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Cited by 722

The DOI matches its Crossref record; 439 of the 439 references it cites were found in a registry or an index.

Interstitial Fluid and Lymph Formation and Transport: Physiological Regulation and Roles in Inflammation and Cancer

Open access
Wiig, Helge, Swartz, Melody A.·2012·Physiological Reviews
DOI 10.1152/physrev.00037.2011
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Abstract

The interstitium describes the fluid, proteins, solutes, and the extracellular matrix (ECM) that comprise the cellular microenvironment in tissues. Its alterations are fundamental to changes in cell function in inflammation, pathogenesis, and cancer. Interstitial fluid (IF) is created by transcapillary filtration and cleared by lymphatic vessels. Herein we discuss the biophysical, biomechanical, and functional implications of IF in normal and pathological tissue states from both fluid balance and cell function perspectives. We also discuss analysis methods to access IF, which enables quantification of the cellular microenvironment; such methods have demonstrated, for example, that there can be dramatic gradients from tissue to plasma during inflammation and that tumor IF is hypoxic and acidic compared with subcutaneous IF and plasma. Accumulated recent data show that IF and its convection through the interstitium and delivery to the lymph nodes have many and diverse biological effects, including in ECM reorganization, cell migration, and capillary morphogenesis as well as in immunity and peripheral tolerance. This review integrates the biophysical, biomechanical, and biological aspects of interstitial and lymph fluid and its transport in tissue physiology, pathophysiology, and immune regulation.

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Crossref · 10.1152/physrev.00037.2011

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Metadata

Authors
Wiig, H., & Swartz, M. A.
Venue
Physiological Reviews
Publisher
American Physiological Society
Published
2012-07
Volume
92
Issue
3
Pages
1005-1060
ISSN
  • 0031-9333 (ISSN-L)
  • 1522-1210
DOI
10.1152/physrev.00037.2011
OpenAlex
W2115352852
Cited by
722
References
439
FWCI
2.87
Type
journal article
Language
en
Open access
green

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