Impact of the gut microbiota on inflammation, obesity, and metabolic disease
Open accessAbstract
The human gut harbors more than 100 trillion microbial cells, which have an essential role in human metabolic regulation via their symbiotic interactions with the host. Altered gut microbial ecosystems have been associated with increased metabolic and immune disorders in animals and humans. Molecular interactions linking the gut microbiota with host energy metabolism, lipid accumulation, and immunity have also been identified. However, the exact mechanisms that link specific variations in the composition of the gut microbiota with the development of obesity and metabolic diseases in humans remain obscure owing to the complex etiology of these pathologies. In this review, we discuss current knowledge about the mechanistic interactions between the gut microbiota, host energy metabolism, and the host immune system in the context of obesity and metabolic disease, with a focus on the importance of the axis that links gut microbes and host metabolic inflammation. Finally, we discuss therapeutic approaches aimed at reshaping the gut microbial ecosystem to regulate obesity and related pathologies, as well as the challenges that remain in this area.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Changes in the aging intestinal microbiota can adversely affect host metabolism and immunity and are associated with development of cardiovascular, autoimmune, metabolic, and neurodegenerative disorders.
“These changes can adversely affect the host metabolism and immunity [25–27, 40, 64, 86, 110, 112, 118] and are associated with the development of cardiovascular, autoimmune, metabolic, and neurodegenerative disorders [17, 90, 122, 132].”
From Fecal microbiota transfer between young and aged mice reverses hallmarks of the aging gut, eye, and brain (2022) · cites this paper as [17]
Dysbiosis has been linked to obesity, diabetes mellitus, and inflammatory bowel disease, and altering the microbiome may treat these conditions.
“Alterations of the microbiome, known as dysbiosis, have also been shown to be related to obesity, diabetes mellitus and inflammatory bowel disease64, and manipulation of the microbiome may be a pathway to treating these pathological conditions.”
From Clinical metagenomics (2019) · cites this paper as [64]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
An obesity-associated gut microbiome with increased capacity for energy harvest
Turnbaugh, P. J., Ley, R. E., Mahowald, M. A., Magrini, V., Mardis, E. R., & Gordon, J. I. (2006) · Nature · doi:10.1038/nature05414 · Cited by 12,444 · see citing works
Diet rapidly and reproducibly alters the human gut microbiome
David, L. A., Maurice, C. F., Carmody, R. N., Gootenberg, D. B., Button, J. E., Wolfe, B. E., Ling, A. V., Devlin, A. S., Varma, Y., Fischbach, M. A., et al. (2014) · Nature · doi:10.1038/nature12820 · Cited by 10,100 · see citing works
Hill (2014) · doi:10.1038/nrgastro.2014.66 · Cited by 9,592 · see citing works
The metabolic syndrome—a new worldwide definition
Alberti, K. G. M., Zimmet, P., & Shaw, J. (2005) · The Lancet · doi:10.1016/s0140-6736(05)67402-8 · Cited by 9,352 · see citing works
Metabolic Endotoxemia Initiates Obesity and Insulin Resistance
Cani, P. D., Amar, J., Iglesias, M. A., Poggi, M., Knauf, C., Bastelica, D., Neyrinck, A. M., Fava, F., Tuohy, K. M., Chabo, C., et al. (2007) · Diabetes · doi:10.2337/db06-1491 · Cited by 6,638 · see citing works
The gut microbiota as an environmental factor that regulates fat storage
Bäckhed, F., Ding, H., Wang, T., Hooper, L. V., Koh, G. Y., Nagy, A., Semenkovich, C. F., & Gordon, J. I. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0407076101 · Cited by 6,245 · see citing works
