Protease-activated receptors in health and disease

Cites (635)

Items 401–600 of 635

1. Protease‐activated receptor (PAR)‐1 and PAR‐2 participate in the cell growth of alveolar capillary endothelium in primary lung adenocarcinomas
   Enjing Jin, Masakazu Fujiwara, Xin Pan · 2003 · Cancer
2. Hepatocyte Growth Factor-regulated Tyrosine Kinase Substrate (HRS) Mediates Post-endocytic Trafficking of Protease-activated Receptor 2 and Calcitonin Receptor-like Receptor
   Burcu Hasdemir, Nigel W. Bunnett, Graeme Stuart Cottrell · 2007 · Journal of Biological Chemistry
3. Protease-Activated Receptor 1 Inhibition by SCH79797 Attenuates Left Ventricular Remodeling and Profibrotic Activities of Cardiac Fibroblasts
   Dmitry L Sonin, Tetsuro Wakatsuki, Kasi Viswanath Routhu, Leanne M. Harmann, Matthew Petersen, Jennifer Meyer, Jennifer L. Strande · 2013 · Journal of Cardiovascular Pharmacology and Therapeutics
4. Identification of the integrin-binding site on coagulation factor VIIa required for proangiogenic PAR2 signaling
   Andrea S. Rothmeier, Enbo Liu, Sagarika Chakrabarty, Jennifer Disse, Barbara M. Mueller, Henrik Østergaard, Wolfram Ruf · 2017 · Blood
5. Protease-activated Receptor-2 (PAR-2)-mediated Nf-κB Activation Suppresses Inflammation-associated Tumor Suppressor MicroRNAs in Oral Squamous Cell Carcinoma
   Jeff J. Johnson, Daniel L. Miller, Rong Jiang, Yueying Liu, Zonggao Shi, Laura Tarwater, Russell Williams, Rashna D. Balsara, Edward R. Sauter, Mary Sharon Stack · 2016 · Journal of Biological Chemistry
6. Determinants of Thrombin Receptor Cleavage. RECEPTOR DOMAINS INVOLVED, SPECIFICITY, AND ROLE OF THE P3 ASPARTATE
   Kenji Ishii, Robert Edgardo Gerszten, Yao Wu Zheng · 1995 · Journal of Biological Chemistry
7. Phosphorylation of Protease-activated Receptor-2 Differentially Regulates Desensitization and Internalization
   Tiffany K. Ricks, JoAnn Trejo · 2009 · Journal of Biological Chemistry
8. N-linked glycosylation of protease-activated receptor-1 at extracellular loop 2 regulates G-protein signaling bias
   Antonio G. Soto, Thomas Horace Smith, Buxin Chen · 2015 · Proceedings of the National Academy of Sciences
9. A Potent Antagonist of Protease-Activated Receptor 2 That Inhibits Multiple Signaling Functions in Human Cancer Cells
   Yuhong Jiang, Mei‐Kwan Yau, Junxian Lim, Kai‐Chen Wu, Weijun Xu, Jacky Yung Suen, David P. Fairlie · 2017 · Journal of Pharmacology and Experimental Therapeutics
10. Activated Protein C is Neuroprotective and Mediates New Blood Vessel Formation and Neurogenesis After Controlled Cortical Impact
    Anthony L. Petraglia, Andrew H. Marky, Corey T. Walker, Meenakshisundaram Thiyagarajan, Berislav V. Zloković · 2009 · Neurosurgery
11. Tethered ligand‐derived peptides of proteinase‐activated receptor 3 (PAR3) activate PAR1 and PAR2 in Jurkat T cells
    Kristina K. Hansen, Mahmoud Saifeddine, Morley Donald Hollenberg · 2004 · Immunology
12. Circulating CD14+ CD16+ Monocytes Are Expanded in Sarcoidosis Patients
    Hiroyuki Okamoto, Kana Mizuno, Takeshi Horio · 2003 · The Journal of Dermatology
13. Identification of an antithrombotic allosteric modulator that acts through helix 8 of PAR1
    Louisa M. Dowal, Derek Sim, James R. Dilks, Price S. Blair, Sarah Beaudry, Bradley M. Denker, Γεώργιος Κούκος, Athan Kuliopulos, Robert C. Flaumenhaft · 2011 · Proceedings of the National Academy of Sciences
14. An Activated Protein C Analog Stimulates Neuronal Production by Human Neural Progenitor Cells via a PAR1-PAR3-S1PR 1 -Akt Pathway
    Huang Guo, Zhen Zhao, Qi Yang, Min Wang, Robert D. Bell, Su Wang, Nienwen Chow, Thomas P. Davis, John H. Griffin, Steven A. Goldman et al. · 2013 · Journal of Neuroscience
15. Signal Transduction for Proteinase-Activated Receptor-2-Triggered Prostaglandin E2 Formation in Human Lung Epithelial Cells
    Naoyuki Kawao, Mami Nagataki, Keita Nagasawa, Satoko Kubo, Kelly C. Cushing, Tetsuyuki Wada, Fumiko Sekiguchi, Seiji Ichida, Morley Donald Hollenberg, Wallace Keith MacNaughton et al. · 2005 · Journal of Pharmacology and Experimental Therapeutics
16. Proteinase-activated receptor 4 (PAR4): action of PAR4-activating peptides in vascular and gastric tissue and lack of cross-reactivity with PAR1and PAR2
    Morley Donald Hollenberg, Mahmoud Saifeddine, Bahjat Al‐Ani · 1999 · Canadian Journal of Physiology and Pharmacology
17. Factor VIIa induces anti-inflammatory signaling via EPCR and PAR1
    Vijay Kumar Reddy Kondreddy, Jue Wang, Shiva Keshava, Charles T. Esmon, L. Vijaya Mohan Rao, Usha R. Pendurthi · 2018 · Blood
18. Proteinase-activated Receptor 2 (PAR2) Decreases Apoptosis in Colonic Epithelial Cells
    Vadim Iablokov, Christina L. Hirota, Michael A. Peplowski, Rithwik Ramachandran, Koichiro Mihara, Morley Donald Hollenberg, Wallace Keith MacNaughton · 2014 · Journal of Biological Chemistry
19. Opposing Actions of Thrombin and Protease Nexin‐1 on Amyloid β‐Peptide Toxicity and on Accumulation of Peroxides and Calcium in Hippocampal Neurons
    Virginia L. Smith‐Swintosky, Stephen G. Zimmer, John W. Fenton, Mark P. Mattson · 1995 · Journal of Neurochemistry
20. Action of thrombin receptor polypeptide in gastric smooth muscle: identification of a core pentapeptide retaining full thrombin-mimetic intrinsic activity.
