The DOI matches its Crossref record; 372 of the 372 references it cites were found in a registry or an index.
Calcitonin Gene-Related Peptide: Physiology and Pathophysiology
Open accessAbstract
Calcitonin gene-related peptide (CGRP) is a 37-amino acid neuropeptide. Discovered 30 years ago, it is produced as a consequence of alternative RNA processing of the calcitonin gene. CGRP has two major forms (α and β). It belongs to a group of peptides that all act on an unusual receptor family. These receptors consist of calcitonin receptor-like receptor (CLR) linked to an essential receptor activity modifying protein (RAMP) that is necessary for full functionality. CGRP is a highly potent vasodilator and, partly as a consequence, possesses protective mechanisms that are important for physiological and pathological conditions involving the cardiovascular system and wound healing. CGRP is primarily released from sensory nerves and thus is implicated in pain pathways. The proven ability of CGRP antagonists to alleviate migraine has been of most interest in terms of drug development, and knowledge to date concerning this potential therapeutic area is discussed. Other areas covered, where there is less information known on CGRP, include arthritis, skin conditions, diabetes, and obesity. It is concluded that CGRP is an important peptide in mammalian biology, but it is too early at present to know if new medicines for disease treatment will emerge from our knowledge concerning this molecule.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Items 201–372 of 372
Nitroxyl (HNO) as a Vasoprotective Signaling Molecule
Bullen, M. L., Miller, A. A., Andrews, K. L., Irvine, J. C., Ritchie, R. H., Sobey, C. G., & Kemp‐Harper, B. K. (2010) · Antioxidants and Redox Signaling · doi:10.1089/ars.2010.3327 · Cited by 77
NGF modulates CGRP synthesis in human B-lymphocytes: a possible anti-inflammatory action of NGF?
Bracci‐Laudiero, L., Aloe, L., Buanne, P., Finn, A., Stenfors, C., Vigneti, E., Theodorsson, E., & Lundeberg, T. (2002) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(01)00475-1 · Cited by 77
Choksi, T., Hay, D. L., Legon, S., Poyner, D. R., Hagner, S., Bloom, S. R., & Smith, D. M. (2002) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0704761 · Cited by 76
The role of the CGRP-receptor component protein (RCP) in adrenomedullin receptor signal transduction
Prado, M. A., Evans-Bain, B., Oliver, K. R., & Dickerson, I. M. (2001) · Peptides · doi:10.1016/s0196-9781(01)00517-4 · Cited by 76
Gillardon, F., Moll, I., Michel, S., Benrath, J., Weihe, E., & Zimmermann, M. (1995) · European Journal of Pharmacology · doi:10.1016/0926-6917(95)90060-8 · Cited by 75
Gennari, C., Nami, R., Agnusdei, D., & Fischer, J. A. (1990) · Cardiovascular Research · doi:10.1093/cvr/24.3.239 · Cited by 75
Randomized, controlled trial of telcagepant over four migraine attacks
Ho, A. P., Dahlöf, C. G. H., Silberstein, S. D., Saper, J. R., Ashina, M., Kost, J. T., Froman, S., Leibensperger, H., Lines, C. R., & Ho, T. W. (2010) · Cephalalgia · doi:10.1177/0333102410370878 · Cited by 75
Muff, R., Leuthäuser, K., Bühlmann, N., Foord, S. M., Fischer, J. A., & Born, W. (1998) · FEBS Letters · doi:10.1016/s0014-5793(98)01587-7 · Cited by 74
Wang, Y., & Wang, D. H. (2005) · Hypertension · doi:10.1161/01.hyp.0000197390.10412.c4 · Cited by 74
Circadian rhythm of calcitonin gene-related peptide in uncomplicated essential hypertension
Portaluppi, F., Trasforini, G., Margutti, A., Vergnani, L., Ambrosio, M. R., Rossi, R., Bagni, B., Pansini, R., & Uberti, E. C. D. (1992) · Journal of Hypertension · doi:10.1097/00004872-199210000-00017 · Cited by 74
Edvinsson, L. I., Sams, A. G., Jansen‐Olesen, I., Tajti, J., Kane, S. A., Rutledge, R. Z., Koblan, K. S., Hill, R. G., & Longmore, J. (2001) · European Journal of Pharmacology · doi:10.1016/s0014-2999(00)00934-1 · Cited by 74
Hay, D. L., Walker, C. S., & Poyner, D. R. (2010) · Endocrine Related Cancer · doi:10.1677/erc-10-0244 · Cited by 74
CGRP receptor antagonists: an expanding drug class for acute migraine?
