The DOI matches its Crossref record; 230 of the 230 references it cites were found in a registry or an index.
Physiology of the Endometrium and Regulation of Menstruation
Open accessAbstract
The physiological functions of the uterine endometrium (uterine lining) are preparation for implantation, maintenance of pregnancy if implantation occurs, and menstruation in the absence of pregnancy. The endometrium thus plays a pivotal role in reproduction and continuation of our species. Menstruation is a steroid-regulated event, and there are alternatives for a progesterone-primed endometrium, i.e., pregnancy or menstruation. Progesterone withdrawal is the trigger for menstruation. The menstruating endometrium is a physiological example of an injured or “wounded” surface that is required to rapidly repair each month. The physiological events of menstruation and endometrial repair provide an accessible in vivo human model of inflammation and tissue repair. Progress in our understanding of endometrial pathophysiology has been facilitated by modern cellular and molecular discovery tools, along with animal models of simulated menses. Abnormal uterine bleeding (AUB), including heavy menstrual bleeding (HMB), imposes a massive burden on society, affecting one in four women of reproductive age. Understanding structural and nonstructural causes underpinning AUB is essential to optimize and provide precision in patient management. This is facilitated by careful classification of causes of bleeding. We highlight the crucial need for understanding mechanisms underpinning menstruation and its aberrations. The endometrium is a prime target tissue for selective progesterone receptor modulators (SPRMs). This class of compounds has therapeutic potential for the clinical unmet need of HMB. SPRMs reduce menstrual bleeding by mechanisms still largely unknown. Human menstruation remains a taboo topic, and many questions concerning endometrial physiology that pertain to menstrual bleeding are yet to be answered.
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Cites
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Cited by
Endometriosis: Etiology, pathobiology, and therapeutic prospects
Saunders, P. T. K., & Horne, A. W. (2021) · Cell · doi:10.1016/j.cell.2021.04.041 · Cited by 961
Mapping the temporal and spatial dynamics of the human endometrium in vivo and in vitro
(2021) · doi:10.1038/s41588-021-00972-2 · Cited by 662
Jamaluddin, M. F. B., Ghosh, A., Ingle, A., Mohammed, R., Ali, A., Bahrami, M., Kaiko, G., Gibb, Z., Filipe, E. C., Cox, T. R., et al. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2208040119 · Cited by 84
The Double Engines and Single Checkpoint Theory of Endometriosis
Hsu, C.-F., Khine, A. A., Huang, H.-S., & Chu, T.-Y. (2022) · Biomedicines · doi:10.3390/biomedicines10061403 · Cited by 12
Metadata
- Authors
- Critchley, H. O. D., Maybin, J. A., Armstrong, G. M., & Williams, A. R. W.
- Venue
- Physiological Reviews
- Publisher
- American Physiological Society
- Published
- 2020-07-01
- Volume
- 100
- Issue
- 3
- Pages
- 1149-1179
- ISSN
- 0031-9333 (ISSN-L)
- 1522-1210
- OpenAlex
- W3004831330
- Cited by
- 536
- References
- 230
- FWCI
- 12.77
- Type
- journal article
- Language
- en
- Open access
- hybrid
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