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Cited by 269Drug Transport and Resistance MechanismsGut microbiota and healthGastrointestinal motility and disorders

Guts and Gall: Bile Acids in Regulation of Intestinal Epithelial Function in Health and Disease

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Hegyi, Peter, Maléth, Jozsef, Walters, Julian R., Hofmann, Alan F., Keely, Stephen J.·2018·Physiological Reviews
DOI 10.1152/physrev.00054.2017
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Abstract

Epithelial cells line the entire surface of the gastrointestinal tract and its accessory organs where they primarily function in transporting digestive enzymes, nutrients, electrolytes, and fluid to and from the luminal contents. At the same time, epithelial cells are responsible for forming a physical and biochemical barrier that prevents the entry into the body of harmful agents, such as bacteria and their toxins. Dysregulation of epithelial transport and barrier function is associated with the pathogenesis of a number of conditions throughout the intestine, such as inflammatory bowel disease, chronic diarrhea, pancreatitis, reflux esophagitis, and cancer. Driven by discovery of specific receptors on intestinal epithelial cells, new insights into mechanisms that control their synthesis and enterohepatic circulation, and a growing appreciation of their roles as bioactive bacterial metabolites, bile acids are currently receiving a great deal of interest as critical regulators of epithelial function in health and disease. This review aims to summarize recent advances in this field and to highlight how bile acids are now emerging as exciting new targets for disease intervention.

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  • De-conjugated bile acids are less effectively re-absorbed from the small intestine and can leak into the large intestine.

    “De-conjugated bile acids are less effectively re-absorbed from the small intestine and thus can leak into the large intestine, as recently reviewed (Hegyi et al., 2018).”

    From The Microbiota-Gut-Brain Axis (2019) · cites this paper as Hegyi et al., 2018

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Authors
Hegyi, P., Maléth, J., Walters, J. R., Hofmann, A. F., & Keely, S. J.
Affiliations
  • Momentum Translational Gastroenterology Research Group, Hungarian Academy of Sciences–University of Szeged, Szeged, Hungary; Institute for Translational Medicine, Medical School, University of Pécs, Pécs, Hungary; Momentum Epithelial Cell Signalling and Secretion Research Group and First Department of Medicine, University of Szeged, Szeged, Hungary; Division of Digestive Diseases, Department of Gastroenterology, Hammersmith Hospital, Imperial College London, London, United Kingdom; Division of...
  • Royal College of Surgeons in Ireland (IE)
ORCID
Venue
Physiological Reviews
Publisher
American Physiological Society
Published
2018-10-01
Volume
98
Issue
4
Pages
1983-2023
ISSN
  • 0031-9333 (ISSN-L)
  • 1522-1210
DOI
10.1152/physrev.00054.2017
OpenAlex
W2885512756
Cited by
269
References
525
Citations by year
2026: 23 · 2025: 31 · 2024: 37 · 2023: 40 · 2022: 42 · 2021: 37 · 2020: 41 · 2019: 15 · 2018: 3
FWCI
2.51
Type
journal article
Language
en
Open access
Locations
  • Physiological Reviews (publishedVersion)
  • PubMed (publishedVersion)
  • SZTE Publicatio Repozitórium (University of Szeged) (acceptedVersion, other-oa)
  • Spiral (Imperial College London) (submittedVersion)
Funders
  • Science Foundation Ireland (SFI) (16/IA/4445)
  • Crohn's and Colitis Foundation of America (CCFA) (354322)
  • Országos Tudományos Kutatási Alapprogramok (Hungarian Scientific Research Fund) (K116634)
  • Hungarian National Reseach Deveopment and Innovation Office (PD115974)
  • Hungarian National Development and Innovation Office (PD115974)
  • Bolyai Research Fellowship (BO/00440/16/5)
  • Hungarian Academy of Sciences | Magyar Tudomanyos Akademia Szamitastechnikai es Automatizalasi Kutatointezet (MTA SZTAKI) (LP2017-18/2017)
Topics
  • Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
  • Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
Keywords
bile acids, epithelial barrier function, epithelial transport, enterohepatic circulation, bile acid receptors, bacterial metabolites, inflammatory bowel disease, chronic diarrhea, pancreatitis, reflux esophagitis, intestinal cancer, therapeutic target
MeSH terms
Animals, Bile Acids and Salts, Epithelial Cells, Gastrointestinal Diseases, Humans, Intestinal Mucosa, Intestines

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