Molecular physiology of bile acid signaling in health, disease, and aging

Perino, Alessia, Demagny, Hadrien, Velazquez-Villegas, Laura, Schoonjans, Kristina·2021·Physiological Reviews

Cited by (480)

Items 101–200 of 480

  1. Intestinal FGF15 regulates bile acid and cholesterol metabolism but not glucose and energy balance
    Nadejda Bozadjieva-Kramer, Jae Hoon Shin, Ziru Li, Alan C. Rupp, Nicole Miller, Stace Kernodle, Nicolas Lanthier, Paulina Henry, Nikhil Seshadri, Andriy Myronovych et al. · 2024 · JCI Insight
  2. The secondary bile acid isoursodeoxycholate correlates with post-prandial lipemia, inflammation, and appetite and changes post-bariatric surgery
    Panayiotis Louca, Abraham Stijn Meijnikman, Ana Nogal, Francesco Asnicar, Ilias Attaye, Amrita Vijay, Afroditi Kouraki, Alessia Visconti, Kari E. Wong, Sarah E. Berry et al. · 2023 · Cell Reports Medicine
  3. Intrahepatic cholestasis of pregnancy: insights into pathogenesis and advances in omics studies
    Mi Tang, Liling Xiong, Jianghui Cai, Jinzhu Fu, Hong Liu, Ying Ye, Yang Li, Shasha Xing, Xiao Yang · 2023 · Hepatology International
  4. Improving intestinal inflammaging to delay aging? A new perspective
    Lan Zhang, Junbin Yan, Chi Zhang, Shuyan Feng, Zheli Zhan, Yang Bao, Zheli Zhan, Guanqun Chao · 2023 · Mechanisms of Ageing and Development
  5. The role of bile acids in human aging
    Lihua Jin, Linsen Shi, Wendong Huang · 2024 · Medical Review
  6. Postbiotics Prepared Using Lactobacillus reuteri Ameliorates Ethanol‐Induced Liver Injury by Regulating the FXR/SHP/SREBP‐1c Axis
    Chen Liu, Tianying Cai, Yonglang Cheng, Junjie Bai, Mo Li, Boyuan Gu, Meizhou Huang, Wenguang Fu · 2024 · Molecular Nutrition & Food Research
  7. Biological tuners to reshape the bile acid pool for therapeutic purposes in non-alcoholic fatty liver disease
    Justine Gillard, Isabelle Anne Leclercq · 2023 · Clinical Science
  8. Effects of cholesterol-lowering probiotics on non-alcoholic fatty liver disease in FXR gene knockout mice
    Minghua Yang, Haoyang Wang, Ihtisham Bukhari, Zhao Ye, Huang Huang, Yong Yu, Xiangdong Sun, Yang Mi, Mei Lü, Pengyuan Zheng · 2023 · Frontiers in Nutrition
  9. Loss of Bacteroides thetaiotaomicron bile acid-altering enzymes impacts bacterial fitness and the global metabolic transcriptome
    Arthur S. McMillan, Matthew H. Foley, Caroline E. Perkins, Casey M. Theriot · 2023 · Microbiology Spectrum
  10. Free Deoxycholic Acid Exacerbates Vascular Calcification in CKD through ER Stress-Mediated ATF4 Activation
    Shinobu Miyazaki‐Anzai, Masashi Masuda, Yuji Shiozaki, Audrey L. Keenan, Michel Chonchol, Claus Kremoser, Makoto Miyazaki · 2021 · Kidney360
  11. Unraveling the complexities of fibrosis and ductular reaction in liver disease: pathogenesis, mechanisms, and therapeutic insights
    Corinn N. Marakovits, Heather Francis · 2023 · American Journal of Physiology-Cell Physiology
  12. Interorgan communication with the liver: novel mechanisms and therapeutic targets
    Jiulu Zhao, Xi Zhang, Yuewen Li, Jizhang Yu, Zhang Chen, Yuqing Niu, Shuan Ran, Song Wang, Weicong Ye, Zilong Luo et al. · 2023 · Frontiers in Immunology
  13. The microbiota-derived bile acid taurodeoxycholic acid improves hepatic cholesterol levels in mice with cancer cachexia
    Morgane M. Thibaut, Martin Roumain, Edwige Piron, Justine Gillard, Axelle E. Loriot, Audrey M. Neyrinck, Julie Rodriguez, Isabelle S. Massart, Jean‐Paul Thissen, Joshua R. Huot et al. · 2025 · Gut Microbes