Negro, A., Lionetto, L., Simmaco, M., & Martelletti, P. (2012) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.2012.681044 · Cited by 74
Buckley, T. L., Brain, S. D., Rampart, M., & Williams, T. J. (1991) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1991.tb09819.x · Cited by 73
Self-citationCalcitonin Gene–Related Peptide Is a Depressor of Deoxycorticosterone-Salt Hypertension in the Rat
Supowit, S. C., Zhao, H., Hallman, D. M., & DiPette, D. J. (1997) · Hypertension · doi:10.1161/01.hyp.29.4.945 · Cited by 73
Schaeffer, C., Vandroux, D., Thomassin, L., Athias, P., Rochette, L., & Connat, J. (2003) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2003.09.005 · Cited by 72
Calcitonin Gene-Related Peptide and Regulation of Human Cardiovascular Homeostasis
Preibisz, J. (1993) · American Journal of Hypertension · doi:10.1093/ajh/6.5.434 · Cited by 72
Calcitonin gene-related peptide is metabolized by an endopeptidase hydrolyzing substance P
Grevès, P. L., Nyberg, F., Hökfelt, T. G. M., & Terenius, L. Y. (1989) · Regulatory Peptides · doi:10.1016/0167-0115(89)90176-6 · Cited by 71
Guo, T., Wei, T., Shi, X., Li, W., Hou, S., Wang, L., Tsujikawa, K., Rice, K. C., Cheng, K., Clark, J. D., et al. (2012) · Molecular Pain · doi:10.1186/1744-8069-8-85 · Cited by 71
Yu, L., Hansson, P. T., Brodda‐Jansen, G., Theodorsson, E., & Lundeberg, T. (1996) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1996.tb15152.x · Cited by 71
Mapp, P. I., McWilliams, D. F., Turley, M. J., Hargin, E., & Walsh, D. A. (2012) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2012.01848.x · Cited by 70
Saxler, G., Löer, F., Skumavc, M., Pförtner, J., & Hanesch, U. (2007) · Cited by 70
Pozsgai, G., Hajna, Z., Bagoly, T., et al. (2012) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2012.05.053 · Cited by 69
Production and secretion of calcitonin gene-related peptide from human lymphocytes
Wang, H., Xing, L., Li, W., Hou, L., Guo, J., & Wang, X. (2002) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(02)00221-7 · Cited by 69
Russell, F. A., Fernandes, E. S., Courade, J., et al. (2009) · Pain · doi:10.1016/j.pain.2009.01.021 · Cited by 69
Self-citationCalcitonin gene-related peptide facilitates revascularization during hindlimb ischemia in mice
Mishima, T., Ito, Y., Hosono, K., Tamura, Y., Uchida, Y., Hirata, M., Suzsuki, T., Amano, H., Kato, S., Kurihara, Y., et al. (2010) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00466.2010 · Cited by 69
Yu, L.-C., Hansson, P. T., & Lundeberg, T. (1996) · Neuroscience · doi:10.1016/0306-4522(95)00428-9 · Cited by 68
Schifter, S. (1991) · Peptides · doi:10.1016/0196-9781(91)90027-m · Cited by 68
Structure–activity relationships for α‐calcitonin gene‐related peptide
Watkins, H. A., Rathbone, D. L., Barwell, J., Hay, D. L., & Poyner, D. R. (2012) · British Journal of Pharmacology · doi:10.1111/bph.12072 · Cited by 66
Yu, L.-C., Hansson, P. T., & Lundeberg, T. (1994) · Brain Research · doi:10.1016/0006-8993(94)90393-x · Cited by 66
Interaction of calcitonin-gene-related peptide with its receptors
Conner, A. C., Hay, D. L., Howitt, S. G., Kilk, K., Langel, Ü., Wheatley, M., Smith, D. M., & Poyner, D. R. (2002) · Biochemical Society Transactions · doi:10.1042/bst0300451 · Cited by 65
Gangula, P. R., Supowit, S. C., Wimalawansa, S. J., Zhao, H., Hallman, D. M., DiPette, D. J., & Yallampalli, C. (1997) · Hypertension · doi:10.1161/01.hyp.29.1.248 · Cited by 65
Lou, H. J., & Gagel, R. (1998) · Journal of Endocrinology · doi:10.1677/joe.0.1560401 · Cited by 65
Structure and function of small arteries in hypertension.
Mulvany, M. J. (1990) · PubMed · Cited by 65
TRPV1 activation prevents high-salt diet-induced nocturnal hypertension in mice
Hao, X., Chen, J., Luo, Z., He, H., Yu, H., Ma, L., Ma, S., Zhu, T., Liu, D., & Zhu, Z. (2011) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-011-0921-x · Cited by 64
Puttfarcken, P. S., Han, P., Joshi, S. K., Neelands, T. R., Gauvin, D. M., Baker, S. J., Lewis, L. G. R., Bianchi, B. R., Mikusa, J. P., Koenig, J. R., et al. (2010) · Pain · doi:10.1016/j.pain.2010.05.015 · Cited by 64
Changes of plasma calcitonin gene–related peptide levels in postmenopausal women
Valentini, Petraglia, Vita, D., Nappi, R. E., Margutti, Uberti, E. C. D., & Genazzani (1996) · American Journal of Obstetrics and Gynecology · doi:10.1053/ob.1996.v175.a74287 · Cited by 64
