Urothelial Signaling

The capsaicin receptor: a heat-activated ion channel in the pain pathway

Caterina, M. J., Schumacher, M. A., Tominaga, M., Rosen, T. A., Levine, J. D., & Julius, D. (1997) · Nature · doi:10.1038/39807 · Cited by 9,107

Vanilloid (Capsaicin) Receptors and Mechanisms

Szallasi, A., & Blumberg, P. M. (1999) · Pharmacological Reviews · doi:10.1016/s0031-6997(24)01403-0 · Cited by 1,903

p38 MAPK Activation by NGF in Primary Sensory Neurons after Inflammation Increases TRPV1 Levels and Maintains Heat Hyperalgesia

Ji, R.-R., Samad, T. A., Jin, S.-X., Schmoll, R., & Woolf, C. J. (2002) · Neuron · doi:10.1016/s0896-6273(02)00908-x · Cited by 1,238

Intracellular Bacterial Biofilm-Like Pods in Urinary Tract Infections

Anderson, G. G., Palermo, J. J., Schilling, J. D., Roth, R., Heuser, J., & Hultgren, S. J. (2003) · Science · doi:10.1126/science.1084550 · Cited by 1,161

Protease-Activated Receptors: Contribution to Physiology and Disease

OSSOVSKAYA, V. S., & BUNNETT, N. W. (2004) · Physiological Reviews · doi:10.1152/physrev.00028.2003 · Cited by 1,078

Urinary bladder hyporeflexia and reduced pain-related behaviour in P2X3-deficient mice

Cockayne, D. A., Hamilton, S. G., Zhu, Q.-M., Dunn, P. M., Zhong, Y., Novakovic, S., Malmberg, A. B., Cain, G., Berson, A., Kassotakis, L., et al. (2000) · Nature · doi:10.1038/35039519 · Cited by 1,030

Mechanisms of sensory transduction in the skin

Lumpkin, E. A., & Caterina, M. J. (2007) · Nature · doi:10.1038/nature05662 · Cited by 859

Altered urinary bladder function in mice lacking the vanilloid receptor TRPV1

Birder, L. A., Nakamura, Y., Kiss, S., Nealen, M. L., Barrick, S., Kanai, A. J., Wang, E., Ruiz, G., de Groat, W. C., Apodaca, G., et al. (2002) · Nature Neuroscience · doi:10.1038/nn902 · Cited by 703

ATP is released from rabbit urinary bladder epithelial cells by hydrostatic pressure changes–possible sensory mechanism?

Ferguson, D. R., Kennedy, I., & Burton, T. J. (1997) · The Journal of Physiology · doi:10.1111/j.1469-7793.1997.503bb.x · Cited by 653

Chronic pain may change the structure of the brain

May, A. (2008) · Pain · doi:10.1016/j.pain.2008.02.034 · Cited by 652

Vanilloid receptor expression suggests a sensory role for urinary bladder epithelial cells

Birder, L. A., Kanai, A., de Groat, W. C., Kiss, S., Nealen, M. L., Burke, N. E., Dineley, K. E., Watkins, S. C., Reynolds, I. J., & Caterina, M. J. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.231243698 · Cited by 517

General Anosmia Caused by a Targeted Disruption of the Mouse Olfactory Cyclic Nucleotide–Gated Cation Channel

Brunet, L. J., Gold, G. H., & Ngai, J. (1996) · Neuron · doi:10.1016/s0896-6273(00)80200-7 · Cited by 516

Tension receptors in the stomach and the urinary bladder

Iggo, A. (1955) · The Journal of Physiology · doi:10.1113/jphysiol.1955.sp005327 · Cited by 510

Microbial adherence to and invasion through proteoglycans

Rostand, K. S., & Esko, J. D. (1997) · Infection and Immunity · doi:10.1128/iai.65.1.1-8.1997 · Cited by 490

Pharmacology of the Lower Urinary Tract: Basis for Current and Future Treatments of Urinary Incontinence

Andersson, K.-E., & Wein, A. J. (2004) · Pharmacological Reviews · doi:10.1124/pr.56.4.4 · Cited by 484

P2X3Knock-Out Mice Reveal a Major Sensory Role for Urothelially Released ATP

Vlaskovska, M., Kasakov, L., Rong, W., Bodin, P., Bardini, M., Cockayne, D. A., Ford, A. P. D. W., & Burnstock, G. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-15-05670.2001 · Cited by 465

