The DOI matches its Crossref record; 20 of the 20 references it cites were found in a registry or an index.
Physiological Implications of Hydrogen Sulfide: A Whiff Exploration That Blossomed
Abstract
The important life-supporting role of hydrogen sulfide (H 2 S) has evolved from bacteria to plants, invertebrates, vertebrates, and finally to mammals. Over the centuries, however, H 2 S had only been known for its toxicity and environmental hazard. Physiological importance of H 2 S has been appreciated for about a decade. It started by the discovery of endogenous H 2 S production in mammalian cells and gained momentum by typifying this gasotransmitter with a variety of physiological functions. The H 2 S-catalyzing enzymes are differentially expressed in cardiovascular, neuronal, immune, renal, respiratory, gastrointestinal, reproductive, liver, and endocrine systems and affect the functions of these systems through the production of H 2 S. The physiological functions of H 2 S are mediated by different molecular targets, such as different ion channels and signaling proteins. Alternations of H 2 S metabolism lead to an array of pathological disturbances in the form of hypertension, atherosclerosis, heart failure, diabetes, cirrhosis, inflammation, sepsis, neurodegenerative disease, erectile dysfunction, and asthma, to name a few. Many new technologies have been developed to detect endogenous H 2 S production, and novel H 2 S-delivery compounds have been invented to aid therapeutic intervention of diseases related to abnormal H 2 S metabolism. While acknowledging the challenges ahead, research on H 2 S physiology and medicine is entering an exponential exploration era.
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Metadata
- Authors
- Wang, R.
- Venue
- Physiological Reviews
- Publisher
- American Physiological Society
- Published
- 2012-04
- Volume
- 92
- Issue
- 2
- Pages
- 791-896
- ISSN
- 0031-9333 (ISSN-L)
- 1522-1210
- OpenAlex
- W2073876100
- Cited by
- 1,939
- References
- 20
- FWCI
- 5.25
- Type
- journal article
- Language
- en
- Open access
- closed
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