Obesity alters gut microbial ecology
Ley, R. E., Bäckhed, F., Turnbaugh, P., Lozupone, C. A., Knight, R. D., & Gordon, J. I. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0504978102 · Cited by 6,176 · see citing works
Mechanisms linking obesity to insulin resistance and type 2 diabetes
Kahn, S. E., Hull, R. L., & Utzschneider, K. M. (2006) · Nature · doi:10.1038/nature05482 · Cited by 5,448 · see citing works
Smith, P. M., Howitt, M. R., Panikov, N., Michaud, M., Gallini, C. A., Bohlooly-Y, M., Glickman, J. N., & Garrett, W. S. (2013) · Science · doi:10.1126/science.1241165 · Cited by 5,413 · see citing works
Insulin signalling and the regulation of glucose and lipid metabolism
Saltiel, A. R., & Kahn, C. R. (2001) · Nature · doi:10.1038/414799a · Cited by 5,326 · see citing works
Cani, P. D., Bibiloni, R., Knauf, C., Waget, A., Neyrinck, A. M., Delzenne, N. M., & Burcelin, R. (2008) · Diabetes · doi:10.2337/db07-1403 · Cited by 4,819 · see citing works
Host-gut microbiota metabolic interactions
Nicholson, J. K., Holmes, E., Kinross, J., Burcelin, R., Gibson, G., Jia, W., & Pettersson, S. (2012) · Science · doi:10.1126/science.1223813 · Cited by 4,760 · see citing works
Self-citationRichness of human gut microbiome correlates with metabolic markers
Le Chatelier, E., Nielsen, T., Qin, J., Prifti, E., Hildebrand, F., Falony, G., Almeida, M., Arumugam, M., Batto, J.-M., Kennedy, S., et al. (2013) · Nature · doi:10.1038/nature12506 · Cited by 4,662 · see citing works
Interactions Between the Microbiota and the Immune System
Hooper, L. V., Littman, D. R., & Macpherson, A. J. (2012) · Science · doi:10.1126/science.1223490 · Cited by 4,173 · see citing works
Gut Microbiota from Twins Discordant for Obesity Modulate Metabolism in Mice
Ridaura, V. K., Faith, J. J., Rey, F. E., Cheng, J., Duncan, A. E., Kau, A. L., Griffin, N. W., Lombard, V., Henrissat, B., Bain, J. R., et al. (2013) · Science · doi:10.1126/science.1241214 · Cited by 3,788 · see citing works
Inflammatory Mechanisms in Obesity
Gregor, M. F., & Hotamisligil, G. S. (2011) · Annual Review of Immunology · doi:10.1146/annurev-immunol-031210-101322 · Cited by 3,754 · see citing works
TLR4 links innate immunity and fatty acid-induced insulin resistance
Shi, H., Kokoeva, M. V., Inouye, K., Tzameli, I., Yin, H., & Flier, J. S. (2006) · Journal of Clinical Investigation · doi:10.1172/jci28898 · Cited by 3,690 · see citing works
Vrieze, A., Van Nood, E., Holleman, F., Salojärvi, J., Kootte, R. S., Bartelsman, J. F. W. M., Dallinga–Thie, G. M., Ackermans, M. T., Serlie, M. J., Oozeer, R., et al. (2012) · Gastroenterology · doi:10.1053/j.gastro.2012.06.031 · Cited by 2,913 · see citing works
Dietary modulation of the human colonic microbiota: updating the concept of prebiotics
Gibson, G. R., Probert, H. M., Loo, J. V., Rastall, R. A., & Roberfroid, M. B. (2004) · Nutrition Research Reviews · doi:10.1079/nrr200479 · Cited by 2,539 · see citing works
Inflammatory links between obesity and metabolic disease
Lumeng, C. N., & Saltiel, A. R. (2011) · Journal of Clinical Investigation · doi:10.1172/jci57132 · Cited by 2,319 · see citing works
The gut microbiota and host health: a new clinical frontier
Marchesi, J. R., Adams, D. H., Fava, F., Hermes, G. D. A., Hirschfield, G. M., Hold, G., Quraishi, M. N., Kinross, J., Smidt, H., Tuohy, K. M., et al. (2016) · Gut · doi:10.1136/gutjnl-2015-309990 · Cited by 2,302 · cited 3× · see citing works
“In particular, the gut microbiota is believed to contribute to metabolic diseases via stimulation of low-grade inflammation [13].”