    Morley D. Hollenberg, Song‐Gui Yang, Adebayo A. Laniyonu · 1992 · Molecular Pharmacology
21. Brain development influences the appearance of glial factor-like activity in rat brain primary cultures
    Y. SCHURCH-RATHGEB, Denis Monard · 1978 · Nature
22. MASSIVE ALVEOLAR THROMBIN ACTIVATION IN PSEUDOMONAS AERUGINOSA-INDUCED ACUTE LUNG INJURY
    Éric Kipnis, Benoit P. Guery, Antoine Tournoys · 2004 · Shock
23. The tyrosine kinase inhibitor bafetinib inhibits PAR 2‐induced activation of TRPV 4 channels in vitro and pain in vivo
    Megan S. Grace, T Lieu, B Darby · 2014 · British Journal of Pharmacology
24. Mechanism of Race-Dependent Platelet Activation Through the Protease-Activated Receptor-4 and Gq Signaling Axis
    Benjamin E. Tourdot, Stanley Conaway, Katrin Niisuke, Leonard C. Edelstein, Paul F. Bray, Michael A. Holinstat · 2014 · Arteriosclerosis Thrombosis and Vascular Biology
25. Prevention of the Hypercontractile Response to Thrombin by Proteinase-Activated Receptor-1 Antagonist in Subarachnoid Hemorrhage
    Yasutoshi Kai, Katsuya Hirano, Yoshihisa Maeda · 2007 · Stroke
26. TMPRSS2, a novel membrane-anchored mediator in cancer pain
    David K. Lam, Dongmin Dang, Andrea N. Flynn · 2015 · Pain
27. Legumain Induces Oral Cancer Pain by Biased Agonism of Protease-Activated Receptor-2
    Nguyen Huu Tu, Dane D. Jensen, Bethany M. Anderson et al. · 2020 · Journal of Neuroscience
28. Protease-Activated Receptor 2, Dipeptidyl Peptidase I, and Proteases Mediate Clostridium difficile Toxin A Enteritis
    Cottrell, Graeme S., Amadesi, Silvia, Pikios, Stella, Camerer, Eric, Willardsen, J. Adam, Murphy, Brett R., Caughey, George H., Wolters, Paul J., Coughlin, Shaun R., Peterson, Anders et al. · 2007 · Gastroenterology
29. Protease-activated receptor 2 activation is sufficient to induce the transition to a chronic pain state
    Dipti V. Tillu, Shayne N. Hassler, C. Burgos-Vega, Tammie L. Quinn, Robert E. Sorge, Gregory O. Dussor, Scott A. Boitano, Josef Vágner, Theodore John Price · 2015 · Pain
30. Thrombin Induces IL-6 but Not TNFα Secretion by Mouse Mast Cells: Threshold-Level Thrombin Receptor and Very Low Level FcϵRI Signaling Synergistically Enhance IL-6 Secretion
    John Gordon, Xiaobei Zhang, Kevin Stevenson · 2000 · Cellular Immunology
31. Dysregulation of Macrophage-Secreted Cathepsin B Contributes to HIV-1-Linked Neuronal Apoptosis
    Eillen Rodriguez-Franco, Yisel M. Cantres-Rosario, Marinés Plaud, Rafael Romeu, Yolanda Rodríguez, Richard L. Skolasky, Viviana Meléndez, Carmen Lydia Cadilla, Loyda M. Meléndez · 2012 · PLoS ONE
32. Colonic luminal proteases activate colonocyte proteinase‐activated receptor‐2 and regulate paracellular permeability in mice
    R Róka, Julien Demaude, Nicolas Cénac, Laurent Ferrier, Christel Salvador–Cartier, R. Garcia‐villar, Jean Fioramonti, Lionel P. Bueno · 2006 · Neurogastroenterology & Motility
33. Protease-Activated Receptor (PAR) 1 but Not PAR2 or PAR4 Mediates Endothelium-Dependent Relaxation to Thrombin and Trypsin in Human Pulmonary Arteries
    Justin R. Hamilton, James D. Moffatt, Albert G. Frauman · 2001 · Journal of Cardiovascular Pharmacology
34. Proteolytically Active Allergens Cause Barrier Breakdown
    Truus Roelandt, Carol Heughebaert, Jean Pierre Hachem · 2008 · Journal of Investigative Dermatology
35. Protease-Activated Receptor-2 (PAR-2): Structure-Function Study of Receptor Activation by Diverse Peptides Related to Tethered-Ligand Epitopes
    Bruce E. Maryanoff, Rosemary J. Santulli, David F. McComsey · 2001 · Archives of Biochemistry and Biophysics
36. PGE2/EP3/SRC signaling induces EGFR nuclear translocation and growth through EGFR ligands release in lung adenocarcinoma cells
    Lorenzo Bazzani, Sandra Donnini, Federica Finetti, Gerhard Christofori, Marina Ziche · 2017 · Oncotarget
37. GPCR ‐mediated EGF receptor transactivation regulates TRPV 4 action in the vasculature
    Mahmoud Saifeddine, Mahmoud El‐Daly, Koichiro Mihara, Nigel W. Bunnett, Peter McIntyre, Christophe Altier, Morley Donald Hollenberg, Rithwik Ramachandran · 2015 · British Journal of Pharmacology
38. Role for β3 integrins in human melanoma growth and survival
    Mohit Trikha, József Tı́már, Alex Zacharek · 2002 · International Journal of Cancer
39. Separate Signals for Agonist-independent and Agonist-triggered Trafficking of Protease-activated Receptor 1
    Michael J. Shapiro, Shaun R. Coughlin · 1998 · Journal of Biological Chemistry
40. Identification and Characterization of Novel Small-Molecule Protease-Activated Receptor 2 Agonists
    Luis R. Gardell, Jian‐Nong Ma, Jimmi Gerner Seitzberg, Anne Eeg Knapp, Hans H. Schiffer, Ali Tabatabaei, Christopher N. Davis, Michelle Owens, Bryan Clemons, Kenneth K. Wong et al. · 2008 · Journal of Pharmacology and Experimental Therapeutics
41. Effect of protease‐activated receptor (PAR)‐1, −2 and −4‐activating peptides, thrombin and trypsin in rat isolated airways
    Jean M Chow, James D. Moffatt, Thomas M. Cocks · 2000 · British Journal of Pharmacology
42. Differential Neuroprotection and Risk for Bleeding From Activated Protein C With Varying Degrees of Anticoagulant Activity
    Yaoming Wang, Meenakshisundaram Thiyagarajan, Nienwen Chow, Itender Singh, Huang Guo, Thomas P. Davis, Berislav V. Zloković · 2008 · Stroke
43. Thrombin‐induced p38 mitogen‐activated protein kinase activation is mediated by epidermal growth factor receptor transactivation pathway
    Yasunari Kanda, Katsushige Mizuno, Yasutomi Kuroki · 2001 · British Journal of Pharmacology
44. The response to thrombin of human neutrophils: Evidence for two novel receptors
    Alison L. Jenkins, Gareth L. Howells, Emma Scott · 1995 · Journal of Cell Science
45. Immunologic analysis of the cloned platelet thrombin receptor activation mechanism: evidence supporting receptor cleavage, release of the N-terminal peptide, and insertion of the tethered ligand into a protected environment
    KJ Norton, R. M. Scarborough, JL Kutok · 1993 · Blood
46. Dual effect mediated by protease‐activated receptors on the mechanical activity of rat colon
    Flavia Mulè, Maria Carmela Baffi, Maria Carmela Cerra · 2002 · British Journal of Pharmacology
47. Agonist that activates the µ-opioid receptor in acidified microenvironments inhibits colitis pain without side effects
    Nestor Nivardo Jiménez-Vargas, Yang Yu, Dane D. Jensen, Diana D. Bok, Matthew Wisdom, Rocco Latorre, Cintya D. Lopez Lopez, Josue Jaramillo-Polanco, Claudius E. Degro, Mabel Guzmán-Rodríguez et al. · 2021 · Gut
48. Trypsin is produced by and activates protease-activated receptor-2 in human cancer colon cells
    Robert A. Ducroc, C. Bontemps, Katia Marazova · 2002 · Life Sciences
49. Protease Activated Receptor-2 Mediates Activated Protein C–Induced Cutaneous Wound Healing via Inhibition of p38
    Sohel M. Julovi, Meilang Xue, Suat Dervish · 2011 · American Journal Of Pathology
50. Novel antagonists for proteinase‐activated receptor 2: inhibition of cellular and vascular responsesin vitroandin vivo
    Toru Kanke, Mototsugu Kabeya, Satoko Kubo, Shinichi Kondo, Kasane Yasuoka, J Tagashira, Hiroyuki Ishiwata, M Saka, T Furuyama, T Nishiyama et al. · 2009 · British Journal of Pharmacology
51. Profiling Gene Expression Induced by Protease-Activated Receptor 2 (PAR2) Activation in Human Kidney Cells
    Jacky Yung Suen, Brooke Gardiner, Sean Michael Grimmond · 2010 · PLoS ONE
52. MicroRNA-34a Mediates the Autocrine Signaling of PAR2-Activating Proteinase and Its Role in Colonic Cancer Cell Proliferation
    Yiming Ma, Wuyun Bao-Han, Xue Lv · 2013 · PLoS ONE
53. Platelet activation via PAR4 is involved in the initiation of thrombin generation and in clot elasticity development
    Sofia Ramström, Maria Bjerke, Tomas L. Lindahl · 2007 · Thrombosis and Haemostasis
