Molecular physiology of bile acid signaling in health, disease, and aging

Cited by (480)

Items 401–480 of 480

1. Ácidos biliares: moléculas de señalización
   Felipe Neri Piñol Jiménez, Virginia Capó de Paz, Guillermo Otoya, S B Martinez · 2023 · Belize Journal of Medicine
2. Znaczenie kwasów żółciowych w terapii wybranych chorób
   Aleksandra Boguszewska, Anna Kiersztan · 2024 · Postępy Biochemii
3. TGR5 protects against pSNL-induced mechanical allodynia by alleviating neuroinflammation in the injured nerves of male mice
   Wen-Ge Shi, Yao Yao, Yajing Liang, Jie Lei, Shi‐Yang Feng, Yue Tian, Zi-Xian Zhang, Jie Cai, Guo‐Gang Xing, Kai‐Yuan Fu · 2024 · Research Square
4. The bile acid receptor TGR5 is a modulator of bone marrow adipose tissue and the hematopoietic niche
   Alejandro Alonso Calleja, Alessia Perino, Frédérica Schyrr, Silvia Ferreira Lopes, Vasiliki Delitsikou, Antoine Jalil, Ulrike Kettenberger, Maria Chiara Galavotti, Angela Martins, Charles Bataclan et al. · 2024 · eLife
5. Metabolomics-based Investigation of Primary Biliary Cholangitis: A Cholestatic Liver Disease
   Juliana Magalhães de Oliveira, Thaís de Assis Lopes, Alex Castro, Étore De Favari Signini, Aparecida Maria Catai, Antonio Gilberto Ferreira, Eduardo Luiz Rachid Cançado, Regina V. Oliveira · 2024 · Research Square
6. Association between cholelithiasis and frailty index in US adults: a population-based epidemiological study
   Meng Zhu, Lingjuan Jia, Xiangfeng Tian, Yongsheng Zhang · 2024 · Research Square
7. Correlation between Trimethylamine Oxide, a Metabolite of Intestinal Flora, and Coronary Heart Disease
   蓉 李 · 2024 · Advances in Clinical Medicine
8. Research Progress of Cholestatic Liver Disease-Related Pruritus in Chinese Medicine and Western Medicine
   Wenzhang Dai, Hong Nie · 2024 · Chinese medicine and natural products
9. Dietary Inulin Supplementation Modulates Fecal Microbiota and Vaccine Response in Cats—A Double-Blind Randomized Controlled Pilot Study
   Isabelle C. Jeusette, Emmanuelle Apper, Marina Luisa Meli, Regina Hofmann‐Lehmann, Anna Salas, Anna Fernández-Pinteño, Olga Francino, Celina Torre · 2024 · Pets
10. Biological, experimental and analytical determinants influencing bile acids concentrations in human blood: a review and meta-analysis
    Sebastian Joseph, Sophie de Buyl, Isabelle A. Leclercq, Laure‐Alix Clerbaux · 2025 · medRxiv
11. TGR5-mediated Ca 2+ signaling in cholangiocytes
    Xuanmeng Chen, Amr Al‐Shebel, Thibault Pebrier, Thierry Tordjmann, Olivier Dellis · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
12. Exploring Microbial Utilization of Iron via Mass Spectrometry
    Anastasiia Kostenko · 2025
13. Physiopathologie de la cholestase
    Thierry Tordjmann · 2025 · EMC - Hépatologie
14. A cardiometabolic patient and microbiota
    Т. В. Богослав · 2025 · Zaporozhye Medical Journal
15. Association between Cholelithiasis and Anxiety Disorder Based on the “Dan Zhu Jueduan”—A Two-Sample Mendelian Randomization Study
    蕊 谭 · 2025 · Advances in Clinical Medicine
16. Plasma membrane Bile acid TGR5 receptor specific stimulation induces Ca2+ mobilisation, ATP secretion and P2Y receptors activation in cholangiocytes
