Defining Physiological Normoxia for Improved Translation of Cell Physiology to Animal Models and Humans

Cited by (332)

Items 101–200 of 332

1. Origins and molecular effects of hypoxia in cancer
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2. Dysregulation of 2-oxoglutarate-dependent dioxygenases by hyperglycaemia: does this link diabetes and vascular disease?
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3. Oxidative phosphorylation system and cell culture media
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4. Nitric oxide biosensor uncovers diminished ferrous iron-dependency of cultured cells adapted to physiological oxygen levels
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5. Hypoxia Induces Autophagy in Human Dendritic Cells: Involvement of Class III PI3K/Vps34
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6. Enhanced Microvasculature Formation and Patterning in iPSC–Derived Kidney Organoids Cultured in Physiological Hypoxia
   Anika Schumacher, Nadia J. T. Roumans, Timo Rademakers, Virginie Joris, Maria José Eischen-Loges, Martijn van Griensven, Vanessa L.S. LaPointe · 2022 · Frontiers in Bioengineering and Biotechnology
7. Relationship of Effective Circulating Volume with Sublingual Red Blood Cell Velocity and Microvessel Pressure Difference: A Clinical Investigation and Computational Fluid Dynamics Modeling
   Athanasios F. Chalkias, Michalis A. Xenos · 2022 · Journal of Clinical Medicine
8. Bile acid fitness determinants of a Bacteroides fragilis isolate from a human pouchitis patient
   Aretha Fiebig, Matthew K. Schnizlein, Selymar Pena-Rivera, Florian Trigodet, Abhishek Anil Dubey, Miette Hennessy, Anindita Basu, Sebastian Pott, Sushila Dalal, David Rubin et al. · 2023 · mBio
9. Docosahexaenoic Acid Attenuates Mitochondrial Alterations and Oxidative Stress Leading to Cell Death Induced by Very Long-Chain Fatty Acids in a Mouse Oligodendrocyte Model
   Thomas Nury, Margaux Doria, Gérard Lizard, Anne Véjux · 2020 · International Journal of Molecular Sciences
10. Physiological skin oxygen levels: An important criterion for skin cell functionality and therapeutic approaches
    Nadira Chettouh-Hammas, Catherine Grillon · 2024 · Free Radical Biology and Medicine
11. A redox switch in p21-CDK feedback during G2 phase controls the proliferation-cell cycle exit decision
    Julia Vorhauser, Theodoros I. Roumeliotis, David Coupe, Jacky Kieran Leung, Lu Yu, Kristin Böhlig, Thomas Zerjatke, Ingmar Glauche, André Nadler, Jyoti Sharma Choudhary et al. · 2025 · Molecular Cell
12. Nano-Electrochemical Characterization of a 3D Bioprinted Cervical Tumor Model
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13. Candidate transmission survival genome of Mycobacterium tuberculosis
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14. Optical 4D oxygen mapping of microperfused tissue models with tunable <i>in vivo</i> -like 3D oxygen microenvironments
    Wesseler, Milan Finn, Johansen, Mathias Nørbæk, Kızıltay, Aysel, Mortensen, Kim I., Larsen, Niels B. · 2022 · Lab on a Chip
15. Building blocks of microphysiological system to model physiology and pathophysiology of human heart
    Hanna Vuorenpää, Miina Björninen, Hannu Välimäki, Antti Ahola, Mart Kroon, Laura Honkamäki, Jussi T. Koivumäki, Mari Pekkanen-Mattila · 2023 · Frontiers in Physiology
16. Functionalized Annealed Microgels for Spatial Control of Osteogenic and Chondrogenic Differentiation
