Calcitonin Gene-Related Peptide: Physiology and Pathophysiology

The capsaicin receptor: a heat-activated ion channel in the pain pathway

Caterina, M. J., Schumacher, M. A., Tominaga, M., Rosen, T. A., Levine, J. D., & Julius, D. (1997) · Nature · doi:10.1038/39807 · Cited by 9,107

Estimates of the prevalence of arthritis and other rheumatic conditions in the United States: Part II

Lawrence, R. C., Felson, D. T., Helmick, C. G., Arnold, L. M., Choi, H., Deyo, R. A., Gabriel, S., Hirsch, R., Hochberg, M. C., Hunder, G. G., et al. (2008) · Arthritis & Rheumatism · doi:10.1002/art.23176 · Cited by 5,499

Production of a novel neuropeptide encoded by the calcitonin gene via tissue-specific RNA processing

Rosenfeld, M. G., Mermod, J.-J., Amara, S. G., Swanson, L. W., Sawchenko, P. E., Rivier, J., Vale, W. W., & Evans, R. M. (1983) · Nature · doi:10.1038/304129a0 · Cited by 2,302

Vanilloid receptors on sensory nerves mediate the vasodilator action of anandamide

Zygmunt, P. M., Petersson, J., Andersson, D. A., Chuang, H.-H., Sørgård, M., Di Marzo, V., Julius, D., & Högestätt, E. D. (1999) · Nature · doi:10.1038/22761 · Cited by 2,142

RAMPs regulate the transport and ligand specificity of the calcitonin-receptor-like receptor

McLatchie, L. M., Fraser, N. J., Main, M. J., Wise, A., Brown, J., Thompson, N., Solari, R., Lee, M. G., & Foord, S. M. (1998) · Nature · doi:10.1038/30666 · Cited by 2,134

Alternative RNA processing in calcitonin gene expression generates mRNAs encoding different polypeptide products

Amara, S. G., Jonas, V., Rosenfeld, M. G., Ong, E. S., & Evans, R. M. (1982) · Nature · doi:10.1038/298240a0 · Cited by 2,105

Calcitonin gene-related peptide is a potent vasodilator

Brain, S. D., Williams, T. J., Tippins, J. R., Morris, H. R., & MacIntyre, I. (1985) · Nature · doi:10.1038/313054a0 · Cited by 2,086

Estimates of the prevalence of arthritis and other rheumatic conditions in the United States: Part I

Helmick, C. G., Felson, D. T., Lawrence, R. C., Gabriel, S., Hirsch, R., Kwoh, C. K., Liang, M. H., Kremers, H. M., Mayes, M. D., Merkel, P. A., et al. (2008) · Arthritis & Rheumatism · doi:10.1002/art.23177 · Cited by 2,058

The induction of pain: an integrative review

Millan, M. J. (1999) · Progress in Neurobiology · doi:10.1016/s0301-0082(98)00048-3 · Cited by 1,774

Vasoactive peptide release in the extracerebral circulation of humans during migraine headache

Goadsby, P. J., Edvinsson, L., & Ekman, R. (1990) · Annals of Neurology · doi:10.1002/ana.410280213 · Cited by 1,597

Purification and characterization of a peptide from amyloid-rich pancreases of type 2 diabetic patients.

Cooper, G. J., Willis, A. C., Clark, A., Turner, R. C., Sim, R. B., & Reid, K. B. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.23.8628 · Cited by 1,299 · cited 1×

Calcitonin Gene–Related Peptide Receptor Antagonist BIBN 4096 BS for the Acute Treatment of Migraine

Olesen, J., Diener, H.-C., Husstedt, I. W., Goadsby, P. J., Hall, D., Meier, U., Pollentier, S., & Lesko, L. M. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa030505 · Cited by 1,189

Osteoarthritis

Goldring, M. B., & Goldring, S. R. (2007) · Journal of Cellular Physiology · doi:10.1002/jcp.21258 · Cited by 1,179

The trigeminovascular system and migraine: Studies characterizing cerebrovascular and neuropeptide changes seen in humans and cats

Goadsby, P. J., & Edvinsson, L. (1993) · Annals of Neurology · doi:10.1002/ana.410330109 · Cited by 1,158

Cgrp May Play A Causative Role in Migraine

Lassen, L., Haderslev, P., Jacobsen, V., Iversen, H., Sperling, B., & Olesen, J. (2002) · Cephalalgia · doi:10.1046/j.1468-2982.2002.00310.x · Cited by 1,027

Calcitonin gene-related peptide immunoreactivity in the spinal cord of man and of eight other species

Gibson, S., Polak, J., Bloom, Sr., Sabate, I., Mulderry, P., Ghatei, M., McGregor, G., Morrison, J., Kelly, J., & Evans, R. (1984) · The Journal of Neuroscience · doi:10.1523/jneurosci.04-12-03101.1984 · Cited by 1,022

Release of vasoactive peptides in the extracerebral circulation of humans and the cat during activation of the trigeminovascular system

Goadsby, P. J., Edvinsson, L., & Ekman, R. (1988) · Annals of Neurology · doi:10.1002/ana.410230214 · Cited by 863

Influence of aging on peripheral nerve function and regeneration

Verdu, E., Ceballos, D., Vilches, J. J., & Navarro, X. (2000) · Journal of the Peripheral Nervous System · doi:10.1046/j.1529-8027.2000.00026.x · Cited by 855

Vascular Actions of Calcitonin Gene-Related Peptide and Adrenomedullin

Brain, S. D., & Grant, A. D. (2004) · Physiological Reviews · doi:10.1152/physrev.00037.2003 · Cited by 765

Peripheral nerve regeneration and neurotrophic factors

TERENGHI, G. (1999) · Journal of Anatomy · doi:10.1046/j.1469-7580.1999.19410001.x · Cited by 695

Neuronal Control of Skin Function: The Skin as a Neuroimmunoendocrine Organ

Roosterman, D., Goerge, T., Schneider, S. W., Bunnett, N. W., & Steinhoff, M. (2006) · Physiological Reviews · doi:10.1152/physrev.00026.2005 · Cited by 665

Co-localization of calcitonin gene-related peptide-like immunoreactivity with substance P in cutaneous, vascular and visceral sensory neurons of guinea pigs

Gibbins, I. L., Furness, J. B., Costa, M., MacIntyre, I., Hillyard, C. J., & Girgis, S. (1985) · Neuroscience Letters · doi:10.1016/0304-3940(85)90050-3 · Cited by 633

Expression in Brain of a Messenger RNA Encoding a Novel Neuropeptide Homologous to Calcitonin Gene-Related Peptide

Amara, S. G., Arriza, J. L., Leff, S. E., Swanson, L. W., Evans, R. M., & Rosenfeld, M. G. (1985) · Science · doi:10.1126/science.2994212 · Cited by 610

Increased content and transport of substance P and calcitonin gene-related peptide in sensory nerves innervating inflamed tissue: Evidence for a regulatory function of nerve growth factor in vivo

Donnerer, J., Schuligoi, R., & Stein, C. (1992) · Neuroscience · doi:10.1016/0306-4522(92)90237-v · Cited by 607

Triptans (Serotonin, 5-HT1B/1D Agonists) in Migraine: Detailed Results and Methods of A Meta-Analysis of 53 Trials

Ferrari, M., Goadsby, P., Roon, K., & Lipton, R. (2002) · Cephalalgia · doi:10.1046/j.1468-2982.2002.00404.x · Cited by 605

Co-existence of substance P and calcitonin gene-related peptide-like immunoreactivities in sensory nerves in relation to cardiovascular and bronchoconstrictor effects of capsaicin

Lundberg, J. M., Franco-Cereceda, A., Hua, X., Hökfelt, T., & Fischer, J. A. (1985) · European Journal of Pharmacology · doi:10.1016/0014-2999(85)90456-x · Cited by 592

Transcriptional and posttranslational plasticity and the generation of inflammatory pain

Woolf, C. J., & Costigan, M. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.14.7723 · Cited by 555

