Neuronal Cell Death

Hippocampal Damage in the Human Brain after Cardiac Arrest

Fujioka, M., Nishio, K., Miyamoto, S., Hiramatsu, K.-I., Sakaki, T., Okuchi, K., Taoka, T., & Fujioka, S. (2000) · Cerebrovascular Diseases · doi:10.1159/000016018 · Cited by 86

The JNK- and AKT/GSK3β- Signaling Pathways Converge to Regulate Puma Induction and Neuronal Apoptosis Induced by Trophic Factor Deprivation

Ambacher, K. K., Pitzul, K. B., Karajgikar, M., Hamilton, A., Ferguson, S. S. G., & Cregan, S. P. (2012) · PLoS ONE · doi:10.1371/journal.pone.0046885 · Cited by 86

Granulovacuolar degeneration: a neurodegenerative change that accompanies tau pathology

Köhler, C. N. (2016) · Acta Neuropathologica · doi:10.1007/s00401-016-1562-0 · Cited by 86

The proapoptotic proteins Bax and Bak are not involved in Wallerian degeneration

Whitmore, A. V., Lindsten, T., RAFF, M. C., & Thompson, C. B. (2003) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4401147 · Cited by 85

Alterations to glutathione and nicotinamide nucleotides during the mitochondrial permeability transition induced by peroxynitrite

Scarlett, J. L., Packer, M. A., Porteous, C. M., & Murphy, M. P. (1996) · Biochemical Pharmacology · doi:10.1016/0006-2952(96)99426-5 · Cited by 85

Apoptosis-inducing factor mediates dopaminergic cell death in response to LPS-induced inflammatory stimulus

Burguillos, M. Á., Hajji, N., Englund, E. M., Persson, A., Cenci, M. A., Machado, A., Cano, J., Joseph, B., & Venero, J. L. (2010) · Neurobiology of Disease · doi:10.1016/j.nbd.2010.09.005 · Cited by 84

BH3-only proteins are tail-anchored in the outer mitochondrial membrane and can initiate the activation of Bax

Wilfling, F., Weber, A., Potthoff, S., Vögtle, F. ‐., Meisinger, C., Paschen, S. A., & Häcker, G. A. (2012) · Cell Death and Differentiation · doi:10.1038/cdd.2012.9 · Cited by 84

Phosphoinositide 3-kinase couples NMDA receptors to superoxide release in excitotoxic neuronal death

Brennan, A., Shen, Y., Benna, J. E., & Swanson, R. A. (2013) · Cell Death and Disease · doi:10.1038/cddis.2013.111 · Cited by 84

Cystatin C protects neuronal cells against mutant copper-zinc superoxide dismutase-mediated toxicity

Watanabe, S., Hayakawa, T., Wakasugi, K., & Yamanaka, K. (2014) · Cell Death and Disease · doi:10.1038/cddis.2014.459 · Cited by 83

Characterizing Apolipoprotein E ε4 Carriers and Noncarriers With the Clinical Diagnosis of Mild to Moderate Alzheimer Dementia and Minimal β-Amyloid Peptide Plaques

Monsell, S. E., Kukull, W. A., Roher, A. E., Maarouf, C. L., Serrano, G., Beach, T. G., Caselli, R. J., Montine, T. J., & Reiman, E. M. (2015) · JAMA Neurology · doi:10.1001/jamaneurol.2015.1721 · Cited by 82

PolyADP-Ribosylation Is Involved in Neurotrophic Activity

Visochek, L., Steingart, R. A., Vulih-Shultzman, I., Klein, R., Priel, E., Gozes, I., & Cohen‐Armon, M. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.0333-05.2005 · Cited by 82

Necroptosis contributes to the NMDA-induced excitotoxicity in rat’s cultured cortical neurons

Li, Y., Yang, X., Ma, C., Qiao, J., & Zhang, C. (2008) · Neuroscience Letters · doi:10.1016/j.neulet.2008.08.037 · Cited by 82