    Xuanmeng Chen, Amr Al‐Shebel, Thibault Pebrier, Thierry Tordjmann, Olivier Dellis · 2025 · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
17. The conjugation-resistant bile acid norUDCA cures liver fibrosis but impairs systemic energy metabolism
    Jöerg Heeren, Ioannis Evangelakos, Esther Verkade, Folkert Kuipers, Julia Sarah Rohde, Markus Heine, Anna Worthmann, Sebastian Graute, Manka M. Fuh, Karthikeyan Gunasekaran et al. · 2025 · Research Square
18. Additional file 2 of Gut microbiome is linked to functions of peripheral immune cells in transition cows during excessive lipolysis
    Gu, Fengfei, Senlin Zhu, Tang, Yifan, Liu, Xiaohan, Jia, Minghui, Nilusha Malmuthuge, Teresa G. Valencak, McFadden, Joseph W., Jianxin Liu, Sun, Hui-Zeng · 2023 · Figshare
19. Additional file 1 of Circulating concentrations of bile acids and prevalent chronic kidney disease among newly diagnosed type 2 diabetes: a cross-sectional study
    Tingting Geng, Lu, Qi, Limiao Jiang, 郭昆全, Yang, Kun, Liao, Yun-Fei, He, Meian, Liu, Gang, Huiru Tang, Pan, An · 2024 · Figshare
20. Additional file 1 of Sex differences in lipidomic and bile acid plasma profiles in patients with and without coronary artery disease
    Benjamin Bay, Marceline Manka Fuh, Julia Sarah Rohde, Anna Worthmann, Alina Goßling, Arnold, Natalie, Lukas Koester, Thiess Lorenz, Christopher M. Blaum, Kirchhof, Paulus et al. · 2024 · Figshare
21. GPR39-mediated molecular signaling by bile acids
    Yanyun Huang, Zhentao Zi, Chenliang Xia, Yi Rao · 2026 · Journal of Biological Chemistry
22. Natural products as modulators of bile acid receptor FXR: therapeutic opportunities and challenges in drug discovery
    Yong Li, Bo Ma · 2026 · Elsevier eBooks
23. Developmental expression patterns of the FXR-IGF axis during early skeletal muscle growth in ducks
    Liang CHEN, Xiaoyu Wang, Jie Luo, Lei Wu, Shuai Ma, Tonghui Mao, Wei Sun, Dengliang Li, Yanhan Zhao, Fengming Zhou et al. · 2026 · Poultry Science
24. Gene dosage imbalance disrupts systemic metabolism in the Dp16 Down syndrome mouse model
    Fangluo Chen, Muzna Saqib, Christy M Nguyen, Dylan C. Sarver, Y Eugene Yu, Susan M. Aja, Marcus Michael Seldin, Guang William Wong · 2026 · eLife
25. Dietary bile acids supplementation improves the growth performance, glycolipid metabolism and bile acids homeostasis of blunt snout bream (Megalobrama amblycephala) fed a high-carbohydrate diet
    Yanzou Dong, Kelong Sun, Han Chen, YueYun Guo, Zishang Liu, SiSi Xiong, Wenbin Liu, Xiangfei Li · 2026 · Aquaculture
26. The conjugation-resistant bile acid norUDCA cures liver fibrosis but impairs systemic energy metabolism
    Ioannis Evangelakos, Esther Verkade, Julia K. Rohde, Alex Zaufel, Martin Vargek, Markus Heine, Anna Worthmann, Sebastian Graute, Marceline Manka Fuh, Karthikeyan Gunasekaran et al. · 2026 · Molecular Metabolism
27. Influence of bile acids metabolism on hepatic immunity in mice
    Valentine Guinot · 2022 · theses.fr (ABES)
28. Gut-restricted farnesoid X receptor agonist fexaramine improves abnormal metabolic and reproductive phenotypes in polycystic ovary syndrome model mice
    Yang Wang, Chu-Jun Zhang, Jiaqi Yang, Yu-Hui Wang, An-Hui Kang, Xi-Tong Liu, Yan Liu, Qing-Qing Cai, Xin Li, Fei-Fei Zhang et al. · 2026 · Reproductive and Developmental Medicine