Identification of a seven transmembrane helix receptor for corticotropin-releasing factor and sauvagine in mammalian brain

Chang, C.-P., Pearse, R. V., O'Connell, S., & Rosenfeld, M. G. (1993) · Neuron · doi:10.1016/0896-6273(93)90230-o · Cited by 537

Efficacy and tolerability of MK-0974 (telcagepant), a new oral antagonist of calcitonin gene-related peptide receptor, compared with zolmitriptan for acute migraine: a randomised, placebo-controlled, parallel-treatment trial

Ho, T. W., Ferrari, M. D., Dodick, D. W., Galet, V., Kost, J., Fan, X., Leibensperger, H., Froman, S., Assaid, C., Lines, C., et al. (2008) · The Lancet · doi:10.1016/s0140-6736(08)61626-8 · Cited by 531

Migraine prevalence by age and sex in the United States: A life-span study

Victor, T., Hu, X., Campbell, J., Buse, D., & Lipton, R. (2010) · Cephalalgia · doi:10.1177/0333102409355601 · Cited by 508

Cellular Mechanisms of Neurogenic Inflammation

Richardson, J. D., & Vasko, M. R. (2002) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.102.032797 · Cited by 497

Calcitonin Gene-Related Peptide and Its Receptors: Molecular Genetics, Physiology, Pathophysiology, and Therapeutic Potentials

WIMALAWANSA, S. J. (1996) · Endocrine Reviews · doi:10.1210/edrv-17-5-533 · Cited by 494

Tachykinins and calcitonin gene-related peptide (CGRP) as co-transmitters released from peripheral endings of sensory nerves

Maggi, C. A. (1995) · Progress in Neurobiology · doi:10.1016/0301-0082(94)e0017-b · Cited by 470

Calcitonin gene-related peptide regulates muscle acetylcholine receptor synthesis

New, H. V., & Mudge, A. W. (1986) · Nature · doi:10.1038/323809a0 · Cited by 469

Interictal increase of CGRP levels in peripheral blood as a biomarker for chronic migraine

Cernuda-Morollón, E., Larrosa, D., Ramón, C., Vega, J., Martínez-Camblor, P., & Pascual, J. (2013) · Neurology · doi:10.1212/wnl.0b013e3182a6cb72 · Cited by 468

Pharmacological profile of BIBN4096BS, the first selective small molecule CGRP antagonist

Doods, H., Hallermayer, G., Wu, D., Entzeroth, M., Rudolf, K., Engel, W., & Eberlein, W. (2000) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0703110 · Cited by 466

Calcitonin gene-related peptide acts as a novel vasodilator neurotransmitter in mesenteric resistance vessels of the rat

Kawasaki, H., Takasaki, K., Saito, A., & Goto, K. (1988) · Nature · doi:10.1038/335164a0 · Cited by 458

Arterial dilations in response to calcitonin gene-related peptide involve activation of K+ channels

Nelson, M. T., Huang, Y., Brayden, J. E., Hescheler, J., & Standen, N. B. (1990) · Nature · doi:10.1038/344770a0 · Cited by 455

Inflammatory oedema induced by synergism between calcitonin gene‐related peptide (CGRP) and mediators of increased vascular permeability

Brain, S. D., & Williams, T. J. (1985) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1985.tb11107.x · Cited by 447

The Prevalence and Disability Burden of Adult Migraine in England and their Relationships to Age, Gender and Ethnicity

Steiner, T., Scher, A., Stewart, W., Kolodner, K., Liberman, J., & Lipton, R. (2003) · Cephalalgia · doi:10.1046/j.1468-2982.2003.00568.x · Cited by 433

Isolation and characterization of human calcitonin gene-related peptide

Morris, H. R., Panico, M., Etienne, T., Tippins, J., Girgis, S. I., & MacIntyre, I. (1984) · Nature · doi:10.1038/308746a0 · Cited by 424

Pharmacology of Vanilloid Transient Receptor Potential Cation Channels

Vriens, J., Appendino, G., & Nilius, B. (2009) · Molecular Pharmacology · doi:10.1124/mol.109.055624 · Cited by 418

Protease-Activated Receptor 2 Sensitizes the Capsaicin Receptor Transient Receptor Potential Vanilloid Receptor 1 to Induce Hyperalgesia

Amadesi, S., Nie, J., Vergnolle, N., Cottrell, G. S., Grady, E. F., Trevisani, M., Manni, C., Geppetti, P., McRoberts, J. A., Ennes, H., et al. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.5679-03.2004 · Cited by 412

Activation of Transient Receptor Potential Vanilloid Type-1 Channel Prevents Adipogenesis and Obesity

Zhang, L. L., Yan Liu, D., Ma, L. Q., Luo, Z. D., Cao, T. B., Zhong, J., Yan, Z. C., Wang, L. J., Zhao, Z. G., Zhu, S. J., et al. (2007) · Circulation Research · doi:10.1161/01.res.0000262653.84850.8b · Cited by 407

Stimulation of noradrenergic sympathetic outflow by calcitonin gene-related peptide

Fisher, L. A., Kikkawa, D. O., Rivier, J. E., Amara, S. G., Evans, R. M., Rosenfeld, M. G., Vale, W. W., & Brown, M. R. (1983) · Nature · doi:10.1038/305534a0 · Cited by 401

Neuropeptides in the skin: interactions between the neuroendocrine and the skin immune systems

Scholzen, T., Armstrong, C. A., Bunnett, N. W., Luger, T. A., Olerud, J. E., & Ansel, J. C. (1998) · Experimental Dermatology · doi:10.1111/j.1600-0625.1998.tb00307.x · Cited by 391

Mechanisms of peptide and nonpeptide ligand binding to Class B G-protein-coupled receptors

Hoare, S. R. J. (2005) · Drug Discovery Today · doi:10.1016/s1359-6446(05)03370-2 · Cited by 379

Perivascular peptides relax cerebral arteries concomitant with stimulation of cyclic adenosine monophosphate accumulation or release of an endothelium-derived relaxing factor in the cat

Edvinsson, L., Fredholm, B. B., Hamel, E., Jansen, I., & Verrecchia, C. (1985) · Neuroscience Letters · doi:10.1016/0304-3940(85)90166-1 · Cited by 372

Safety and efficacy of ALD403, an antibody to calcitonin gene-related peptide, for the prevention of frequent episodic migraine: a randomised, double-blind, placebo-controlled, exploratory phase 2 trial

Dodick, D. W., Goadsby, P. J., Silberstein, S. D., Lipton, R. B., Olesen, J., Ashina, M., Wilks, K., Kudrow, D., Kroll, R., Kohrman, B., et al. (2014) · The Lancet Neurology · doi:10.1016/s1474-4422(14)70209-1 · Cited by 372

Neurobiology of migraine

Goadsby, P. J., Charbit, A. R., Andreou, A. P., Akerman, S., & Holland, P. R. (2009) · Neuroscience · doi:10.1016/j.neuroscience.2009.03.019 · Cited by 371

Calcitonin gene-related peptide receptor antagonist human CGRP-(8-37)

Chiba, T., Yamaguchi, A., Yamatani, T., Nakamura, A., Morishita, T., Inui, T., Fukase, M., Noda, T., & Fujita, T. (1989) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1989.256.2.e331 · Cited by 360

Calcitonin gene-related peptide promotes mechanical nociception by potentiating release of substance P from the spinal dorsal horn in rats

Oku, R., Satoh, M., Fujii, N., Otaka, A., Yajima, H., & Takagi, H. (1987) · Brain Research · doi:10.1016/0006-8993(87)90074-6 · Cited by 356

Activation of TRPV1 by Dietary Capsaicin Improves Endothelium-Dependent Vasorelaxation and Prevents Hypertension

Yang, D., Luo, Z., Ma, S., Wong, W. T., Ma, L., Zhong, J., He, H., Zhao, Z., Cao, T., Yan, Z., et al. (2010) · Cell Metabolism · doi:10.1016/j.cmet.2010.05.015 · Cited by 349

