Molecular physiology of bile acid signaling in health, disease, and aging

Perino, Alessia, Demagny, Hadrien, Velazquez-Villegas, Laura, Schoonjans, Kristina·2021·Physiological Reviews

Cited by (480)

Items 301–400 of 480

  1. Clinical Significance of Serum Bile Acid Profiles in Fatty Liver
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  2. Multiple Timescale Dynamic Analysis of Functionally-Impairing Mutations in Human Ileal Bile Acid-Binding Protein
    Gergő Horváth, Bence Balterer, András Micsonai, József Kardos, Orsolya Tőke · 2022 · International Journal of Molecular Sciences
  3. Fecal microbiota transplantation in the treatment of astrovirus infection in a recipient of an allogeneic hematopoietic stem cell transplant: a clinical case
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  5. Cortex Dictamni induces cholestatic liver injury via the bile acid-gut-liver axis mediated by FXR signaling pathway in rats
    Xiaomin Xu, Fang Lü, Donghua Yu, Yu Wang, Pingping Chen, Wenkai Hu, Suxia Jia, Jiameixue Wo, Shumin Liu · 2025 · Journal of Ethnopharmacology
  6. Chitosan lactate mitigates metabolic-associated fatty liver disease via TGR5-mediated anti-inflammatory mechanisms and the gut-hepatic-bile acid axis
    Yiyu Lin, Weijun Lun, Yan Bai, Qi-Shi Che, Huan Cao, Jiao Guo, Zheng-Quan Su · 2025 · Journal of Functional Foods
  7. An integrin-based quercetin 7-rhamnoside liver-targeted delivery liposomes for intrahepatic cholestasis in pregnancy
    Xiaoying Feng, Ling Dai, Yanfang Guo, Liuting Zhong, Yuxiu Zheng, Senling Feng, Liping Cao, Zhongwen Yuan · 2025 · Materials Today Bio
  8. Chenodeoxycholic acid improves oocyte maturation and embryo quality during bisphenol A exposure by activating the EGFR-ERK1/2 signaling pathway
    Zhi-Yong An, Tuo Zhang, Gao-Jie Lu, X. Xu, Xue Fang, Sheng‐Zhong Han, Shuang-Yan Chang, Xi‐Jun Yin, Lin‐Hu Quan, Jin‐Dan Kang · 2025 · Ecotoxicology and Environmental Safety
  9. Harnessing the gut-heart axis for cardiovascular drug innovation: microbiome, metabolites, and personalized treatment strategies.
    Qhelen Mayline Chandra, Davini Clister, Princella Halim, Aminah Dalimunthe, M. Ichwan, Dina Keumala Sari, Chindy Umaya, Nahida Aktary, Amama Rani, Moon Nyeo Park et al. · 2026 · Clinica chimica acta; international journal of clinical chemistry
  10. Microbiota–gut–brain axis dysregulation in obesity: Neuroimmune-endocrine mechanisms and precision therapeutic targets
    Polu Picheswara Rao · 2026 · Obesity Medicine
  11. The alteration of bile acids and gut microbiota is associated with intestinal barrier dysfunction and inflammaging in human
    Yu-Mei Xu, Liang Zhang, Tian-Ci Li, Yanqin Zhao, Shuo Wang, Junwen Qi, Lin-Sen Shi · 2026 · Frontiers in Aging
  12. Taxonomic and functional remodeling of the gut microbiota during aging and implications for microbiota-derived biomarkers
    Burcu Tekin, Rafig Gurbanov · 2026 · World Journal of Microbiology and Biotechnology
  13. Oxysterol Signaling Within the Microbiome‐Regulated Gut–Liver–Brain Axis: Implications for Metabolic Homeostasis and Neurodegeneration
    Nila Ganamurali, Sarvesh Sabarathinam · 2026 · Comprehensive physiology
  14. Subclinical cholestasis is a hallmark of gut dysbiosis causing resistance to cancer immunotherapy
    Anne-Laure Mallard de La Varende, Ai-Ling Tian, Simon Thomas, Imran Lahmar, Meriem Messaoudene, Sijing Li, Omar Motiño, Hortense Guillaume-dit-Taunière, Valerio Iebba, Yoan Hurtado et al. · 2026 · Cancer Cell
  15. Secondary bile acid lithocholic acid attenuates neurally evoked ion transport in the rat distal colon
    Kohei Takahashi, Yuko Kuwahara, Ikuo Kato, Shinji Asano, Takaharu Kozakai, Yoshinori Marunaka, Atsukazu Kuwahara · 2022 · Biomedical Research