  14. A simple and reliable bile acid assay in human serum by LC‐MS/MS
    Ying Shen, Ke Liu, Xia Luo, Qing Guan, Liming Cheng · 2022 · Journal of Clinical Laboratory Analysis
  15. Ameliorative Effect of Ellagic Acid on Aging in Rats with the Potential Mechanism Relying on the Gut Microbiota and Urolithin A-Producing Ability
    Wenyan Xian, Yu Deng, Yuzhe Yang, Zhaolun Tan, Chunlian Chen, Wu Li, Ruili Yang · 2023 · Journal of Agricultural and Food Chemistry
  16. Integrated gut metabolome and microbiome fingerprinting reveals that dysbiosis precedes allergic inflammation in IgE‐mediated pediatric cow's milk allergy
    Ellen De Paepe, Vera Plekhova, Pablo Vangeenderhuysen, Nele Baeck, Dominique M. A. Bullens, Tania Claeys, Marilyn De Graeve, Kristien Kamoen, Anneleen Notebaert, Tom Van de Wiele et al. · 2024 · Allergy
  17. Bile salt signaling and bile salt-based therapies in cardiometabolic disease
    Claire Groenen, Thuc-Anh Nguyen, Coen C. Paulusma, Stan F.J. van de Graaf · 2024 · Clinical Science
  18. Effectiveness of bile acids as a feed supplement to improve growth performance, feed utilization, lipid metabolism, digestive enzymes, and hepatic antioxidant status in aquaculture animals: A meta-analysis
    Ling Li, Tianyu Liu, Jiarou Li, Yanchao Yang, Haiyan Liu, Peiyu Zhang · 2024 · Aquaculture Reports
  19. Gut microbiota preserves bone mass through modulating the hyodeoxycholic acid–TGR5 axis
    Xuan-Qi Zheng, Jie Huang, Wan-Qiong Yuan, Tong Wu, Huan Wang, Hao Liu, Yun-Di Zhang, Jie He, Chen Huang, Chunli Song · 2025 · Gut Microbes
  20. Effects of acute administration of trimethylamine N-oxide on endothelial function: a translational study
    Anne Jomard, Luca Liberale, Petia Doytcheva, Martin F. Reiner, Daniel Müller, Michele Visentin, Marco Bueter, Thomas Felix Lüscher, Roberto Vettor, Thomas A. Lutz et al. · 2022 · Scientific Reports
  21. The time is now: accounting for time-of-day effects to improve reproducibility and translation of metabolism research
    Shaunak Deota, Julie S. Pendergast, Ullas Kolthur‐Seetharam, Karyn Ann Esser, Frédéric Gachon, Gad Asher, Charna Dibner, Salvador Aznar Benitah, Carolina Escobar, Deborah M. Muoio et al. · 2025 · Nature Metabolism
  22. Multitasking Na+/Taurocholate Cotransporting Polypeptide (NTCP) as a Drug Target for HBV Infection: From Protein Engineering to Drug Discovery
    Dariusz Zakrzewicz, Joachim Geyer · 2022 · Biomedicines
  23. Dietary bile acids improve breast muscle growth in chickens through FXR/IGF2 pathway
    Liang Chen, Yanghong Shi, Jinbao Li, Shao Caimei, Shuai Ma, Chao Shen, Ruqian Zhao · 2023 · Poultry Science
  24. Bile acid signaling in MASLD: From pathogenesis to therapeutic applications
    Benedikt Simbrunner, Rafael Paternostro, Thomas Reiberger, Michael Trauner · 2025 · Hepatology
  25. Age-dependent effects of gut microbiota metabolites on brain resident macrophages
    Dilara Hasavci, Thomas Blank · 2022 · Frontiers in Cellular Neuroscience
  26. Bile Acids—A Peek Into Their History and Signaling
    James ThienToan Nguyen, Ryan Philip Henry Shaw, Sayeepriyadarshini Anakk · 2022 · Endocrinology
  27. Role of Microbiota-Modified Bile Acids in the Regulation of Intracellular Organelles and Neurodegenerative Diseases
    Yoshimitsu Kiriyama, Hiromi Nochi · 2023 · Genes
  28. The bile acid profile
    Zhenhua Liu, Chongge You · 2024 · Clinica Chimica Acta
  29. Synergy of genetics and lipid metabolism driving feed utilization efficiency in chickens
