doi:10.3390/nu9070700 · Cited by 109 · see citing works
Association of short sleep duration and rapid decline in renal function
McMullan, C. J., Curhan, G. C., & Forman, J. P. (2016) · Kidney International · doi:10.1016/j.kint.2015.12.048 · Cited by 108 · see citing works
Engberink, R. O., van den Hoek, T. C., van Noordenne, N. D., van den Born, B. H., Sengers, H. P., & Vogt, L. (2017) · Circulation · doi:10.1161/circulationaha.117.029028 · Cited by 106 · see citing works
Salt sensitivity and hypertension
Balafa, O. C., & Kalaitzidis, R. (2020) · Journal of Human Hypertension · doi:10.1038/s41371-020-00407-1 · Cited by 108 · see citing works
Birukov, A., Rakova, N., Lerchl, K., Engberink, R. O., Johannes, B. W., Wabel, P., Moissl, U. M., Rauh, M., Luft, F. C., & Titze, J. M. (2016) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.116.132951 · Cited by 104 · see citing works
PGE2, Kidney Disease, and Cardiovascular Risk
Nasrallah, R., Hassouneh, R., & Hébert, R. (2015) · Journal of the American Society of Nephrology · doi:10.1681/asn.2015050528 · Cited by 98 · see citing works
Hammon, M., Grossmann, S., Linz, P., Kopp, C., Dahlmann, A., Garlichs, C., Janka, R., Cavallaro, A., Luft, F. C., Uder, M., et al. (2015) · PLOS ONE · doi:10.1371/journal.pone.0141336 · Cited by 93 · see citing works
Self-citationMancia, G., Oparil, S., Whelton, P. K., McKee, M., Dominiczak, A. F., Luft, F. C., AlHabib, K. F., Lanas, F. T., Damasceno, A. A. M., Prabhakaran, D., et al. (2016) · European Heart Journal · doi:10.1093/eurheartj/ehw549 · Cited by 92 · see citing works
Speculations on salt and the genesis of arterial hypertension
Titze, J. M., & Luft, F. C. (2017) · Kidney International · doi:10.1016/j.kint.2017.02.034 · Cited by 92 · see citing works
Adding salt to foods and hazard of premature mortality
Ma, H., Xue, Q., Wang, X., Li, X., Franco, O. H., Li, Y., Heianza, Y., Manson, J. E., & Qi, L. (2022) · European Heart Journal · doi:10.1093/eurheartj/ehac208 · Cited by 88 · see citing works
Mechanisms of sodium balance: total body sodium, surrogate variables, and renal sodium excretion
Bie, P. (2018) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00363.2017 · Cited by 90 · see citing works
Peng, Y., Li, W., Wang, Y., Chen, H., Bo, J., Wang, X., & Liu, L. (2016) · PLoS ONE · doi:10.1371/journal.pone.0149655 · Cited by 88 · see citing works
Evaluation of Renal Blood Flow and Oxygenation in CKD Using Magnetic Resonance Imaging
Khatir, D. S., Pedersen, M., Jespersen, B., & Buus, N. H. (2015) · American Journal of Kidney Diseases · doi:10.1053/j.ajkd.2014.11.022 · Cited by 83 · see citing works
A different view on sodium balance
Titze, J. M. (2014) · Current Opinion in Nephrology & Hypertension · doi:10.1097/mnh.0000000000000085 · Cited by 82 · see citing works
Sodium Intake and Renal Outcomes: A Systematic Review