Randomized, Controlled Study of Telcagepant in Patients With Migraine and Coronary Artery Disease
Ho, T. W., Ho, A. P., CHAITMAN, B. R., Johnson, C. J., Mathew, N. T., Kost, J. T., Fan, X. F., Aurora, S. K., Brandes, J. L., Fei, K., et al. (2012) · Headache The Journal of Head and Face Pain · doi:10.1111/j.1526-4610.2011.02052.x · Cited by 64
Analysis of the cellular expression pattern of β‐CGRP in α‐CGRP‐deficient mice
Schütz, B., Mauer, D., Salmon, A., Changeux, J., & Zimmer, A. (2004) · The Journal of Comparative Neurology · doi:10.1002/cne.20211 · Cited by 63
Zhou, Z., Hu, C.-P., Wang, C., Li, T., Peng, J., & Li, Y. (2010) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2010.08.050 · Cited by 62
Vascular and neural dysfunction in Zucker diabetic fatty rats: a difficult condition to reverse
Oltman, C. L., Davidson, E. P., Coppey, L. J., Kleinschmidt, T. L., Lund, D. D., Adebara, E. T., & Yorek, M. A. (2007) · Diabetes Obesity and Metabolism · doi:10.1111/j.1463-1326.2007.00814.x · Cited by 62
CGRP and somatostatin modulate chronic hypoxic pulmonary hypertension
Tjen‐A‐Looi, S. C., Ekman, R., Lippton, H. L., Cary, J. R., & Keith, I. M. (1992) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1992.263.3.h681 · Cited by 61
Influence of Arterial Baroreceptors on Heart Rate Variability
Piepoli, M. F., & Bernardi, L. (1998) · Medical Principles and Practice · doi:10.1159/000026028 · Cited by 60
BIGAL, M. E., Walter, S., Bronson, M. D., Alibhoy, A., & Escandon, R. D. (2014) · Cephalalgia · doi:10.1177/0333102414527646 · Cited by 60
Graepel, R., Fernandes, E. S., Aubdool, A. A., Andersson, D. A., Bevan, S., & Brain, S. D. (2011) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.110.172403 · Cited by 60
Self-citationThe biological effects and mechanisms of calcitonin gene-related peptide on human endothelial cell
Tuo, Y., Guo, X., Zhang, X., Wang, Z., Zhou, J., Xia, L., Zhang, Y., Wen, J., & Jin, D. (2013) · Journal of Receptors and Signal Transduction · doi:10.3109/10799893.2013.770528 · Cited by 59
Monneret, G., Arpin, M., Venet, F., Maghni, K., Debard, A., Pachot, A., Lepape, A., & Bienvenu, J. (2003) · Intensive Care Medicine · doi:10.1007/s00134-003-1759-2 · Cited by 58
Massaad, C. A., Safieh‐Garabedian, B., Poole, S., Atweh, S., Jabbur, S. J., & Saadé, N. E. (2004) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2004.05.007 · Cited by 58
Scholzen, T. E., Brzoska, T., Fastrich, M., Schiller, M., Böhm, M., Schwarz, T., Luger, T. A., Kalden, D.-H., Armstrong, C. A., & Ansel, J. C. (2000) · Journal of Investigative Dermatology · doi:10.1046/j.1523-1747.2000.00174.x · Cited by 58
Crystal structure of the human receptor activity‐modifying protein 1 extracellular domain
Kusano, S., Kukimoto‐Niino, M., Akasaka, R., Toyama, M., Terada, T., Shirouzu, M., Shindo, T., & Yokoyama, S. (2008) · Protein Science · doi:10.1110/ps.036012.108 · Cited by 57
Capsaicin effects on substance P and CGRP in rat adjuvant arthritis
Ahmed, M., Bjurholm, A., Srinivasan, G. R., Lundeberg, T., Theodorsson, E., Schultzberg, M., & Andris Kreicbergs, A. (1995) · Regulatory Peptides · doi:10.1016/0167-0115(94)00095-f · Cited by 57
Calcitonin gene‐related peptide regulates gene transcription in primary afferent neurons
Anderson, L. E., & Seybold, V. S. (2004) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2004.02833.x · Cited by 56
Huang, J., Stohl, L. L., Zhou, X. K., Ding, W., & Granstein, R. D. (2011) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2011.02.007 · Cited by 55
Reinnervation and neuropeptides in mouse skin flaps
Karanth, S., Dhital, S. K., Springall, D. R., et al. (1990) · Journal of the Autonomic Nervous System · doi:10.1016/0165-1838(90)90069-u · Cited by 55
Tam, C. W., Husmann, K., Clark, N. C., Clark, J., Lázár, Z., Ittner, L. M., Götz, J., Douglas, G., Grant, A. D., Sugden, D., et al. (2005) · Circulation Research · doi:10.1161/01.res.0000200737.63865.58 · Cited by 55
Self-citationRaap, T., Jüsten, H., Miller, L. E., Cutolo, M., Schölmerich, J., & Straub, R. H. (2000) · PubMed · Cited by 55
Hasbak, P., Opgaard, O. S., Eskesen, K., Schifter, S., Arendrup, H. C., Longmore, J., & Edvinsson, L. I. (2003) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.102.037754 · Cited by 54
Calcitonin gene-related peptide gene expression in the spontaneously hypertensive rat.