BackgroundInfluentialLocal and systemic insulin resistance resulting from hepatic activation of IKK-β and NF-κB
Cai, D., Yuan, M., Frantz, D. F., Melendez, P. A., Hansen, L., Lee, J., & Shoelson, S. E. (2005) · Nature Medicine · doi:10.1038/nm1166 · Cited by 2,245 · see citing works
Microbiota-Generated Metabolites Promote Metabolic Benefits via Gut-Brain Neural Circuits
De Vadder, F., Kovatcheva-Datchary, P., Goncalves, D., Vinera, J., Zitoun, C., Duchampt, A., Bäckhed, F., & Mithieux, G. (2014) · Cell · doi:10.1016/j.cell.2013.12.016 · Cited by 2,200 · see citing works
Metabolic Syndrome and Altered Gut Microbiota in Mice Lacking Toll-Like Receptor 5
Vijay-Kumar, M., Aitken, J. D., Carvalho, F. A., Cullender, T. C., Mwangi, S., Srinivasan, S., Sitaraman, S. V., Knight, R., Ley, R. E., & Gewirtz, A. T. (2010) · Science · doi:10.1126/science.1179721 · Cited by 2,068 · see citing works
Dietary intervention impact on gut microbial gene richness
Cotillard, A., Kennedy, S. P., Kong, L. C., Prifti, E., Pons, N., Le Chatelier, E., Almeida, M., Quinquis, B., Levenez, F., Galleron, N., et al. (2013) · Nature · doi:10.1038/nature12480 · Cited by 1,832 · see citing works
Interleukin-1-receptor antagonist in type 2 diabetes mellitus
Larsen, C. M., Faulenbach, M., Vaag, A., Vølund, A., Ehses, J. A., Seifert, B., Mandrup-Poulsen, T., & Donath, M. Y. (2007) · New England Journal of Medicine · doi:10.1056/nejmoa065213 · Cited by 1,798 · see citing works
Cani, P. D., Neyrinck, A. M., Fava, F., Knauf, C., Burcelin, R., Tuohy, K. M., Gibson, G. R., & Delzenne, N. M. (2007) · Diabetologia · doi:10.1007/s00125-007-0791-0 · Cited by 1,770 · see citing works
Abdominal obesity and the metabolic syndrome: contribution to global cardiometabolic risk
Després, J.-P., Lemieux, I., Bergeron, J., Pibarot, P., Mathieu, P., Larose, E., Rodés-Cabau, J., Bertrand, O. F., & Poirier, P. (2008) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.107.159228 · Cited by 1,589 · see citing works
Samuel, B. S., Shaito, A., Motoike, T., Rey, F. E., Backhed, F., Manchester, J. K., Hammer, R. E., Williams, S. C., Crowley, J., Yanagisawa, M., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0808567105 · Cited by 1,564 · see citing works
The Application of Ecological Theory Toward an Understanding of the Human Microbiome
Costello, E. K., Stagaman, K., Dethlefsen, L., Bohannan, B. J. M., & Relman, D. A. (2012) · Science · doi:10.1126/science.1224203 · Cited by 1,437 · see citing works
The composition of the gut microbiota throughout life, with an emphasis on early life
Rodríguez, J. M., Murphy, K., Stanton, C., Ross, R. P., Kober, O. I., Juge, N., Avershina, E., Rudi, K., Narbad, A., Jenmalm, M. C., et al. (2015) · Microbial Ecology in Health and Disease · doi:10.3402/mehd.v26.26050 · Cited by 1,320 · see citing works
Human colonic microbiota associated with diet, obesity and weight loss
Duncan, S. H., Lobley, G. E., Holtrop, G., Ince, J., Johnstone, A. M., Louis, P., & Flint, H. J. (2008) · International Journal of Obesity · doi:10.1038/ijo.2008.155 · Cited by 1,222 · see citing works
Minireview: Gut microbiota: The neglected endocrine organ
Clarke, G., Stilling, R. M., Kennedy, P. J., Stanton, C., Cryan, J. F., & Dinan, T. G. (2014) · Molecular Endocrinology · doi:10.1210/me.2014-1108 · Cited by 1,192 · see citing works
The first 1000 cultured species of the human gastrointestinal microbiota
Rajilić-Stojanović, M., & de Vos, W. M. (2014) · FEMS Microbiology Reviews · doi:10.1111/1574-6976.12075 · Cited by 1,182 · see citing works
The role of hepatic lipids in hepatic insulin resistance and type 2 diabetes