Smyth, A., O'Donnell, M. J., Yusuf, S., Clase, C. M., Teo, K. K., Canavan, M. D., Reddan, D. N., & Mann, J. F. E. (2014) · American Journal of Hypertension · doi:10.1093/ajh/hpt294 · Cited by 77 · see citing works
Sodium and its manifold impact on our immune system
Jobin, K., Müller, D. N., Jantsch, J., & Kurts, C. (2021) · Trends in Immunology · doi:10.1016/j.it.2021.04.002 · Cited by 79 · see citing works
Novel Mechanism for Buffering Dietary Salt in Humans
Selvarajah, V., Maki-Petaja, K. M., Pedro, L. D., Bruggraber, S. F. A., Burling, K., Goodhart, A. K., Brown, M. J., McEniery, C. M., & Wilkinson, I. B. (2017) · Hypertension · doi:10.1161/hypertensionaha.117.10003 · Cited by 74 · see citing works
Haase, S., Kissel, J., Manzel, A., Kleinewietfeld, M., Haghikia, A., Gold, R., Müller, D. N., & Linker, R. A. (2016) · Experimental Neurology · doi:10.1016/j.expneurol.2016.03.010 · Cited by 73 · see citing works
Role of the Vascular Wall in Sodium Homeostasis and Salt Sensitivity
Engberink, R. O., Rorije, N. M. G., van der Heide, J. J. H., van den Born, B. H., & Vogt, L. (2014) · Journal of the American Society of Nephrology · doi:10.1681/asn.2014050430 · Cited by 69 · see citing works
Water Conservation Overrides Osmotic Diuresis During SGLT2 Inhibition in Patients With Heart Failure
Marton, A., Saffari, S. E., Rauh, M., Sun, R.-N., Nagel, A. M., Linz, P. R., Lim, T. T., Takase‐Minegishi, K., Pajarillaga, A., Saw, S., et al. (2024) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2024.02.020 · Cited by 71 · see citing works
Canaud, B., Kooman, J., Selby, N., Taal, M., Francis, S., Kopperschmidt, P., Maierhofer, A., Kotanko, P., & Titze, J. (2019) · Kidney International · doi:10.1016/j.kint.2018.09.024 · Cited by 58 · see citing works
Anderson, C. A. M., Cobb, L. K., Miller, E. R., Woodward, M., Hottenstein, A. W., Chang, A. R., Mongraw‐Chaffin, M., White, K. N., Charleston, J. B., Tanaka, T., et al. (2015) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.114.100750 · Cited by 68 · see citing works
Nikpey, E., Karlsen, T. V., Rakova, N., Titze, J. M., Tenstad, O., & Wiig, H. (2017) · Hypertension · doi:10.1161/hypertensionaha.116.08539 · Cited by 69 · see citing works
A Modern View of the Interstitial Space in Health and Disease
Stewart, R. H. (2020) · Frontiers in Veterinary Science · doi:10.3389/fvets.2020.609583 · Cited by 67 · see citing works
Measurement Error Corrected Sodium and Potassium Intake Estimation Using 24-Hour Urinary Excretion
Huang, Y., Horn, L. V., Tinker, L. F., Neuhouser, M. L., Carbone, L. D., Mossavar‐Rahmani, Y., Thomas, F., & Prentice, R. L. (2013) · Hypertension · doi:10.1161/hypertensionaha.113.02218 · Cited by 68 · see citing works
Estimation of Sodium and Potassium Intake: Current Limitations and Future Perspectives
Ginos, B. N. R., & Engberink, R. O. (2020) · Nutrients · doi:10.3390/nu12113275 · Cited by 66 · see citing works
Glucocorticoids: Fuelling the Fire of Atherosclerosis or Therapeutic Extinguishers?