54. Increased levels of macrophage-secreted cathepsin S during prostate cancer progression in TRAMP mice and patients.
    Charlotta Lindahl, Monika Simonsson, Anders R. J. Bergh · 2009 · PubMed
55. RWJ‐58259: A Selective Antagonist of Protease Activated Receptor‐1
    Bruce P. Damiano, Claudia K. Derian, Bruce E. Maryanoff · 2003 · Cardiovascular Drug Reviews
56. Activated PAR-2 Regulates Pancreatic Cancer Progression through ILK/HIF-α–Induced TGF-α Expression and MEK/VEGF-A–Mediated Angiogenesis
    Li-Hsun Chang, Shiow‐Lin Pan, Chin-Yu Lai · 2013 · American Journal Of Pathology
57. The protease-activated receptor-3 (PAR-3) can signal autonomously to induce interleukin-8 release
    E. Ostrowska, Georg Reiser · 2008 · Cellular and Molecular Life Sciences
58. Thrombin and Protease-Activated Receptor-1 Agonists Promote Lipopolysaccharide-Induced Hepatocellular Injury in Perfused Livers
    Bryan Lloyd Copple, Frederic Moulin, Umesh Hanumegowda · 2003 · Journal of Pharmacology and Experimental Therapeutics
59. The novel and orally active thrombin receptor antagonist E5555 (Atopaxar) inhibits arterial thrombosis without affecting bleeding time in guinea pigs
    Motoji Kogushi, Toshiyuki Matsuoka, Tsutomu Kawata et al. · 2011 · European Journal of Pharmacology
60. EGF receptor transactivation and MAP kinase mediate proteinase-activated receptor-2-induced chloride secretion in intestinal epithelial cells
    Jacques Q. van der Merwe, Morley Donald Hollenberg, Wallace Keith MacNaughton · 2007 · American Journal of Physiology-Gastrointestinal and Liver Physiology
61. Factor Xa and thrombin evoke additive calcium and proinflammatory responses in endothelial cells subjected to coagulation
    Valéry Daubie, Sandra Cauwenberghs, Nicole H. M. Senden · 2006 · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
62. Protease signaling through protease activated receptor 1 mediate nerve activation by mucosal supernatants from irritable bowel syndrome but not from ulcerative colitis patients
    Sabine Bühner, Hannes Hahne, Kerstin Hartwig, Qin Li, Sheila Vignali, Daniela Ostertag, Chen Meng, Gabriele Hörmannsperger, Breg Braak, Christian Pehl et al. · 2018 · PLoS ONE
63. The development of proteinase-activated receptor-2 modulators and the challenges involved
    Kathryn McIntosh, Margaret Cunningham, Trevor John Bushell · 2020 · Biochemical Society Transactions
64. Protease-Activated Receptor-1 Can Mediate Responses to SFLLRN in Thrombin-Desensitized Cells: Evidence for a Novel Mechanism for Preventing or Terminating Signaling by PAR1's Tethered Ligand
    Stephen R. Hammes, Shaun R. Coughlin · 1999 · Biochemistry
65. Protease activated receptor-1 inhibits the Maspin tumor-suppressor gene to determine the melanoma metastatic phenotype
    Gabriel J. Villares, Maya Zigler, Andrey S. Dobroff, Hua Wang, Renduo Song, Vladislava O. Melnikova, Li Feng Huang, Russell R. Braeuer, Menashe Bar‐Eli · 2010 · Proceedings of the National Academy of Sciences
66. Agonists of proteinase-activated receptor 2 excite guinea pig ileal myenteric neurons
    David Robert Linden, Brian P. Manning, Nigel W. Bunnett, Gary M. Mawe · 2001 · European Journal of Pharmacology
67. Noncanonical Matrix Metalloprotease-1-Protease-activated Receptor-1 Signaling Triggers Vascular Smooth Muscle Cell Dedifferentiation and Arterial Stenosis
    Karyn M. Austin, Nga Nguyen, Golrokh Javid, Lidija Covic, Athan Kuliopulos · 2013 · Journal of Biological Chemistry
68. Discovery of 1,3-Diaminobenzenes as Selective Inhibitors of Platelet Activation at the PAR1 Receptor
    Chris Dockendorff, Omozuanvbo R. Aisiku, Lynn VerPlank et al. · 2012 · ACS Medicinal Chemistry Letters
69. Proteinase-Activated Receptor 2: Differential Activation of the Receptor by Tethered Ligand and Soluble Peptide Analogs
    Bahjat Al‐Ani, Suranga J. Wijesuriya, Morley Donald Hollenberg · 2002 · Journal of Pharmacology and Experimental Therapeutics
70. Possible role of rivaroxaban in attenuating pressure-overload-induced atrial fibrosis and fibrillation
    Hidekazu Kondo, Ichitaro Abe, Akira Fukui, Shotaro Saito, Miho Miyoshi, Kohei Aoki, Tetsuji Shinohara, Yasushi Teshima, Kunio Yufu, Naohiko Takahashi · 2017 · Journal of Cardiology
71. Intrathecal Administration of Proteinase-Activated Receptor-2 Agonists Produces Hyperalgesia by Exciting the Cell Bodies of Primary Sensory Neurons
    Kwai A. Alier, Jaclyn A. Endicott, Patrick L. Stemkowski, Nicolas Cénac, Laurie Cellars, Kevin Chapman, Patricia Andrade‐Gordon, Nathalie Vergnolle, Peter A. Smith · 2007 · Journal of Pharmacology and Experimental Therapeutics
72. Positive crosstalk between EGFR and the TF-PAR2 pathway mediates resistance to cisplatin and poor survival in cervical cancer
    Vitor Hugo de Almeida, Isabella dos Santos Guimarães, Lucas R. Almendra · 2018 · Oncotarget
73. TF/FVIIa Transactivate PDGFRβ to Regulate PDGF-BB–Induced Chemotaxis in Different Cell Types
    Agneta Siegbahn, Matilda Johnell, Anna Nordin, Mikael Åberg, Teet Velling · 2007 · Arteriosclerosis Thrombosis and Vascular Biology
74. Protease activated receptors modulate aortic vascular tone
    Harold I. Magazine, Jonathan M. King, Kamal D Srivastava · 1996 · International Journal of Cardiology
75. Protease‐activated receptor 2 signalling promotes dendritic cell antigen transport and T‐cell activationin vivo
    Giancarlo Ramelli, Silvia A. Fuertes Marraco, Sharmal Narayan, Nathalie Busso, Hans Acha‐Orbea, Alexander K.-L. So · 2009 · Immunology
76. Neue Untersuchungen über die Faserstoffgerinnung
    Alexander Schmidt · 1872 · Pflügers Archiv - European Journal of Physiology
