Student or educator? Sign up with your school email and get 6 months of Pro free.
CoChat
Sign Up
Cited by 859

The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.

Mechanisms of sensory transduction in the skin

Lumpkin, Ellen A., Caterina, Michael J.·2007·Nature
DOI 10.1038/nature05662
Open this paper in CoChat — free account

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1038/nature05662

Cites

1 of 1 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Show all 1 references

Research works printed but not linked: 82

  1. Gardner, E. P., Martin, J. H. & Jessell, T. M. in Principles of Neural Science (eds Kandel, E. R., Schwartz, J. H. & Jessell, T. M.) 430–449 (Oxford Univ. Press, New York, 2000).
  2. Caterina, M. J. & Julius, D. The vanilloid receptor: a molecular gateway to the pain pathway. Annu. Rev. Neurosci. 24, 487–517 (2001). · DOI · Paper page
  3. Ramsey, I. S., Delling, M. & Clapham, D. E. An introduction to TRP channels. Annu. Rev. Physiol. 68, 619–647 (2006). · DOI · Paper page
  4. Dhaka, A., Viswanath, V. & Patapoutian, A. TRP ion channels and temperature sensation. Annu. Rev. Neurosci. 29, 135–161 (2006). · DOI · Paper page
  5. Lee, H. & Caterina, M. J. TRPV channels as thermosensory receptors in epithelial cells. Pflügers Arch. 451, 160–167 (2005). · DOI
  6. Zimmermann, K. et al. The TRPV1/2/3 activator 2-aminoethoxydiphenyl borate sensitizes native nociceptive neurons to heat in wildtype but not TRPV1 deficient mice. Neuroscience 135, 1277–1284 (2005). · DOI
  7. Woodbury, C. J. et al. Nociceptors lacking TRPV1 and TRPV2 have normal heat responses. J. Neurosci. 24, 6410–6415 (2004). · DOI · Paper page
  8. Szallasi, A., Cruz, F. & Geppetti, P. TRPV1: a therapeutic target for novel analgesic drugs? Trends Mol. Med. 12, 545–554 (2006). · DOI
  9. Togashi, K. et al. TRPM2 activation by cyclic ADP-ribose at body temperature is involved in insulin secretion. EMBO J. 25, 1804–1815 (2006). · DOI · Paper page
  10. Peier, A. M. et al. A TRP channel that senses cold stimuli and menthol. Cell 108, 705–715 (2002). · DOI · Paper page
  11. McKemy, D. D., Neuhausser, W. M. & Julius, D. Identification of a cold receptor reveals a general role for TRP channels in thermosensation. Nature 416, 52–58 (2002). · DOI · Paper page
  12. Story, G. M. et al. ANKTM1, a TRP-like channel expressed in nociceptive neurons, is activated by cold temperatures. Cell 112, 819–829 (2003). · DOI · Paper page
  13. Bautista, D. M. et al. Pungent products from garlic activate the sensory ion channel TRPA1. Proc. Natl Acad. Sci. USA 102, 12248–12252 (2005). · DOI · Paper page
  14. Jordt, S. E. et al. Mustard oils and cannabinoids excite sensory nerve fibres through the TRP channel ANKTM1. Nature 427, 260–265 (2004). · DOI · Paper page
  15. Bandell, M. et al. Noxious cold ion channel TRPA1 is activated by pungent compounds and bradykinin. Neuron 41, 849–857 (2004). · DOI · Paper page
  16. Reid, G. ThermoTRP channels and cold sensing: what are they really up to? Pflügers Arch. 451, 250–263 (2005). · DOI · Paper page
  17. Kwan, K. Y. et al. TRPA1 contributes to cold, mechanical, and chemical nociception but is not essential for hair-cell transduction. Neuron 50, 277–289 (2006). · DOI · Paper page
  18. Obata, K. et al. TRPA1 induced in sensory neurons contributes to cold hyperalgesia after inflammation and nerve injury. J. Clin. Invest. 115, 2393–2401 (2005). · DOI · Paper page
  19. Nagata, K., Duggan, A., Kumar, G. & Garcia-Anoveros, J. Nociceptor and hair cell transducer properties of TRPA1, a channel for pain and hearing. J. Neurosci. 25, 4052–4061 (2005). · DOI · Paper page
  20. Bautista, D. M. et al. TRPA1 mediates the inflammatory actions of environmental irritants and proalgesic agents. Cell 124, 1269–1282 (2006). · DOI · Paper page