CGRP-RCP, a Novel Protein Required for Signal Transduction at Calcitonin Gene-related Peptide and Adrenomedullin Receptors

Evans, B. N., Rosenblatt, M. I., Mnayer, L. O., Oliver, K. R., & Dickerson, I. M. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m005604200 · Cited by 337

Differential expression of α-CGRP and β-CGRP by primary sensory neurons and enteric autonomic neurons of the rat

Mulderry, P. K., Ghatki, M. A., Spokks, R. A., Jonhs, P. M., Pierson, A. M., Hamid, Q. A., Kanse, S., Amara, S. G., Burrik, J. M., Legon, S., et al. (1988) · Neuroscience · doi:10.1016/0306-4522(88)90018-8 · Cited by 333

Differential distribution of calcitonin gene-related peptide and its receptor components in the human trigeminal ganglion

Eftekhari, S., Salvatore, C. A., Calamari, A., Kane, S. A., Tajti, J., & Edvinsson, L. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2010.05.016 · Cited by 329

Calcitonin receptor‐like receptor (CLR), receptor activity‐modifying protein 1 (RAMP1), and calcitonin gene‐related peptide (CGRP) immunoreactivity in the rat trigeminovascular system: Differences between peripheral and central CGRP receptor distribution

Lennerz, J. K., Rühle, V., Ceppa, E. P., Neuhuber, W. L., Bunnett, N. W., Grady, E. F., & Messlinger, K. (2008) · Journal of Comparative Neurology · doi:10.1002/cne.21607 · Cited by 325

Calcitonin gene-related peptide (CGRP): perivascular distribution and vasodilatory effects

Uddman, R., Edvinsson, L., Ekblad, E., Håkanson, R., & Sundler, F. (1986) · Regulatory Peptides · doi:10.1016/0167-0115(86)90071-6 · Cited by 323

Calcitonin gene-related peptide is a potent inhibitor of substance P degradation

Le Greves, P., Nyberg, F., Terenius, L., & Hökfelt, T. (1985) · European Journal of Pharmacology · doi:10.1016/0014-2999(85)90706-x · Cited by 322

A cDNA Encoding the Calcitonin Gene-related Peptide Type 1 Receptor

Aiyar, N., Rand, K., Elshourbagy, N. A., Zeng, Z., Adamou, J. E., Bergsma, D. J., & Li, Y. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.19.11325 · Cited by 320

Expression and secretion of procalcitonin and calcitonin gene-related peptide by adherent monocytes and by macrophage-activated adipocytes*

Linscheid, P., Seboek, D., Schaer, D. J., Zulewski, H., Keller, U., & Müller, B. (2004) · Critical Care Medicine · doi:10.1097/01.ccm.0000134404.63292.71 · Cited by 315

Substance P regulates the vasodilator activity of calcitonin gene-related peptide

Brain, S. D., & Williams, T. J. (1988) · Nature · doi:10.1038/335073a0 · Cited by 310

Nitroxyl anion exerts redox-sensitive positive cardiac inotropy in vivo by calcitonin gene-related peptide signaling

Paolocci, N., Saavedra, W. F., Miranda, K. M., Martignani, C., Isoda, T., Hare, J. M., Espey, M. G., Fukuto, J. M., Feelisch, M., Wink, D. A., et al. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.181191198 · Cited by 298

BMS-927711 for the acute treatment of migraine: A double-blind, randomized, placebo controlled, dose-ranging trial

Marcus, R., Goadsby, P. J., Dodick, D., Stock, D., Manos, G., & Fischer, T. Z. (2014) · Cephalalgia · doi:10.1177/0333102413500727 · Cited by 296

Awake Systolic Blood Pressure Variability Correlates With Target-Organ Damage in Hypertensive Subjects

Tatasciore, A., Renda, G., Zimarino, M., Soccio, M., Bilo, G., Parati, G., Schillaci, G., & De Caterina, R. (2007) · Hypertension · doi:10.1161/hypertensionaha.107.090084 · Cited by 292

Vasoactive Peptide Levels in The Plasma of Young Migraine Patients With and Without Aura Assessed Both Interictally and Ictally

Gallai, V., Sarchielli, P., Floridi, A., Franceschini, M., Codini, M., Glioti, G., Trequattrini, A., & Palumbo, R. (1995) · Cephalalgia · doi:10.1046/j.1468-2982.1995.1505384.x · Cited by 288

Synaptobrevin I mediates exocytosis of CGRP from sensory neurons and inhibition by botulinum toxins reflects their anti-nociceptive potential

Meng, J., Wang, J., Lawrence, G., & Dolly, J. O. (2007) · Journal of Cell Science · doi:10.1242/jcs.012211 · Cited by 267

Nitric Oxide Metabolites, Prostaglandins and Trigeminal Vasoactive Peptides in Internal Jugular Vein Blood During Spontaneous Migraine Attacks

Sarchielli, P., Alberti, A., Codini, M., Floridi, A., & Gallai, V (2000) · Cephalalgia · doi:10.1046/j.1468-2982.2000.00146.x · Cited by 264

Randomized controlled trial of the CGRP receptor antagonist MK-3207 in the acute treatment of migraine

Hewitt, D. J., Aurora, S. K., Dodick, D. W., Goadsby, P. J., Ge, Y. (., Bachman, R., Taraborelli, D., Fan, X., Assaid, C., Lines, C., et al. (2011) · Cephalalgia · doi:10.1177/0333102411398399 · Cited by 263

Peptidergic CGRPα Primary Sensory Neurons Encode Heat and Itch and Tonically Suppress Sensitivity to Cold

McCoy, E. S., Taylor-Blake, B., Street, S. E., Pribisko, A. L., Zheng, J., & Zylka, M. J. (2013) · Neuron · doi:10.1016/j.neuron.2013.01.030 · Cited by 263

Islet amyloid in type 2 human diabetes mellitus and adult diabetic cats contains a novel putative polypeptide hormone.

Westermark, P., Wernstedt, C., O’Brien, T. D., Hayden, D. W., & Johnson, K. H. (1987) · PubMed · Cited by 261

Acute Effects of Substance P and Calcitonin Gene-Related Peptide in Human Skin – A Microdialysis Study

Weidner, C., Klede, M., Rukwied, R., Lischetzki, G., Neisius, U., Schmelz, M., Skov, P. S., & Petersen, L. J. (2000) · Journal of Investigative Dermatology · doi:10.1046/j.1523-1747.2000.00142.x · Cited by 257

Release of the predicted calcitonin gene-related peptide from cultured rat trigeminal ganglion cells

Mason, R. T., Peterfreund, R. A., Sawchenko, P. E., Corrigan, A. Z., Rivier, J. E., & Vale, W. W. (1984) · Nature · doi:10.1038/308653a0 · Cited by 250

Sensory neuropeptides: their role in inflammation and wound healing

Brain, S. D. (1997) · Immunopharmacology · doi:10.1016/s0162-3109(97)00055-6 · Cited by 246

Occurrence, distribution and ontogeny of CGRP immunoreactivity in the rat lower respiratory tract: Effect of capsaicin treatment and surgical denervations

Cadieux, A., Springall, D. R., Mulderry, P. K., Rodrigo, J., Ghatei, M. A., Terenghi, G., Bloom, S. R., & Polak, J. M. (1986) · Neuroscience · doi:10.1016/0306-4522(86)90285-x · Cited by 244

Alternative RNA Processing: Determining Neuronal Phenotype

Rosenfeld, M. G., Amara, S. G., & Evans, R. M. (1984) · Science · doi:10.1126/science.6089345 · Cited by 230

Increased vascular penetration and nerve growth in the meniscus: a potential source of pain in osteoarthritis

Ashraf, S., Wibberley, H., Mapp, P. I., Hill, R., Wilson, D., & Walsh, D. A. (2011) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2010.137844 · Cited by 229

Differential effect of alpha-latrotoxin on exocytosis from small synaptic vesicles and from large dense-core vesicles containing calcitonin gene-related peptide at the frog neuromuscular junction.