29. Inter-organ communication in physiology and pathophysiology : a role for the ChREBP-FGF21 axis?
    Thaïs Carbinatti · 2024 · theses.fr (ABES)
30. Metabolic Signatures Resulting From Acute (Postprandial) Intake Of Milk Or Yoghurt In Men : Effect Of Age
    Jinyoung Kim · 2021 · theses.fr (ABES)
31. Small intestinal microbiome, the underrated maestro of SIMO disease
    C. Deschamps, Alexandre Tronel, É. Bailly, Maurice Raoul Sohnagou Tanfede, Sophie Gilibert, S. Denis, Thomas Soranzo, T. van de Wiele, L. Marinelli, Stéphanie Blanquet-Diot · 2026 · FEMS Microbiology Reviews
32. Modular synthesis of steroid–hecogenin hybrids via „click” chemistry – characterization and structure–activity relationships
    Anna Kawka, Hanna Koenig, Joanna Wysocka, Izabella Jastrzębska, Tomasz Pospieszny · 2026 · Journal of Molecular Structure
33. The bile acid TUDCA promotes chemoresistance and predicts survival through MAPK signaling in pancreatic ductal adenocarcinoma
    Yanling Wang, Shengbai Xue, Haiyan Xu, Jingyu Ma, Siming Wu, Keying Guo, 方 雅群, Jiujie Cui, Liwei Wang · 2026 · Cellular and Molecular Life Sciences
34. Oroxin A in Linggui Zhugan Decoction in the treatment of MASH by regulating cholesterol-bile acid metabolism
    Pan Gao, Sili Wang, Mingjiao Jia, Meng Jingke, Bochao Jia, Yulong Chen, Qingzheng Xing, Wei Wang, Yongsheng Zhang, Xinlou Chai · 2026 · Journal of Ethnopharmacology
35. Functionally related internal fluctuations in human ileal bile acid‐binding protein by high pressure nuclear magnetic resonance
    Tamara Teski, Bence Balterer, Gergő Horváth, Gábor Turczel, Orsolya Tőke · 2026 · Protein Science
36. Multi-omics analysis reveals that puerarin modulates the gut-liver axis to improve hepatic health in aged laying hens
    Xubin Du, Dong Zhao, Yuchen Zhang, Xinyue Wu, Jiawen He, Fei Liu, Debing Yu · 2026 · BMC Genomics
37. Letter to the Editor: Gut microbiota–bile acid crosstalk - Prevotellaceae NK3B31 and 7-ketolithocholic acid drive metabolic benefits of distal bowel resection with preservation of terminal ileum
    Xu Cui, Long-Yao Xu, Bing-Qian Yin, Liu Chen, Zheng Liang, Chao-Ming Zhou · 2026 · World Journal of Hepatology
38. Research Progress of TGR5 in Non-Alcoholic Fatty Liver Disease
    家豪 廖 · 2026 · Advances in Clinical Medicine
39. Hepatic CREB Binding Protein/E1A Binding Protein p300 Maintain Bile Acid Homeostasis Through Histone Acetylation-Mediated Kruppel-Like Transcription Factor 10–Bile Salt Export Pump Axis
    Mingzhu Li, Yiru Wang, Libin Zhou, Chunxiang Sheng, Ruyuan Deng, Li Shao · 2026 · Cellular and Molecular Gastroenterology and Hepatology
40. Gastric Ulcer With Liver‐Stomach Disharmony Protection by Coptidis Rhizoma: A Multi‐Organ Metabolomics Study
    Zhenkai Zhang, Yajuan Zheng, Bingxian Zhang, Ruifeng Wang, Long Chen, Yongxiang Wang, Weisheng FENG, Xiaoke Zheng, Kai Li, Ning Zhou · 2026 · Chemistry & Biodiversity
41. Plasma metabolomic profiling reveals systemic metabolic dysregulation and its association with cognitive impairment in moyamoya disease
    Jun Shen, Sisi Peng, Juan Du, Ziwei Xu, Dan Wang, Mingxuan Lv, Yu Duan, Wenshi Wei · 2026 · World Neurosurgery X
42. Prenatal caffeine exposure disrupts the fetal-placental-maternal bile acid circulation and its associated placental transport mechanisms