Supowit, S. C., Ramana, C. V., Westlund, K. N., & DiPette, D. J. (1993) · Hypertension · doi:10.1161/01.hyp.21.6.1010 · Cited by 54
Huang, R., Karve, A. M., Shah, I., Bowers, M. C., DiPette, D. J., Supowit, S. C., & Abela, G. S. (2008) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00749.2007 · Cited by 54
Wyon, Y., Frisk, J., Lundeberg, T., Theodorsson, E., & Hammar, M. L. (1998) · Maturitas · doi:10.1016/s0378-5122(98)00047-4 · Cited by 54
Luo, D., Zhang, Y.-W., Peng, W., Peng, J., Chen, Q., Dai, L., Deng, H., & Li, Y. (2008) · Regulatory Peptides · doi:10.1016/j.regpep.2008.05.007 · Cited by 54
Hong, K. W., Yoo, S.-S., Yu, S. S., Lee, J. Y., & Rhim, B.-Y. (1996) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1996.270.1.h317 · Cited by 54
Release and effects of calcitonin gene-related peptide in myocardial ischaemia
Källner, G. (1998) · Scandinavian Cardiovascular Journal · doi:10.1080/140174398427956 · Cited by 53
Grant, A. D., Gerard, N. P., & Brain, S. D. (2002) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0704485 · Cited by 52
Self-citationPharmacology of SB-273779, a Nonpeptide Calcitonin Gene-Related Peptide 1 Receptor Antagonist
Aiyar, N. V., Daines, R. A., Disa, J., Chambers, P. A., Sauermelch, C. F., Quiniou, M.-J., Khandoudi, N., Gout, B., Douglas, S. A., & Willette, R. N. (2001) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)38815-9 · Cited by 51
Changes in cutaneous sensory nerve fibers induced by skin-scratching in mice
Yamaoka, J., Di, Z. H., Sun, W., & Kawana, S. (2007) · Journal of Dermatological Science · doi:10.1016/j.jdermsci.2006.12.007 · Cited by 51
Alpha-calcitonin gene-related peptide is protective against pressure overload-induced heart failure
Li, J., Levick, S. P., DiPette, D. J., Janicki, J. S., & Supowit, S. C. (2013) · Regulatory Peptides · doi:10.1016/j.regpep.2013.06.008 · Cited by 50
Salvatore, C., Mallee, J. J., Bell, I. M., et al. (2006) · Biochemistry · doi:10.1021/bi052044w · Cited by 50
Ichinose, M., & Sawada, M. (1996) · Peptides · doi:10.1016/s0196-9781(96)00198-2 · Cited by 50
Gardiner, S. M., Compton, A. M., Kemp, P. A., Bennett, T., Bose, C., Foulkes, R., & Hughes, B. (1991) · Diabetes · doi:10.2337/diab.40.8.948 · Cited by 50
Calcitonin Gene-Related Peptide Protects Against Hypertension-Induced Heart and Kidney Damage
Supowit, S. C., Rao, A., Bowers, M. C., Zhao, H., Fink, G. D., Steficek, B. A., Patel, P. C., Katki, K. A., & DiPette, D. J. (2004) · Hypertension · doi:10.1161/01.hyp.0000151130.34874.fa · Cited by 50
Innervation and Effects of Dilatory Neuropeptides on Cerebral Vessels
Edvinsson, L. I. (2008) · Blood Vessels · doi:10.1159/000158841 · Cited by 49
Deng, P.-Y., Ye, F., Cai, W.-J., Tan, G., Hu, C., Deng, H., & Li, Y. (2004) · Journal of Hypertension · doi:10.1097/00004872-200409000-00028 · Cited by 49
Bucelli, R. C., Gonsiorek, E. A., Kim, W.-Y., Bruun, D. A., Rabin, R. A., Higgins, D. M., & Lein, P. J. (2007) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.107.132795 · Cited by 49
Peptidomics approach to elucidate the proteolytic regulation of bioactive peptides
Kim, Y., Lone, A. M., Nolte, W. M., & Saghatelian, A. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1203195109 · Cited by 48
Sabharwal, R., Zhang, Z., Lu, Y., Abboud, F. M., Russo, A. F., & Chapleau, M. W. (2010) · Hypertension · doi:10.1161/hypertensionaha.109.148171 · Cited by 48
Three-week neonatal hypoxia reduces blood CGRP and causes persistent pulmonary hypertension in rats
Keith, I. M., Tjen‐A‐Looi, S. C., Kraiczi, H., & Ekman, R. (2000) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.2000.279.4.h1571 · Cited by 48
Antinociceptive Effects of Eugenol Evaluated in a Monoiodoacetate‐induced Osteoarthritis Rat Model
Ferland, C. E., Beaudry, F., & Vachon, P. (2012) · Phytotherapy Research · doi:10.1002/ptr.3725 · Cited by 47
Calcitonin gene-related peptide in myocardial ischaemia and reperfusion in the pig
Källner, G. (1998) · Cardiovascular Research · doi:10.1016/s0008-6363(98)00016-9 · Cited by 47
Turn Structures in CGRP C-Terminal Analogues Promote Stable Arrangements of Key Residue Side Chains
Carpenter, K. A., Schmidt, R., von Mentzer, B., Haglund, U., Roberts, E., & Walpole, C. (2001) · Biochemistry · doi:10.1021/bi0102860 · Cited by 47
Pregnancy and steroid hormones enhance the vasodilation responses to CGRP in rats