Matteoli, M., Haimann, C., Torri-Tarelli, F., Polak, J. M., Ceccarelli, B., & De Camilli, P. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.19.7366 · Cited by 225

Peptidergic sensory neurons in the control of vascular functions: Mechanisms and significance in the cutaneous and splanchnic vascular beds

Holzer, P. (2005) · Reviews of Physiology, Biochemistry and Pharmacology · doi:10.1007/bfb0033194 · Cited by 219

Protein Kinase C-ζ Mediates Angiotensin II Activation of ERK1/2 in Vascular Smooth Muscle Cells

Liao, D.-F., Monia, B., Dean, N., & Berk, B. C. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.10.6146 · Cited by 219

Randomized, controlled trial of telcagepant for the acute treatment of migraine

Connor, K. M., Shapiro, R. E., Diener, H. C., Lucas, S., Kost, J., Fan, X., Fei, K., Assaid, C., Lines, C., & Ho, T. W. (2009) · Neurology · doi:10.1212/wnl.0b013e3181b87942 · Cited by 217

BI 44370 TA, an oral CGRP antagonist for the treatment of acute migraine attacks: Results from a phase II study

Diener, H.-C., Barbanti, P., Dahlöf, C., Reuter, U., Habeck, J., & Podhorna, J. (2011) · Cephalalgia · doi:10.1177/0333102410388435 · Cited by 214

Calcitonin gene-related peptide is present in mammalian cerebrovascular nerve fibres and dilates pial and peripheral arteries

Hanko, J., Hardebo, J. E., Kåhrström, J., Owman, C., & Sundler, F. (1985) · Neuroscience Letters · doi:10.1016/0304-3940(85)90045-x · Cited by 202

No increase of calcitonin gene–related peptide in jugular blood during migraine

Tvedskov, J. F., Lipka, K., Ashina, M., Iversen, H. K., Schifter, S., & Olesen, J. (2005) · Annals of Neurology · doi:10.1002/ana.20605 · Cited by 199

Neuropeptides and their receptors: innovative science providing novel therapeutic targets

Brain, S. D., & Cox, H. M. (2006) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0706461 · Cited by 197

Calcitonin gene-related peptide stimulates cyclic AMP formation in rat aortic smooth muscle cells

Kubota, M., Moseley, J. M., Butera, L., Dusting, G. J., MacDonald, P. S., & Martin, T. J. (1985) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(85)90992-1 · Cited by 197

The efferent projections of the pretectal complex: an autoradiographic and horseradish peroxidase analysis

Weber, J. T., & Harting, J. K. (1980) · Brain Research · doi:10.1016/0006-8993(80)91315-3 · Cited by 192

Receptor Activity-modifying Protein 1 Determines the Species Selectivity of Non-peptide CGRP Receptor Antagonists

Mallee, J. J., Salvatore, C. A., LeBourdelles, B., Oliver, K. R., Longmore, J., Koblan, K. S., & Kane, S. A. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m109661200 · Cited by 190

Potent Vasodilator Activity of Calcitonin Gene-Related Peptide in Human Skin

Brain, S. D., Tippins, J. R., Morris, H. R., Maclntyre, I., & Williams, T. J. (1986) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12455620 · Cited by 189

Crystal Structure of the Ectodomain Complex of the CGRP Receptor, a Class-B GPCR, Reveals the Site of Drug Antagonism

ter Haar, E., Koth, C. M., Abdul-Manan, N., Swenson, L., Coll, J. T., Lippke, J. A., Lepre, C. A., Garcia-Guzman, M., & Moore, J. M. (2010) · Structure · doi:10.1016/j.str.2010.05.014 · Cited by 189

The CGRP-Antagonist, BIBN4096BS Does not Affect Cerebral or Systemic Haemodynamics in Healthy Volunteers

Petersen, K., Birk, S., Lassen, L., Kruuse, C., Jonassen, O., Lesko, L., & Olesen, J. (2005) · Cephalalgia · doi:10.1111/j.1468-2982.2004.00830.x · Cited by 181

Calcitonin Gene-Related Peptide Receptor Activation Produces PKA- and PKC-Dependent Mechanical Hyperalgesia and Central Sensitization

Sun, R.-Q., Tu, Y.-J., Lawand, N. B., Yan, J.-Y., Lin, Q., & Willis, W. D. (2004) · Journal of Neurophysiology · doi:10.1152/jn.00339.2004 · Cited by 180

Calcitonin gene-related peptide in the cardiovascular system: characterization of receptor populations and their (patho)physiological significance.

Bell, D., & McDermott, B. J. (1996) · Pharmacological Reviews · doi:10.1016/s0031-6997(25)06943-1 · Cited by 175

BIBN4096BS Antagonizes Human α-calcitonin Gene Related Peptide–induced Headache and Extracerebral Artery Dilatation*

Petersen, K. A., Lassen, L. H., Birk, S., Lesko, L., & Olesen, J. (2005) · Clinical Pharmacology & Therapeutics · doi:10.1016/j.clpt.2004.10.001 · Cited by 173

Delayed Upregulation of ATP P2X3 Receptors of Trigeminal Sensory Neurons by Calcitonin Gene-Related Peptide

Fabbretti, E., D'Arco, M., Fabbro, A., Simonetti, M., Nistri, A., & Giniatullin, R. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.0647-06.2006 · Cited by 173

Beyond blood pressure: the endothelium and atherosclerosis progression*

Schiffrin, E. L. (2002) · American Journal of Hypertension · doi:10.1016/s0895-7061(02)03006-6 · Cited by 168

Cardiovascular action of calcitonin gene-related peptide in humans

Gennari, C., & Fischer, J. A. (1985) · Calcified Tissue International · doi:10.1007/bf02554909 · Cited by 168

Angiogenesis in osteoarthritis

Ashraf, S., & Walsh, D. A. (2008) · Current Opinion in Rheumatology · doi:10.1097/bor.0b013e3283103d12 · Cited by 166

Regulation of signal transduction by calcitonin gene-related peptide receptors

Walker, C. S., Conner, A. C., Poyner, D. R., & Hay, D. L. (2010) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2010.06.006 · Cited by 166

In pursuit of P2X3 antagonists: novel therapeutics for chronic pain and afferent sensitization

Ford, A. P. (2012) · Purinergic Signalling · doi:10.1007/s11302-011-9271-6 · Cited by 165

Epidermal Nerve Fibers Modulate Keratinocyte Growth via Neuropeptide Signaling in an Innervated Skin Model

Roggenkamp, D., Köpnick, S., Stäb, F., Wenck, H., Schmelz, M., & Neufang, G. (2013) · Journal of Investigative Dermatology · doi:10.1038/jid.2012.464 · Cited by 161

Neuroplasticity of sensory and sympathetic nerve fibers in a mouse model of a painful arthritic joint

Ghilardi, J. R., Freeman, K. T., Jimenez‐Andrade, J. M., Coughlin, K. A., Kaczmarska, M. J., Castaneda‐Corral, G., Bloom, A. P., Kuskowski, M. A., & Mantyh, P. W. (2012) · Arthritis & Rheumatism · doi:10.1002/art.34385 · Cited by 161

Variable sensitivity to noxious heat is mediated by differential expression of the CGRP gene

Mogil, J. S., Miermeister, F., Seifert, F., Strasburg, K., Zimmermann, K., Reinold, H., Austin, J.-S., Bernardini, N., Chesler, E. J., Hofmann, H. A., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0503264102 · Cited by 160

Dilation by CGRP of middle meningeal artery and reversal by sumatriptan in normal volunteers

Asghar, M. S., Hansen, A. E., Kapijimpanga, T., van der Geest, R. J., van der Koning, P., Larsson, H. B. W., Olesen, J., & Ashina, M. (2010) · Neurology · doi:10.1212/wnl.0b013e3181f9626a · Cited by 158

A Receptor Activity Modifying Protein (RAMP)2-Dependent Adrenomedullin Receptor Is a Calcitonin Gene-Related Peptide Receptor when Coexpressed with Human RAMP1