MacLeod, C., Hadoke, P. W. F., & Nixon, M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22147622 · Cited by 66 · see citing works
Salt, water and nephron: Mechanisms of action and link to hypertension and chronic kidney disease
Qian, Q. (2018) · Nephrology · doi:10.1111/nep.13465 · Cited by 64 · see citing works
Validation of the Spot Urine in Evaluating 24-Hour Sodium Excretion in Chinese Hypertension Patients
Han, W., Sun, N., Chen, Y., Wang, H., Yang, X., & Ma, Z. (2015) · American Journal of Hypertension · doi:10.1093/ajh/hpv037 · Cited by 63 · see citing works
Dietary reference values for chloride
EFSA Panel on Nutrition, N. F. A. F. A. (., Turck, D., Castenmiller, J. J. M., Henauw, S. D., Hirsch‐Ernst, K. I., Kearney, J., Knutsen, H. K., Maciuk, A., Mangelsdorf, I., McArdle, H. J., et al. (2019) · EFSA Journal · doi:10.2903/j.efsa.2019.5779 · Cited by 65 · see citing works
Sodium storage in human tissues is mediated by glycosaminoglycan expression
Fischereder, M., Michalke, B., Schmoeckel, E., Habicht, A., Kunisch, R., Pavelic, I., Szabados, B. E., Schönermarck, U., Nelson, P. J., & Stangl, M. J. (2017) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00703.2016 · Cited by 61 · see citing works
Pathogenesis of Hypertension in Metabolic Syndrome: The Role of Fructose and Salt
Soleimani, M., Barone, S., Luo, H., & Zahedi, K. A. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24054294 · Cited by 60 · see citing works
Graudal, N. A., Hubeck‐Graudal, T., Jűrgens, G., & McCarron, D. A. (2015) · Advances in Nutrition · doi:10.3945/an.114.007708 · Cited by 59 · see citing works
Kovarik, J. J., Morisawa, N., Wild, J., Marton, A., Takase‐Minegishi, K., Minegishi, S., Daub, S., Sands, J. M., Klein, J. D., Bailey, J. L., et al. (2021) · Acta Physiologica · doi:10.1111/apha.13629 · Cited by 59 · see citing works
Engberink, R. O., Rorije, N. M. G., van den Born, B. H., & Vogt, L. (2017) · Kidney International · doi:10.1016/j.kint.2016.12.004 · Cited by 57 · see citing works
Rhythms of behavior: are the times changin’?
Häfker, N. S., & Tessmar‐Raible, K. (2019) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2019.10.005 · Cited by 58 · see citing works
Iwahori, T., Miura, K., Ueshima, H., Chan, Q. M., Dyer, A. R., Elliott, P., & Stamler, J. (2016) · International Journal of Epidemiology · doi:10.1093/ije/dyw287 · Cited by 57 · see citing works
Seizure occurrence is linked to multiday cycles in diverse physiological signals
Gregg, N. M., Attia, T. P., Nasseri, M., Joseph, B., Karoly, P. J., Cui, J., Stirling, R. E., Viana, P. F., Richner, T. J., Nurse, E. S., et al. (2023) · Epilepsia · doi:10.1111/epi.17607 · Cited by 51 · see citing works
Johansson, S. A., Rosenbaum, D. P., Knutsson, M., & Leonsson‐Zachrisson, M. (2016) · Clinical and Experimental Nephrology · doi:10.1007/s10157-016-1302-8 · Cited by 55 · see citing works
Karlsen, T. V., Nikpey, E., Han, J., Reikvam, T., Rakova, N., Castorena‐Gonzalez, J. A., Davis, M. J., Titze, J. M., Tenstad, O., & Wiig, H. (2018) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.118.311149 · Cited by 52 · see citing works
Dietary potassium and the kidney: lifesaving physiology
Wei, K., Gritter, M., Vogt, L., de Borst, M. H., Rotmans, J. I., & Hoorn, E. J. (2020) · Clinical Kidney Journal · doi:10.1093/ckj/sfaa157 · Cited by 56 · see citing works
Mercado, C. I., Cogswell, M. E., Valderrama, A. L., Wang, C., Loria, C. M., Moshfegh, A. J., Rhodes, D. G., & Carriquiry, A. L. (2014) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.113.081604 · Cited by 52 · see citing works
Skin Sodium and Hypertension: a Paradigm Shift?