  16. Improvement of heat treated spirulina proteins and their enzymatic hydrolysates on osteoporosis under simulated microgravity
    Jian Zhang, Yuying Sun, Yaxin Huang, Huan Ruan, Bowen Yan, Nana Zhang, Hao Zhang, Wei Chen, Daming Fan · 2024 · Food Bioscience
  17. Comprehensive bile acid pool analysis during ex-vivo liver perfusion in a porcine model of ischemia-reperfusion injury
    Guillaume Rossignol, Xavier Muller, Thomas Alexandre Brunet, V. Bidault, Valérie Hervieu, Yohann Clément, Sophie Ayciriex, Jean‐Yves Mabrut, Arnaud Salvador, Kayvan Mohkam · 2024 · Scientific Reports
  18. Rise in plasma bile acids following hypoabsorptive bariatric surgeries predicts beneficial metabolic and homeostatic outcomes in male rats
    Paulette Mukorako, Audrey-Anne Lavoie, Jocelyn Trottier, Natacha Lemoine, Laurent D. Biertho, Stéfane Lebel, Julie Plamondon, André Tchernof, David H. St-Pierre, André Marette et al. · 2024 · American Journal of Physiology-Gastrointestinal and Liver Physiology
  19. Stard1 promotes cholestatic liver injury and disease progression by sensitizing to bile acid hepatotoxicity
    Laura Conde de la Rosa, Laura Fàbrega, Sandra Torres, Susana Núñez, Vicent Ribas, Paula Segalés, Ricardo A. Espinosa-Escudero, Estel Solsona‐Vilarrasa, María Jesús Monte, Álvaro Díaz‐González et al. · 2024 · Hepatology
  20. Yinchen-Gancao decoction ameliorated NASH in mice by reducing hepatic lipid accumulation, inhibiting hepatic inflammatory and endoplasmic reticulum stress
    Jing Zhao, Jingyi Jin, Yue Li, Shuang Zhang, Fengling Li, Jiamin Cui, Zhuoyuan Wang, Dongming Yan, Furong Qiu · 2025 · Journal of Ethnopharmacology
  21. Fxr-alpha Skips Alternatively in Liver Metabolism
    Sayeepriyadarshini Anakk, Angela Elizabeth Dean · 2020 · Gastroenterology
  22. MS/MS fragmentation pattern analysis confirms the production of the new esterified bile acids by the human gut microbiota
    Carlos J. García, Rocío Garcı́a-Villalba, David Beltrán, María Dolores Frutos-Lisón, Francisco Abraham Tomás-Barberán · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
  23. The Covert Surge: Murine Bile Acid Levels Are Associated With Pruritus in Pediatric Autoimmune Sclerosing Cholangitis
    Katharina Meinel, Dolóresz Szabó, Antal Dezsőfi, Sina Pohl, Tanja Strini, Theresa Greimel, Victor Aguiriano-Moser, Harald Haidl, Martin Wagner, Axel Schlagenhauf et al. · 2022 · Frontiers in Pediatrics
  24. Protecting liver health with microbial-derived succinylated bile acids
    Hadrien Demagny, Alessia Perino, Kristina Schoonjans · 2024 · Life Metabolism
  25. Microbiota-related metabolites correlated with the severity of COVID-19 patients
    Xinghuan Wang, Jing-Yu Wang, Fei Yu, Ding Shi, Jiaojiao Xie, Lanjuan Li, Baohong Wang · 2024 · Hepatobiliary & pancreatic diseases international
  26. Mechanisms of efficacy of drug therapy in type 2 diabetes: the role of microbiomes
    Yushan Li, Ziling HE, Chunyan Li, Jing Huang, Zheng YU · 2025 · Minerva Endocrinology
  27. Celastrol modulates calcium signaling in mouse taste bud cells and gustatory preference for a dietary fatty acid in the mouse
    Manal Benmouna, Chahid Benammar, Amira Sayed Khan, Aziz Hichami, Naim A. Khan · 2025 · Biochimie
  28. ORP2 regulates free cholesterol accumulation in hepatocytes during MASH
    Jin Wu, Yudi Zhao, Liwen Qiu, Qiaoli Chen, Xiaowei Wang, Jingwen Gu, Yan Liang, Yingjie Zhang, Hongyu Wang, Yang Liu et al. · 2025 · Hepatology Communications
  29. Towards the clinical use of peripheral bile acids: Recommendations to limit their preanalytical and analytical sources of variability
    Sebastian Joseph, Sophie de Buyl, Isabelle A. Leclercq, Kristian Serafimov, Olivier Féron, Laure‐Alix Clerbaux · 2025 · Practical Laboratory Medicine