  21. Viana, F., de la Pena, E. & Belmonte, C. Specificity of cold thermotransduction is determined by differential ionic channel expression. Nature Neurosci. 5, 254–260 (2002). · DOI · Paper page
  22. Olausson, H. et al. Unmyelinated tactile afferents signal touch and project to insular cortex. Nature Neurosci. 5, 900–904 (2002). · DOI · Paper page
  23. Kung, C. A possible unifying principle for mechanosensation. Nature 436, 647–654 (2005). · DOI · Paper page
  24. Jiang, Y. et al. Crystal structure and mechanism of a calcium-gated potassium channel. Nature 417, 515–522 (2002). · DOI · Paper page
  25. LeMasurier, M. & Gillespie, P. G. Hair-cell mechanotransduction and cochlear amplification. Neuron 48, 403–415 (2005). · DOI
  26. Syntichaki, P. & Tavernarakis, N. Genetic models of mechanotransduction: the nematode Caenorhabditis elegans. Physiol. Rev. 84, 1097–1153 (2004). · DOI
  27. Kahn-Kirby, A. H. et al. Specific polyunsaturated fatty acids drive TRPV-dependent sensory signaling in vivo. Cell 119, 889–900 (2004). · DOI
  28. Corey, D. P. & Hudspeth, A. J. Response latency of vertebrate hair cells. Biophys. J. 26, 499–506 (1979). · DOI
  29. O'Hagan, R., Chalfie, M. & Goodman, M. B. The MEC-4 DEG/ENaC channel of Caenorhabditis elegans touch receptor neurons transduces mechanical signals. Nature Neurosci. 8, 43–50 (2005). · DOI · Paper page
  30. Walker, R. G., Willingham, A. T. & Zuker, C. S. A Drosophila mechanosensory transduction channel. Science 287, 2229–2234 (2000). · DOI · Paper page
  31. Suzuki, H. et al. In vivo imaging of C. elegans mechanosensory neurons demonstrates a specific role for the MEC-4 channel in the process of gentle touch sensation. Neuron 39, 1005–1017 (2003). · DOI · Paper page
  32. Wetzel, C. et al. A stomatin-domain protein essential for touch sensation in the mouse. Nature 445, 206–209 (2007). · DOI · Paper page
  33. Lumpkin, E. A. & Bautista, D. M. Feeling the pressure in mammalian somatosensation. Curr. Opin. Neurobiol. 15, 382–388 (2005). · DOI
  34. Mogil, J. S. et al. Transgenic expression of a dominant-negative ASIC3 subunit leads to increased sensitivity to mechanical and inflammatory stimuli. J. Neurosci. 25, 9893–9901 (2005). · DOI
  35. Li, W., Feng, Z., Sternberg, P. W. & Xu, X. Z. A C. elegans stretch receptor neuron revealed by a mechanosensitive TRP channel homologue. Nature 440, 684–687 (2006). · DOI · Paper page
  36. Eberl, D. F., Hardy, R. W. & Kernan, M. J. Genetically similar transduction mechanisms for touch and hearing in Drosophila. J. Neurosci. 20, 5981–5988 (2000). · DOI · Paper page
  37. Gopfert, M. C., Albert, J. T., Nadrowski, B. & Kamikouchi, A. Specification of auditory sensitivity by Drosophila TRP channels. Nature Neurosci. 9, 999–1000 (2006). · DOI
  38. Sidi, S., Friedrich, R. W. & Nicolson, T. NompC TRP channel required for vertebrate sensory hair cell mechanotransduction. Science 301, 96–99 (2003). · DOI · Paper page
  39. Shin, J. B. et al. Xenopus TRPN1 (NOMPC) localizes to microtubule-based cilia in epithelial cells, including inner-ear hair cells. Proc. Natl Acad. Sci. USA 102, 12572–12577 (2005). · DOI
  40. Corey, D. P. et al. TRPA1 is a candidate for the mechanosensitive transduction channel of vertebrate hair cells. Nature 432, 723–730 (2004). · DOI · Paper page
  41. Tracey, W. D., Wilson, R. I., Laurent, G. & Benzer, S. painless, a Drosophila gene essential for nociception. Cell 113, 261–273 (2003). · DOI · Paper page
  42. Kahn-Kirby, A. H. & Bargmann, C. I. TRP channels in C. elegans. Annu. Rev. Physiol. 68, 719–736 (2006). · DOI
  43. Gong, Z. et al. Two interdependent TRPV channel subunits, Inactive and Nanchung, mediate hearing in Drosophila. J. Neurosci. 24, 9059–9066 (2004). · DOI · Paper page
  44. Kim, J. et al. A TRPV family ion channel required for hearing in Drosophila. Nature 424, 81–84 (2003). · DOI · Paper page