Selvarajah, V., Connolly, K., McEniery, C. M., & Wilkinson, I. B. (2018) · Current Hypertension Reports · doi:10.1007/s11906-018-0892-9 · Cited by 54 · see citing works
Prentice, R. L., Huang, Y., Neuhouser, M. L., Manson, J. E., Mossavar‐Rahmani, Y., Thomas, F., Tinker, L. F., Allison, M., Johnson, K., Wassertheil-Smoller, S. W., et al. (2017) · American Journal of Epidemiology · doi:10.1093/aje/kwx238 · Cited by 49 · see citing works
Salt controls endothelial and vascular phenotype
Kusche‐Vihrog, K., Schmitz, B., & Brand, E. (2014) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-014-1657-1 · Cited by 49 · see citing works
EJE Prize 2013: Regulation of aldosterone secretion: from physiology to disease
Beuschlein, F. (2013) · European Journal of Endocrinology · doi:10.1530/eje-13-0263 · Cited by 48 · see citing works
The role of salt for immune cell function and disease
Willebrand, R., & Kleinewietfeld, M. (2018) · Immunology · doi:10.1111/imm.12915 · Cited by 48 · see citing works
Diurnal variation of urinary sodium-to-potassium ratio in free-living Japanese individuals
Iwahori, T., Ueshima, H., Torii, S., Saito, Y., Kondo, K., Tanaka‐Mizuno, S., Arima, H., & Miura, K. (2017) · Hypertension Research · doi:10.1038/hr.2016.187 · Cited by 48 · see citing works
Iwahori, T., Miura, K., Ueshima, H., Tanaka‐Mizuno, S., Chan, Q. M., Arima, H., Dyer, A. R., Elliott, P., & Stamler, J. (2019) · Hypertension Research · doi:10.1038/s41440-019-0263-1 · Cited by 44 · see citing works
Kurtz, T. W., Dominiczak, A. F., DiCarlo, S. E., Pravenec, M., & Morris, R. C. (2015) · Hypertension · doi:10.1161/hypertensionaha.114.05092 · Cited by 43 · see citing works
Time-course human urine proteomics in space-flight simulation experiments
Binder, H., Loeffler‐Wirth, H., Arakelyan, A., Lembcke, K., Tiys, E., Иванисенко, В. А., Kolchanov, N. A., Kononikhin, A. S., Popov, I. A., Николаев, Е. Н., et al. (2014) · BMC Genomics · doi:10.1186/1471-2164-15-s12-s2 · Cited by 42 · see citing works
Nishimoto, M., & Fujita, T. (2014) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00477.2013 · Cited by 42 · see citing works
Evans, R. G., & Bie, P. (2015) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00254.2015 · Cited by 43 · see citing works
Ware, L. J., Charlton, K. E., Schutte, A. E., Cockeran, M., Naidoo, N., & Kowal, P. R. (2017) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2017.06.017 · Cited by 42 · see citing works
Chang, A. R., Bailey-Davis, L. D., Hetherington, V., Ziegler, A., Yule, C., Kwiecen, S., Graboski, E., Melough, M. M., Collins, C., & Anderson, C. A. M. (2019) · Journal of Renal Nutrition · doi:10.1053/j.jrn.2019.03.080 · Cited by 40 · see citing works
Sodium Handling and Interaction in Numerous Organs
Minegishi, S., Luft, F. C., Titze, J. M., & Kitada, K. (2020) · American Journal of Hypertension · doi:10.1093/ajh/hpaa049 · Cited by 41 · see citing works
Gray, C., Al‐Dujaili, E. A. S., Sparrow, A. J., Gardiner, S. M., Craigon, J., Welham, S. J. M., & Gardner, D. S. (2013) · PLoS ONE · doi:10.1371/journal.pone.0072682 · Cited by 38 · see citing works
Reinberg, A., Dejardin, L., Smolensky, M. H., & Touitou, Y. (2016) · Chronobiology International · doi:10.1080/07420528.2016.1236807 · Cited by 37 · see citing works
Clinical impact of tissue sodium storage