  30. Research progress on the prevention and treatment of diseases with traditional Chinese medicine: A focus on BA receptors
    Xin Guo, Mei Zhang, Mengjun Xie · 2025 · The Journal of Steroid Biochemistry and Molecular Biology
  31. Integrating bile acid metabolism into precision nutrition strategies for improved swine performance
    Siying Li, Yanmin He, Weike Shaoyong, Yizhen Wang, Mingliang Jin · 2025 · Animal nutrition
  32. Smilax china L. Extract Alleviates Metabolic-Associated Fatty Liver Disease by Regulating Gut Microbiota and Bile Acid Metabolism
    Shiyuan Cheng, Huijun Li, Zhiying Sun, Yue Xiong, Jing Li, Jiaying Tian, Yue Shen, Li Shen, Jingyu Yang, Yuying Yang et al. · 2025 · Metabolites
  33. Distinct fasting and postprandial bile acid responses following Roux-en-Y and one-anastomosis gastric bypass
    Matti Jänis, Tuure Saarinen, Jari E. Karppinen, Per-Henrik Groop, Mikko Neuvonen, Mikko Niemi, Anne Juuti, Kirsi Hannele Pietiläinen, Sini Heinonen · 2026 · International Journal of Obesity
  34. Rethinking on bile acid-brain axis: decoding neurotoxic and neuroprotective landscape in aging and Alzheimer’s disease
    Gursimran Singh, Khadga Raj Aran · 2026 · Biogerontology
  35. Mechanistic insights into cholesterol–bile acid metabolic dysregulation in ovarian aging
    Ziqi Yang, Xinyu Qi, Jie Qiao · 2026 · Chinese Science Bulletin (Chinese Version)
  36. The role of the microbial-immune-bone axis in bone tumor development: mechanistic integration, systems modeling, and intervention prospects
    Yan Guo, Xue Wang, Yaokun Wu, Yongzhong Li, Xueyan Wei · 2026 · Frontiers in Cellular and Infection Microbiology
  37. Dysregulation of Farnesoid X Receptor on Neutrophil Homeostasis Exacerbates Intestinal Inflammation via the mTORC1‐Glycolysis Signaling Pathway
    Dengfeng Kang, Ai Q. Li, Xiangqi Xie, Han Liu, Liang Chen, Zhongsheng Feng, Xiang Gao, Han Gao, Xiaohan Wu, Huiying Lu et al. · 2026 · MedComm
  38. Secondary bile acids impact hepatic energy metabolism in rainbow trout, Oncorhynchus mykiss
    Gabriel Pérez-Tierra, Jessica Calo, Sara Comesaña, Cristina Velasco, Jose Luis Soengas, Ayelén Melisa Blanco · 2026 · Journal of Experimental Biology
  39. Gut-Derived FGF15 Modulates Lean Mass, Bone, and Bile Acid Responses to Weight Loss
    Nadejda Bozadjieva-Kramer, Garrett McMahon, Ziru Li, Jordan Wean, Jae Hoon Shin, Andriy Myronovych, Robert W. O’Rourke, Ormond A. MacDougald, Randy J. Seeley · 2026 · Diabetes
  40. Bile Acids and the Gut–X Axis: TCM-Mediated Systemic Protection and Therapeutic Opportunities for Multi-Organ Diseases
    Jialu He, Linjie Qin, Xian Sun · 2026 · Metabolites
  41. Microbiome remodeling during aging: Integrative multi-omics and spatiotemporal perspectives on immune and metabolic regulation
    Xinyue Ren, Jingwen Ma, Yijie Zhao, Mingyu Yang, Yilin Li, Wei Song, Nan Wang · 2026 · Ageing Research Reviews
  42. Gut Microbiota-Targeted Nutrition for Healthy Aging: Mechanistic Roles of Polyphenols and Dietary Fiber in Geroscience
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  43. Yin-Yang control of energy balance by lipids in the hypothalamus: The endocannabinoids vs bile acids case
    Thomas Ho-yin Lee, Daniela Cota, Carmelo Quarta · 2022 · Biochimie
  44. Interaction of Intestinal Microbiota with Medications
    Mengchen Liu, Jiaqiang Xu, Qianna Jin, Yunqiao Li · 2023 · Current Drug Metabolism
  45. Honokiol attenuates ductular reaction, regulates of bile acids metabolism, and inhibits inflammatory response in murine cholestatic liver injury model
    Juan Hao, Xiaoyu Shen, Xiaohong Shao, Chunling Zhu, Kan Lu, Yi Xu, Yiyue Chen, Jibo Liu, Yaqin Ding, Xin Xie et al. · 2023 · Arabian Journal of Chemistry