Perry, R. J., Samuel, V. T., Petersen, K. F., & Shulman, G. I. (2014) · Nature · doi:10.1038/nature13478 · Cited by 1,136 · see citing works
Understanding 'Global' Systems Biology: Metabonomics and the Continuum of Metabolism
Nicholson, J. K., & Wilson, I. D. (2003) · Nature Reviews Drug Discovery · doi:10.1038/nrd1157 · Cited by 1,121 · see citing works
Self-citationVenkatesh, M., Mukherjee, S., Wang, H., Li, H., Sun, K., Benechet, A. P., Qiu, Z., Maher, L., Redinbo, M. R., Phillips, R. S., et al. (2014) · Immunity · doi:10.1016/j.immuni.2014.06.014 · Cited by 1,066 · see citing works
Self-citationDumas, M.-E., Barton, R. H., Toye, A., Cloarec, O., Blancher, C., Rothwell, A., Fearnside, J., Tatoud, R., Blanc, V., Lindon, J. C., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0601056103 · Cited by 1,042 · see citing works
Self-citationAMP-activated protein kinase, a metabolic master switch: possible roles in Type 2 diabetes
Winder, W. W., & Hardie, D. G. (1999) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1999.277.1.e1 · Cited by 1,000 · see citing works
Gut microorganisms, mammalian metabolism and personalized health care
Nicholson, J. K., Holmes, E., & Wilson, I. D. (2005) · Nature Reviews Microbiology · doi:10.1038/nrmicro1152 · Cited by 945 · see citing works
Self-citationMurphy, E. F., Cotter, P. D., Healy, S., Marques, T. M., O’Sullivan, Ó., Fouhy, F., Clarke, S. F., O’Toole, P. W., Quigley, E. M. M., Stanton, C., et al. (2010) · Gut · doi:10.1136/gut.2010.215665 · Cited by 942 · see citing works
Cani, P. D., Osto, M., Geurts, L., & Everard, A. (2012) · Gut Microbes · doi:10.4161/gmic.19625 · Cited by 864 · see citing works
Cani, P. D., Lecourt, E., Dewulf, E. M., Sohet, F. M., Pachikian, B. D., Naslain, D., Backer, F. D., Neyrinck, A. M., & Delzenne, N. M. (2009) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.2009.28095 · Cited by 763 · see citing works
Parnell, J. A., & Reimer, R. A. (2009) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.2009.27465 · Cited by 728 · see citing works
Chylomicrons promote intestinal absorption of lipopolysaccharides
Ghoshal, S., Witta, J., Zhong, J., de Villiers, W., & Eckhardt, E. (2009) · Journal of Lipid Research · doi:10.1194/jlr.m800156-jlr200 · Cited by 662 · see citing works
Teflon Bearings in Base Isolation II: Modeling
Constantinou, M. C., Mokha, A. S., & Reinhorn, A. M. (1990) · Journal of Structural Engineering · doi:10.1061/(asce)0733-9445(1990)116:2(455 · Cited by 631 · see citing works
Interactions Between Gut Microbiota and Host Metabolism Predisposing to Obesity and Diabetes
Musso, G., Gambino, R., & Cassader, M. (2011) · Annual Review of Medicine · doi:10.1146/annurev-med-012510-175505 · Cited by 598 · see citing works
Ussar, S., Griffin, N. W., Bézy, O., Fujisaka, S., Vienberg, S. G., Softic, S., Deng, L., Bry, L., Gordon, J. I., & Kahn, C. R. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.07.007 · Cited by 529 · see citing works
Ghanim, H., Abuaysheh, S., Sia, C. L., Korzeniewski, K., Chaudhuri, A., Fernandez-Real, J. M., & Dandona, P. (2009) · Diabetes Care · doi:10.2337/dc09-0979 · Cited by 494 · see citing works
Adaptive immunity in obesity and insulin resistance
Sell, H., Habich, C., & Eckel, J. (2012) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2012.114 · Cited by 486 · see citing works
Microbiota-induced obesity requires farnesoid X receptor
Parséus, A., Sommer, N., Sommer, F., Caesar, R., Molinaro, A., Ståhlman, M., Greiner, T. U., Perkins, R., & Bäckhed, F. (2016) · Gut · doi:10.1136/gutjnl-2015-310283 · Cited by 481 · see citing works