Engberink, R. O., Selvarajah, V., & Vogt, L. (2019) · Pediatric Nephrology · doi:10.1007/s00467-019-04305-8 · Cited by 39 · see citing works
Polychronopoulou, E., Braconnier, P., & Burnier, M. (2019) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2019.00136 · Cited by 38 · see citing works
Normotensive Blood Pressure in Pregnancy
Gennari‐Moser, C., Escher, G., Kramer, S., Dick, B., Eisele, N., Baumann, M. U., Raio, L., Frey, F. J., Surbek, D., & Mohaupt, M. G. (2013) · Hypertension · doi:10.1161/hypertensionaha.113.02320 · Cited by 37 · see citing works
Kurtz, T. W., DiCarlo, S. E., Pravenec, M., Schmidlin, O., Tanaka, M., & Morris, R. C. (2016) · Kidney International · doi:10.1016/j.kint.2016.05.032 · Cited by 36 · see citing works
Sodium chloride triggers Th17 mediated autoimmunity
Haase, S., Wilck, N., Kleinewietfeld, M., Müller, D. N., & Linker, R. A. (2018) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2018.06.016 · Cited by 40 · see citing works
Tissue sodium accumulation and peripheral insulin sensitivity in maintenance hemodialysis patients
Değer, S. M., Wang, P., Fissell, R. B., Ellis, C. D., Booker, C., Sha, F., Morse, J. L., Stewart, T. G., Gore, J. C., Siew, E. D., et al. (2017) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.12179 · Cited by 36 · see citing works
Treatment of Disorders of Sodium Balance in Chronic Kidney Disease
Ellison, D. H. (2017) · Advances in Chronic Kidney Disease · doi:10.1053/j.ackd.2017.07.003 · Cited by 35 · see citing works
- Authors
- Rakova, N., Jüttner, K., Dahlmann, A., Schröder, A., Linz, P., Kopp, C., Rauh, M., Goller, U., Beck, L., Agureev, A., Vassilieva, G., Lenkova, L., Johannes, B., Wabel, P., Moissl, U., Vienken, J., Gerzer, R., Eckardt, K.-U., Müller, D. N., Kirsch, K., Morukov, B., Luft, F. C., & Titze, J.
- Affiliations
- Russian Academy of Sciences (RU)
- Friedrich-Alexander-Universität Erlangen-Nürnberg (DE)
- Deutsches Zentrum für Luft- und Raumfahrt e. V. (DLR) (DE)
- Fresenius Medical Care (Germany) (DE)
- Charité – Universitätsmedizin Berlin (DE)
- Vanderbilt University (US)
- Corresponding author
- Titze, Jens
- ORCID
- Venue
- Cell Metabolism
- Publisher
- Elsevier BV
- Published
- 2013-01
- Volume
- 17
- Issue
- 1
- Pages
- 125-131
- ISSN
- 1550-4131 (ISSN-L)
- OpenAlex
- W1975967728
- Cited by
- 328
- References
- 33
- Citations by year
- 2026: 7 · 2025: 10 · 2024: 10 · 2023: 17 · 2022: 28 · 2021: 37 · 2020: 25 · 2019: 37 · 2018: 25 · 2017: 38 · 2016: 25 · 2015: 33 · 2014: 23 · 2013: 12
- FWCI
- 28.66
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell Metabolism (publishedVersion)
- PubMed (publishedVersion)
- MDC Repository (Max-Delbrueck-Center for Molecular Medicine) (submittedVersion)
- elib (German Aerospace Center) (submittedVersion)
- Funders
- Bundesministerium für Wirtschaft und Technologie
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Sodium Intake and Health
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Renin-Angiotensin System Studies
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Electrolyte and hormonal disorders
- Keywords
- sodium homeostasis, infradian rhythms, circaseptan rhythm, sodium excretion, aldosterone, cortisol, salt restriction, extracellular water
- MeSH terms
- Adult, Aldosterone, Blood Pressure, Humans, Hydrocortisone, Ions, Male, Periodicity, Sodium, Sodium Chloride, Dietary, Space Simulation
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