    Jeremy M. Lowen, Erika E. Wheeler, Nathan K. Shimamoto, David H. Ramos‐Rodriguez, Katherine H. Griffin, Gabriella C. Bond, Jonathan Kent Leach · 2024 · Advanced Functional Materials
17. Extended hypoxia‐mediated H2S production provides for long‐term oxygen sensing
    Kenneth R. Olson, Yan Gao, Eric R. DeLeon, Troy A. Markel, Natalie A. Drucker, David L. Boone, Matt Whiteman, Andrea K. Steiger, Michael D. Pluth, Charles R. Tessier et al. · 2019 · Acta Physiologica
18. Warburg Effect, Glutamine, Succinate, Alanine, When Oxygen Matters
    Frédéric Bouillaud, Noureddine Hammad, Laurent H. Schwartz · 2021 · Biology
19. Cellular senescence, rejuvenation and potential immortality
    A. R. SHELDRAKE · 2022 · Proceedings of the Royal Society B Biological Sciences
20. Mitochondrial Oxygenation During Cardiopulmonary Bypass: A Pilot Study
    Floor A. Harms, Rinse Ubbink, Calvin Jay de Wijs, Max Ligtenberg, Maarten ter Horst, Egbert Gezinus Mik · 2022 · Frontiers in Medicine
21. The Tolerance of Gut Commensal Faecalibacterium to Oxidative Stress Is Strain Dependent and Relies on Detoxifying Enzymes
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22. Personalized redox biology: Designs and concepts
    Nikos V. Margaritelis · 2023 · Free Radical Biology and Medicine
23. Comparative analysis of N-terminal cysteine dioxygenation and prolyl-hydroxylation as oxygen-sensing pathways in mammalian cells
    Ya‐Min Tian, Philip Holdship, Trang Quynh To, Peter John Ratcliffe, Thomas P. Keeley · 2023 · Journal of Biological Chemistry
24. Controlling Pericellular Oxygen Tension in Cell Culture Reveals Distinct Breast Cancer Responses to Low Oxygen Tensions
    Zachary J. Rogers, Thibault Colombani, Saad Khan, Khushbu Bhatt, Alexandra Nukovic, Guanyu Zhou, Benjamin M. Woolston, Cormac T. Taylor, Daniele M. Gilkes, Nikolai Slavov et al. · 2024 · Advanced Science
25. Mitochondrial oxygen monitoring with COMET: verification of calibration in man and comparison with vascular occlusion tests in healthy volunteers
    Rinse Ubbink, Mark A. Wefers Bettink, Willem van Weteringen, Egbert Gezinus Mik · 2020 · Journal of Clinical Monitoring and Computing
26. Biofabrication of advanced in vitro 3D models to study ischaemic and doxorubicin-induced myocardial damage
    Poonam Sharma, Clara Liu Chung Ming, Xiaowei Wang, Laura A. Bienvenu, Dominik Beck, Gemma Alexandra Figtree, Andrew Boyle, Carmine Gentile · 2022 · Biofabrication
27. Probing interfacial electrochemical processes in metal biodegradation via in operando pH microscopy: A review with perspectives
    Cheng Wang, Q.W. Dong, Yi Shao, Yulong Wu, Yanbin Zhao, Ming Yin, Di Mei, Chenglin Chu, Feng Xue, Jing Bai et al. · 2025 · TrAC Trends in Analytical Chemistry
28. Vascular protection afforded by zinc supplementation in human coronary artery smooth muscle cells mediated by NRF2 signaling under hypoxia/reoxygenation
    Fan Yang, Matthew J. Smith, Alex Griffiths, Alexander P. Morrell, Sarah J. Chapple, Richard C. M. Siow, Theodora J. Stewart, Wolfgang Maret, Giovanni E. Mann · 2023 · Redox Biology
29. Patient Derived Colonoids as Drug Testing Platforms–Critical Importance of Oxygen Concentration
    Helene Kolstad Skovdahl, Shreya Gopalakrishnan, Tarjei Dahl Svendsen, Atle van Beelen Granlund, Ingunn Bakke, Zekarias Ginbot, Silje Thorsvik, Arnar Flatberg, Bjørnar Sporsheim, Jenny Ostrop et al. · 2021 · Frontiers in Pharmacology
30. Effect of hypoxia-inducible factor 1 on vascular endothelial growth factor expression in exercised human skeletal muscle: a systematic review and meta-analysis