    Yuhong Lin, Man Fang, Hui Gao, Kexin Liu, Wen Huang, Wen Hu, Yuanzhen Zhang, Hui Wang · 2026 · Food and Chemical Toxicology
43. The multifaceted role of bile acids in breast cancer: pathogenesis, therapeutic potential, and drug delivery
    Qinghong Yu, Haining Ding, Yuehua Chen, Xiufei Gao · 2026 · PeerJ
44. Risk factors for postoperative growth retardation in children with biliary atresia after Kasai portoenterostomy: A retrospective analysis
    Xinyue Tan, Guantong Li, Xuming Liu, D D Wang, Yong Zhao, Yanan Zhang, Dayan Sun, Shuangshuang Li, Kaiyun Hua, Y Gu et al. · 2026 · Journal of Pediatric Surgery
45. Spatial metabolite profiling identifies taurocholic acid as a protective mediator in hepatic ischemia-reperfusion injury: A mass spectrometry imaging and pharmacological study
    Chuang Du, Chu-Ting Xu, Qi Zhang, Lei Chen, Shan-Shan Zhao, Yi-Zhe Fan, Guangbo Ge, Zhan-You Wang, Huixin Liu · 2026 · Drug Metabolism and Disposition
46. Aging-driven metabolic abnormalities remodel intercellular communication through the gut–liver–heart axis and may promote coronary artery disease: the key role of bile acid metabolism
    Wei Chen, Yue Sun, Chu-fan Meng, Si-tong Wu, Xin-yi Jiang, Meng Xian-meng, Qing-feng Wang · 2026 · Frontiers in Immunology
47. ASAP3 deficiency alleviates hepatic senescence and correlates with extended healthspan in mice
    Zhen Tian, Yuhua Song, Xinyue Ao, Changhao Sun · 2026 · Free Radical Biology and Medicine
48. Bioinformatics analysis reveals the association of bile acid metabolism-related genes with sepsis
    Juan Xie, Yu Ling, Yun-Yu Sun, Yun Yao, Ming-Shun Zhang, Xiao-Yu Zhou · 2026 · PLoS ONE
49. Genetic or pharmacological inhibition of hepatic TMEM141 attenuates MASH and fibrosis via the ROS-HNF4α signaling pathway
    Jiayou Wang, C Y Chen, Raja Gopoju, Shuwei Hu, Yang Wang, Hui Wang, Zaid Batayneh, Xiaoli Pan, Yeong‐Renn Chen, Jeffrey G. Mellott et al. · 2026 · Nature Communications
50. Hepatic FXR deficiency exacerbates dyslipidemia by disrupting the gut-liver axis via bile acid disorder and gut microbiota dysbiosis
    Yunlu Liu, Jiahua Wang, Chenchen Zhang, Zhiyong Li, Yinglan Nie, Yanhong Hu, Chuan Liu, Ya Tu · 2026 · Journal of Translational Medicine
51. Gene dosage imbalance disrupts systemic metabolism in the Dp16 Down syndrome mouse model
    Fangluo Chen, Muzna Saqib, Christy M Nguyen, Dylan C. Sarver, Y Eugene Yu, Susan M. Aja, Marcus Michael Seldin, Guang William Wong · 2026 · eLife
52. Gut Microbiota in Metabolic Syndrome: Differences in Microbial Signatures and Clinical Profiles
    Giuseppe Guido Maria Scarlata, Andrej Belančić, Emidio Scarpellini, Almir Fajkić, Tomislav Meštrović, Roberto Vicinanza, Davor Štimac, Ludovico Abenavoli · 2026 · Medicina
53. Mulberry leaf flavonoids alleviate type 2 diabetes by remodeling the gut microbiota-bile acid axis and activating FXR signaling
    Lu Shi, Yige Zhao, Yang Yang, Gaiting Liu, Sitong Bu, Guohua Wang, Shuchang Liu, Yuhang Du, Jiamei Xie, Changhao He et al. · 2026 · Journal of Ethnopharmacology
54. Elucidating 6PPD-Q-induced metabolic reprogramming and systemic injury via ultrasensitive breathomics
    Jiawei Dong, Bo Yang, Qirun Li, Zhen Li, Haiyan Wu, Mo Zhang, Meng Wang, Ting Lan, Zhongbing Lu, Liwei Cui et al. · 2026 · Environmental Pollution