Gangula, P. R., Zhao, H., Supowit, S. C., Wimalawansa, S. J., DiPette, D. J., & Yallampalli, C. (1999) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1999.276.1.h284 · Cited by 47
Koth, C. M., Abdul-Manan, N., Lepre, C. A., Connolly, P. J., Yoo, S., Mohanty, A. K., Lippke, J. A., Zwahlen, J., Coll, J. T., Doran, J., et al. (2010) · Biochemistry · doi:10.1021/bi901848m · Cited by 46
Tanaka, H., Shimaya, A., Kiso, T., Kuramochi, T., Shimokawa, T., & Shibasaki, M. (2011) · Life Sciences · doi:10.1016/j.lfs.2011.01.016 · Cited by 46
White, B., Smith, P. A., & Dunn, W. R. (2012) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2012.02187.x · Cited by 45
Antúnez, C., Torres, M. J., López, S., Rodríguez‐Pena, R., Blanca, M., Mayorga, C., & Santamaria‐Babí, L. F. (2009) · British Journal of Dermatology · doi:10.1111/j.1365-2133.2009.09318.x · Cited by 45
Supowit, S. C., Zhao, H., & DiPette, D. J. (2001) · Hypertension · doi:10.1161/01.hyp.37.2.728 · Cited by 45
Jusek, G., Reim, D., Tsujikawa, K., & Holzmann, B. (2012) · Immunobiology · doi:10.1016/j.imbio.2012.04.009 · Cited by 44
Sensory CGRP depletion by capsaicin exacerbates hypoxia-induced pulmonary hypertension in rats
Tjen‐A‐Looi, S. C., Kraiczi, H., Ekman, R., & Keith, I. M. (1998) · Regulatory Peptides · doi:10.1016/s0167-0115(98)00007-x · Cited by 44
Sensory-Nerve-Derived Neuropeptides: Possible Therapeutic Targets
Fernandes, E. S., Schmidhuber, S. M., & Brain, S. D. (2009) · Handbook of experimental pharmacology · doi:10.1007/978-3-540-79090-7_11 · Cited by 43
Self-citationSiney, L., & Brain, S. D. (1996) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1996.tb16698.x · Cited by 43
Self-citationTRPV1 Ablation Aggravates Inflammatory Responses and Organ Damage during Endotoxic Shock
Wang, Y., & Wang, D. H. (2013) · Clinical and Vaccine Immunology · doi:10.1128/cvi.00674-12 · Cited by 43
Gupta, P., Harte, A. L., Sturdee, D. W., Sharma, A., Barnett, A. H., Kumar, S., & McTernan, P. G. (2008) · Climacteric · doi:10.1080/13697130802378493 · Cited by 42
Arulmani, U., Schuijt, M. P., Heiligers, S., Willems, H., Villalón, C. M., & Saxena, P. R. (2004) · Basic & Clinical Pharmacology & Toxicology · doi:10.1111/j.1742-7843.2004.pto940606.x · Cited by 42
Attenuation of antigen-induced airway hyperresponsiveness in CGRP-deficient mice
Aoki‐Nagase, T., Nagase, T., Oh-hashi, Y., Shindo, T., Kurihara, Y., Yamaguchi, Y., Yamamoto, H., Tomita, T., Ohga, E., Nagai, R., et al. (2002) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00130.2002 · Cited by 42
Hartopo, A. B., Emoto, N., Vignon‐Zellweger, N., Suzuki, Y., Yagi, K., Nakayama, K., & Hirata, K. (2013) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2012-0354oc · Cited by 42
Mikami, N., Miyagi, Y., Sueda, K., Takatsuji, M., Fukada, S., Yamamoto, H., & Tsujikawa, K. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1203102 · Cited by 41
Meens, M., Mattheij, N. J. A., van Loenen, P. B., Spijkers, L. J. A., Lemkens, P., Nelissen, J., Compeer, M. G., Alewijnse, A. E., & Mey, J. G. R. D. (2011) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2011.01774.x · Cited by 40
Evidence for CGRP re‐uptake in rat dura mater encephali
Gupta, S., Amrutkar, D. V., Mataji, A., Salmasi, H., Hay‐Schmidt, A., Sheykhzade, M., Meßlinger, K., Olesen, J., & Jansen‐Olesen, I. (2010) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2010.01012.x · Cited by 40
Uren, N. G., Seydoux, C., & Davies, G. J. (1993) · Cardiovascular Research · doi:10.1093/cvr/27.8.1477 · Cited by 40
Crossman, D., Dashwood, M. R., Brain, S. D., McEwan, J. R., & Pearson, J. D. (1990) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1990.tb14656.x · Cited by 40
Self-citationRole of calcitonin gene-related peptide (CGRP) in ovine burn and smoke inhalation injury
Lange, M., Enkhbaatar, P., Traber, D. L., Cox, R. A., Jacob, S., Mathew, B. P., Hamahata, A., Traber, L. D., Herndon, D. N., & Hawkins, H. K. (2009) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00094.2009 · Cited by 40
Axoplasmic transport of calcitonin gene-related peptide in rat peripheral nerve as function of age
Fernández, H. L., & Hodges-Savola, C. A. (1994) · Neurochemical Research · doi:10.1007/bf00972465 · Cited by 40
Ditting, T., Tiegs, G., Rodionova, K., Reeh, P. W., Neuhuber, W., Freisinger, W., & Veelken, R. (2009) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.90599.2008 · Cited by 39
Isolation, purification and characterization of β-hCGRP from human spinal cord
Wimalawansa, S. J., Morris, H. R., Etienne, A., Blench, I., Panico, M., & Macintyre, I. J. (1990) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(90)90621-s · Cited by 39
Dai, L., Peng, J., Xin, H., Luo, D., Zhang, Y., Zhou, Z., Jiang, D., Deng, H., & Li, Y. (2008) · Peptides · doi:10.1016/j.peptides.2008.06.010 · Cited by 39
Role of sensory nervous system vasoactive peptides in hypertension
Watson, R. E., Supowit, S. C., Zhao, H., Katki, K. A., & DiPette, D. J. (2002) · Brazilian Journal of Medical and Biological Research · doi:10.1590/s0100-879x2002000900004 · Cited by 39
Li, X.-W., Hu, C.-P., Wu, W., Zhang, W., Zou, X., & Li, Y. (2012) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2012.01.015 · Cited by 38
Inotropic and lusitropic effects of calcitonin gene-related peptide in the heart
AlRubaiee, M., Gangula, P. R., Millis, R. M., Walker, R. K., Umoh, N., Cousins, V. M., Jeffress, M., & Haddad, G. E. (2013) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00874.2012 · Cited by 38
Levels of vasodilators (SP, CGRP) and vasoconstrictor (NPY) peptides in early human burns
Onuoha, G. N., & Alpar, E. K. (2001) · European Journal of Clinical Investigation · doi:10.1046/j.1365-2362.2001.00787.x · Cited by 38
Moore, E. L., Gingell, J. J., Kane, S. A., Hay, D. L., & Salvatore, C. (2010) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2010.02.131 · Cited by 37
Hasbak, P., Sams, A. G., Schifter, S., Longmore, J., & Edvinsson, L. I. (2001) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0704210 · Cited by 37
Pharmacological evidence for CGRP uptake into perivascular capsaicin sensitive nerve terminals
Sams, A. G., Ørskov, C., & Jansen‐Olesen, I. (2001) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0703910 · Cited by 37
Pathophysiology and therapeutic possibilities of calcitonin gene-related peptide in hypertension
Márquez‐Rodas, I., Longo, F., Rothlin, R. P., & Balfagón, G. (2006) · Journal of Physiology and Biochemistry · doi:10.1007/bf03165805 · Cited by 36
Effect of CGRP and sumatriptan on the BOLD response in visual cortex
Asghar, M. S., Hansen, A. E., Larsson, H. B. W., Olesen, J., & Ashina, M. (2012) · The Journal of Headache and Pain · doi:10.1007/s10194-011-0415-4 · Cited by 36
Desensitisation of adrenomedullin and CGRP receptors
Hay, D. L., Poyner, D. R., & Smith, D. M. (2003) · Regulatory Peptides · doi:10.1016/s0167-0115(03)00032-6 · Cited by 36
Hemodynamic effects of calcitonin gene-related peptide in spontaneously hypertensive rats
Ando, K., Pegram, B. L., & Frohlich, E. D. (1990) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1990.258.2.r425 · Cited by 36
Zhou, Y., Zhang, M., Sun, G., Liu, Y.-P., Ran, W., Peng, L., & Guan, C. (2013) · Regulatory Peptides · doi:10.1016/j.regpep.2013.03.020 · Cited by 35
Supowit, S. C., Gururaj, A., Ramana, C. V., Westlund, K. N., & DiPette, D. J. (1995) · Hypertension · doi:10.1161/01.hyp.25.6.1333 · Cited by 35
Kawase, T., Okuda, K., Wu, C., Yoshie, H., Hara, K., & Burns, D. M. (1999) · Journal of Periodontal Research · doi:10.1111/j.1600-0765.1999.tb02237.x · Cited by 35
Meens, M. J. P. M. T., Fazzi, G. E., van Zandvoort, M. A. M. J., & Mey, J. G. R. D. (2009) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.109.155143 · Cited by 35
Portaluppi, F., Vergnani, L., Margutti, A., Ambrosio, M. R., Bondanelli, M., Trasforini, G., Rossi, R., & Uberti, E. C. D. (1993) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.77.3.8370703 · Cited by 34
Thomas, D. A., Dubner, R. A., & Ruda, M. A. (1994) · Neuroscience Letters · doi:10.1016/0304-3940(94)90615-7 · Cited by 34
Dai, L., Chen, B.-M., Peng, J., Zhang, Y., Li, X., Yuan, Q., Hu, C.-P., Deng, H., & Li, Y. (2009) · Journal of Hypertension · doi:10.1097/hjh.0b013e328329bbd7 · Cited by 34
Bennett, G. S., Garrett, N. E., Diemel, L. T., Brain, S. D., & Tomlinson, D. R. (1998) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0701986 · Cited by 34
Self-citationGangula, P. R., Chauhan, M., Reed, L. C., & Yallampalli, C. (2009) · Neuroscience Letters · doi:10.1016/j.neulet.2009.02.068 · Cited by 33
Kawase, T., Okuda, K., & Burns, D. M. (2005) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00504.2004 · Cited by 33
Role of Calcitonin Gene-Related Peptide in Hypertension-Induced Renal Damage
Bowers, M. C., Katki, K. A., Rao, A., Koehler, M., Patel, P. C., Spiekerman, A. M., DiPette, D. J., & Supowit, S. C. (2005) · Hypertension · doi:10.1161/01.hyp.0000168926.44648.ed · Cited by 33
Sun, W. M., Wang, L., Zhang, Z., Chen, M., & Wang, X. (2003) · European Journal of Immunology · doi:10.1002/immu.200390026 · Cited by 32
Development of angiotensin II-induced hypertension: role of CGRP and its receptor
Li, J., & Wang, D. H. (2005) · Journal of Hypertension · doi:10.1097/00004872-200501000-00020 · Cited by 32
Supowit, S. C., Hallman, D. M., Zhao, H., & DiPette, D. J. (1998) · Brain Research · doi:10.1016/s0006-8993(97)01277-8 · Cited by 32
Howitt, S. G., Kilk, K., Wang, Y., Smith, D. M., Langel, Ü., & Poyner, D. R. (2003) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0705040 · Cited by 31
Chao, T., Cheng, H.-P., & Walter, R. J. (1995) · Regulatory Peptides · doi:10.1016/0167-0115(95)00051-c · Cited by 31
Ma, Y.-X., Guo, Z., & Sun, T. (2013) · Neuroscience Letters · doi:10.1016/j.neulet.2013.05.028 · Cited by 30
Drake, W. M., Ajayi, A. A. L., Lowe, S. R., Mirtella, A., Bartlett, T., & Clark, A. (1999) · Endocrinology · doi:10.1210/endo.140.1.6606 · Cited by 29
Qin, X.-P., Zeng, S.-Y., Li, D., Chen, Q., Luo, D., Zhang, Z., Hu, G., Deng, H., & Li, Y. (2007) · Journal of Cardiovascular Pharmacology · doi:10.1097/fjc.0b013e3181579e7e · Cited by 28
Li, W., Wang, T., Ma, C., Xiong, T., Zhu, Y., & Wang, X. (2006) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00538.2005 · Cited by 28
Endogenous CGRP protects against neointimal hyperplasia following wire-induced vascular injury
Yang, L., Sakurai, T., Kamiyoshi, A., Ichikawa‐Shindo, Y., Kawate, H., Yoshizawa, T., Koyama, T., Iesato, Y., Uetake, R., Yamauchi, A., et al. (2013) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2013.02.002 · Cited by 27
Calcitonin gene-related peptide, adrenomedullin and flushing
Hay, D. L., & Poyner, D. R. (2009) · Maturitas · doi:10.1016/j.maturitas.2009.08.011 · Cited by 27
Deng, P.-Y., Ye, F., Zhu, H.-Q., Cai, W., Deng, H., & Li, Y. (2003) · Regulatory Peptides · doi:10.1016/s0167-0115(03)00124-1 · Cited by 26
Jiang, Y., Nyengaard, J. R., Zhang, J., et al. (2004) · Diabetes · doi:10.2337/diabetes.53.10.2669 · Cited by 25
Chrissobolis, S., Zhang, Z., Kinzenbaw, D. A., Lynch, C. M., Russo, A. F., & Faraci, F. M. (2010) · Stroke · doi:10.1161/strokeaha.110.589648 · Cited by 25
Deng, W., Hilaire, R. S., Chattergoon, N. N., Jeter, J. R., & Kadowitz, P. J. (2005) · Life Sciences · doi:10.1016/j.lfs.2005.08.042 · Cited by 24
Gupta, S., Mehrotra, S., Villalón, C. M., VRIES, R. D., Garrelds, I. M., Saxena, P. R., & MaassenVanDenBrink, A. (2006) · Headache The Journal of Head and Face Pain · doi:10.1111/j.1526-4610.2006.00596.x · Cited by 24
Connat, J., Busseuil, D., Gambert, S., Ody, M., Tébaldini, M., Gamboni, S., Faivre, B., Quiquerez, A., Millet, M., Michaut, P., et al. (2001) · Anatomy and Embryology · doi:10.1007/s429-001-8002-0 · Cited by 24
Characterization of the Structure of RAMP1 by Mutagenesis and Molecular Modeling
Simms, J., Hay, D. L., Wheatley, M., & Poyner, D. R. (2006) · Biophysical Journal · doi:10.1529/biophysj.106.084582 · Cited by 23
Bretherton-Watt, D., Ghatei, M. A., Jamal, H., Gilbey, S. G., JONES, P. M., & Bloom, S. R. (1992) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1992.tb22777.x · Cited by 23
Drake, W., Lowe, S., Mirtella, A., et al. (2000) · Journal of Endocrinology · doi:10.1677/joe.0.1650133 · Cited by 22
Targeted Disruption of Adrenomedullin and αCGRP Genes Reveals Their Distinct Biological Roles
Kurihara, H., Shindo, T., Oh-hashi, Y., Kurihara, Y., & Kuwaki, T. (2003) · Hypertension Research · doi:10.1291/hypres.26.s105 · Cited by 21
Itabashi, A., Kashiwabara, H., Shibuya, M., Tanaka, K., MASAOKA, H., Katayama, S., & Ishii, J. (1988) · Journal of Hypertension · doi:10.1097/00004872-198812040-00131 · Cited by 21
Calcitonin gene-related peptide: an endogenous mediator of preconditioning.
Li, Y., Song, Q. J., & Xiao, J. (2000) · PubMed · Cited by 21
Coronary atherosclerosis: Current therapeutic approaches and future trends
DeFeudis, F. V. (1991) · Life Sciences · doi:10.1016/0024-3205(91)90101-g · Cited by 20
Zhao, F.-P., Guo, Z., & Wang, P. (2010) · Neuroscience Letters · doi:10.1016/j.neulet.2010.07.025 · Cited by 19
Li, J., Carnevale, K. A., DiPette, D. J., & Supowit, S. C. (2013) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00434.2012 · Cited by 19
Calcitonin gene-related peptide modulates Langerhans cell antigen-presenting function.