Bühlmann, N., Leuthäuser, K., Muff, R., Fischer, J. A., & Born, W. (1999) · Endocrinology · doi:10.1210/endo.140.6.6783 · Cited by 158

The norepinephrine transporter and its regulation

Mandela, P., & Ordway, G. A. (2006) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.03717.x · Cited by 156

Alleviation of mechanical and thermal allodynia by CGRP8-37 in a rodent model of chronic central pain

Bennett, A. D., Chastain, K. M., & Hulsebosch, C. E. (2000) · Pain · doi:10.1016/s0304-3959(00)00242-6 · Cited by 156

Arthritic calcitonin/α calcitonin gene-related peptide knockout mice have reduced nociceptive hypersensitivity

Zhang, L., Hoff, A. O., Wimalawansa, S. J., Cote, G. J., Gagel, R. F., & Westlund, K. N. (2001) · Pain · doi:10.1016/s0304-3959(00)00378-x · Cited by 156

Regulation of calcitonin gene-related peptide and TRPV1 in a rat model of osteoarthritis

Fernihough, J. K., Gentry, C., Bevan, S., & Winter, J. (2005) · Neuroscience Letters · doi:10.1016/j.neulet.2005.06.044 · Cited by 155

Calcitonin Gene-Related Peptide Is an Important Regulator of Cutaneous Immunity: Effect on Dendritic Cell and T Cell Functions

Mikami, N., Matsushita, H., Kato, T., Kawasaki, R., Sawazaki, T., Kishimoto, T., Yusuke, O., Watanabe, K., Miyagi, Y., Sueda, K., et al. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1100028 · Cited by 154

Calcitonin Gene‐Related Peptide ( CGRP ) and Migraine Current Understanding and State of Development

BIGAL, M. E., Walter, S., & Rapoport, A. M. (2013) · Headache The Journal of Head and Face Pain · doi:10.1111/head.12179 · Cited by 152

Elevated Sympathetic Nervous Activity in Mice Deficient in αCGRP

Oh-hashi, Y., Shindo, T., Kurihara, Y., Imai, T., Wang, Y., Morita, H., Imai, Y., Kayaba, Y., Nishimatsu, H., Suematsu, Y., et al. (2001) · Circulation Research · doi:10.1161/hh2301.100812 · Cited by 152

Structure and expression of the human calcitonin/CGRP genes

Steenbergh, P. H., Höppener, J. W. M., Zandberg, J., Visser, A., Lips, C. J. M., & Jansz, H. S. (1986) · FEBS Letters · doi:10.1016/0014-5793(86)81091-2 · Cited by 149

Potent, Orally Bioavailable Calcitonin Gene-Related Peptide Receptor Antagonists for the Treatment of Migraine: Discovery of N -[(3 R ,6 S )-6-(2,3-Difluorophenyl)-2-oxo-1- (2,2,2-trifluoroethyl)azepan-3-yl]-4- (2-oxo-2,3-dihydro-1 H -imidazo[4,5- b ]pyridin- 1-yl)piperidine-1-carboxamide (MK-0974)

Paone, D. V., Shaw, A. W., Nguyen, D. N., Burgey, C. S., Deng, J. Z., Kane, S. A., Koblan, K. S., Salvatore, C., Mosser, S. D., Johnston, V. K., et al. (2007) · Journal of Medicinal Chemistry · doi:10.1021/jm070668p · Cited by 149

Capsaicin‐sensitive sensory fibers in the islets of Langerhans contribute to defective insulin secretion in Zucker diabetic rat, an animal model for some aspects of human type 2 diabetes

Gram, D. X., Åhrén, B., Nagy, I., Olsen, U. B., Brand, C. L., Sundler, F., y Palacios, R. T., Svendsen, O., Carr, R. D., Sántha, P., et al. (2007) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2006.05261.x · Cited by 149

Pharmacological Characterization of MK-0974 [N-[(3 R,6 S)-6-(2,3-Difluorophenyl)-2-oxo-1-(2,2,2-trifluoroethyl)azepan-3-yl]-4-(2-oxo-2,3-dihydro-1 H-imidazo[4,5-b]pyridin-1-yl)piperidine-1-carboxamide], a Potent and Orally Active Calcitonin Gene-Related Peptide Receptor Antagonist for the Treatment of Migraine

Salvatore, C., Hershey, J. C., Corcoran, H. A., Fay, J. F., Johnston, V. K., Moore, E. L., Mosser, S. D., Burgey, C. S., Paone, D. V., Shaw, A. W., et al. (2007) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.107.130344 · Cited by 148

Molecular Mechanisms of Sensitization of Pain-transducing P2X3 Receptors by the Migraine Mediators CGRP and NGF

Giniatullin, R. A., Nistri, A., & Fabbretti, E. (2008) · Molecular Neurobiology · doi:10.1007/s12035-008-8020-5 · Cited by 147

Increased Blood Pressure in α-Calcitonin Gene–Related Peptide/Calcitonin Gene Knockout Mice

Gangula, P. R., Zhao, H., Supowit, S. C., Wimalawansa, S. J., DiPette, D. J., Westlund, K. N., Gagel, R. F., & Yallampalli, C. (2000) · Hypertension · doi:10.1161/01.hyp.35.1.470 · Cited by 147

Evidence for the pathophysiological relevance of TRPA1 receptors in the cardiovascular system in vivo

Pozsgai, G., Bodkin, J. V., Graepel, R., Bevan, S., Andersson, D. A., & Brain, S. D. (2010) · Cardiovascular Research · doi:10.1093/cvr/cvq118 · Cited by 146

Human α‐calcitonin gene‐related peptide stimulates adenylate cyclase and guanylate cyclase and relaxes rat thoracic aorta by releasing nitric oxide

Gray, D. W., & Marshall, I. (1992) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1992.tb14508.x · Cited by 145

Increased concentration of circulating calcitonin gene related peptide during normal human pregnancy.

Stevenson, J. C., Macdonald, D. W., Warren, R. C., Booker, M. W., & Whitehead, M. (1986) · BMJ · doi:10.1136/bmj.293.6558.1329 · Cited by 144

Calcitonin gene-related peptide inhibits interleukin 2 production by murine T lymphocytes.

Wang, F., Millet, I., Bottomly, K., & Vignery, A. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)36796-1 · Cited by 143

Distribution and chromatographic characterisation of CGRP-like immunoreactivity in the brain and gut of the rat

Mulderry, P. K., Ghatei, M. A., Bishop, A. E., Allen, Y. S., Polak, J. M., & Bloom, S. R. (1985) · Regulatory Peptides · doi:10.1016/0167-0115(85)90194-6 · Cited by 141

Agonist-promoted Internalization of a Ternary Complex between Calcitonin Receptor-like Receptor, Receptor Activity-modifying Protein 1 (RAMP1), and β-Arrestin

Hilairet, S., Bélanger, C., Bertrand, J., Laperrière, A., Foord, S. M., & Bouvier, M. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m107323200 · Cited by 139

Gait analysis and pain response of two rodent models of osteoarthritis

Ferland, C. E., Laverty, S., Beaudry, F., & Vachon, P. (2010) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2010.11.003 · Cited by 138

Hypertension and dysregulated proinflammatory cytokine production in receptor activity-modifying protein 1-deficient mice

Tsujikawa, K., Yayama, K., Hayashi, T., Matsushita, H., Yamaguchi, T., Shigeno, T., Ogitani, Y., Hirayama, M., Kato, T., Fukada, S.-I., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0705974104 · Cited by 136

Keratinocyte expression of calcitonin gene-related peptide β: Implications for neuropathic and inflammatory pain mechanisms

Hou, Q., Barr, T. P., Gee, L. E., Vickers, J., Wymer, J. P., Borsani, E., Rodella, L. F., Getsios, S., Burdo, T., Eisenberg, E., et al. (2011) · Pain · doi:10.1016/j.pain.2011.04.033 · Cited by 136