Analysis of the PKC-γ-Related Immunocrossreactive Region of a Novel Leukocyte Protein γ-rp

Smallwood, J. I., & Malawista, S. E. (1999) · Inflammation · doi:10.1023/a:1020265701407 · Cited by 81

Tau aggregation and progressive neuronal degeneration in the absence of changes in spine density and morphology after targeted expression of Alzheimer's disease-relevant tau constructs in organotypic hippocampal slices

Shahani, N., Subramaniam, S., Wolf, T., Tackenberg, C., & Brandt, R. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.4245-05.2006 · Cited by 81

Mutually Exclusive Subsets of BH3-Only Proteins Are Activated by the p53 and c-Jun N-Terminal Kinase/c-Jun Signaling Pathways during Cortical Neuron Apoptosis Induced by Arsenite

Wong, H. K., Fricker, M., Wyttenbach, A., Villunger, A., Michalak, E. M., Strasser, A., & Tolkovsky, A. M. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.19.8732-8747.2005 · Cited by 81

Apaf-1 deficiency and neural tube closure defects are found in fog mice

Honarpour, N., Gilbert, S. L., Lahn, B. T., Wang, X., & Herz, J. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.171283198 · Cited by 81

Common and Divergent Mechanisms in Developmental Neuronal Remodeling and Dying Back Neurodegeneration

Yaron, A., & Schuldiner, O. (2016) · Current Biology · doi:10.1016/j.cub.2016.05.025 · Cited by 81

Tau Oligomers as Potential Targets for Immunotherapy for Alzheimers Disease and Tauopathies

A. Lasagna-Reeves, C., L. Castillo-Carranza, D., R. Jackson, G., & Kayed, R. (2011) · Current Alzheimer Research · doi:10.2174/156720511796717177 · Cited by 80

Mislocalization of neuronal mitochondria reveals regulation of Wallerian degeneration and NMNAT/WLDS-mediated axon protection independent of axonal mitochondria

Kitay, B. M., McCormack, R., Wang, Y., Tsoulfas, P., & Zhai, R. G. (2013) · Human Molecular Genetics · doi:10.1093/hmg/ddt009 · Cited by 80

Receptor Interacting Protein 3-Mediated Necroptosis Promotes Lipopolysaccharide-Induced Inflammation and Acute Respiratory Distress Syndrome in Mice

Wang, L., Wang, T., Li, H., Liu, Q. L., Zhang, Z., Xie, W., Feng, Y., Socorburam, T., Wu, G., Xia, Z., et al. (2016) · PLoS ONE · doi:10.1371/journal.pone.0155723 · Cited by 80

Neuronal death after perinatal cerebral hypoxia‐ischemia: Focus on autophagy—mediated cell death

Descloux, C., Ginet, V., Clarke, P. G. H., Puyal, J., & Truttmann, A. C. (2015) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2015.06.008 · Cited by 79

Intracellular pH reduction prevents excitotoxic and ischemic neuronal death by inhibiting NADPH oxidase

Lam, T. I., Brennan-Minnella, A. M., Won, S. J., Shen, Y., Hefner, C., Shi, Y., Sun, D., & Swanson, R. A. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1313029110 · Cited by 79

Increased Nuclear Apoptosis-Inducing Factor after Transient Focal Ischemia: A 12/15-Lipoxygenase-dependent Organelle Damage Pathway

Pallast, S., Arai, K., Pekcec, A., Yiğitkanlı, K., Yu, Z., Wang, X., Lo, E. H., & van Leyen, K. (2010) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2009.281 · Cited by 79

The proapoptotic BCL-2 family member BIM mediates motoneuron loss in a model of amyotrophic lateral sclerosis

Hetz, C. A., Thielen, P., Fisher, J. K., Pasinelli, P., Brown, R. H., Korsmeyer, S. J., & Glimcher, L. H. (2007) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4402166 · Cited by 79

Neuronal response in Alzheimer’s and Parkinson’s disease: the effect of toxic proteins on intracellular pathways

Majd, S., Power, J. H. T., & Grantham, H. J. M. (2015) · BMC Neuroscience · doi:10.1186/s12868-015-0211-1 · Cited by 79

Therapeutic hypothermia attenuates tissue damage and cytokine expression after traumatic brain injury by inhibiting necroptosis in the rat

Liu, T., Zhao, D.-X., Cui, H., Chen, L., Bao, Y., Wang, Y., & Jiang, J. (2016) · Scientific Reports · doi:10.1038/srep24547 · Cited by 79

Cell Death: History and Future

Zakeri, Z. F., & Lockshin, R. A. (2007) · Advances in experimental medicine and biology · doi:10.1007/978-1-4020-6554-5_1 · Cited by 78

The trophic theory of neural concentrations

Purves, D. (1986) · Trends in Neurosciences · doi:10.1016/0166-2236(86)90155-4 · Cited by 78

Different pathways for iNOS‐mediated toxicity in vitro dependent on neuronal maturation and NMDA receptor expression

Golde, S., Chandran, S., Brown, G. C., & Compston, A. (2002) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2002.00973.x · Cited by 77

Neuroprotection by cyclosporin A following transient brain ischemia correlates with the inhibition of the early efflux of cytochrome C to cytoplasm

Domańska‐Janik, K., Bużańska, L., Dłużniewska, J., Kozłowska, H., Sarnowska, A., & Zabłocka, B. (2004) · Molecular Brain Research · doi:10.1016/j.molbrainres.2003.11.006 · Cited by 77

The role of PARP activation in glutamate-induced necroptosis in HT-22 cells

Xu, X., Chua, C. C., Zhang, M., Geng, D., Liu, C., Hamdy, R. C., & Chua, B. H. L. (2010) · Brain Research · doi:10.1016/j.brainres.2010.04.080 · Cited by 77

Critical role of the Mac1/NOX2 pathway in mediating reactive microgliosis-generated chronic neuroinflammation and progressive neurodegeneration

Chen, S.-H., Oyarzabal, E. A., & Hong, J.-S. (2016) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2015.10.001 · Cited by 76

Cyclosporin A Enhances Survival, Ameliorates Brain Damage, and Prevents Secondary Mitochondrial Dysfunction after a 30-Minute Period of Transient Cerebral Ischemia

Li, P. A., Kristián, T., He, Q. P., & Siesjö, B. K. (2000) · Experimental Neurology · doi:10.1006/exnr.2000.7459 · Cited by 76

Role of cyclophilin D in the resistance of brain mitochondria to the permeability transition

Eliseev, R. A., Filippov, G., Velos, J., VanWinkle, B., Goldman, A. J., Rosier, R. N., & Gunter, T. E. (2006) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2006.06.022 · Cited by 76

A Small Molecule That Protects the Integrity of the Electron Transfer Chain Blocks the Mitochondrial Apoptotic Pathway

Jiang, X., Li, L., Ying, Z., Pan, C., Huang, S., Li, L., Dai, M., Yan, B., Li, M., Jiang, H., et al. (2016) · Molecular Cell · doi:10.1016/j.molcel.2016.06.016 · Cited by 76

Inhibition of receptor-interacting protein 3 upregulation and nuclear translocation involved in Necrostatin-1 protection against hippocampal neuronal programmed necrosis induced by ischemia/reperfusion injury

Yin, B., Xu, Y., Wei, R., He, F., Luo, B., & Wang, J. (2015) · Brain Research · doi:10.1016/j.brainres.2015.03.024 · Cited by 75

Calpains Are Downstream Effectors ofbax-Dependent Excitotoxic Apoptosis

D’Orsi, B., Bonner, H. P., Tuffy, L. P., Düßmann, H., Woods, I., Courtney, M. J., Ward, M. W., & Prehn, J. H. M. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.2345-11.2012 · Cited by 75

Phosphorylation of Puma modulates its apoptotic function by regulating protein stability

Fricker, M., O’Prey, J., Tolkovsky, A. M., & Ryan, K. M. (2010) · Cell Death and Disease · doi:10.1038/cddis.2010.38 · Cited by 75

Physiological and Pathophysiological Implications of Synaptic Tau

Regan, P. L., Whitcomb, D. J., & Cho, K. (2016) · The Neuroscientist · doi:10.1177/1073858416633439 · Cited by 75

Impaired protein degradation in FTLD and related disorders

Götzl, J. K., Lang, C. M., Haass, C., & Capell, A. (2016) · Ageing Research Reviews · doi:10.1016/j.arr.2016.04.008 · Cited by 75

The restricted binding repertoire of Bcl-B leaves Bim as the universal BH3-only prosurvival Bcl-2 protein antagonist

Rautureau, G. J. P., Yabal, M., Yang, H. J., Huang, D. C. S., Kvansakul, M., & Hinds, M. G. (2012) · Cell Death and Disease · doi:10.1038/cddis.2012.178 · Cited by 74

Neuronal Deletion of Caspase 8 Protects against Brain Injury in Mouse Models of Controlled Cortical Impact and Kainic Acid-Induced Excitotoxicity

Krajewska, M., You, Z., Rong, J., Kress, C. L., Huang, X., Yang, J., Kyoda, T., Leyva, R., Banares, S., Hu, Y., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0024341 · Cited by 74

AMINO ACID CONTROL OF PROTEIN SYNTHESIS AND DEGRADATION IN ISOLATED RAT HEPATOCYTES*

Seglen, P. O., Solheim, A. E., Grinde, B., Gordon, P. B., Schwarze, P. E., Gjessing, R., & Poli, A. (1980) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1980.tb29510.x · Cited by 74

The Progranulin Cleavage Products, Granulins, Exacerbate TDP-43 Toxicity and Increase TDP-43 Levels

Salazar, D. A., Butler, V. J., Argouarch, A. R., Hsu, T.-Y., Mason, A. R., Nakamura, A., McCurdy, H., Cox, D., Ng, R., Pan, G., et al. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.4808-14.2015 · Cited by 73

Spatial resolution of phospholipid scramblase 1 (PLSCR1), caspase-3 activation and DNA-fragmentation in the human hippocampus after cerebral ischemia

Rami, A., Sims, J. A., Botez, G., & Winckler, J. (2003) · Neurochemistry International · doi:10.1016/s0197-0186(02)00194-8 · Cited by 73

Redox Stress and the Contributions of BH3-Only Proteins to Infarction

Webster, K. A., Graham, R. M., Thompson, J. W., Spiga, M., Frazier, D. P., Wilson, A., & Bishopric, N. H. (2006) · Antioxidants and Redox Signaling · doi:10.1089/ars.2006.8.1667 · Cited by 73

Motor neuron trophic factors: Therapeutic use in ALS?

Gould, T. W., & Oppenheim, R. W. (2010) · Brain Research Reviews · doi:10.1016/j.brainresrev.2010.10.003 · Cited by 73

Detection of focal hypoxic-ischemic injury and neuronal stress in a rodent model of unilateral MCA occlusion/reperfusion using radiolabeled annexin V

Aparici, C. M., Karabiyikoglu, M., Goris, M. L., Tait, J. F., Yenari, M. A., & Blankenberg, F. G. (2004) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s00259-004-1473-5 · Cited by 73

Brain μ‐Calpain Autolysis During Global Cerebral Ischemia

Neumar, R. W., Hagle, S. M., DeGracia, D. J., Krause, G. S., & White, B. C. (1996) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1996.66010421.x · Cited by 73

Ballooned neurons in progressive supranuclear palsy are usually due to concurrent argyrophilic grain disease

Togo, T., & Dickson, D. W. (2002) · Acta Neuropathologica · doi:10.1007/s00401-002-0520-1 · Cited by 72

Anti-Necroptosis Chemical Necrostatin-1 Can Also Suppress Apoptotic and Autophagic Pathway to Exert Neuroprotective Effect in Mice Intracerebral Hemorrhage Model

Chang, P., Dong, W., Zhang, M., Wang, Z., Wang, Y., Wang, T., Gao, Y. Z., Meng, H., Luo, B., Luo, C., et al. (2013) · Journal of Molecular Neuroscience · doi:10.1007/s12031-013-0132-3 · Cited by 72

Cloning of a Novel Apaf-1-Interacting Protein: A Potent Suppressor of Apoptosis and Ischemic Neuronal Cell Death

Cao, G., Xiao, M., Sun, F., Xiao, X., Pei, W., Li, J., Graham, S. H., Simon, R. P., & Chen, J. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.1426-04.2004 · Cited by 72

Fragmentation of the Golgi apparatus of the ballooned neurons in patients with corticobasal degeneration and Creutzfeldt-Jakob disease

Sakurai, A., Okamoto, K., Fujita, Y., et al. (2000) · Acta Neuropathologica · doi:10.1007/s004010000182 · Cited by 71

Targeted Gene Inactivation of Calpain-1 Suppresses Cortical Degeneration Due to Traumatic Brain Injury and Neuronal Apoptosis Induced by Oxidative Stress

Yamada, K. H., Kozlowski, D. A., Seidl, S. E., Lance, S., Wieschhaus, A. J., Sundivakkam, P. C., Tiruppathì, C., Chishti, I., Herman, I. M., Kuchay, S., et al. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.302612 · Cited by 71

Lysosomal membrane permeabilization in Parkinson disease

Vila, M., Bové, J., Dehay, B., Rodríguez‐Muela, N., & Boya, P. (2010) · Autophagy · doi:10.4161/auto.7.1.13933 · Cited by 71

Prions: Generation and Spread Versus Neurotoxicity

Halliday, M., Radford, H., & Mallucci, G. R. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.r114.568477 · Cited by 71

Intracellular amyloid β oligomers impair organelle transport and induce dendritic spine loss in primary neurons

Umeda, T., Ramser, E. M., Yamashita, M., Nakajima, K., Mori, H., Silverman, M. A., & Tomiyama, T. (2015) · Acta Neuropathologica Communications · doi:10.1186/s40478-015-0230-2 · Cited by 70

Erratum: Phosphoinositide 3-kinase couples NMDA receptors to superoxide release in excitotoxic neuronal death

Brennan, A., Shen, Y., Benna, J. E., & Swanson, R. A. (2013) · Cell Death and Disease · doi:10.1038/cddis.2013.164 · Cited by 69

The UPR and synaptic dysfunction in neurodegeneration

Freeman, O. J., & Mallucci, G. R. (2016) · Brain Research · doi:10.1016/j.brainres.2016.03.029 · Cited by 69

Cyclosporine in acute ischemic stroke

Nighoghossian, N., Berthezène, Y., Mechtouff, L., Derex, L., Cho, T., Ritzenthaler, T., Rheims, S., Chauveau, F., Béjot, Y., Jacquin, A., et al. (2015) · Neurology · doi:10.1212/wnl.0000000000001639 · Cited by 68

NADPH Oxidase: A Potential Target for Treatment of Stroke

Zhang, L., Wu, J., Duan, X., Tian, X., Shen, H., Sun, Q., & Chen, G. (2016) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2016/5026984 · Cited by 68

Inhibition of apoptotic Bax translocation to the mitochondria is a central function of parkin

Charan, R. A., Johnson, B. N., Zaganelli, S., Nardozzi, J. D., & LaVoie, M. J. (2014) · Cell Death & Disease · doi:10.1038/cddis.2014.278 · Cited by 67

Reversible Cyclosporin A-sensitive Mitochondrial Depolarization Occurs within Minutes of Stroke Onset in Mouse Somatosensory Cortex in Vivo

Liu, R. R., & Murphy, T. H. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.055301 · Cited by 67

Inhibition of the AIF/CypA complex protects against intrinsic death pathways induced by oxidative stress

Doti, N., Reuther, C., Scognamiglio, P. L., Dolga, A. M., Plesnila, N., Ruvo, M., & Culmsee, C. (2014) · Cell Death and Disease · doi:10.1038/cddis.2013.518 · Cited by 67

Poly(ADP-Ribose) Polymerase-1 Causes Mitochondrial Damage and Neuron Death Mediated by Bnip3

Lü, P., Kamboj, A. K., Gibson, S. B., & Anderson, C. M. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.2499-14.2014 · Cited by 67

Nitric oxide‐dependent damage to neuronal mitochondria involves the NMDA receptor

Stewart, V. C., Heslegrave, A., Brown, G. C., Clark, J. B., & Heales, S. (2002) · European Journal of Neuroscience · doi:10.1046/j.0953-816x.2001.01878.x · Cited by 67

Brain‐derived respiring mitochondria exhibit homogeneous, complete and cyclosporin‐sensitive permeability transition

Hansson, M. J., Månsson, R., Mattiasson, G., Ohlsson, J., Karlsson, J., Keep, M. F., & Elmér, E. (2004) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2004.02400.x · Cited by 67

Combined inhibition of cell death induced by apoptosis inducing factor and caspases provides additive neuroprotection in experimental traumatic brain injury

Piao, C.-S., Loane, D. J., Stoica, B. A., Li, S., Hanscom, M., Cabatbat, R. M., Blomgren, K., & Faden, A. I. (2012) · Neurobiology of Disease · doi:10.1016/j.nbd.2012.03.018 · Cited by 66

Enduring Elevations of Hippocampal Amyloid Precursor Protein and Iron Are Features of β-Amyloid Toxicity and Are Mediated by Tau

Li, X., Lei, P., Tuo, Q., Ayton, S., Li, Q., Moon, S., Volitakis, I., Liu, R., Masters, C. L., Finkelstein, D. I., et al. (2015) · Neurotherapeutics · doi:10.1007/s13311-015-0378-2 · Cited by 65

Kainate-Mediated Excitotoxicity Induces Neuronal Death in the Rat Spinal Cord In Vitro via a PARP-1 Dependent Cell Death Pathway (Parthanatos)

Kuzhandaivel, A., Nistri, A., & Mladinić, M. (2010) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-010-9531-y · Cited by 64

Genetic Analysis Reveals that Amyloid Precursor Protein and Death Receptor 6 Function in the Same Pathway to Control Axonal Pruning Independent of β-Secretase

Olsen, O., Kallop, D. Y., McLaughlin, T., Huntwork-Rodriguez, S., Wu, Z., Duggan, C. D., Simon, D. J., Lu, Y., Easley-Neal, C., Takeda, K., et al. (2014) · The Journal of Neuroscience · doi:10.1523/jneurosci.3522-13.2014 · Cited by 64

Microglial NADPH oxidase activation mediates rod cell death in the retinal degeneration in rd mice

Zeng, H., Ding, M., Chen, X.-X., & Lu, Q. (2014) · Neuroscience · doi:10.1016/j.neuroscience.2014.05.065 · Cited by 64

In vivo Contributions of BH3-Only Proteins to Neuronal Death Following Seizures, Ischemia, and Traumatic Brain Injury

Engel, T., Plesnila, N., Prehn, J. H. M., & Henshall, D. C. (2011) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2011.26 · Cited by 64

SARM1, Not MyD88, Mediates TLR7/TLR9-Induced Apoptosis in Neurons

Mukherjee, P., Winkler, C. W., Taylor, K. G., Woods, T. A., Nair, V., Khan, B. A., & Peterson, K. E. (2015) · The Journal of Immunology · doi:10.4049/jimmunol.1500953 · Cited by 64

Endoplasmic reticulum stress-induced apoptosis requires bax for commitment and Apaf-1 for execution in primary neurons

Smith, M. I., & Deshmukh, M. (2007) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4402089 · Cited by 63

bcl-2 Overexpression Eliminates Deprivation-Induced Cell Death of Brainstem Auditory Neurons

Mostafapour, S. P., del Puerto, N. M., & Rubel, E. W. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-11-04670.2002 · Cited by 63

Can ‘calpain-cathepsin hypothesis’ explain Alzheimer neuronal death?

Yamashima, T. (2016) · Ageing Research Reviews · doi:10.1016/j.arr.2016.05.008 · Cited by 63

Disruption of Bax Protein Prevents Neuronal Cell Death but Produces Cognitive Impairment in Mice following Traumatic Brain Injury

Tehranian, R., Rose, M. E., Vagni, V., Pickrell, A. M., Griffith, R. P., Liu, H., Clark, R. S. B., Dixon, C. E., Kochanek, P. M., & Graham, S. H. (2008) · Journal of Neurotrauma · doi:10.1089/neu.2007.0441 · Cited by 62

Calpain inhibitor entrapped in liposome rescues ischemic neuronal damage

Yokota, M., Tani, E., Tsubuki, S., Yamaura, I., Nakagaki, I., Hori, S., & Saido, T. C. (1999) · Brain Research · doi:10.1016/s0006-8993(98)01334-1 · Cited by 62

The emerging generality of the neurotrophic hypothesis

Davies, A. M. (1988) · Trends in Neurosciences · doi:10.1016/0166-2236(88)90099-9 · Cited by 62

Mitochondrial Optic Atrophy (OPA) 1 Processing Is Altered in Response to Neonatal Hypoxic-Ischemic Brain Injury

Baburamani, A. A., Hurling, C., Stolp, H. B., Sobotka, K. S., Gressèns, P., Hagberg, H., & Thornton, C. (2015) · International Journal of Molecular Sciences · doi:10.3390/ijms160922509 · Cited by 62

Visual and functional demonstration of growing Bax-induced pores in mitochondrial outer membranes

Gillies, L. A., Du, H., Peters, B., Knudson, C. M., Newmeyer, D. D., & Kuwana, T. (2014) · Molecular Biology of the Cell · doi:10.1091/mbc.e13-11-0638 · Cited by 61

Activation of autophagy and paraptosis in retinal ganglion cells after retinal ischemia and reperfusion injury in rats

WEI, T., Kang, Q., Ma, B., Gao, S., Li, X., & Liu, Y. (2014) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2014.2084 · Cited by 60

Contributions of poly(ADP‐ribose) polymerase‐1 and ‐2 to nuclear translocation of apoptosis‐inducing factor and injury from focal cerebral ischemia

Li, X., Klaus, J. A., Zhang, J., Xu, Z., Kibler, K. K., Andrabi, S. A., Rao, K., Yang, Z., Dawson, T. M., Dawson, V. L., et al. (2010) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2010.06667.x · Cited by 60

Bax Regulates Neuronal Ca2+Homeostasis

D’Orsi, B., Kilbride, S. M., Chen, G., Perez‐Alvarez, S., Bonner, H. P., Pfeiffer, S., Plesnila, N., Engel, T., Henshall, D. C., Düßmann, H., et al. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.2453-14.2015 · Cited by 59

Necrostatin-1 Reduces Neurovascular Injury after Intracerebral Hemorrhage

King, M. D., Whitaker-Lea, W. A., Campbell, J. M., Alleyne, C. H., & Dhandapani, K. M. (2014) · International Journal of Cell Biology · doi:10.1155/2014/495817 · Cited by 59

The First Molecular Evidence That Autophagy Relates Rimmed Vacuole Formation in Chloroquine Myopathy

Suzuki, T., Nakagawa, M. M., Yoshikawa, A., Sasagawa, N., Yoshimori, T., Ohsumi, Y., Nishino, I., Ishiura, S., & Nonaka, I. (2002) · The Journal of Biochemistry · doi:10.1093/oxfordjournals.jbchem.a003147 · Cited by 59

AIF, reactive oxygen species, and neurodegeneration: A “complex” problem

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