  46. Dimethyl Sulfoxide Inhibits Bile Acid Synthesis in Healthy Mice but Does Not Protect Mice from Bile-Acid-Induced Liver Damage
    Xi Chen, Huiqiao Li, Yue Liu, Jing Qi, Bingning Dong, Shixia Huang, Shangang Zhao, Yi Zhu · 2023 · Biology
  47. Exploring the interaction between bile acid and intestinal microbiota in acute-on-chronic liver failure and the progress of treatment strategies
    Yuyu Zeng, Dakai Gan, Yuhe Zeng, Molong Xiong · 2024
  48. Hormone based therapy and crosstalk beyond hormones
    Tianru Jin · 2024 · Medical Review
  49. Gut Microbiota: Role in Health and Diseases
    Kanchan Bhardwaj, Bhabatosh Das, Tao Zuo, Sudhanshu Vrati · 2025 · IntechOpen eBooks
  50. The mood stabilizers lithium and valproate disrupt hepatic and intestinal farnesoid X receptor signalling and increase bile synthesis in the rat
    Sofia Cussotto, Anna V. Golubeva, Alvaro Lopez Gallardo, Thomaz F. S. Bastiaanssen, Alexander V. Zhdanov, Gerard M. Moloney, Caitríona Scaife, Jane A. English, Susan A. Joyce, Timothy G. Dinan et al. · 2025 · Experimental Physiology
  51. Determinants of site-selectivity in human ileal bile acid-binding protein by NMR dynamic analysis of a functionally-impaired mutant
    Tamara Teski, Gergő Horváth, Orsolya Tőke · 2025 · Journal of Structural Biology
  52. The year 2020 in Atherosclerosis
    Christoph J. Binder, Jan Borén, Alberico Luigi Catapano, Florian Kronenberg, Ziad Mallat, Simona Negrini, Katariina Öörni, Paolo Raggi, Arnold von Eckardstein · 2021 · Atherosclerosis
  53. Promoting longevity with less cancer: The 2022 International Conference on Aging and Cancer
    Yan Cui, Kai Wang, Danli Jiang, Yi-Zhou Jiang, Dawei Shi, James V. DeGregori, Samuel Waxman, Ruibao Ren · 2023 · Aging and Cancer
  54. D-limonene supplementation does not alter postprandial metabolism of postmenopausal women challenged with a mixed macronutrient tolerance test: a pilot study
    Amanda Pereira Vasconcelos, Carlos Mario Donado-Pestana, Tushar H. More, Graziela Biude Silva Duarte, Stephany Gonçalves Duarte, Caroline Gieseler Dias, Larissa Rodrigues, Guilherme Noronha Hernandez, Ricardo Ambrósio Fock, Karsten Hiller et al. · 2024 · Food Production Processing and Nutrition
  55. Editorial: Postprandial physiology
    Jarlei Fiamoncini, John W. I. Newman, Lorraine Brennan · 2022 · Frontiers in Nutrition
  56. VSV infection and LPS treatment alter serum bile acid profiles, bile acid biosynthesis, and bile acid receptors in mice
    Yamei Li, Yan Luo, Chao Wang, Lei Xu, Xinhua Dai, Yunfei An, Lin He, Dongmei Zeng, Yangjuan Bai, Hua Zhang · 2024 · Microbiology Spectrum
  57. Results of oral litholysis with ursodeoxycholic acid in a patient with cholesterol cholecystolithiasis
    Pavel Vasilievich Seliverstov, В Г Радченко, Ольга Петровна Дуданова, Надежда Алексеевна Ларина, Курбатова Ирина Валерьевна, A. A. Shipovskaya · 2024 · Terapevticheskii arkhiv
  58. Maternal exposure to high level of ursodeoxycholic acid during pregnancy promotes hepatic lipid deposition in the offspring by reducing the methylation level of Fasn gene
    Dan Hu, Xiaoting Wu, Manman Hou, Pin Song, Chen Qu, Yingdong Ni · 2025 · Biochemical Pharmacology
  59. Bile Acids Are Potential Negative Allosteric Modulators of M1 Muscarinic Receptors
    Wenbo Yu, Alexander D. MacKerell, David J. Weber, Jean‐Pierre Raufman · 2025 · Biomolecules
  60. The synergistic effects of inulin and rumen‐bypass fat on host immunity, bile acid profiles, and gut microbiota in weaned goats
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  61. Associations of serum bile acids and amino acids with low skeletal muscle mass among Chinese population: a cross-sectional study
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  62. Yixintai treats chronic heart failure in rats by regulating gut microbiota and bile acid
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  63. Prominin-1 Regulates Retinal Pigment Epithelium Homeostasis: Transcriptomic Insights into Degenerative Mechanisms
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  64. Gene dosage imbalance disrupts systemic metabolism in the Dp16 Down syndrome mouse model
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  65. Quercetin Ameliorates Glucose Metabolism Dysregulation in CUMS Model Rats via the Bile Acid–FXR/TGR5 Axis
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  66. Material basis and mechanism of Tangzhiqing in alleviating diabetic atherosclerosis: integrated serum pharmacochemistry, pharmacokinetics, metabolomics, bile acid profiling and 16S rRNA sequencing study
    Xuelian Gao, Fengying Wang, Hongli Duan, Yaxue Sun, Xin Meng, Shuang Tian, Yuhong Huang, Ziqiang Li · 2026 · Journal of Ethnopharmacology
  67. Capsaicin Improves Lipid Metabolism Disorders Caused by LPS-Induced Immune Stress in Weaned Piglets
    Jianlei Zhao, Wenyi Liu, Xin Zhang, Zechen Xie, Shuhan Liu, Wenjun Zhou, Lili Zhang · 2026 · Veterinary Sciences
  68. Synergistic Effects of Fu Brick Tea Extract and Millet on Antiobesity in High-Fat Diet-Fed Mice through Gut Microbiota Modulation and Activation of the Ffar2 – Gcg / Pyy Molecular Pathway
    Ning Han, Xinwei Tian, Zhuo Shen, Lulu Wang, Haoyan Zhu, Yan Zhao, Xingbin Yang · 2026 · Journal of Agricultural and Food Chemistry
  69. Inhibition of ferroptosis by microbiota‐derived lithocholic acid underlies the intestinal radioprotection of a host defensin‐derived oligopeptide
    Xue Ouyang, Yingjuan He, Zihao Jin, Shaobo Wang, Gaomei Zhao, Xiaona Su, Jia Du, Yin Chen, Chengzhang Tan, Xin Li et al. · 2026 · iMeta
  70. Immune cytokines as a bridge linking the gut–liver–ovary axis in the pathogenesis of premature ovarian failure
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  71. Bile acid metabolism and sleep: Mechanistic interplay and clinical implications of the gut–liver–brain axis
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  72. Microcystin-LR Disrupts Bile Acid Homeostasis, Driving Cholestatic Liver Injury and Gallstones via FXR/SHP Antagonism
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  73. Combined Use of Tryptophan and Fu Brick Tea in Low Doses Promotes Weight Loss in Mice by Modulating AhR-Mediated Tryptophan Metabolism and Reshaping the Gut Microbiota
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  74. Multi-omics reveals that chenodeoxycholic acid promotes calcium oxalate kidney stone formation by targeting catalase
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  75. Active bile acid metabolism could contribute to muscle preservation in hibernating bears via the TGR5 pathway
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  76. Arid1a deficiency promotes metabolic dysfunction-associated steatohepatitis and hepatocellular carcinoma by disrupting the FXR-gut microbiota-bile acid axis
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  77. White Adipose Tissue as a Functional Target of Secondary Bile Acids in Rainbow Trout (Oncorhynchus mykiss)
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  78. Bile acids in the tumor immune microenvironment of hepatocellular carcinoma: Mechanisms of immunotherapy resistance and therapeutic opportunities
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  79. Role of the gut microbiota–bile acid axis in liver fibrosis based on microbiomics and targeted metabolomics
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