A Human Orphan Calcitonin Receptor-like Structure

Fluhmann, B., Muff, R., Hunziker, W., Fischer, J. A., & Born, W. (1995) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1995.1047 · Cited by 132

TRPV1 Deletion Enhances Local Inflammation and Accelerates the Onset of Systemic Inflammatory Response Syndrome

Fernandes, E. S., Liang, L., Smillie, S.-J., Kaiser, F., Purcell, R. H., Rivett, D. W., Alam, S., Howat, S., Collins, H., Thompson, S. J., et al. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1102147 · Cited by 131

Roles of calcitonin gene-related peptide in facilitation of wound healing and angiogenesis

Toda, M., Suzuki, T., Hosono, K., Kurihara, Y., Kurihara, H., Hayashi, I., Kitasato, H., Hoka, S., & Majima, M. (2008) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2008.02.003 · Cited by 130

CGRPα-Expressing Sensory Neurons Respond to Stimuli that Evoke Sensations of Pain and Itch

McCoy, E. S., Taylor‐Blake, B., & Zylka, M. J. (2012) · PLoS ONE · doi:10.1371/journal.pone.0036355 · Cited by 130

Inhibition of mitogen-stimulated T lymphocyte proliferation by calcitonin gene-related peptide

Umeda, Y., Takamiya, M., Yoshizaki, H., & Arisawa, M. (1988) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(88)90674-2 · Cited by 129

Calcitonin gene-related peptide (CGRP) and its role in hypertension

Smillie, S.-J., & Brain, S. D. (2011) · Neuropeptides · doi:10.1016/j.npep.2010.12.002 · Cited by 127

CALCITONIN GENE-RELATED PEPTIDE INHIBITS LOCAL ACUTE INFLAMMATION AND PROTECTS MICE AGAINST LETHAL ENDOTOXEMIA

Gomes, R. N., Castro-Faria-Neto, H. C., Bozza, P. T., Soares, M. B. P., Shoemaker, C. B., David, J. R., & Bozza, M. T. (2005) · Shock · doi:10.1097/01.shk.0000183395.29014.7c · Cited by 127

Mice Lacking α-Calcitonin Gene-Related Peptide Exhibit Normal Cardiovascular Regulation and Neuromuscular Development

Lu, J. T., Son, Y., Lee, J., Jetton, T. L., Shiota, M., Moscoso, L. M., Niswender, K. D., Loewy, A. D., Magnuson, M. A., Sanes, J. R., et al. (1999) · Molecular and Cellular Neuroscience · doi:10.1006/mcne.1999.0767 · Cited by 125

Renal Nerves Drive Interstitial Fibrogenesis in Obstructive Nephropathy

Kim, J., & Padanilam, B. J. (2012) · Journal of the American Society of Nephrology · doi:10.1681/asn.2012070678 · Cited by 125

Nerve Growth Factor Is Critical for Cardiac Sensory Innervation and Rescues Neuropathy in Diabetic Hearts

Ieda, M., Kanazawa, H., Ieda, Y., Kimura, K., Matsumura, K., Tomita, Y., Yagi, T., Onizuka, T., Shimoji, K., Ogawa, S., et al. (2006) · Circulation · doi:10.1161/circulationaha.106.627588 · Cited by 124

An Ongoing Role of α-Calcitonin Gene–Related Peptide as Part of a Protective Network Against Hypertension, Vascular Hypertrophy, and Oxidative Stress

Smillie, S.-J., King, R., Kodji, X., Outzen, E. M., Pozsgai, G., Fernandes, E. S., Marshall, N. J., de Winter, P., Heads, R. J., Dessapt-Baradez, C., et al. (2014) · Hypertension · doi:10.1161/hypertensionaha.113.02517 · Cited by 123

Calcitonin gene-related peptide-immunoreactive nerves in the tongue, epiglottis and pharynx of the rat: Occurrence, distribution and origin

Terenghi, G., Polak, J. M., Rodrigo, J., Mulderry, P. K., & Bloom, S. R. (1986) · Brain Research · doi:10.1016/0006-8993(86)90716-x · Cited by 122

Sensory and sympathetic nerve fibers undergo sprouting and neuroma formation in the painful arthritic joint of geriatric mice

Jiménez‐Andrade, J. M., & Mantyh, P. W. (2012) · Arthritis Research & Therapy · doi:10.1186/ar3826 · Cited by 121

Localization of SP‐ and CGRP‐immunopositive nerve fibers in the hip joint of patients with painful osteoarthritis and of patients with painless failed total hip arthroplasties

Saxler, G., Löer, F., Skumavc, M., Pförtner, J., & Hanesch, U. (2006) · European Journal of Pain · doi:10.1016/j.ejpain.2005.12.011 · Cited by 120

Development of a novel antibody to calcitonin gene-related peptide for the treatment of osteoarthritis-related pain

Benschop, R. J., Collins, E. C., Darling, R. J., Allan, B. W., Leung, D., Conner, E. M., Nelson, J., Gaynor, B., Xu, J., Wang, X.-F., et al. (2014) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2014.01.009 · Cited by 120

Circulating CGRP comes from the perivascular nerves

Zaidi, M., Bevis, P. J. R., Girgis, S. I., Lynch, C., Stevenson, J. C., & MacIntyre, I. M. (1985) · European Journal of Pharmacology · doi:10.1016/0014-2999(85)90616-8 · Cited by 119

Plasma and saliva levels of nerve growth factor and neuropeptides in chronic migraine patients

Jang, M., Park, J., Kho, H., Chung, S., & Chung, J. (2010) · Oral Diseases · doi:10.1111/j.1601-0825.2010.01717.x · Cited by 119

Calcitonin gene-related peptide and hypertension

Deng, P.-Y., & Li, Y. (2005) · Peptides · doi:10.1016/j.peptides.2005.02.002 · Cited by 117

Identification of a protein that confers calcitonin gene-related peptide responsiveness to oocytes by using a cystic fibrosis transmembrane conductance regulator assay.

Luebke, A. E., Dahl, G., Roos, B. A., & Dickerson, I. M. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.8.3455 · Cited by 116

β-Endorphin, Met-enkephalin and corresponding opioid receptors within synovium of patients with joint trauma, osteoarthritis and rheumatoid arthritis

Mousa, S. A., Straub, R. H., Schäfer, M., et al. (2007) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2006.067066 · Cited by 116

Cell-Specific Expression and Lipopolysaccharide-Induced Regulation of Tumor Necrosis Factor α (TNFα) and TNF Receptors in Rat Dorsal Root Ganglion

Li, Y., Ji, A., Weihe, E., & Schäfer, M. K.-H. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.2392-04.2004 · Cited by 115

Protein-Protein Interaction and Not Glycosylation Determines the Binding Selectivity of Heterodimers between the Calcitonin Receptor-like Receptor and the Receptor Activity-modifying Proteins

Hilairet, S., Foord, S. M., Marshall, F. H., & Bouvier, M. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m102722200 · Cited by 114

TRPV1 gene knockout impairs preconditioning protection against myocardial injury in isolated perfused hearts in mice

Zhong, B., & Wang, D. H. (2007) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00169.2007 · Cited by 114

Calcitonin gene-related peptide increases survival of a musculocutaneous critical flap in the rat

Kjartansson, J., & Dalsgaard, C. (1987) · European Journal of Pharmacology · doi:10.1016/0014-2999(87)90073-2 · Cited by 110

Calcitonin gene-related peptide in human obesity

ZELISSEN, P. M. J., Koppeschaar, H. P. F., Lips, C. J. M., & Hackeng, W. H. L. (1991) · Peptides · doi:10.1016/0196-9781(91)90147-h · Cited by 110

BIOLOGY OF PEPTIDES FROM THE CALCITONIN GENES

Zaidi, M., Breimer, L. H., & MacIntyre, I. M. (1987) · Quarterly Journal of Experimental Physiology · doi:10.1113/expphysiol.1987.sp003084 · Cited by 109

Calcitonin receptor-like receptor: identification and distribution in human peripheral tissues