55. Multiomics Dissection of the Mechanisms Underlying Eicosapentaenoic Acid Astaxanthin Ester-Mediated Protection Against High-Fat Diet-Induced Gut Barrier Injury
    Xiaoran Li, B Q Jing, 夏春森, Jiaxin Duan, Tiantian Zhang, Hongyan Li, Hongxia Che · 2026 · Journal of Agricultural and Food Chemistry
56. Gut Microbiota and Psoriatic Arthritis: From Pathogenesis to Microbiota-Targeted Therapies
    Silvia Valentini, Sauro Lorenzini, Stefano Gentileschi, Luca Cantarini, Bruno Frediani, Caterina Baldi · 2026 · Rheumato
57. The bile acid receptor TGR5 is a modulator of bone marrow adipose tissue and the hematopoietic niche
    Alejandro Alonso Calleja, Alessia Perino, Frédérica Schyrr, Silvia Ferreira Lopes, Vasiliki Delitsikou, Antoine Jalil, Ulrike Kettenberger, Maria Chiara Galavotti, Angela Martins, Charles Bataclan et al. · 2026 · eLife
58. Bile acid-axis dysregulation in MASLD/MASH progression: from metabolic mismatch to inflammatory-fibrotic remodeling
    Yang Du, Lin Qi, Yunze Shi, Xingyuan Huang, Xiaopei Shi, Mingfeng Liu, Ying Fang, Xiaoyang Hu · 2026 · Frontiers in Medicine
59. Pathogenic mechanisms and comprehensive therapeutic strategies of ovarian aging: targeting gut microbiota
    Yao Chen, Sainan Tian, Zeng Jing, Meifang Wu, Pei Tang, Lei Lei, Wene Liu, Li Tang · 2026 · Frontiers in Microbiology
60. Bile Acids as Integrators of Nutrient Sensing and Postprandial Metabolism
    Larissa Rodrigues, Carlos Mario Donado-Pestana, Guilherme Noronha Hernandez, Vinícius Leonardo Sousa Diniz, Marina Robles de Paola, Jarlei Fiamoncini · 2026 · Annual Review of Nutrition
61. Swertiamarin improves glucose and lipid metabolism disorders in T2DM via targeting FXR
    Yazhou Zhang, Zhanchi Xu, Qun Wang, Yue Han, Guijia Long, Tangqian Wu, Lu Yang, Yanning Nong, Qingfeng Ruan · 2026 · Phytomedicine
62. The gut microbiome organ
    Yang Bi, Weibin Song, Maria Glymenaki, Jie Hu, Xiru Li, Heng Huang, Yousong Peng, Shuaishuai Ni, Ornuma Haonon, Zhu Liu et al. · 2026 · iMeta
63. Metabolic Profiling of Epigenetic Aging and Its Associations With Aging‐Related Phenotypes and Modifiable Lifestyle Factors
    Xunying Zhao, Tianpei Ma, Maoyao Xia, Xinyang Dui, Yangdan Zhong, Xin Chen, Yang Qu, Bowen Lei, Qingwen Zhao, Xueyao Wu et al. · 2026 · Aging Cell
64. Carboxymethylcellulose ameliorates high-fat diet-associated colitis through the reduction of deoxycholic acid and restoration of mitochondrial complex I in macrophages
    Limei Shao, Linglong Ji, W.H. Liu, Wei Lv, Yingying Liu, Tian He, Jing Li, Qinghua Tan, Ling Liu · 2026 · Research Square
65. Gut Microbiota‐Isoallolithocholic Acid Crosstalk Promotes Calcium Oxalate Kidney Stone Formation via PARP1‐Mediated Parthanatos
    Zijian Zhou, Ruixi Yu, Xuan Zhou, Feng Shi, Zeyu Lin, Peng Gao, Lujia Wang, Ninghan Feng, Zhong Wu, Dawei Wang · 2026 · Advanced Science
66. Immunometabolic crosstalk in gallstone disease: driving roles of bacterial infection, NETs and MMP activation
    Sanjana Murali, R B Devi Krishna, Nandini Krishnamurthy, Jashwanth Balu, Pradeep Narahari Ram, Shanthi Vijayaraghavan, Rajesh Kumar Shanmugam, Harish Kumar P, Andrea Mary Francis · 2026 · Molecular Biology Reports
67. Bile acid-based therapeutics: recent advances in bile acid conjugates and derivatives
    Minho Seo, Jae-Hyeon Lee, Seong-Bin Yang, Gaeun Ma, Haneul Lee, Jimin Han, Yeonsu Ryu, Jooho Park · 2026 · Journal of Pharmaceutical Investigation