  45. Liedtke, W. TRPV4 as osmosensor: a transgenic approach. Pflügers Arch. 451, 176–180 (2005). · DOI
  46. Liedtke, W. et al. Vanilloid receptor-related osmotically activated channel (VR-OAC), a candidate vertebrate osmoreceptor. Cell 103, 525–535 (2000). · DOI · Paper page
  47. Strotmann, R., Harteneck, C., Nunnenmacher, K., Schultz, G. & Plant, T. D. OTRPC4, a nonselective cation channel that confers sensitivity to extracellular osmolarity. Nature Cell Biol. 2, 695–702 (2000). · DOI · Paper page
  48. Vriens, J. et al. Cell swelling, heat, and chemical agonists use distinct pathways for the activation of the cation channel TRPV4. Proc. Natl Acad. Sci. USA 101, 396–401 (2004). · DOI · Paper page
  49. Liedtke, W. & Friedman, J. M. Abnormal osmotic regulation in trpv4−/− mice. Proc. Natl Acad. Sci. USA 100, 13698–13703 (2003). · DOI · Paper page
  50. Suzuki, M., Mizuno, A., Kodaira, K. & Imai, M. Impaired pressure sensation in mice lacking TRPV4. J. Biol. Chem. 278, 22664–22668 (2003). · DOI · Paper page
  51. Alessandri-Haber, N., Joseph, E., Dina, O. A., Liedtke, W. & Levine, J. D. TRPV4 mediates pain-related behavior induced by mild hypertonic stimuli in the presence of inflammatory mediator. Pain 118, 70–79 (2005). · DOI · Paper page
  52. Birder, L. A. et al. Altered urinary bladder function in mice lacking the vanilloid receptor TRPV1. Nature Neurosci. 5, 856–860 (2002). · DOI · Paper page
  53. Sharif Naeini, R., Witty, M. F., Seguela, P. & Bourque, C. W. An N-terminal variant of Trpv1 channel is required for osmosensory transduction. Nature Neurosci. 9, 93–98 (2006). · DOI · Paper page
  54. Muraki, K. et al. TRPV2 is a component of osmotically sensitive cation channels in murine aortic myocytes. Circ. Res. 93, 829–838 (2003). · DOI · Paper page
  55. Maroto, R. et al. TRPC1 forms the stretch-activated cation channel in vertebrate cells. Nature Cell Biol. 7, 179–185 (2005). · DOI · Paper page
  56. Alloui, A. et al. TREK-1, a K+ channel involved in polymodal pain perception. EMBO J. 25, 2368–2376 (2006). · DOI · Paper page
  57. Roper, S. D. Signaling in the chemosensory systems: cell communication in taste buds. Cell Mol. Life Sci. 63, 1494–1500 (2006). · DOI
  58. Zylka, M. J., Rice, F. L. & Anderson, D. J. Topographically distinct epidermal nociceptive circuits revealed by axonal tracers targeted to Mrgprd. Neuron 45, 17–25 (2005). · DOI · Paper page
  59. Snider, W. D. & McMahon, S. B. Tackling pain at the source: new ideas about nociceptors. Neuron 20, 629–632 (1998). · DOI · Paper page
  60. Hilliges, M., Wang, L. & Johansson, O. Ultrastructural evidence for nerve fibers within all vital layers of the human epidermis. J. Invest. Dermatol. 104, 134–137 (1995). · DOI · Paper page
  61. Chateau, Y. & Misery, L. Connections between nerve endings and epidermal cells: are they synapses? Exp. Dermatol. 13, 2–4 (2004). · DOI
  62. Shu, X. Q. & Mendell, L. M. Neurotrophins and hyperalgesia. Proc. Natl Acad. Sci. USA 96, 7693–7696 (1999). · DOI · Paper page
  63. Khodorova, A., Fareed, M. U., Gokin, A., Strichartz, G. R. & Davar, G. Local injection of a selective endothelin-B receptor agonist inhibits endothelin-1-induced pain-like behavior and excitation of nociceptors in a naloxone-sensitive manner. J. Neurosci. 22, 7788–7796 (2002). · DOI
  64. Xu, H., Delling, M., Jun, J. C. & Clapham, D. E. Oregano, thyme and clove-derived flavors and skin sensitizers activate specific TRP channels. Nature Neurosci. 9, 628–635 (2006). · DOI · Paper page
  65. Koizumi, S. et al. Ca2+ waves in keratinocytes are transmitted to sensory neurons: the involvement of extracellular ATP and P2Y2 receptor activation. Biochem. J. 380, 329–338 (2004). · DOI · Paper page