Colman, R. J., & Rubin, D. T. (2014) · Journal of Crohn's and Colitis · doi:10.1016/j.crohns.2014.08.006 · Cited by 475 · see citing works
Free fatty acids and insulin resistance
Delarue, J., & Magnan, C. (2007) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0b013e328042ba90 · Cited by 463 · see citing works
Zhou, J., Martin, R. J., Tulley, R. T., Raggio, A. M., McCutcheon, K. L., Shen, L., Danna, S. C., Tripathy, S., Hegsted, M., & Keenan, M. J. (2008) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.90637.2008 · Cited by 460 · see citing works
Vulevic, J., Drakoularakou, A., Yaqoob, P., Tzortzis, G., & Gibson, G. R. (2008) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.2008.26242 · Cited by 451 · see citing works
Phosphatidylcholine biosynthesis and lipoprotein metabolism
Cole, L., Vance, J. E., & Vance, D. E. (2011) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2011.09.009 · Cited by 439 · see citing works
Enterocyte TLR4 Mediates Phagocytosis and Translocation of Bacteria Across the Intestinal Barrier
Neal, M. D., Leaphart, C. L., Levy, R. M., Prince, J. M., Billiar, T. R., Watkins, S. C., Li, J., Çetin, S., Ford, H. R., Schreiber, A. D., et al. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.176.5.3070 · Cited by 434 · see citing works
Russell, W. R., Duncan, S. H., Scobbie, L., Duncan, G., Cantlay, L., Calder, A. G., Anderson, S. E., & Flint, H. J. (2013) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201200594 · Cited by 417 · see citing works
Zhang, C., Yin, A., Li, H., Wang, R., Wu, G. G., Shen, J., Zhang, M. H., Wang, L., Hou, Y., OuYang, H., et al. (2015) · EBioMedicine · doi:10.1016/j.ebiom.2015.07.007 · Cited by 416 · see citing works
Self-citationCani, P. D., Knauf, C., Iglesias, M. A., Drucker, D. J., Delzenne, N. M., & Burcelin, R. (2006) · Diabetes · doi:10.2337/db05-1360 · Cited by 404 · see citing works
Behaviour of the double concave Friction Pendulum bearing
Fenz, D. M., & Constantinou, M. C. (2006) · Earthquake Engineering & Structural Dynamics · doi:10.1002/eqe.589 · Cited by 403 · see citing works
Larsson, E., Tremaroli, V., Lee, Y. S., Koren, O., Nookaew, I., Fricker, A. D., Nielsen, J., Ley, R. E., & Bäckhed, F. (2011) · Gut · doi:10.1136/gutjnl-2011-301104 · Cited by 386 · see citing works
Probiotics in prevention and treatment of obesity: a critical view
Kobyliak, N. M., Conte, C., Cammarota, G., Haley, A. P., Štyriak, I., Gašpar, Ľ., Fusek, J., Rodrigo, L., & Kružliak, P. (2016) · Nutrition & Metabolism · doi:10.1186/s12986-016-0067-0 · Cited by 359 · see citing works
Colonic bacterial metabolites and human health
Russell, W. R., Hoyles, L., Flint, H. J., & Dumas, M. (2013) · Current Opinion in Microbiology · doi:10.1016/j.mib.2013.07.002 · Cited by 353 · see citing works
Self-citationSanchez, M., Darimont, C., Drapeau, V., Emady-Azar, S., Lepage, M., Rezzonico, E., Ngom-Bru, C., Berger, B., Philippe, L., Ammon-Zuffrey, C., et al. (2014) · British Journal of Nutrition · doi:10.1017/s0007114513003875 · Cited by 351 · see citing works
Vulevic, J., Juric, A., Tzortzis, G., & Gibson, G. R. (2013) · The Journal of Nutrition · doi:10.3945/jn.112.166132 · Cited by 349 · see citing works
Expression of the short-chain fatty acid receptor, GPR43, in the human colon
Karaki, S.-I., Tazoe, H., Hayashi, H., Kashiwabara, H., Tooyama, K., Suzuki, Y., & Kuwahara, A. (2007) · Journal of Molecular Histology · doi:10.1007/s10735-007-9145-y · Cited by 336 · see citing works
Expression of short-chain fatty acid receptor GPR41 in the human colon
Tazoe, H., Otomo, Y., