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Cited by 1,108

The DOI matches its Crossref record; 797 of the 797 references it cites were found in a registry or an index.

Neuronal Cell Death

Open access
Fricker, Michael, Tolkovsky, Aviva M., Borutaite, Vilmante, Coleman, Michael, Brown, Guy C.·2018·Physiological Reviews
DOI 10.1152/physrev.00011.2017
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Abstract

Neuronal cell death occurs extensively during development and pathology, where it is especially important because of the limited capacity of adult neurons to proliferate or be replaced. The concept of cell death used to be simple as there were just two or three types, so we just had to work out which type was involved in our particular pathology and then block it. However, we now know that there are at least a dozen ways for neurons to die, that blocking a particular mechanism of cell death may not prevent the cell from dying, and that non-neuronal cells also contribute to neuronal death. We review here the mechanisms of neuronal death by intrinsic and extrinsic apoptosis, oncosis, necroptosis, parthanatos, ferroptosis, sarmoptosis, autophagic cell death, autosis, autolysis, paraptosis, pyroptosis, phagoptosis, and mitochondrial permeability transition. We next explore the mechanisms of neuronal death during development, and those induced by axotomy, aberrant cell-cycle reentry, glutamate (excitoxicity and oxytosis), loss of connected neurons, aggregated proteins and the unfolded protein response, oxidants, inflammation, and microglia. We then reassess which forms of cell death occur in stroke and Alzheimer’s disease, two of the most important pathologies involving neuronal cell death. We also discuss why it has been so difficult to pinpoint the type of neuronal death involved, if and why the mechanism of neuronal death matters, the molecular overlap and interplay between death subroutines, and the therapeutic implications of these multiple overlapping forms of neuronal death.

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Crossref · 10.1152/physrev.00011.2017

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Citations

Cites

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Metadata

Authors
Fricker, M., Tolkovsky, A. M., Borutaite, V., Coleman, M., & Brown, G. C.
Venue
Physiological Reviews
Publisher
American Physiological Society
Published
2018-04-01
Volume
98
Issue
2
Pages
813-880
ISSN
  • 0031-9333 (ISSN-L)
  • 1522-1210
DOI
10.1152/physrev.00011.2017
OpenAlex
W2789018622
Cited by
1,108
References
797
FWCI
6.95
Type
journal article
Language
en
Open access
green

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