  66. Khodorova, A. et al. Endothelin-B receptor activation triggers an endogenous analgesic cascade at sites of peripheral injury. Nature Med. 9, 1055–1061 (2003). · DOI · Paper page
  67. Moqrich, A. et al. Impaired thermosensation in mice lacking TRPV3, a heat and camphor sensor in the skin. Science 307, 1468–1472 (2005). · DOI · Paper page
  68. Biro, T. et al. Hair cycle control by vanilloid receptor-1 (TRPV1): evidence from TRPV1 knockout mice. J. Invest. Dermatol. 126, 1909–1912 (2006). · DOI
  69. Asakawa, M. et al. Association of a mutation in TRPV3 with defective hair growth in rodents. J. Invest. Dermatol. 126, 2664–2672 (2006). · DOI · Paper page
  70. Halata, Z., Grim, M. & Bauman, K. I. Friedrich Sigmund Merkel and his 'Merkel cell', morphology, development, and physiology: review and new results. Anat. Rec. 271A, 225–239 (2003). · DOI · Paper page
  71. Sekerkova, G. et al. Espins are multifunctional actin cytoskeletal regulatory proteins in the microvilli of chemosensory and mechanosensory cells. J. Neurosci. 24, 5445–5456 (2004). · DOI
  72. Ben-Arie, N. et al. Functional conservation of atonal and Math1 in the CNS and PNS. Development 127, 1039–1048 (2000). · DOI · Paper page
  73. Wallis, D. et al. The zinc finger transcription factor Gfi1, implicated in lymphomagenesis, is required for inner ear hair cell differentiation and survival. Development 130, 221–232 (2003). · DOI · Paper page
  74. Cahusac, P. M. & Senok, S. S. Metabotropic glutamate receptor antagonists selectively enhance responses of slowly adapting type I mechanoreceptors. Synapse 59, 235–242 (2006). · doi:10.1002/syn.20236
  75. Cahusac, P. M., Senok, S. S., Hitchcock, I. S., Genever, P. G. & Baumann, K. I. Are unconventional NMDA receptors involved in slowly adapting type I mechanoreceptor responses? Neuroscience 133, 763–773 (2005). · DOI
  76. Fagan, B. M. & Cahusac, P. M. Evidence for glutamate receptor mediated transmission at mechanoreceptors in the skin. Neuroreport 12, 341–347 (2001). · DOI
  77. Haeberle, H. et al. Molecular profiling reveals synaptic release machinery in Merkel cells. Proc. Natl Acad. Sci. USA 101, 14503–14508 (2004). · DOI
  78. Tachibana, T. & Nawa, T. Immunohistochemical reactions of receptors to met-enkephalin, VIP, substance P, and CGRP located on Merkel cells in the rat sinus hair follicle. Arch. Histol. Cytol. 68, 383–391 (2005). · DOI
  79. Jordt, S. E. & Julius, D. Molecular basis for species-specific sensitivity to 'hot' chili peppers. Cell 108, 421–430 (2002). · DOI · Paper page
  80. Bandell, M. et al. High-throughput random mutagenesis screen reveals TRPM8 residues specifically required for activation by menthol. Nature Neurosci. 9, 493–500 (2006). · DOI
  81. Voets, T. et al. The principle of temperature-dependent gating in cold- and heat-sensitive TRP channels. Nature 430, 748–54 (2004). · DOI · Paper page
  82. Feske, S. et al. A mutation in Orai1 causes immune deficiency by abrogating CRAC channel function. Nature 441, 179–185 (2006). · DOI · Paper page

Cited by

See all 859

Metadata

Authors
Lumpkin, E. A., & Caterina, M. J.
Venue
Nature
Publisher
Springer Science and Business Media LLC
Published
2007-02-21
Volume
445
Issue
7130
Pages
858-865
ISSN
  • 0028-0836 (ISSN-L)
  • 1476-4687
DOI
10.1038/nature05662
OpenAlex
W2112486201
Cited by
859
References
1
FWCI
17.24
Type
journal article
Language
en
Open access
closed
Licence

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

How to cite

Cite CoChat for the checks on this page, and the paper for its own findings.

This page
CoChat. (2026). Citation check: Mechanisms of sensory transduction in the skin. https://app.cochat.ai/papers/10.1038/nature05662
The paper
Lumpkin, E. A., & Caterina, M. J. (2007). Mechanisms of sensory transduction in the skin. Nature. https://doi.org/10.1038/nature05662

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.