68. Molecular Mechanisms of the Gut–Liver–Placenta Axis in Intrahepatic Cholestasis of Pregnancy: Microbiota-Associated Pathogenesis and Next-Generation Therapeutic Strategies
    Ningwei Liu, Shuai‐Ran Zhang, Yiling Li · 2026 · International Journal of Molecular Sciences
69. Microbiome‐Derived Metabolites as Molecular Mediators of Gut‐Organ Communication: Mechanisms and Therapeutic Opportunities
    Giriprasad Venugopal, Anjali Anne Jacob, Jisha Elsa Varghese, George Chandy Mattethra · 2026 · Comprehensive physiology
70. Gut microbiota-derived small molecules, peptides, and proteins in GPCR signaling: current evidence for β-arrestin involvement
    Yushan Hu, Yiru Liu, Haiyan Yao, Siteng Wang, Yice Gao, Ruixue Li, Hui Sun · 2026 · Frontiers in Microbiology
71. Gut microbiota-driven imbalance of the gut-brain-immune homeostatic network in constipation: Pathogenic mechanisms and evolving therapeutic prospects
    Jianing Zhu, Binbin Zeng, Wenxu Zhu, Ying Liu, Xin Li, Yapei Zhang, Zhiheng Xu, Qingqing Xu, Wenjin Wu, Jialu Li et al. · 2026 · iScience
72. The Gut–Muscle Axis in Polycystic Ovary Syndrome: Proposed Mechanistic Roles of Intestinal Permeability, Bile Acid Signalling, and Skeletal Muscle Dysfunction
    Aiswarya Prasad, Ashwini Kishan, Sreedhish Keezhadath · 2026 · Metabolites
73. Research on the Intervention of Bile Stasis-Induced Pruritus Using Small Molecules Targeting MRGPRX4 Through High-Throughput Screening
    Qi Liang, Jiahao Kuang, Liangchen Wang, Hanghang Gou, Dandan Tang, Wei Peng, Chunjie Wu · 2026 · Molecules
74. Evaluating traditional Chinese medicine modulation of the gut microbiota–bile acid axis in metabolic and inflammatory diseases: mechanistic evidence and translational priorities
    Yanyan Yu, Jian Wang, Qingbao Yuan, Linghui Yu, Chunling Zhang · 2026 · Frontiers in Microbiology
75. Bile Acids and Their Receptors in Respiratory Diseases: Mechanistic and Therapeutic Perspectives
    Juanjuan Wan, Hui Zong, Dongdong He, Dingtao Li, Jing Yu, Guodong Wang, Liting Liu, Chuansheng Huang, Xinchun Wang, Liping Wang · 2026 · Biomolecules
76. Gut-liver axis dysregulation and restoration in decompensated hepatitis B cirrhosis: rationale and research progress of fecal microbiota transplantation
    Shu-Juan Gao, Jie Zhuang, Hui Cheng, Kai-Hong Hu, Li-Wei Zhuang, Yong Pan · 2026 · Frontiers in Microbiology
77. Gut microbial metabolism in aging: from metabolite production to organ-specific immunometabolic effects
    Zhen Wang, Yang Liu · 2026 · Frontiers in Nutrition
78. Analysis of Multi-Site Bile Acid Metabolic Profile Reveals an Association Between Bile Acid–FXR Signaling and Visceral Hypersensitivity in Heterotypic Intermittent Stress-Induced IBS
    Shiyuan Jiang, Chang Gao, Yafang Song, Ninan Zhang, Zhiyun Zhang, Xiaoyu Liu, Yangshuai Su, Xiaoyu Wang, Tao Li · 2026 · International Journal of Molecular Sciences
79. Cholesterol Absorption: Mechanisms, Regulation, and Therapeutic Targets
    Nyan Abdalqadir, Khosrow Adeli · 2026 · Elsevier eBooks
80. The Gut–Liver–Brain Axis in Neurodegeneration: Unraveling Metabolic–Immune Crosstalk from Peripheral Sensing to Central Vulnerability
    Jiahui ZHOU, Jiahui Wang, Xiaopu Li, Jiaxing Dou, Shihan Chen, Feng Xue · 2026 · Life