    Xiaoli Guo, Jianbo Li, Xiaochang Li, Jia Sun, Xian Zou, Jian Ji, Hao Qu, Dingming Shu, Chenglong Luo · 2025 · Poultry Science
  30. Bile acid 7α-dehydroxylating bacteria accelerate injury-induced mucosal healing in the colon
    Antoine Jalil, Alessia Perino, Yuan Dong, Jéromine Imbach, Colin Volet, Eduard Vico Oton, Hadrien Demagny, Lucie Plantade, Héctor Gallart‐Ayala, Julijana Ivanišević et al. · 2025 · EMBO Molecular Medicine
  31. Bile Acids and the Microbiome: Making Sense of This Dynamic Relationship in Their Role and Management in Crohn’s Disease
    Aditi Kumar, Hafid Omar Al-Hassi, Helen Steed, Oliver Phipps, Matthew Brookes · 2022 · Canadian Journal of Gastroenterology and Hepatology
  32. Quantitative Profiling of Bile Acids in Feces of Humans and Rodents by Ultra-High-Performance Liquid Chromatography–Quadrupole Time-of-Flight Mass Spectrometry
    Xiaoxu Zhang, Xiaoxue Liu, Jiufang Yang, Fazheng Ren, Yixuan Li · 2022 · Metabolites
  33. Serum Metabolomic Profiling in Aging Mice Using Liquid Chromatography—Mass Spectrometry
    Tong Yue, Huiling Tan, Yu Shi, Mengyun Xu, Sihui Luo, Jianping Weng, Suowen Xu · 2022 · Biomolecules
  34. The Pan-liver Network Theory
    Yaxing Zhang, Xian-Ming Fang · 2023 · The Chinese Journal of Physiology
  35. The anticancer activity of bile acids in drug discovery and development
    Weijian Li, Lu Zou, Shuai Huang, Huijie Miao, Ke Liu, Yajun Geng, Yingbin Liu, Wenguang Wu · 2024 · Frontiers in Pharmacology
  36. Chenodeoxycholic acid modulates cholestatic niche through FXR/Myc/P-selectin axis in liver endothelial cells
    Peng Zhang, Xinying Li, Jinyuan Liang, Yuanwen Zheng, Yao Tong, Jing Shen, Yatai Chen, Penghu Han, Shuzheng Chu, Ruirui Liu et al. · 2025 · Nature Communications
  37. Merging Continuous Flow Technology, Photochemistry and Biocatalysis to Streamline Steroid Synthesis
    Elena Tomarelli, Bruno Cerra, Francesco G. Mutti, Antimo Gioiello · 2023 · Advanced Synthesis & Catalysis
  38. Alternative pathway of bile acid biosynthesis contributes to ameliorate NASH after induction of NAMPT/NAD+/SIRT1 axis
    Na Yang, Runbin Sun, Xiaoli Zhang, Jing Wang, Lulu Wang, Huaijun Zhu, Man Yuan, Yifan Xu, Chun Ge, Jun Bao He et al. · 2023 · Biomedicine & Pharmacotherapy
  39. Chicoric Acid Effectively Mitigated Dextran Sulfate Sodium (DSS)-Induced Colitis in BALB/c Mice by Modulating the Gut Microbiota and Fecal Metabolites
    Jiani Yang, Lin Jie, Ting Gu, Quancai Sun, Weidong Xu, Ye Peng · 2024 · International Journal of Molecular Sciences
  40. Vancomycin relieves tacrolimus-induced hyperglycemia by eliminating gut bacterial beta-glucuronidase enzyme activity
    Peixia Li, Rui Zhang, Jinping Zhou, Pengpeng Guo, Yani Liu, Shaojun Shi · 2024 · Gut Microbes
  41. Role of Bile Acid Receptors in the Development and Function of Diabetic Nephropathy
    Yuanyuan Fang, Minjing Qin, Qitong Zheng, Kuilong Wang, Xin Han, Qiao Yang, Xia’nan Sang, Gang Cao · 2024 · Kidney International Reports
  42. Bile acid‐activated receptors in innate and adaptive immunity: targeted drugs and biological agents
    Kenneth C. P. Cheung, Jiao Ma, Rodrigo Azevedo Loiola, Xingxuan Chen, Wei Ping Jia · 2023 · European Journal of Immunology
  43. An intestinal-targeting near-infrared probe for imaging nitroreductase in inflammatory bowel disease
    Ting Li, Qing-Song Gu, Jing‐Jing Chao, Ting Liu, Guojiang Mao, Yongfei Li, Chunyan Li · 2023 · Sensors and Actuators B Chemical
  44. The bile acid receptor TGR5 inhibits platelet activation and thrombus formation