77. Protease-activated receptor-1 activation by granzyme B causes neurotoxicity that is augmented by interleukin-1β
    Paul R. Lee, T. Johnson, S. Gnanapavan, G. Giovannoni, Tong-Guang Wang, J. Steiner, Marie Medynets, M. Vaal, Valerie Gartner, A. Nath · 2017 · Journal of Neuroinflammation
78. The α-arrestin ARRDC3 suppresses breast carcinoma invasion by regulating G protein–coupled receptor lysosomal sorting and signaling
    Aleena K. S. Arakaki, Wen‐An Pan, Huilan Lin · 2018 · Journal of Biological Chemistry
79. Mice expressing fluorescent PAR 2 reveal that endocytosis mediates colonic inflammation and pain
    Rocco Latorre, Alan Hégron, Chloe J. Peach, Shavonne L. Teng, Raquel Tonello, Jeffri S. Retamal, Rafael Klein-Cloud, Diana D. Bok, Dane D. Jensen, Lena Gottesman-Katz et al. · 2022 · Proceedings of the National Academy of Sciences
80. Distinctive G Protein-Dependent Signaling by Protease-Activated Receptor 2 (PAR2) in Smooth Muscle: Feedback Inhibition of RhoA by cAMP-Independent PKA
    Wimolpak Sriwai, Sunila Mahavadi, Othman Abdullah Al-Shboul · 2013 · PLoS ONE
81. Involvement of ERK1/2/NF-κB signal transduction pathway in TF/FVIIa/PAR2-induced proliferation and migration of colon cancer cell SW620
    Donglin Guo, Hong Zhou, Ying Wu · 2011 · Tumor Biology
82. Legumain is activated in macrophages during pancreatitis
    Laura E. Edgington‐Mitchell, Thomas Wartmann, Alicia K. Fleming Martinez, Vasilena Gocheva, Wouter A. van der Linden, Nimali P. Withana, Martijn Verdoes, Luigi Aurelio, Daniel Edgington-Mitchell, TinaMarie Lieu et al. · 2016 · American Journal of Physiology-Gastrointestinal and Liver Physiology
83. Protease-activated receptor-4 and purinergic receptor P2Y12 dimerize, co-internalize, and activate Akt signaling via endosomal recruitment of β-arrestin
    Thomas Horace Smith, Julia G. Li, Michael Robert Dores · 2017 · Journal of Biological Chemistry
84. The amount of cytokine-release defines different shades of Sars-Cov2 infection
    Sara Bindoli, Mara Felicetti, Paolo Sfriso, Andrea Doria · 2020 · Experimental Biology and Medicine
85. Dual effect of the novel peptide antagonist K‐14585 on proteinase‐activated receptor‐2‐mediated signalling
    Fui G. Goh, Pei Yuen Ng, Mary Nilsson, Toru Kanke, Robin J. Plevin · 2009 · British Journal of Pharmacology
86. Proteinase‐activated receptors induce interleukin‐8 expression by intestinal epithelial cells through ERK/RSK90 activation and histone acetylation
    Hongying Wang, France Moreau, Christina L. Hirota, Wallace Keith MacNaughton · 2010 · The FASEB Journal
87. Contributions of Protease-Activated Receptors PAR1 and PAR4 to Thrombin-Induced GPIIbIIIa Activation in Human Platelets
    Matthew Thomas Duvernay, Kayla J. Temple, Jae G. Maeng · 2016 · Molecular Pharmacology
88. Shutoff and Agonist-Triggered Internalization of Protease-Activated Receptor 1 Can Be Separated by Mutation of Putative Phosphorylation Sites in the Cytoplasmic Tail
    Stephen R. Hammes, Michael J. Shapiro, Shaun R. Coughlin · 1999 · Biochemistry
89. Met receptor tyrosine kinase transactivation is involved in proteinase-activated receptor-2-mediated hepatocellular carcinoma cell invasion
    Roland Kaufmann, C. Oettel, A. Horn et al. · 2009 · Carcinogenesis
90. Expression of protease-activated receptor 1 in oral squamous cell carcinoma
    Yanna Liu, Michael Z. Gilcrease, Ying C. Henderson · 2001 · Cancer Letters
91. Growth and survival of lung cancer cells: regulation by kallikrein-related peptidase 6 via activation of proteinase-activated receptor 2 and the epidermal growth factor receptor
    Noémie Michel, Nathalie Heuzé‐Vourc'h, Elise Lavergne · 2014 · Biological Chemistry
92. Protease-activated receptor 1 is implicated in irritable bowel syndrome mediators–induced signaling to thoracic human sensory neurons
    Cléo Désormeaux, Tereza Bautzová, Sonia Garcia‐Caraballo, Corinne Rolland, Maria Raffaella Barbaro, Stuart M. Brierley, Giovanni Barbara, Nathalie Vergnolle, Nicolas Cénac · 2018 · Pain
93. Thrombin receptors in vascular smooth muscle cells – function and regulation by vasodilatory prostaglandins
    Ellen Bretschneider, Kerstin Fischer, Jens W. Fischer · 2010 · Thrombosis and Haemostasis
94. Trypsin, Tryptase, and Thrombin Polarize Macrophages towards a Pro-Fibrotic M2a Phenotype
    Michael J. V. White, R. Gomer · 2015 · PLoS ONE
95. Cathepsin S acts via protease-activated receptor 2 to activate sensory neurons and induce itch-like behaviour
    Keshi Chung, Thomas Pitcher, Andrew D. Grant · 2019 · Neurobiology of Pain
96. Enhanced Effector Function of CD8+ T Cells From Healthy Controls and HIV-Infected Patients Occurs Through Thrombin Activation of Protease-Activated Receptor 1
    Amanda Hurley, Mindy Smith, Tatiana Karpova, Rebecca B. Hasley, Natalya Belkina, Stephen Michael Shaw, Nariman Aghaei Bandbon Balenga, Kirk M. Druey, Erin Nickel, Beverly Z. Packard et al. · 2012 · The Journal of Infectious Diseases
97. Major Role for TRPV1 and InsP3R in PAR2-Elicited Inflammatory Mediator Production in Differentiated Human Keratinocytes
    Olivier Gouin, Killian L’Hérondelle, Paul Buscaglia et al. · 2018 · Journal of Investigative Dermatology
98. Protease activated receptor 2 and the cardiovascular system
    Carla Cicala · 2002 · British Journal of Pharmacology
99. Innovative Management of Pruritus
    Jamison D. Feramisco, Timothy G. Berger, Martin S. Steinhoff · 2010 · Dermatologic Clinics
100. Mechanism of Thrombin-Induced Endothelium-Dependent Coronary Vasodilation in Dogs: Role of its Proteolytic Enzymatic Activity
     David D. Ku · 1986 · Journal of Cardiovascular Pharmacology
101. Dual modulation by thrombin of the motility of rat oesophageal muscularis mucosae via two distinct protease‐activated receptors (PARs): a novel role for PAR‐4 as opposed to PAR‐1
     Atsufumi Kawabata, Ryotaro Kuroda, Naoko Kuroki, Hiroyuki Nishikawa, Kenzo Kawai · 2000 · British Journal of Pharmacology
102. The novel PAR 2 ligand C 391 blocks multiple PAR 2 signalling pathways in vitro and in vivo
     Scott A. Boitano, Justin Hoffman, Andrea N. Flynn et al. · 2015 · British Journal of Pharmacology
103. Discovery of Potent and Selective Small-Molecule PAR-2 Agonists
     Jimmi Gerner Seitzberg, Anne Eeg Knapp, Birgitte Winther Lund · 2008 · Journal of Medicinal Chemistry
104. Activation of protease‐activated receptor‐4 inhibits the intrinsic excitability of colonic dorsal root ganglia neurons
     Karanjia, R., Spreadbury, I., Bautista‐cruz, F., Tsang, M. E., Vanner, S. · 2009 · Neurogastroenterology & Motility
105. Mesotrypsin, a brain trypsin, activates selectively proteinase‐activated receptor‐1, but not proteinase‐activated receptor‐2, in rat astrocytes
     Yingfei Wang, Weibo Luo, Thomas Wartmann · 2006 · Journal of Neurochemistry
106. Recycling and Endosomal Sorting of Protease-activated Receptor-1 Is Distinctly Regulated by Rab11A and Rab11B Proteins
     Neil Justin Grimsey, Luisa J. Coronel, Isabel Canto Cordova · 2015 · Journal of Biological Chemistry
107. Rivaroxaban Suppresses the Progression of Ischemic Cardiomyopathy in a Murine Model of Diet-Induced Myocardial Infarction
     Jingyi Liu, Makoto Nishida, Hiroyasu Inui, Jiuyang Chang, Yinghong Zhu, Kotaro Kanno, Hibiki Matsuda, Masami Sairyo, Takeshi Okada, Hajime Nakaoka et al. · 2019 · Journal of Atherosclerosis and Thrombosis
108. Cathepsin S silencing induces apoptosis of human hepatocellular carcinoma cells.
     Xuedi Wang, Xiong Li, Guotang Yu · 2015 · PubMed
109. Atherosclerosis proceeds independently of thrombin-induced platelet activation in ApoE−/− mice
     J.R. Hamilton, Ivo Cornelissen, Jessica K. Mountford, Shaun R. Coughlin · 2009 · Atherosclerosis
110. The PAR-1-activating peptide attenuates carrageenan-induced hyperalgesia in rats
     Atsufumi Kawabata, Naoyuki Kawao, Ryotaro Kuroda, Atsuko Tanaka, Chiho Shimada · 2002 · Peptides
111. Potentiation of the Transient Receptor Potential Vanilloid 1 Channel Contributes to Pruritogenesis in a Rat Model of Liver Disease
     Majedeline Belghiti, Judith Estévez‐Herrera, Carla Giménez‐Garzó, Alba González‐Usano, Carmina Montoliu, Antonio Vicente Ferrer-Montiel, Vicente Felipo, Rosa Planells‐Cases · 2013 · Journal of Biological Chemistry
112. Activated protein C analog with reduced anticoagulant activity improves functional recovery and reduces bleeding risk following controlled cortical impact
     Corey T. Walker, Andrew H. Marky, Anthony L. Petraglia, Tracy Ali, Nienwen Chow, Berislav V. Zloković · 2010 · Brain Research
113. Activation of mouse protease‐activated receptor‐2 induces lymphocyte adhesion and generation of reactive oxygen species
     Shiang Yong Lim, Georgia M. Tennant, Simon Kennedy, Cherry L. Wainwright, Kathleen A. Kane · 2006 · British Journal of Pharmacology
114. Derivatized 2-Furoyl-LIGRLO-amide, a Versatile and Selective Probe for Proteinase-Activated Receptor 2: Binding and Visualization
     Morley Donald Hollenberg, Bernard S. RENAUX, Eric Hyun, Steeve Houle, Nathalie Vergnolle, Mahmoud Saifeddine, Rithwik Ramachandran · 2008 · Journal of Pharmacology and Experimental Therapeutics
115. Sensitization of ASIC3 by proteinase-activated receptor 2 signaling contributes to acidosis-induced nociception
     Jing Wu, Tingting Liu, Yimei Zhou · 2017 · Journal of Neuroinflammation
116. The PAR2 inhibitor I-287 selectively targets Gαq and Gα12/13 signaling and has anti-inflammatory effects
     Charlotte Avet, Claudio F. Sturino, Sébastien Grastilleur et al. · 2020 · Communications Biology
117. Species‐dependent neuroprotection by activated protein C mutants with reduced anticoagulant activity
     Huang Guo, Yaoming Wang, Itender Singh, Dong Liu, José A. Fernández, John H. Griffin, Nienwen Chow, Berislav V. Zloković · 2009 · Journal of Neurochemistry
118. Protease-activated Receptor-4 Signaling and Trafficking Is Regulated by the Clathrin Adaptor Protein Complex-2 Independent of β-Arrestins
     Thomas Horace Smith, Luisa J. Coronel, Julia G. Li · 2016 · Journal of Biological Chemistry
119. Phosphoproteomic analysis of protease-activated receptor-1 biased signaling reveals unique modulators of endothelial barrier function
     Ying Lin, Jacob M. Wozniak, Neil Justin Grimsey, Sravan Girada, Anand Patwardhan, Olivia Molinar‐Inglis, Thomas Horace Smith, John D. Lapek, David J. Gonzalez, JoAnn Trejo · 2020 · Proceedings of the National Academy of Sciences
120. Serine Protease Inhibition Reduces Post-Ischemic Granulocyte Recruitment in Mouse Intestine
     Thomas Gobbetti, Nicolas Cénac, Jean‐Paul Motta, Corinne Rolland, Laurence Martin, Patricia Andrade‐Gordon, Martin S. Steinhoff, Elisabetta Barocelli, Nathalie Vergnolle · 2011 · American Journal Of Pathology
121. PAR2-dependent activation of GSK3β regulates the survival of colon stem/progenitor cells
     Imen Nasri, Delphine Bonnet, Bailey Zwarycz, Emilie d'Aldebert, Sokchea Khou, Raoudha Mezghani Jarraya, Muriel Quaranta, Corinne Rolland, Chrystelle Bonnart, Emmanuel Mas et al. · 2016 · American Journal of Physiology-Gastrointestinal and Liver Physiology
122. 177Lu-labeled HPMA copolymers utilizing cathepsin B and S cleavable linkers: Synthesis, characterization and preliminary in vivo investigation in a pancreatic cancer model
     Sunny M. Ogbomo, Wen Shi, Nilesh K. Wagh · 2013 · Nuclear Medicine and Biology
123. Impairment of PAR‐2‐mediated relaxation system in colonic smooth muscle after intestinal inflammation
     Koichi Sato, Hiromichi Ninomiya, Shinsuke Ohkura · 2006 · British Journal of Pharmacology
124. Effects of inhaled thrombin receptor agonists in mice
     James D. Moffatt, Rebecca Lever, Clive Peter Page · 2004 · British Journal of Pharmacology
125. Endothelial cytoskeletal reorganization in response to PAR1 stimulation is mediated by membrane rafts but not caveolae
     MaryEllen Carlile-Klusacek, Victor Rizzo · 2007 · American Journal of Physiology-Heart and Circulatory Physiology
126. Immunocytes and abnormal gastrointestinal motor activity during ileitis in dogs
     P. Jouet, Sushil K. Sarna, Chandar Singaram · 1995 · American Journal of Physiology-Gastrointestinal and Liver Physiology
127. Hepatic and extrahepatic factors critical for liver injury during lipopolysaccharide exposure
     Frederic Moulin, Bryan Lloyd Copple, Patricia E. Ganey · 2001 · American Journal of Physiology-Gastrointestinal and Liver Physiology
128. Protease-Activated Receptor 4 Uses Anionic Residues To Interact with α-Thrombin in the Absence or Presence of Protease-Activated Receptor 1
     Marvin T. Nieman · 2008 · Biochemistry
129. Activation of human tonsil and skin mast cells by agonists of proteinase activated receptor-2
     Shaoheng He, Hua Xie, Yiling Fu · 2005 · Acta Pharmacologica Sinica
130. Proteinase-activated receptors (PARs)—the PAR3 Neo-N-terminal peptide TFRGAP interacts with PAR1
     Roland Kaufmann, Beate Schulze, Gerd Krause · 2004 · Regulatory Peptides
131. Agonists of proteinase‐activated receptor‐2 affect transendothelial migration and apoptosis of human neutrophils
     Victoria M. Shpacovitch, Stephan Seeliger, Markus Stefan Huber-Lang et al. · 2007 · Experimental Dermatology
132. Differential Expression, Time Course and Distribution of Four PARs in Rats with Endotoxin-induced Acute Lung Injury
     Subrina Jesmin, Satoshi Gando, Sohel Zaedi · 2006 · Inflammation
133. Characterization of the protease-activated receptor-1-mediated contraction and relaxation in the rat duodenal smooth muscle
     Atsufumi Kawabata, Ryotaro Kuroda, Naoko Kuroki, Hiroyuki Nishikawa, Kenzo Kawai, Hiromasa Araki · 2000 · Life Sciences
134. Factor Xa induces pro-inflammatory cytokine expression in RAW 264.7 macrophages via protease-activated receptor-2 activation.
     Pengfei Zuo, Zhi Zuo, Xin Wang, Long Chen, Yueyue Zheng, Genshan Ma, Qianxing Zhou · 2015 · PubMed Central
135. Protease‐activated receptor 2 activates airway apical membrane chloride permeability and increases ciliary beating
     Derek B. McMahon, Alan D. Workman, Michael A. Kohanski et al. · 2017 · The FASEB Journal
136. Molecular basis for activation and biased signaling at the thrombin-activated GPCR proteinase activated receptor-4 (PAR4)
     Pierre E. Thibeault, Jordan C LeSarge, D’Arcy Arends · 2019 · Journal of Biological Chemistry
137. SCH-530348, a thrombin receptor (PAR-1) antagonist for the prevention and treatment of atherothrombosis.
     Julie H. Oestreich · 2009 · PubMed
138. Ectopic αIIbβ3 Integrin Signaling Involves 12-Lipoxygenaseand PKC-mediated Serine Phosphorylation Events in Melanoma Cells
     Erzsébet Rásó, József Tóvári, Krisztina Tóth · 2001 · Thrombosis and Haemostasis
139. Protease-activated receptor 2 expression in trigeminal neurons innervating the rat nasal mucosa
     Q. Thai Dinh, Annette Cryer, Stephen Dinh, Marcello Trevisani, Petra Georgiewa, Kian Fan Chung, Pierangelo Geppetti, Werner J. Heppt, Burghard F. Klapp, Axel Fischer · 2005 · Neuropeptides
140. FVIIa (Factor VIIa) Induces Biased Cytoprotective Signaling in Mice Through the Cleavage of PAR (Protease-Activated Receptor)-1 at Canonical Arg41 (Arginine41) Site
     Vijay Kumar Reddy Kondreddy, Usha R. Pendurthi, Xiao Xu · 2020 · Arteriosclerosis Thrombosis and Vascular Biology
141. Cathepsin S and its inhibitor cystatin C: imbalance in uveal melanoma
     Luminita Paraoan · 2009 · Frontiers in bioscience
142. Paradigm of Biased PAR1 (Protease-Activated Receptor-1) Activation and Inhibition in Endothelial Cells Dissected by Phosphoproteomics
     Bart L. van den Eshof, Arie Johan Hoogendijk, Pelle J. Simpson · 2017 · Arteriosclerosis Thrombosis and Vascular Biology
143. Protease-activated receptors (PAR)-1 and -3 drive epithelial-mesenchymal transition of alveolar epithelial cells – potential role in lung fibrosis
     Miroslava Didiášová, Sebastian Berscheid, Katarzyna Piskulak · 2013 · Thrombosis and Haemostasis
144. Expression pattern of protease activated receptors in lymphoid cells
     Mercedes López, Natalia Soriano-Sarabia, Gustavo Bruges · 2014 · Cellular Immunology
145. Role of Gαq and phospholipase C‐β2 in human platelets activation by thrombin receptors PAR1 and PAR4: studies in human platelets deficient in Gαq and phospholipase C‐β2
     Vijender R. Vaidyula, A. Koneti Rao · 2003 · British Journal of Haematology
146. Protease‐activated receptor ( PAR )‐2 is required for PAR ‐1 signalling in pulmonary fibrosis
     Cong Lin, Jan H. von der Thüsen, Joost B. Daalhuisen, Marieke S. ten Brink, Bruno Crestani, Tom van der Poll, Keren Borensztajn, C. Arnold Spek · 2015 · Journal of Cellular and Molecular Medicine
147. Regulator of G Protein Signaling 2 (RGS2) and RGS4 Form Distinct G Protein-Dependent Complexes with Protease Activated-Receptor 1 (PAR1) in Live Cells
     Sungho Ghil, Kelly L. McCoy, John R. Hepler · 2014 · PLoS ONE
148. Targeting a Proteinase-Activated Receptor 4 (PAR4) Carboxyl Terminal Motif to Regulate Platelet Function
     Rithwik Ramachandran, Koichiro Mihara, Pierre E. Thibeault · 2017 · Molecular Pharmacology