Hedgehog/Wnt feedback supports regenerative proliferation of epithelial stem cells in bladder

Shin, K., Lee, J., Guo, N., Kim, J., Lim, A., Qu, L., Mysorekar, I. U., & Beachy, P. A. (2011) · Nature · doi:10.1038/nature09851 · Cited by 443

Purine-mediated signalling in pain and visceral perception

Burnstock, G. (2001) · Trends in Pharmacological Sciences · doi:10.1016/s0165-6147(00)01643-6 · Cited by 425

Inhibition of the cation channel TRPV4 improves bladder function in mice and rats with cyclophosphamide-induced cystitis

Everaerts, W., Zhen, X., Ghosh, D., Vriens, J., Gevaert, T., Gilbert, J. P., Hayward, N. J., McNamara, C. R., Xue, F., Moran, M. M., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1005333107 · Cited by 416

THE MAMMALIAN URINARY BLADDERAN ACCOMMODATING ORGAN

HICKS, R. M. (1975) · Biological Reviews · doi:10.1111/j.1469-185x.1975.tb01057.x · Cited by 408

Epithelial Dysfunction in Nonbacterial Cystitis (Interstitial Cystitis)

Parsons, C. L., Lilly, J. D., & Stein, P. (1991) · Journal of Urology · doi:10.1016/s0022-5347(17)38437-9 · Cited by 395

Phosphoinositide 3-Kinase Binds to TRPV1 and Mediates NGF-stimulated TRPV1 Trafficking to the Plasma Membrane

Stein, A. T., Ufret-Vincenty, C. A., Hua, L., Santana, L. F., & Gordon, S. E. (2006) · The Journal of General Physiology · doi:10.1085/jgp.200609576 · Cited by 389

P2X2 knockout mice and P2X2/P2X3 double knockout mice reveal a role for the P2X2 receptor subunit in mediating multiple sensory effects of ATP

Cockayne, D. A., Dunn, P. M., Zhong, Y., Rong, W., Hamilton, S. G., Knight, G. E., Ruan, H., Ma, B., Yip, P., Nunn, P., et al. (2005) · The Journal of Physiology · doi:10.1113/jphysiol.2005.088435 · Cited by 381

Cell biology and physiology of the uroepithelium

Khandelwal, P., Abraham, S. N., & Apodaca, G. (2009) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00327.2009 · Cited by 379

Increased nerve growth factor levels in the urinary bladder of women with idiopathic sensory urgency and interstitial cystitis

LOWE, E. M., ANAND, P., TERENGHI, G., WILLIAMS‐CHESTNUT, R. E., SINICROPI, D. V., & OSBORNE, J. L. (1997) · British Journal of Urology · doi:10.1046/j.1464-410x.1997.00097.x · Cited by 365

Mechanisms of Disease: involvement of the urothelium in bladder dysfunction

Birder, L. A., & de Groat, W. C. (2007) · Nature Clinical Practice Urology · doi:10.1038/ncpuro0672 · Cited by 364

Bladder activation: afferent mechanisms

Andersson, K.-E. (2002) · Urology · doi:10.1016/s0090-4295(01)01637-5 · Cited by 363

Release of vasoactive substances from endothelial cells by shear stress and purinergic mechanosensory transduction

BURNSTOCK, G. (1999) · Journal of Anatomy · doi:10.1046/j.1469-7580.1999.19430335.x · Cited by 355

Bladder Surface Glycosaminoglycans: An Epithelial Permeability Barrier

Parsons, L., Boychuk, D., Jones, S., Hurst, R., & Callahan, H. (1990) · Journal of Urology · doi:10.1016/s0022-5347(17)39897-x · Cited by 339

The Uroepithelium: Not Just a Passive Barrier

Apodaca, G. (2004) · Traffic · doi:10.1046/j.1600-0854.2003.00156.x · Cited by 332

Deletion of the transient receptor potential cation channel TRPV4 impairs murine bladder voiding

Gevaert, T., Vriens, J., Segal, A., Everaerts, W., Roskams, T., Talavera, K., Owsianik, G., Liedtke, W., Daelemans, D., Dewachter, I., et al. (2007) · Journal of Clinical Investigation · doi:10.1172/jci31766 · Cited by 331

Distribution and Function of the Hydrogen Sulfide–Sensitive TRPA1 Ion Channel in Rat Urinary Bladder

Streng, T., Axelsson, H. E., Hedlund, P., Andersson, D. A., Jordt, S.-E., Bevan, S., Andersson, K.-E., Högestätt, E. D., & Zygmunt, P. M. (2008) · European Urology · doi:10.1016/j.eururo.2007.10.024 · Cited by 308