    Friedrich Reusswig, Maria Reich, Leonard Wienands, Diran Agaid Herebian, Verena Keitel, Margitta Elvers · 2024 · Platelets
  45. Clostridium Scindens Protects Against Vancomycin‐Induced Cholestasis and Liver Fibrosis by Activating Intestinal FXR‐FGF15/19 Signaling
    Jintao Xiao, Yanliang Hou, Xingyang Luo, Yuhao Zhu, Wenhu Li, Bingbing Li, LinXiang Zhou, Xia Chen, Ying Guo, Xiaomei Zhang et al. · 2024 · Advanced Science
  46. The association of serum total bile acid with new-onset hypertension during pregnancy
    Weinan Deng, Lizi Zhang, Qiting Du, Yulian Li, Jingsi Chen, Lili Du, Dunjin Chen · 2022 · BMC Pregnancy and Childbirth
  47. Progress in the Management of Patients with Cholestatic Liver Disease: Where Are We and Where Are We Going?
    Xin Luo, Lungen Lu · 2024 · Journal of Clinical and Translational Hepatology
  48. Large-scale genomic investigation of pediatric cholestasis reveals a novel hepatorenal ciliopathy caused by PSKH1 mutations
    Sateesh Maddirevula, Mohammad Ali Shagrani, Ae‐Ri Ji, Christopher R. Horne, Samuel N. Young, Lucy J. Mather, Mashael F. Alqahtani, Colin McKerlie, Geoffrey A. Wood, Paul K Potter et al. · 2024 · Genetics in Medicine
  49. Metabolite-mediated crosstalk: unraveling the interactions between gut microbiota and host in fatty liver hemorrhagic syndrome of laying hens
    Shaobo Zhang, Xinghua Zhao, Xin He, Wanyu Shi, Ning Ma · 2026 · Journal of Animal Science and Biotechnology/Journal of animal science and biotechnology
  50. Changes in circulating bile acid subtypes in response to weight-loss diets are associated with improvements in glycemic status and insulin resistance: The POUNDS Lost trial
    Yoriko Heianza, Xuan Wang, Jennifer Carlton Rood, Clary B. Clish, George A. Bray, Frank M. Sacks, Lu Qi · 2022 · Metabolism
  51. Intestinal Stem Cells Damaged by Deoxycholic Acid via AHR Pathway Contributes to Mucosal Barrier Dysfunction in High-Fat Feeding Mice
    Leheng Liu, Jingxian Xu, Xianjun Xu, Tiancheng Mao, Wenlu Niu, Xiaowan Wu, Lungen Lu, Hui Jun Zhou · 2022 · International Journal of Molecular Sciences
  52. Characterization of the mechanism of bile salt hydrolase substrate specificity by experimental and computational analyses
    Dmitry S. Karlov, Sarah L. Long, Ximin Zeng, Fuzhou Xu, Kanhaya Lal, Liu Cao, Karim Hayoun, Jun Lin, Susan A. Joyce, Irina G. Tikhonova · 2023 · Structure
  53. Gut Microbiota Metabolite TMA May Mediate the Effects of TMAO on Glucose and Lipid Metabolism in C57BL/6J Mice
    Xiaoyue Li, Zhu‐Lin Yu, Ying‐Cai Zhao, Dandan Wang, Changhu Xue, Tiantian Zhang, Yuming Wang · 2024 · Molecular Nutrition & Food Research
  54. Bile acid metabolism is altered in learning and memory impairment induced by chronic lead exposure
    Anfei Liu, Yunting Li, Lifan Li, Kaiju Chen, Meitao Tan, Fei Zou, Xingmei Zhang, Xiaojing Meng · 2024 · Journal of Hazardous Materials
  55. Surgery for Crohn’s Disease Is Associated With a Dysbiotic Microbiome and Metabolome: Results From Two Prospective Cohorts
    James D. Lewis, Scott G. Daniel, Hongzhe Li, Fuhua Hao, Andrew D. Patterson, Aaron L. Hecht, Colleen M Brensinger, Gary D. Wu, Kyle L. Bittinger, Douglas C. Wolf et al. · 2024 · Cellular and Molecular Gastroenterology and Hepatology
  56. Gut microbiota, bile acids, and nature compounds
    Hao Cheng, Juan Liu, Dandan Zhang, Yuzhu Tan, Wuwen Feng, Cheng Peng · 2022 · Phytotherapy Research
  57. Gut microbiota-bile acid crosstalk contributes to calcium oxalate nephropathy through Hsp90α-mediated ferroptosis