149. PGE2 mediates EGFR internalization and nuclear translocation via caveolin endocytosis promoting its transcriptional activity and proliferation in human NSCLC cells
     Lorenzo Bazzani, Sandra Donnini, Antonio Giachetti · 2018 · Oncotarget
150. Protease-activated receptor 2 signaling modulates susceptibility of colonic epithelium to injury through stabilization of YAP in vivo
     Longmei He, Yiming Ma, Weiwei Li, Wenxiao Han, Xinhua Zhao, Hongying Wang · 2018 · Cell Death and Disease
151. Damage-free plasma etching of porous organo-silicate low-k using micro-capillary condensation above −50 °C
     Romain Chanson, Lei-Yu Zhang, S. Naumov · 2018 · Scientific Reports
152. The Protease Activated Receptor2 Promotes Rab5a Mediated Generation of Pro-metastatic Microvesicles
     Kaushik Das, Ramesh Prasad, Sreetama Roy · 2018 · Scientific Reports
153. The transient receptor potential vanilloid 4 (TRPV4) ion channel mediates protease activated receptor 1 (PAR1)-induced vascular hyperpermeability
     Scott Peng, Megan S. Grace, Arisbel B. Gondin, Jeffri S. Retamal, Larissa K. Dill, William G. Darby, Nigel W. Bunnett, Fe C. Abogadie, Simona Carbone, Tara A. Tigani et al. · 2020 · Laboratory Investigation
154. Interaction of Protease-Activated Receptor 2 with G Proteins and β-Arrestin 1 Studied by Bioluminescence Resonance Energy Transfer
     Mohammed Akli Ayoub, Jean‐Philippe Pin · 2013 · Frontiers in Endocrinology
155. Retinal Neurons Curb Inflammation and Enhance Revascularization in Ischemic Retinopathies via Proteinase-Activated Receptor-2
     Nicholas Sitaras, José Carlos Rivera, Baraa Noueihed, Milsa Bien-Aimé, Karine Zaniolo, Samy Omri, David Hamel, Tang Zhu, Pierre Hardy, Przemyslaw S. Sapieha et al. · 2014 · American Journal Of Pathology
156. Increased Protease-Activated Receptor-2 (PAR-2) Expression on CD14++CD16+ Peripheral Blood Monocytes of Patients with Severe Asthma
     Nami Shrestha Palikhe, Drew Nahirney, Cheryl R. Laratta · 2015 · PLoS ONE
157. The cellular basis of protease-activated receptor 2–evoked mechanical and affective pain
     Shayne N. Hassler, Moeno Kume, Juliet M. Mwirigi, Ayesha Ahmad, Stephanie I. Shiers, Andi Wangzhou, Pradipta R. Ray, Sergei Belugin, Dhananjay K. Naik, Michael D. Burton et al. · 2020 · JCI Insight
158. Protease activated receptor 4 (PAR4) antagonists: Research progress on small molecules in the field of antiplatelet agents
     Shangde Liu, Shanshan Li, Duo Yuan · 2020 · European Journal of Medicinal Chemistry
159. The effect of heparin on endotoxin shock in the rat.
     William Margaretten, Donald G. McKay, Louise Lang Phillips · 1967 · PubMed
160. Signal transduction for formation/release of interleukin-8 caused by a PAR2-activating peptide in human lung epithelial cells
     Kazumi Moriyuki, Mami Nagataki, Fumiko Sekiguchi, Hiroyuki Nishikawa, Atsufumi Kawabata · 2007 · Regulatory Peptides
161. Differential Expression of Protease-Activated Receptors 1, 2, and 4 on Human Endothelial Cells from Different Vascular Sites
     Masakazu Fujiwara, Enjing Jin, Mohammad Ghazizadeh · 2003 · Pathobiology
162. Functional Interactions Between the Thrombin Receptor and the T-Cell Antigen Receptor in Human T-Cell Lines
     David E. Joyce, Yan Chen, Rochelle A. Erger · 1997 · Blood
163. Regulators of G-protein signaling, RGS2 and RGS4, inhibit protease-activated receptor 4-mediated signaling by forming a complex with the receptor and Gα in live cells
     Yukeyoung Kim, Sungho Ghil · 2020 · Cell Communication and Signaling
164. Protease-activated receptor 1 as a potential therapeutic target for COVID-19
     Emanuel Silva Rovai, Tomaz Alves, Marinella Holzhausen · 2020 · Experimental Biology and Medicine
165. Targeting PAR2 Overcomes Gefitinib Resistance in Non-Small-Cell Lung Cancer Cells Through Inhibition of EGFR Transactivation
     Yuhong Jiang, Xin Zhuo, Xiujuan Fu · 2021 · Frontiers in Pharmacology
166. Protease-activated receptor-2 induces expression of vascular endothelial growth factor and cyclooxygenase-2 via the mitogen-activated protein kinase pathway in gastric cancer cells
     Cheng Zhang, Guangrong Gao, Chenguang Lv · 2012 · Oncology Reports
167. Determinants of the specificity of protease‐activated receptors 1 and 2 signaling by factor Xa and thrombin
     Soumendra Rana, Likui Yang, Seyed Mahdi Hassanian · 2011 · Journal of Cellular Biochemistry
168. Palmitoylation of Protease-activated Receptor-1 Regulates Adaptor Protein Complex-2 and -3 Interaction with Tyrosine-based Motifs and Endocytic Sorting
     Isabel Canto, JoAnn Trejo · 2013 · Journal of Biological Chemistry
169. Insulin Modulates Protease-Activated Receptor 2 Signaling: Implications for the Innate Immune Response
     Eric Hyun, Rithwik Ramachandran, Nicolas Cénac, Steeve Houle, Perrine Rousset, Amit Saxena, Roland Liblau, Morley Donald Hollenberg, Nathalie Vergnolle · 2010 · The Journal of Immunology
170. Activation of PAR 4 Induces a Distinct Actin Fiber Formation via p38 MAPK in Human Lung Endothelial Cells
     Masakazu Fujiwara, Enjing Jin, Mohammad Ghazizadeh · 2005 · Journal of Histochemistry & Cytochemistry
171. Proteinase-activated receptor-2-mediated signaling and inhibition of DNA synthesis in human pancreatic cancer cells
     Roland Kaufmann, Heiko Schafberg, G Nowak · 1998 · International Journal of Pancreatology
172. Expression of Proteinase-Activated Receptor 2 During Taurocholate-Induced Acute Pancreatic Lesion Development in Wistar Rats
     Tomáš Olejár, Radoslav Matěj, Marie Zadinová, PAVLA POUCKOVA · 2001 · International Journal of Gastrointestinal Cancer
173. Protease-Activated Receptor 2: Are Common Functions in Glial and Immune Cells Linked to Inflammation-Related CNS Disorders?
     Trevor John Bushell, Margaret Cunningham, Kathryn McIntosh · 2016 · Current Drug Targets
174. Protein Kinase D and Gβγ Subunits Mediate Agonist-evoked Translocation of Protease-activated Receptor-2 from the Golgi Apparatus to the Plasma Membrane
     Dane D. Jensen, Peishen Zhao, Nestor Nivardo Jiménez-Vargas, TinaMarie Lieu, Marina Gerges, Holly R. Yeatman, Meritxell Canals, Stephen J. Vanner, Daniel P. Poole, Nigel W. Bunnett · 2016 · Journal of Biological Chemistry
175. Identification and immunohistochemical characterization of colospinal afferent neurons in the rat
     Shelby K. Suckow, Robert M. Caudle · 2008 · Neuroscience
176. Evaluation of antibodies directed against human protease-activated receptor-2
     Mark N. Adams, Charles Neil Pagel, Eleanor J. Mackie, John David Hooper · 2012 · Naunyn-Schmiedeberg s Archives of Pharmacology
177. Contribution of bone marrow-derived cells to the pro-inflammatory effects of protease-activated receptor-2 in colitis
     Eric Hyun, Patricia Andrade‐Gordon, Martin S. Steinhoff, Paul L. Beck, Nathalie Vergnolle · 2010 · Inflammation Research
178. House dust mite‐treated PAR2 over‐expressor mouse: A novel model of atopic dermatitis
     Leila Smith, Solène Gatault, Laura Casals‐Diaz, Pamela Kelly, Eric Camerer, Charles Métais, Ulla G. Knaus, Günther Eißner, Martin S. Steinhoff · 2019 · Experimental Dermatology
179. Role of the Helix-8 and C-Terminal Tail in Regulating Proteinase Activated Receptor 2 Signaling
     Pierre E. Thibeault, Rithwik Ramachandran · 2020 · ACS Pharmacology & Translational Science
180. Thrombin‐induced thromboxane generation by neutrophils and lymphocytes: Dependence on enzymic site
     Rena Bizios, Linda Lai, John W. Fenton · 1987 · Journal of Cellular Physiology
181. Human α‐thrombin stimulates proliferation of interferon‐γ differentiated, growth‐arrested U937 cells, overcoming differentiation‐related changes in expression of p21CIP1/WAF1 and cyclin D1
     Antonella Naldini, Darrell H. Carney, Annalisa Pucci · 2002 · Journal of Cellular Physiology
182. HIV-induced neuroinflammation: impact of PAR1 and PAR2 processing by Furin
     Vatsal Sachan, Robert Lodge, Koichiro Mihara, Josée Hamelin, Christopher Power, Benjamin B. Gelman, Morley Donald Hollenberg, Éric A. Cohen, Nabil Georges Seidah · 2019 · Cell Death and Differentiation
183. Streptococcal SpeB Cleaved PAR-1 Suppresses ERK Phosphorylation and Blunts Thrombin-Induced Platelet Aggregation
     Miriam Ender, Federica Andreoni, Annelies Sophie Zinkernagel, Reto Andreas Schuepbach · 2013 · PLoS ONE
184. The Transactivated Epidermal Growth Factor Receptor Recruits Pyk2 to Regulate Src Kinase Activity
     Dag Schauwienold, Alejandra Pérez Sastre, Nadine Genzel, Michael Schaefer, H. Peter Reusch · 2008 · Journal of Biological Chemistry
185. Functional expression of Ca2+ ‐mobilizing α‐thrombin receptors in mRNA‐injected Xenopus oocytes
     Ellen Van Obberghen‐Schilling, Jean‐Claude Chambard, Philippe Lory · 1990 · FEBS Letters
186. Hirudin Suppresses the Invasion of Inflammatory Cells and the Appearance of Vimentin-Positive Astrocytes in the Rat Cerebral Ablation Model
     Osamu Motohashi, Michiyasu Suzuki, Naoki Shida · 1997 · Journal of Neurotrauma
187. Epidermal Proteinase-Activated Receptor-2 Expression is Increased in End-Stage Renal Disease Patients with Pruritus: A Pilot Study
     Sung Jin Moon, Hyun Jung Kim, Sung Bin Cho, Seung Hun Lee, Hoon Young Choi, Hyeong Cheon Park, Sung Kyu Ha · 2014 · Electrolytes & Blood Pressure
188. Protease-activated receptors (PARs) in cancer
     Rachel Bar‐Shavit, Myriam Maoz, Arun Kancharla, M. Jaber, Daniel Agranovich, Sorina Grisaru‐Granovsky, Beatrice Uziely · 2015 · Methods in cell biology
189. Cooperation of protease-activated receptor 1 and integrin ανβ5 in thrombin-mediated lung cancer cell invasion
     Lingyun Zhu, XIUDONG WANG, Jie Wu · 2012 · Oncology Reports
190. Evidence that PAR2‐triggered prostaglandin E2 (PGE2) formation involves the ERK‐cytosolic phospholipase A2‐COX‐1‐microsomal PGE synthase‐1 cascade in human lung epithelial cells
     Mami Nagataki, Kazumi Moriyuki, Fumiko Sekiguchi, Atsufumi Kawabata · 2007 · Cell Biochemistry and Function
191. Protein kinase D and Gβγ mediate sustained nociceptive signaling by biased agonists of protease-activated receptor-2
     Peishen Zhao, Luke A. Pattison, Dane D. Jensen et al. · 2019 · Journal of Biological Chemistry
192. Blockade of PAR‐1 Signaling Attenuates Cardiac Hypertrophy and Fibrosis in Renin‐Overexpressing Hypertensive Mice
     Yoshikazu Yokono, Kenji Hanada, Masato Narita, Yota Tatara, Yousuke Kawamura, Naotake Miura, Kazutaka Kitayama, Masamichi Nakata, Masashi Nozaka, Tomo Kato et al. · 2020 · Journal of the American Heart Association
193. Antiplatelet and antithrombotic effect of F 16618, a new thrombin proteinase‐activated receptor‐1 (PAR1) antagonist
     Monique Dumas, Florence Nadal-Wollbold, Pascale Gaussem · 2011 · British Journal of Pharmacology
194. Activation of trigeminal nociceptive neurons by parotid PAR-2 activation in rats
     Atsufumi Kawabata, Hideki Itoh, Naoyuki Kawao, Ryotaro Kuroda, Fumiko Sekiguchi, Takashi Masuko, Koichi Iwata, Akiko Ogawa · 2004 · Neuroreport
195. Bezafibrate, a peroxisome proliferator–activated receptor α agonist, decreases circulating CD14+CD16+ monocytes in patients with type 2 diabetes
     Tomoko Terasawa, Yoshimasa Aso, Kyoko Omori, Maiko Fukushima, Atsushi Momobayashi, Toshihiko Inukai · 2014 · Translational research
196. Development and Evaluation of Small Peptidomimetic Ligands to Protease-Activated Receptor-2 (PAR2) through the Use of Lipid Tethering
     Scott A. Boitano, Justin Hoffman, Dipti V. Tillu · 2014 · PLoS ONE
197. Protease-Activated Receptor (PAR)2, but Not PAR1, Is Involved in Collateral Formation and Anti-Inflammatory Monocyte Polarization in a Mouse Hind Limb Ischemia Model
     Lisa G. van den Hengel, Alwine A. Hellingman, Anne Yaël Nossent et al. · 2013 · PLoS ONE
198. Modulation of mast cell activity by a peptide agonist of the thrombin receptor: role of nitric oxide.
     Svetlana M. Strukova, I.V. Chistov, Б. А. Умарова · 1999 · PubMed
199. Regulator of G protein signaling 8 inhibits protease-activated receptor 1/Gi/o signaling by forming a distinct G protein-dependent complex in live cells
     Jinyong Lee, Sungho Ghil · 2016 · Cellular Signalling
200. House dust mite potentiates capsaicin‐evoked Ca2+transients in mouse pulmonary sensory neurons via activation of protease‐activated receptor‐2
     Qihai Gu, Lu‐Yuan Lee · 2011 · Experimental Physiology