    Jerónimo Aragón‐Vela, Rafael Antonio Casuso · 2025 · American Journal of Physiology-Cell Physiology
31. A Tale of Two: When Neural Stem Cells Encounter Hypoxia
    Yiting Fan, Jinshi Li, Bo Fang · 2022 · Cellular and Molecular Neurobiology
32. General Critical Care, Temperature Control, and End-of-Life Decision Making in Patients Resuscitated from Cardiac Arrest
    Athanasios F. Chalkias, Georgios Adamos, Spyros D. Mentzelopoulos · 2023 · Journal of Clinical Medicine
33. The mitochondrial Na+/Ca2+ exchanger NCLX is implied in the activation of hypoxia-inducible factors
    Carmen Choya-Foces, Elisa Navarro, Cristóbal de los Rı́os, Manuela G. López, Javier Egea, Pablo Hernansanz‐Agustín, Antonio Martı́nez-Ruiz · 2024 · Redox Biology
34. Two‐ and three‐dimensional in vitro nucleus pulposus cultures: An in silico analysis of local nutrient microenvironments
    Emily E. McDonnell, Conor Timothy Buckley · 2022 · JOR Spine
35. Functional hypoxia reduces mitochondrial calcium uptake
    Chris Donnelly, Tímea Komlódi, Cristiane Cecatto, Luiza H.D. Cardoso, Anne‐Claire Compagnion, Alessandro Matera, Daniele Tavernari, Olivier Campiche, Rosa Chiara Paolicelli, Nadège Zanou et al. · 2024 · Redox Biology
36. Visualizing hydrogen peroxide and nitric oxide dynamics in endothelial cells using multispectral imaging under controlled oxygen conditions
    Hamza Yusuf Altun, Melike Seçilmiş, Fan Yang, Tuba Akgül Çağlar, Emre Vatandaşlar, M. Fatih Toy, Sven Vilain, Giovanni E. Mann, Gürkan Öztürk, Emrah Eroğlu · 2024 · Free Radical Biology and Medicine
37. A Computational Model for Oxygen Depletion Hypothesis in FLASH Effect
    Ankang Hu, Rui Qiu, Zhen Wu, Hui Zhang, Wei Bo Li, Junli Li · 2021 · Radiation Research
38. Glucose Starvation Inhibits Ferroptosis by Activating the LKB1/AMPK Signaling Pathway and Promotes the High Speed Linear Motility of Dairy Goat Sperm
    Yu Li, Guangzhi Zhang, Fei Wen, Ming Xian, Songmao Guo, Xing Zhang, Xianzhou Feng, Zhangtao Hu, Jianhong Hu · 2023 · Animals
39. Ten “Cheat Codes” for Measuring Oxidative Stress in Humans
    Cobley, James N., Margaritelis, Nikos V., Chatzinikolaou, Panagiotis N., Nikolaidis, Michalis G., Davison, Gareth W. · 2024 · Antioxidants
40. Reflections on the Biology of Cell Culture Models: Living on the Edge of Oxidative Metabolism in Cancer Cells
    Alba Morán-Álvarez, Pedro González‐Menéndez, Juan C. Mayo, Rosa María Sainz · 2023 · International Journal of Molecular Sciences
41. Outersphere Approach to Increasing the Persistance of Oxygen‐Sensitive Europium(II)‐Containing Contrast Agents for Magnetic Resonance Imaging with Perfluorocarbon Nanoemulsions toward Imaging of Hypoxia
    Jacob C. Lutter, Andrea L. Batchev, Caitlyn J. Ortiz, Alexander G. Sertage, Jonathan Romero, S. A. Amali S. Subasinghe, Steen E. Pedersen, Md. Abul Hassan Samee, Robia G. Pautler, Matthew J. Allen · 2023 · Advanced Healthcare Materials
42. Accelerated replicative senescence of ataxia‐telangiectasia skin fibroblasts is retained at physiologic oxygen levels, with unique and common transcriptional patterns
    Majd Haj, Amit Levon, Yann Frey, Noa Hourvitz, Judith Campisi, Yehuda Tzfati, Ran Elkon, Yael Ziv, Yosef Shiloh · 2023 · Aging Cell
43. Continuous, but not intermittent, regimens of hypoxia prevent and reverse ataxia in a murine model of Friedreich’s ataxia
    Tslil Ast, Hong Wang, Eizo Marutani, Fumiaki Nagashima, Rajeev Kumar Malhotra, Fumito Ichinose, Vamsi K. Mootha · 2023 · Human Molecular Genetics
44. Microfluidic platform for the reproduction of hypoxic vascular microenvironments
    Naoyuki Takahashi, Daisuke Yoshino, Ryuji Sugahara, Satomi Hirose, Kazuki Sone, Jean-Paul Rieu, Kenichi Funamoto · 2023 · Scientific Reports
45. Moderate hypoxia modulates ABCG2 to promote the proliferation of mouse spermatogonial stem cells by maintaining mild ROS levels
    Juhua Wang, Xiuheng Xue, Kai C. Fan, Qi Liu, Suzi Zhang, Mengling Peng, Jie Zhou, Zubing Cao · 2019 · Theriogenology
46. Effects of Manganese Porphyrins on Cellular Sulfur Metabolism
    Kenneth R. Olson, Yan Gao, Andrea K. Steiger, Michael D. Pluth, Charles R. Tessier, Troy A. Markel, David L. Boone, Robert Virgil Stahelin, Ines Batinic̈‐Haberle, Karl D. Straubg · 2020 · Molecules
47. A guide to reactive oxygen species in tumour hypoxia: measurement and therapeutic implications
    Lina Hacker, Elysia Sarsam, Stuart J. Conway, Ester M. Hammond · 2025 · Molecular Oncology
48. Comprehensive protocols for culturing and molecular biological analysis of IBD patient-derived colon epithelial organoids
    Shreya Gopalakrishnan, Ingunn Bakke, Marianne Doré Hansen, Helene Kolstad Skovdahl, Atle van Beelen Granlund, Arne Kristian Sandvik, Torunn Bruland · 2023 · Frontiers in Immunology
49. Tofacitinib and budesonide treatment affect stemness and chemokine release in IBD patient-derived colonoids
    Arun Sridhar, Ingunn Bakke, Shreya Gopalakrishnan, Nimo Mukhtar Mohamud Osoble, Emilie Prytz Hammarqvist, Henrik Sahlin Pettersen, Arne Kristian Sandvik, Ann Elisabet Østvik, Marianne Doré Hansen, Torunn Bruland · 2025 · Scientific Reports
50. Media composition and O2 levels determine effects of 17β-estradiol and selective estrogen receptor modulators on mitochondrial bioenergetics and cellular reactive oxygen species
    Fereshteh Moradi, Marco Fiocchetti, Maria Marino, Chris Moffatt, Jeffrey Alan Stuart · 2021 · American Journal of Physiology-Cell Physiology
51. Clinical Assessment of the Hyperbaric Oxygen Therapy Efficacy in Mild to Moderate Periodontal Affections: A Simple Randomised Trial
    Alexandru Burcea, Laurența Lelia Mihai, Anamaria Bechir, Mircea Suciu, Edwin Sever Bechir · 2022 · Medicina
52. An Inexpensive Incubator for Mammalian Cell Culture Capable of Regulating O2, CO2, and Temperature
    Philip Samokhin, Georgina L. Gardner, Chris Moffatt, Jeffrey Alan Stuart · 2022 · Oxygen
53. Temperature Profiles and Oxygenation Status in Human Skin and Subcutis Upon Thermography-Controlled wIRA-Hyperthermia
    Andreas R. Thomsen, Michael R. Saalmann, Nils H. Nicolay, Anca‐Ligia Grosu, Peter W. Vaupel · 2022 · Springer eBooks
54. Editorial: Hypoxia and inflammation: A two-way street
    Philippe Saas, Guo‐Chang Fan · 2023 · Frontiers in Immunology
55. Rational modification of PROTACs for tumor-selective protein degradation
    Zhongliang Fu, Meichen Pan, Chunrong Yang, Hongwei Hou, Jinghong Li · 2026 · Advanced Drug Delivery Reviews
56. Reactive Oxygen Species in Embryo Development: Sources, Impacts, and Implications for In Vitro Culture Systems
    Sajuna Sunuwar, Yun Seok Heo · 2026 · Life
57. The Effects of Antioxidant Nutraceuticals on Cellular Sulfur Metabolism and Signaling
    Kenneth R. Olson, Paul J. Derry, Thomas A. Kent, Karl David Straub · 2022 · Antioxidants and Redox Signaling
58. Evidence-based sports supplements: A redox analysis
    Nikos V. Margaritelis, James Nathan Cobley, George G. Nastos, Κωνσταντίνος Παπανικολάου, Stephen J. Bailey, Paraskevi Kritsiligkou, Michalis G. Nikolaidis · 2024 · Free Radical Biology and Medicine
59. Oxygen control in cell culture – Your cells may not be experiencing what you think!
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60. Hypoxic Preconditioning as a Strategy to Maintain the Regenerative Potential of Mesenchymal Stem Cells
    Bushra Bahir, Mahmood Saba Choudhery, Ijaz Hussain · 2020 · IntechOpen eBooks
61. Modeling Preclinical Cancer Studies under Physioxia to Enhance Clinical Translation
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62. Effects of cyclic acute and chronic hypoxia on the expression levels of metabolism related genes in a pancreatic cancer cell line
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63. In vitro modeling of myocardial ischemia/reperfusion injury with murine or human 3D cardiac spheroids
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64. Enzymes in Addressing Hypoxia for Biomaterials Engineering
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65. Chronic hypoxia for the adaptation of extracellular vesicle phenotype
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66. Catecholaminergic Polymorphic Ventricular Tachycardia: Advancing From Molecular Insights to Preclinical Models
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67. Endoplasmic reticulum stress: an emerging therapeutic target for preeclampsia
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68. Insights into human muscle biology from human primary skeletal muscle cell culture
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69. Physiological Differences Underlying Divergent Hypoxia Responses and Altitude Adaptations in Humans, Rats and Mice
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70. Clostridioides difficile superoxide reductase mitigates oxygen sensitivity
    Rebecca Kochanowsky, Katelyn E. Carothers, Bryan P. Roxas, Farhan Anwar, V. K. Viswanathan, Gayatri Vedantam · 2024 · Journal of Bacteriology
71. Naturally Acquired Kelch13 Mutations in Plasmodium falciparum Strains Modulate In Vitro Ring-Stage Artemisinin-Based Drug Tolerance and Parasite Survival in Response to Hyperoxia
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72. Dietary (poly)phenols as modulators of the biophysical properties in endothelial cell membranes: its impact on nitric oxide bioavailability in hypertension
    Ana Reis, Bárbara S. Rocha, João A.N. Laranjinha, Victor Armando Pereira de Freitas · 2024 · FEBS Letters
73. The effect of rs2910686 on ERAP2 expression in IBD and epithelial inflammatory response
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74. Development of an Oxygen-Insensitive Nrf2 Reporter Reveals Redox Regulation under Physiological Normoxia
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75. Defense arsenal of the strict anaerobe Clostridioides difficile against reactive oxygen species encountered during its infection cycle
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76. Nitric Oxide and Hydrogen Sulfide Regulation of Ischemic Vascular Growth and Remodeling
    Saranya Rajendran, Xinggui Shen, John D. Glawe, Gopi K. Kolluru, Christopher G. Kevil · 2019 · Comprehensive physiology
77. Oxygen dynamics and delivery strategies to enhance beta cell replacement therapy
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78. Epidermal Growth Factor Receptor Inhibition Is Protective in Hyperoxia‐Induced Lung Injury
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79. Computational Modeling and Imaging of the Intracellular Oxygen Gradient
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80. Metabolic Priming as a Tool in Redox and Mitochondrial Theragnostics
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81. Reduced oxygen concentrations regulate the phenotype and function of human granulosa cells in vitro and cause a diminished steroidogenic but increased inflammatory cellular reaction
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82. Cellular Pre-Adaptation to the High O2 Concentration Used in Standard Cell Culture Confers Resistance to Subsequent H2O2-Induced Cell Death
    Jack B. Jordan, Miranda J. Smallwood, Gary R. Smerdon, Paul Graham Winyard · 2024 · Antioxidants
83. Near-Infrared Spectroscopy Allows for Monitoring of Bone Fracture Healing via Changes in Oxygenation
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84. Rock Inhibitor Y-27632 Enables Feeder-Free, Unlimited Expansion of Sus scrofa domesticus Swine Airway Stem Cells to Facilitate Respiratory Research
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85. Mitochondrial Oxygen Monitoring During Surgical Repair of Congenital Diaphragmatic Hernia or Esophageal Atresia: A Feasibility Study
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86. A multiwell plate-based system for toxicity screening under multiple static or cycling oxygen environments
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87. An anaerobic in vitro flow model for studying interactions at the gastrointestinal host–microbe interface
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88. The role of glycolysis in inflammation
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89. Development and in-vivo validation of a portable phosphorescence lifetime-based fiber-optic oxygen sensor
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90. Where in the Tissues of Danio rerio Is More H 2 O 2 Produced During Acute Hypoxia?
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91. Physiological role and complex regulation of O 2 -reducing enzymes in the obligate anaerobe Clostridioides difficile
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92. Systematic Engineering for Efficient Uric Acid-Degrading Activity in Probiotic Yeast Saccharomyces boulardii
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93. Tumor microenvironment-like conditions alter pancreatic cancer cell metabolism and behavior
    Georgina L. Gardner, Jeffrey Alan Stuart · 2024 · American Journal of Physiology-Cell Physiology
94. Exploring the Role of Peripheral Macrophages in Glioma Progression: The Metabolic Significance of Cyclooxygenase-2 (COX-2)
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95. Rust and redemption: iron–sulfur clusters and oxygen in human disease and health
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96. Personalized Models of Biological Barriers and Their Diseases: Recent Progress with Organs‐On‐Chips
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97. High-throughput optical sensing of peri-cellular oxygen in cardiac cells: system characterization, calibration, and testing
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98. Low dose Taxol causes mitochondrial dysfunction in actively respiring cancer cells
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99. Insights into The Function and Regulation of Jumonji C Lysine Demethylases as Hypoxic Responsive Enzymes
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100. From Tissue Physoxia to Cancer Hypoxia, Cost-Effective Methods to Study Tissue-Specific O2 Levels in Cellular Biology
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