Hagner, S., Stahl, U., Knoblauch, B., McGregor, G. P., & Lang, R. E. (2002) · Cell and Tissue Research · doi:10.1007/s00441-002-0616-x · Cited by 108

Calcitonin gene-related peptide is involved in the spinal processing of mechanosensory input from the rat's knee joint and in the generation and maintenance of hyperexcitability of dorsal horn neurons during development of acute inflammation

Neugebauer, V., Rümenapp, P., & Schaible, H. (1996) · Neuroscience · doi:10.1016/0306-4522(95)00473-4 · Cited by 107

The nitroxyl anion (HNO) is a potent dilator of rat coronary vasculature

Favaloro, J. L., & Kemp‐Harper, B. K. (2006) · Cardiovascular Research · doi:10.1016/j.cardiores.2006.11.018 · Cited by 107

Endothelin-converting enzyme-1 regulates endosomal sorting of calcitonin receptor-like receptor and β-arrestins

Padilla, B. E., Cottrell, G. S., Roosterman, D., Pikios, S., Muller, L., Steinhoff, M. S., & Bunnett, N. W. (2007) · The Journal of Cell Biology · doi:10.1083/jcb.200704053 · Cited by 107

Modulation of immune responses by the neuropeptide CGRP

Holzmann, B. (2011) · Amino Acids · doi:10.1007/s00726-011-1161-2 · Cited by 104

Calcitonin gene-related peptide levels are elevated in patients with sepsis.

Joyce, C. D., Fiscus, R. R., Wang, X., Dries, D. J., Morris, R. C., & Prinz, R. A. (1990) · PubMed · Cited by 102

The transient receptor potential vanilloid 1 (TRPV1) receptor protects against the onset of sepsis after endotoxin

Clark, N., Keeble, J. E., Fernandes, E. S., et al. (2007) · The FASEB Journal · doi:10.1096/fj.06-7460com · Cited by 101

Nociceptive behavior after intrathecal injections of substance P, neurokinin A and calcitonin gene-related peptide in mice

Gamse, R., & Saria, A. (1986) · Neuroscience Letters · doi:10.1016/0304-3940(86)90453-2 · Cited by 100

Targeting a family B GPCR/RAMP receptor complex: CGRP receptor antagonists and migraine

Moore, E. L., & Salvatore, C. (2012) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2011.01633.x · Cited by 99

The neuropeptide calcitonin gene‐related peptide affects allergic airway inflammation by modulating dendritic cell function

Rochlitzer, S., Veres, T., Kühne, K., Prenzler, F., Pilzner, C., Knothe, S., Winkler, C., Lauenstein, H., Willart, M. A. M., Hammad, H., et al. (2011) · Clinical & Experimental Allergy · doi:10.1111/j.1365-2222.2011.03822.x · Cited by 99

Sensory Peptides as Neuromodulators of Wound Healing in Aged Rats

Khalil, Z. G., & Helme, R. D. (1996) · The Journals of Gerontology Series A · doi:10.1093/gerona/51a.5.b354 · Cited by 99

Catabolism of calcitonin gene-related peptide and substance P by neutral endopeptidase

Katayama, M., Nadel, J. A., Bunnett, N. W., Maria, G. U. D., Haxhiu, M. A., & Borson, D. B. (1991) · Peptides · doi:10.1016/0196-9781(91)90102-u · Cited by 98

The role of calcitonin gene-related peptide (CGRP) in ischemic preconditioning in isolated rat hearts

Chai, W., Mehrotra, S., Danser, A. H. J., et al. (2006) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2005.12.039 · Cited by 98

Mechanisms Mediating the Enhanced Gene Transcription of P2X3 Receptor by Calcitonin Gene-related Peptide in Trigeminal Sensory Neurons

Simonetti, M., Giniatullin, R. A., & Fabbretti, E. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m800296200 · Cited by 96

Solution structure of human calcitonin gene-related peptide by proton NMR and distance geometry with restrained molecular dynamics

Breeze, A. L., Harvey, T. S., Bazzo, R., & Campbell, I. D. (1991) · Biochemistry · doi:10.1021/bi00216a036 · Cited by 96

Pain‐like behaviour and spinal changes in the monosodium iodoacetate model of osteoarthritis in C57Bl /6 mice

Ogbonna, A. C., Clark, A. K., Gentry, C., Hobbs, C., & Malcangio, M. (2012) · European Journal of Pain · doi:10.1002/j.1532-2149.2012.00223.x · Cited by 96

A Role for TRPV1 in Influencing the Onset of Cardiovascular Disease in Obesity

Marshall, N. J., Liang, L., Bodkin, J., Dessapt-Baradez, C., Nandi, M., Collot-Teixeira, S., Smillie, S.-J., Lalgi, K., Fernandes, E. S., Gnudi, L., et al. (2013) · Hypertension · doi:10.1161/hypertensionaha.112.201434 · Cited by 95

CGRP function‐blocking antibodies inhibit neurogenic vasodilatation without affecting heart rate or arterial blood pressure in the rat

Zeller, J., Poulsen, K., Sutton, J. E., Abdiche, Y. N., Collier, S., Chopra, R., García, C., Pons, J., Rosenthal, A., & Shelton, D. L. (2008) · British Journal of Pharmacology · doi:10.1038/bjp.2008.334 · Cited by 95

Calcitonin gene-related peptide receptor antagonist olcegepant acts in the spinal trigeminal nucleus

Sixt, M.-L., Meßlinger, K., & Fischer, M. J. M. (2009) · Brain · doi:10.1093/brain/awp168 · Cited by 95

Calcitonin gene-related peptide vasodilation of human pulmonary vessels

McCormack, D. G., Mak, J., Coupe, M. O., & Barnes, P. J. (1989) · Journal of Applied Physiology · doi:10.1152/jappl.1989.67.3.1265 · Cited by 95

Safety and tolerability of LBR-101, a humanized monoclonal antibody that blocks the binding of CGRP to its receptor: Results of the Phase 1 program

BIGAL, M. E., Escandon, R. D., Bronson, M. D., Walter, S., Sudworth, M., Huggins, J. P., & Garzone, P. D. (2013) · Cephalalgia · doi:10.1177/0333102413517775 · Cited by 95

Mice Lacking the Neuropeptide α-Calcitonin Gene-Related Peptide Are Protected Against Diet-Induced Obesity

Walker, C. S., Li, X., Whiting, L., Glyn-Jones, S., Zhang, S., Hickey, A. J., Sewell, M. A., Ruggiero, K., Phillips, A. R. J., Kraegen, E. W., et al. (2010) · Endocrinology · doi:10.1210/en.2010-0284 · Cited by 93

Perivascular noradrenergic and peptide-containing nerves show different patterns of changes during development and ageing in the guinea-pig

Dhall, U., Cowen, T., Haven, A. J., & Burnstock, G. (1986) · Journal of the Autonomic Nervous System · doi:10.1016/0165-1838(86)90003-2 · Cited by 92

Calcitonin gene-related peptide in treatment of severe peripheral vascular insufficiency in Raynaud's phenomenon

Bunker, C. B., Reavley, C., Dowd, P. M., & O’Shaughnessy, D. J. (1993) · The Lancet · doi:10.1016/0140-6736(93)91286-u · Cited by 92

Discovery of (5 S ,6 S ,9 R )-5-Amino-6-(2,3-difluorophenyl)-6,7,8,9-tetrahydro-5 H -cyclohepta[ b ]pyridin-9-yl 4-(2-oxo-2,3-dihydro-1 H -imidazo[4,5- b ]pyridin-1-yl)piperidine-1-carboxylate (BMS-927711): An Oral Calcitonin Gene-Related Peptide (CGRP) Antagonist in Clinical Trials for Treating Migraine

Luo, G., Chen, L., Conway, C. M., Denton, R., Keavy, D., Signor, L. J., Kostich, W. A., Lentz, K. A., Santone, K. S., Schartman, R., et al. (2012) · Journal of Medicinal Chemistry · doi:10.1021/jm3013147 · Cited by 92

Evidence for the role of neurogenic inflammation components in trypsin‐elicited scratching behaviour in mice

da Costa, R., Marotta, D. M., Manjavachi, M. N., Fernandes, E. S., Lima-Garcia, J. F., Paszcuk, A. F., Quintão, N. L. M., Juliano, L., Brain, S. D., & Calixto, J. Β. (2008) · British Journal of Pharmacology · doi:10.1038/bjp.2008.172 · Cited by 91

Pharmacological Properties of MK-3207, a Potent and Orally Active Calcitonin Gene-Related Peptide Receptor Antagonist

Salvatore, C., Moore, E. L., Calamari, A., Cook, J. J., Michener, M. S., O'Malley, S. S., Miller, P. J., Sur, C., Williams, D. L., Zeng, Z., et al. (2010) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.109.163816 · Cited by 91

Costorage of BDNF and neuropeptides within individual dense‐core vesicles in central and peripheral neurons

Salio, C., Averill, S., Priestley, J. V., & Merighi, A. (2007) · Developmental Neurobiology · doi:10.1002/dneu.20358 · Cited by 89

The calcitonin‐like sequence of the β CGRP gene

Alevizaki, M. K., Shiraishi, A., Rassool, F. V., Ferner, G. J. M., Maclntyre, I., & Legon, S. (1986) · FEBS Letters · doi:10.1016/0014-5793(86)81338-2 · Cited by 89

Effect of neurokinin A, substance P and calcitonin gene related peptide in peripheral hyperalgesia in the rat paw

Nakamura-Craig, M., & Gill, B. K. (1991) · Neuroscience Letters · doi:10.1016/0304-3940(91)90819-f · Cited by 88

Gaze direction affects face perception in humans

Watanabe, S., Miki, K., & Kakigi, R. (2002) · Neuroscience Letters · doi:10.1016/s0304-3940(02)00257-4 · Cited by 88

Inhibition of capsaicin‐induced increase in dermal blood flow by the oral CGRP receptor antagonist, telcagepant (MK‐0974)

Sinclair, S. R., Kane, S. A., der Schueren, B. V., et al. (2009) · British Journal of Clinical Pharmacology · doi:10.1111/j.1365-2125.2009.03543.x · Cited by 87

International Union of Pharmacology. LXIX. Status of the Calcitonin Gene-Related Peptide Subtype 2 Receptor

Hay, D. L., Poyner, D. R., & Quirion, R. (2008) · Pharmacological Reviews · doi:10.1124/pr.108.00372 · Cited by 86

Innervation of the human middle meningeal artery: immunohistochemistry, ultrastructure, and role of endothelium for vasomotility

Edvinsson, L. I., Gulbenkian, S., Barroso, C. P., et al. (1998) · Peptides · doi:10.1016/s0196-9781(98)00066-7 · Cited by 85

Sensitized peripheral nociception in experimental diabetes of the rat

Fuchs, D., Birklein, F., Reeh, P. W., & Sauer, S. K. (2010) · Pain · doi:10.1016/j.pain.2010.08.010 · Cited by 85

Experiments with UCB 6215, a drug which enhances acquisition in rats: Its effects compared with those of metamphetamine

Wolthuis, O. L. (1971) · European Journal of Pharmacology · doi:10.1016/0014-2999(71)90029-x · Cited by 85

Calcitonin gene-related peptide differentially regulates gene and protein expression in trigeminal glia cells: Findings from array analysis

Vause, C. V., & Durham, P. L. (2010) · Neuroscience Letters · doi:10.1016/j.neulet.2010.01.074 · Cited by 84

Long‐Term Tolerability of Telcagepant for Acute Treatment of Migraine in a Randomized Trial

Connor, K. M., Aurora, S. K., Loeys, T., Ashina, M., Jones, C., Giezek, H., Massaad, R., Williams‐Diaz, A., Lines, C., & Ho, T. W. (2010) · Headache The Journal of Head and Face Pain · doi:10.1111/j.1526-4610.2010.01799.x · Cited by 84

Neutralization of Nerve Growth Factor Induces Plasticity of ATP-Sensitive P2X3Receptors of Nociceptive Trigeminal Ganglion Neurons

D’Arco, M., Giniatullin, R. A., Simonetti, M., Fabbro, A., Nair, A., Nistri, A., & Fabbretti, E. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.0713-07.2007 · Cited by 83

Neurotrophins and peripheral neuropathy

Tomlinson, D. R., Fernyhough, P., & Diemel, L. T. (1996) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.1996.0042 · Cited by 83

Calcitonin gene-related peptide as a regulator of neuronal CaMKII–CREB, microglial p38–NFκB and astroglial ERK–Stat1/3 cascades mediating the development of tolerance to morphine-induced analgesia

Wang, Z., Ma, W., Chabot, J., & Quirion, R. (2010) · Pain · doi:10.1016/j.pain.2010.07.006 · Cited by 83

Age-related decrease of calcitonin gene-related peptide-containing vasodilator innervation in the mesenteric resistance vessel of the spontaneously hypertensive rat.

Kawasaki, H., Saito, A., & Takasaki, K. (1990) · Circulation Research · doi:10.1161/01.res.67.3.733 · Cited by 82

The vanilloid receptor and hypertension1

Wang, D. H. (2005) · Acta Pharmacologica Sinica · doi:10.1111/j.1745-7254.2005.00057.x · Cited by 79

Inflammatory edema induced by interactions between IL-1 and the neuropeptide calcitonin gene-related peptide

Buckley, T. L., Brain, S. D., Collins, P. D., & Williams, T. J. (1991) · The Journal of Immunology · doi:10.4049/jimmunol.146.10.3424 · Cited by 78

Plasma CGRP in acute myocardial infarction

Mair, J. M., Lechleitner, P., Längle, T., Wiedermann, C. J., Dienstl, F., & Saria, A. (1990) · The Lancet · doi:10.1016/0140-6736(90)90040-c · Cited by 78

Post-endocytic Sorting of Calcitonin Receptor-like Receptor and Receptor Activity-modifying Protein 1

Cottrell, G. S., Padilla, B. E., Pikios, S., Roosterman, D., Steinhoff, M. S., Grady, E. F., & Bunnett, N. W. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m606338200 · Cited by 78

Characterization of the Calcitonin Gene-Related Peptide Receptor Antagonist Telcagepant (MK-0974) in Human Isolated Coronary Arteries

Chan, K. Y., Edvinsson, L. I., Eftekhari, S., Kimblad, P. O., Kane, S. A., Lynch, J. J., Hargreaves, R. J., de Vries, R., Garrelds, I. M., van den Bogaerdt, A. J., et al. (2010) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.110.165993 · Cited by 78

Pathophysiology of migraine: a disorder of sensory processing

Goadsby, P. J., Holland, P. R., Martins-Oliveira, M., Hoffmann, J., Schankin, C., & Akerman, S. (2017) · Physiological Reviews · doi:10.1152/physrev.00034.2015 · Cited by 1,998

U.S. FDA Approved Drugs from 2015–June 2020: A Perspective

Bhutani, P., Joshi, G., Raja, N., Bachhav, N., Rajanna, P. K., Bhutani, H., Paul, A. T., & Kumar, R. (2021) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.0c01786 · Cited by 815

The role of calcitonin gene–related peptide in peripheral and central pain mechanisms including migraine

Iyengar, S., Ossipov, M. H., & Johnson, K. W. (2017) · Pain · doi:10.1097/j.pain.0000000000000831 · Cited by 584

Maternal Mineral and Bone Metabolism During Pregnancy, Lactation, and Post-Weaning Recovery

Kovacs, C. S. (2016) · Physiological Reviews · doi:10.1152/physrev.00027.2015 · Cited by 544

CGRP and the Trigeminal System in Migraine

Iyengar, S., Johnson, K. W., Ossipov, M. H., & Aurora, S. K. (2019) · Headache: The Journal of Head and Face Pain · doi:10.1111/head.13529 · Cited by 486