    Linhu Liu, Yucheng Ma, Zhongyu Jian, Banghua Liao, Ya Li, Lede Lin, Menghua Wang, Jiawei Chen, Jingwen Wei, Mengzhu Yang et al. · 2025 · Cell Reports
  58. Myocardial Infarction and Coronary Artery Disease in Menopausal Women With Type 2 Diabetes Mellitus Negatively Correlate With Total Serum Bile Acids
    Xunxun Feng, Guangyao Zhai, Jiaqi Yang, Yang Liu, Yujie Zhou, Qianyun Guo · 2021 · Frontiers in Endocrinology
  59. Comparison of bile acids profiles in the enterohepatic circulation system of mice and rats
    Zhicheng Duan, Tingting Yang, Lin Li, Xue Wang, Chujing Wei, Ziyin Xia, Yuanyuan Chai, Xin Huang, Luyong Zhang, Zhenzhou Jiang · 2022 · The Journal of Steroid Biochemistry and Molecular Biology
  60. Hepatic interoception in health and disease
    Hans‐Rudolf Berthoud, Heike Münzberg, Christopher D. Morrison, Winfried Neuhuber · 2024 · Autonomic Neuroscience
  61. Saponin monomers: Potential candidates for the treatment of type 2 diabetes mellitus and its complications
    Lvzhuo Zhang, Shifeng He, Lian Liu, Jiangrong Huang · 2024 · Phytotherapy Research
  62. Intermittent Fasting Improves Insulin Resistance by Modulating the Gut Microbiota and Bile Acid Metabolism in Diet‐Induced Obesity
    Sha Lei, Guanghui Liu, Shouli Wang, Guannan Zong, Xiaoya Zhang, Lingling Pan, Junfeng Han · 2024 · Molecular Nutrition & Food Research
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  64. Chemoproteomic Analysis of Microbiota Metabolite–Protein Targets and Mechanisms
    Xiaohui Zhao, Xinglin Yang, Howard C. Hang · 2022 · Biochemistry
  65. Bile acids in liver and gastrointestinal cancer
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  66. Dynamics and determinants of human plasma bile acid profiles during dietary challenges
    Jarlei Fiamoncini, Manuela J. Rist, Lara Frommherz, Pieter Giesbertz, Birgit Pfrang, Werner Kremer, Fritz Huber, Gabi Kastenmüller, Thomas Skurk, Hans Hauner et al. · 2022 · Frontiers in Nutrition
  67. Mesenchymal stem cell-derived exosomes promote tissue repair injury in rats with liver trauma by regulating gut microbiota and metabolism
    Bo Yi, Juan Pan, Zhaoming Yang, Zemin Zhu, Yongkang Sun, Tao Guo, Zhijian Zhao · 2024 · Molecular and Cellular Probes
  68. Activation of TGR5 in the injured nerve site according to a prevention protocol mitigates partial sciatic nerve ligation–induced neuropathic pain by alleviating neuroinflammation
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  69. Muricholic Acids Promote Resistance to Hypercholesterolemia in Cholesterol-Fed Mice
    Dany Gaillard, David Masson, Erwan Garo, Maâmar Souidi, Jean-Paul Paı̈s de Barros, Kristina Schoonjans, Jacques Grober, Philippe Besnard, Charles Thomas · 2021 · International Journal of Molecular Sciences
  70. Plasma Metabolic Signatures of Healthy Overweight Subjects Challenged With an Oral Glucose Tolerance Test
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  71. Inhibition of microtubule affinity regulating kinase 4 by an acetylcholinesterase inhibitor, Huperzine A: Computational and experimental approaches
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  72. Cholic acid inhibits ovarian steroid hormone synthesis and follicular development through farnesoid X receptor signaling in mice
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  73. The role of microbiota in nonalcoholic fatty liver disease: mechanism of action and treatment strategy
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