The Role of the Urinary Epithelium in the Pathogenesis of Interstitial Cystitis/Prostatitis/Urethritis

Parsons, C. L. (2007) · Urology · doi:10.1016/j.urology.2006.03.084 · Cited by 288

Adrenergic- and capsaicin-evoked nitric oxide release from urothelium and afferent nerves in urinary bladder

Birder, L. A., Apodaca, G. L., de Groat, W. C., & Kanai, A. (1998) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.1998.275.2.f226 · Cited by 276

INTRAVESICAL CAPSAICIN AND RESINIFERATOXIN THERAPY: SPICING UP THE WAYS TO TREAT THE OVERACTIVE BLADDER

CHANCELLOR, M. B., & de GROAT, W. C. (1999) · Journal of Urology · doi:10.1097/00005392-199907000-00002 · Cited by 268

The role of the human bladder lamina propria myofibroblast

Wiseman, O. J., Fowler, C. J., & Landon, D. N. (2003) · BJU International · doi:10.1046/j.1464-410x.2003.03802.x · Cited by 253

Distribution of the tight junction proteins ZO-1, occludin, and claudin-4, -8, and -12 in bladder epithelium

Acharya, P., Beckel, J., Ruiz, W. G., Wang, E., Rojas, R., Birder, L., & Apodaca, G. (2004) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00341.2003 · Cited by 252

β-Adrenoceptor Agonists Stimulate Endothelial Nitric Oxide Synthase in Rat Urinary Bladder Urothelial Cells

Birder, L. A., Nealen, M. L., Kiss, S., de Groat, W. C., Caterina, M. J., Wang, E., Apodaca, G., & Kanai, A. J. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-18-08063.2002 · Cited by 229

ATP and purinergic receptor–dependent membrane traffic in bladder umbrella cells

Wang, E. C. Y., Lee, J.-M., Ruiz, W. G., Balestreire, E. M., von Bodungen, M., Barrick, S., Cockayne, D. A., Birder, L. A., & Apodaca, G. (2005) · Journal of Clinical Investigation · doi:10.1172/jci24086 · Cited by 224

Cyclic AMP–regulated exocytosis of Escherichia coli from infected bladder epithelial cells

Bishop, B. L., Duncan, M. J., Song, J., Li, G., Zaas, D., & Abraham, S. N. (2007) · Nature Medicine · doi:10.1038/nm1572 · Cited by 222

Sensitisation of visceral afferents by nerve growth factor in the adult rat

Dmitrieva, N., & McMahon, S. B. (1996) · Pain · doi:10.1016/0304-3959(96)02993-4 · Cited by 220

Muscarinic receptor subtypes in human bladder detrusor and mucosa, studied by radioligand binding and quantitative competitive RT–PCR: changes in ageing

Mansfield, K. J., Liu, L., Mitchelson, F. J., Moore, K. H., Millard, R. J., & Burcher, E. (2005) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0706147 · Cited by 213

DISTRIBUTION OF P2X RECEPTORS IN THE URINARY BLADDER AND THE URETER OF THE RAT

LEE, H. Y., BARDINI, M., & BURNSTOCK, G. (2000) · Journal of Urology · doi:10.1016/s0022-5347(05)67618-5 · Cited by 210

Activation and sensitisation of low and high threshold afferent fibres mediated by P2X receptors in the mouse urinary bladder

Rong, W., Spyer, K. M., & Burnstock, G. (2002) · The Journal of Physiology · doi:10.1113/jphysiol.2001.013469 · Cited by 208

Mechanisms of Disease: the role of nerve growth factor in the pathophysiology of bladder disorders

Steers, W. D., & Tuttle, J. B. (2006) · Nature Clinical Practice Urology · doi:10.1038/ncpuro0408 · Cited by 204

Capsaicin receptor TRPV1 in urothelium of neurogenic human bladders and effect of intravesical resiniferatoxin

Apostolidis, A., Brady, C. M., Yiangou, Y., Davis, J., Fowler, C. J., & Anand, P. (2005) · Urology · doi:10.1016/j.urology.2004.10.007 · Cited by 201

Oestrogen and progesterone receptor expression in the female lower urinary tract, with reference to oestrogen status

Blakeman, P. J., Hilton, P., & Bulmer, J. N. (2000) · BJU International · doi:10.1046/j.1464-410x.2000.00724.x · Cited by 200

Bladder permeability barrier: recovery from selective injury of surface epithelial cells

Lavelle, J., Meyers, S., Ramage, R., Bastacky, S., Doty, D., Apodaca, G., & Zeidel, M. L. (2002) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00307.2001 · Cited by 185

Chapter 10 Structure and function of neuronal nicotinic acetylcholine receptors

(1996) · Progress in Brain Research · doi:10.1016/s0079-6123(08)62094-4 · Cited by 180

An antiproliferative factor from interstitial cystitis patients is a frizzled 8 protein-related sialoglycopeptide

Keay, S. K., Szekely, Z., Conrads, T. P., Veenstra, T. D., Barchi, J. J., Zhang, C.-O., Koch, K. R., & Michejda, C. J. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0404509101 · Cited by 180

Augmented extracellular ATP signaling in bladder urothelial cells from patients with interstitial cystitis

Sun, Y., & Chai, T. C. (2006) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00552.2004 · Cited by 179

Effects of inhibition of the l‐arginine/nitric oxide pathway in the rat lower urinary tract in vivo and in vitro

Persson, K., Igawa, Y., Mattiasson, A., & Andersson, K. ‐. (1992) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1992.tb14483.x · Cited by 177

Role of PPAR γ and EGFR signalling in the urothelial terminal differentiation programme

Varley, C. L., Stahlschmidt, J., Lee, W.-C., Holder, J., Diggle, C., Selby, P. J., Trejdosiewicz, L. K., & Southgate, J. (2004) · Journal of Cell Science · doi:10.1242/jcs.01042 · Cited by 175

The ultrastructure and chemistry of the luminal plasma membrane of the mammalian urinary bladder: a structure with low permeability to water and ions

Hicks, R. M., Ketterer, B., & Warren, R. C. (1974) · Philosophical Transactions of the Royal Society of London. B, Biological Sciences · doi:10.1098/rstb.1974.0013 · Cited by 173

ATP is released from guinea pig ureter epithelium on distension

Knight, G. E., Bodin, P., De Groat, W. C., & Burnstock, G. (2002) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00293.2000 · Cited by 173

Bacteria-Induced Uroplakin Signaling Mediates Bladder Response to Infection

Thumbikat, P., Berry, R. E., Zhou, G., Billips, B. K., Yaggie, R. E., Zaichuk, T., Sun, T.-T., Schaeffer, A. J., & Klumpp, D. J. (2009) · PLoS Pathogens · doi:10.1371/journal.ppat.1000415 · Cited by 172

P2X3-Immunoreactive Nerve Fibres in Neurogenic Detrusor Overactivity and the Effect of Intravesical Resiniferatoxin*1

BRADY, C. M. (2004) · European Urology · doi:10.1016/j.eururo.2003.12.017 · Cited by 172

The bladder extracellular matrix. Part I: architecture, development and disease

Aitken, K. J., & Bägli, D. J. (2009) · Nature Reviews Urology · doi:10.1038/nrurol.2009.201 · Cited by 171

Alterations in P2X and P2Y purinergic receptor expression in urinary bladder from normal cats and cats with interstitial cystitis

Birder, L. A., Ruan, H. Z., Chopra, B., Xiang, Z., Barrick, S., Buffington, C. A., Roppolo, J. R., Ford, A. P. D. W., de Groat, W. C., & Burnstock, G. (2004) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00118.2004 · Cited by 170

Overexpression of NGF in mouse urothelium leads to neuronal hyperinnervation, pelvic sensitivity, and changes in urinary bladder function

Schnegelsberg, B., Sun, T.-T., Cain, G., Bhattacharya, A., Nunn, P. A., Ford, A. P. D. W., Vizzard, M. A., & Cockayne, D. A. (2010) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00367.2009 · Cited by 169

In pursuit of P2X3 antagonists: novel therapeutics for chronic pain and afferent sensitization

Ford, A. P. (2012) · Purinergic Signalling · doi:10.1007/s11302-011-9271-6 · Cited by 165

Capsaicin receptor VR1 and ATP‐gated ion channel P2X 3 in human urinary bladder

Yiangou, Y., Facer, P., Ford, A., Brady, C., Wiseman, O., Fowler, C. J., & Anand, P. (2001) · BJU International · doi:10.1046/j.1464-410x.2001.02190.x · Cited by 164

Intravesical Botulinum Toxin A Injections Plus Hydrodistension Can Reduce Nerve Growth Factor Production and Control Bladder Pain in Interstitial Cystitis

Liu, H.-T., & Kuo, H.-C. (2007) · Urology · doi:10.1016/j.urology.2007.04.038 · Cited by 164

Expression and functional role of β-adrenoceptors in the human urinary bladder urothelium

Otsuka, A., Shinbo, H., Matsumoto, R., Kurita, Y., & Ozono, S. (2008) · Naunyn-Schmiedeberg's Archives of Pharmacology · doi:10.1007/s00210-008-0274-y · Cited by 163

Bladder afferent sensitivity in wild‐type and TRPV1 knockout mice

Daly, D., Rong, W., Chess‐Williams, R., Chapple, C., & Grundy, D. (2007) · The Journal of Physiology · doi:10.1113/jphysiol.2007.139147 · Cited by 161

Non-neuronal acetylcholine and urinary bladder urothelium

Hanna-Mitchell, A. T., Beckel, J. M., Barbadora, S., Kanai, A. J., de Groat, W. C., & Birder, L. A. (2007) · Life Sciences · doi:10.1016/j.lfs.2007.02.010 · Cited by 159

Urothelial pathophysiological changes in feline interstitial cystitis: a human model

Lavelle, J. P., Meyers, S., Ruiz, W. G., Buffington, C. A. T., Zeidel, M. L., & Apodaca, G. L. (2000) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.2000.278.4.f540 · Cited by 157

Airway epithelium: more than just a barrier!

Folkerts, G., & Nijkamp, F. P. (1998) · Trends in Pharmacological Sciences · doi:10.1016/s0165-6147(98)01232-2 · Cited by 155

Botulinum-A Toxin Injections Into the Detrusor Muscle Decrease Nerve Growth Factor Bladder Tissue Levels in Patients With Neurogenic Detrusor Overactivity

Giannantoni, A., Stasi, S. M. D., Nardicchi, V., Zucchi, A., Macchioni, L., Bini, V., Goracci, G., & Porena, M. (2006) · The Journal of Urology · doi:10.1016/s0022-5347(06)00258-8 · Cited by 154

Activation of Urothelial Transient Receptor Potential Vanilloid 4 by 4α-Phorbol 12,13-Didecanoate Contributes to Altered Bladder Reflexes in the Rat

Birder, L. A., Kullmann, F. A., Lee, H., et al. (2007) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.107.125435 · Cited by 145

Expression and function of bradykinin B1 and B2 receptors in normal and inflamed rat urinary bladder urothelium

Chopra, B., Barrick, S., Meyers, S., Beckel, J. M., Zeidel, M. L., Ford, A. P. D. W., de Groat, W. C., & Birder, L. A. (2004) · The Journal of Physiology · doi:10.1113/jphysiol.2004.071159 · Cited by 140

Evaluation of the effects of stress in cats with idiopathic cystitis

Westropp, J. L., Kass, P. H., & Buffington, C. A. T. (2006) · American Journal of Veterinary Research · doi:10.2460/ajvr.67.4.731 · Cited by 138

AF‐353, a novel, potent and orally bioavailable P2X3/P2X2/3 receptor antagonist

Gever, J. R., Soto, R., Henningsen, R. A., Martin, R. S., Hackos, D. H., Panicker, S., Rubas, W., Oglesby, I. B., Dillon, M. P., Milla, M. E., et al. (2010) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2010.00796.x · Cited by 138

The Uroepithelial-associated sensory web

Apodaca, G. L., Balestreire, E. M., & Birder, L. A. (2007) · Kidney International · doi:10.1038/sj.ki.5002439 · Cited by 135

Disruption of bladder epithelium barrier function after spinal cord injury

Apodaca, G. L., Kiss, S., Ruiz, W. G., Meyers, S., Zeidel, M. L., & Birder, L. A. (2003) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00359.2002 · Cited by 134

Nerve growth factor in bladder dysfunction: Contributing factor, biomarker, and therapeutic target

Ochodnický, P., Cruz, C. D., Yoshimura, N., & Michel, M. C. (2011) · Neurourology and Urodynamics · doi:10.1002/nau.21022 · Cited by 134

IN VIVO MODELS OF INTERSTITIAL CYSTITIS

Westropp, J. L., & Buffington, C. A. T. (2002) · The Journal of Urology · doi:10.1016/s0022-5347(01)69129-8 · Cited by 133

On the origin of bladder sensing: Tr(i)ps in urology

Everaerts, W., Gevaert, T., Nilius, B., & Ridder, D. J. M. K. D. (2007) · Neurourology and Urodynamics · doi:10.1002/nau.20511 · Cited by 133

Interstitial cells in the urinary bladder—localization and function

McCloskey, K. D. (2009) · Neurourology and Urodynamics · doi:10.1002/nau.20739 · Cited by 132

Nerve growth factor and tissue repair remodeling: trkANGFR and p75NTR, two receptors one fate

Micera, A., Lambìase, A., Stampachiacchiere, B., Bonini, S., Bonini, S., & Levi‐Schaffer, F. (2007) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2007.04.004 · Cited by 130

Systemic blockade of P2X3 and P2X2/3 receptors attenuates bone cancer pain behaviour in rats

Kaan, T. K. Y., Yip, P. K., Patel, S., Davies, M., Marchand, F., Cockayne, D. A., Nunn, P. A., Dickenson, A. H., Ford, A. P. D. W., Zhong, Y., et al. (2010) · Brain · doi:10.1093/brain/awq194 · Cited by 130

Histology and fine structure of the muscularis mucosae of the human urinary bladder.

Dixon, J. S., & GOSLING, J. A. (1983) · Europe PMC (PubMed Central) · Cited by 129

Expression of functional nicotinic acetylcholine receptors in rat urinary bladder epithelial cells

Beckel, J. M., Kanai, A., Lee, S., de Groat, W. C., & Birder, L. A. (2005) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00098.2005 · Cited by 129

PTHrP drives breast tumor initiation, progression, and metastasis in mice and is a potential therapy target

Li, J., Karaplis, A. C., Huang, D. C., Siegel, P. M., Camirand, A., Yang, X. F., Muller, W. J., & Kremer, R. B. (2011) · Journal of Clinical Investigation · doi:10.1172/jci46134 · Cited by 128

Changes of urinary nerve growth factor and prostaglandins in male patients with overactive bladder symptom

Kim, J. C., Park, E., Hong, S., Seo, S. I., Park, Y. H., & Hwang, T.-K. (2005) · International Journal of Urology · doi:10.1111/j.1442-2042.2005.01140.x · Cited by 126

Intravesical Adenosine Triphosphate Stimulates the Micturition Reflex in Awake, Freely Moving Rats

Pandita, R. K., & Andersson, K. (2002) · The Journal of Urology · doi:10.1016/s0022-5347(05)64631-9 · Cited by 124

Bladder Defense Molecules, Urothelial Differentiation, Urinary Biomarkers, and Interstitial Cystitis

Hurst, R. E., Moldwin, R., & Mulholland, S. G. (2007) · Urology · doi:10.1016/j.urology.2006.03.083 · Cited by 123

Drug Insight: biological effects of botulinum toxin A in the lower urinary tract

Chancellor, M. B., Fowler, C. J., Apostolidis, A., de Groat, W. C., Smith, C. P., Somogyi, G. T., & Aoki, K. R. (2008) · Nature Clinical Practice Urology · doi:10.1038/ncpuro1124 · Cited by 123

USE OF THE NEODYMIUM: YAG LASER FOR INTERSTITIAL CYSTITIS: A PROSPECTIVE STUDY

Rofeim, O., HOM, D., Freid, R. M., & Moldwin, R. (2001) · The Journal of Urology · doi:10.1016/s0022-5347(05)66093-4 · Cited by 122

The function of suburothelial myofibroblasts in the bladder

Fry, C. H., Sui, G., Kanai, A., & Wu, C. (2007) · Neurourology and Urodynamics · doi:10.1002/nau.20483 · Cited by 121

Nitric oxide synthase and the lower urinary tract: possible implications for physiology and pathophysiology.

Andersson, K., & Persson, K. (1995) · PubMed · Cited by 120

Social stress-induced bladder dysfunction: potential role of corticotropin-releasing factor

Wood, S. K., Baez, M. A., Bhatnagar, S., & Valentino, R. J. (2009) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.91013.2008 · Cited by 119

Roles of estrogen receptor and in modulating urothelial cell proliferation

Teng, J., Wang, Z.-Y., Jarrard, D. F., & Bjorling, D. E. (2008) · Endocrine Related Cancer · doi:10.1677/erc.1.01255 · Cited by 119

Primary Uroepithelial Cultures

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Transient Receptor Potential Vanilloid Subfamily 1 is Essential for the Generation of Noxious Bladder Input and Bladder Overactivity in Cystitis

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