Asahina, A., Hosoi, J., Gf, M., et al. (1995) · PubMed · Cited by 19
Roudenok, V., Gutjar, L., Antipova, V., & Rogov, Y. (2001) · Annals of Anatomy - Anatomischer Anzeiger · doi:10.1016/s0940-9602(01)80176-x · Cited by 18
Bonner, K., Kariyawasam, H. H., Ali, F., Clark, P., & Kay, A. B. (2010) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2010.08.013 · Cited by 18
Endosomal proteolysis regulates calcitonin gene‐related peptide responses in mesenteric arteries
McNeish, A. J., Roux, B. T., Aylett, S., MaassenVanDenBrink, A., & Cottrell, G. (2012) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2012.02129.x · Cited by 17
Donzelli, S., Fischer, G., King, B., Niemann, C., DuMond, J. F., Heeren, J., Wieboldt, H., Baldus, S. E., Gerloff, C. P., Thomas Eschenhagen, A., et al. (2012) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.112.199836 · Cited by 17
Hu, C.-P., Peng, J., Xiao, L., Ye, F., Deng, H.-W., & Li, Y. (2002) · Regulatory Peptides · doi:10.1016/s0167-0115(02)00096-4 · Cited by 16
Supowit, S. C., Katki, K. A., Hein, T. W., Gupta, P., Kuo, L., Dickerson, I. M., & DiPette, D. J. (2011) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00598.2009 · Cited by 16
Long‐Term Increase in CGRP Levels in Rat Spinal Dorsal Horn following Skin Ultraviolet Irradiation
Gillardon, F., Schröck, H., Morano, I. L., & Zimmermann, M. (1992) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1992.tb22810.x · Cited by 15
Lu, R., Zhu, H.-Q., Peng, J., Li, N.-S., & Li, Y.-J. (2002) · Neuropeptides · doi:10.1016/s0143-4179(02)00110-5 · Cited by 15
McGillis, J. P., Miller, C. N., Schneider, D. B., Fernandez, S., & Knopf, M. A. (2002) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(01)00484-2 · Cited by 14
Protein kinase C is a common component of CGRP receptor desensitization induced by distinct agonists
Pin, S. S., & Bahr, B. A. (2008) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2008.02.083 · Cited by 14
Fang, L., Chen, M., Xiao, Z., Liu, Y., Yu, G., Chen, X., & Xie, X. (2011) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-011-0843-0 · Cited by 13
Saxen, M. A., Welch, S. P., & Dewey, W. L. (1993) · Life Sciences · doi:10.1016/0024-3205(93)90643-h · Cited by 12
Peroni, R. N., Abramoff, T., Neuman, I., Podesta, E. J., & Adler‐Graschinsky, E. (2012) · International Journal of Hypertension · doi:10.1155/2012/647856 · Cited by 12
Convergent Recognition of a Triple Helical Hydrophobic Motif in Collagen
Emsley, J. (2010) · Structure · doi:10.1016/j.str.2009.12.004 · Cited by 12
Somasundaram, C., Diz, D. I., Coleman, T., & Bukoski, R. D. (2006) · Journal of Vascular Research · doi:10.1159/000092765 · Cited by 11
Calcitonin gene-related peptide and thermal injury: review of literature.
Gherardini, G., Curinga, G., Colella, G., Freda, N., & Rauso, R. (2009) · PubMed Central · Cited by 10
Wang, X., Ebong, S., Call, D. R., Newcomb, D. E., Bolgos, G. L., & Remick, D. G. (2002) · Inflammation · doi:10.1023/a:1016515712344 · Cited by 10
Calcitonin Gene-Related Peptide during Sweating in Young Healthy Women
Spetz, A.-C. E., Ellefsen, K., Theodorsson, E., Lassvik, C., & Hammar, M. L. (2005) · Gynecologic and Obstetric Investigation · doi:10.1159/000086208 · Cited by 6
Cited by
Pathophysiology of migraine: a disorder of sensory processing
Goadsby, P. J., Holland, P. R., Martins-Oliveira, M., Hoffmann, J., Schankin, C., & Akerman, S. (2017) · Physiological Reviews · doi:10.1152/physrev.00034.2015 · Cited by 1,998
U.S. FDA Approved Drugs from 2015–June 2020: A Perspective
Bhutani, P., Joshi, G., Raja, N., Bachhav, N., Rajanna, P. K., Bhutani, H., Paul, A. T., & Kumar, R. (2021) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.0c01786 · Cited by 815
Iyengar, S., Ossipov, M. H., & Johnson, K. W. (2017) · Pain · doi:10.1097/j.pain.0000000000000831 · Cited by 584
Maternal Mineral and Bone Metabolism During Pregnancy, Lactation, and Post-Weaning Recovery
Kovacs, C. S. (2016) · Physiological Reviews · doi:10.1152/physrev.00027.2015 · Cited by 544
CGRP and the Trigeminal System in Migraine
Iyengar, S., Johnson, K. W., Ossipov, M. H., & Aurora, S. K. (2019) · Headache: The Journal of Head and Face Pain · doi:10.1111/head.13529 · Cited by 486
Metadata
- Authors
- Russell, F. A., King, R., Smillie, S.-J., Kodji, X., & Brain, S. D.
- Venue
- Physiological Reviews
- Publisher
- American Physiological Society
- Published
- 2014-10
- Volume
- 94
- Issue
- 4
- Pages
- 1099-1142
- ISSN
- 0031-9333 (ISSN-L)
- 1522-1210
- OpenAlex
- W2001650386
- Cited by
- 1,258
- References
- 372
- FWCI
- 3.40
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
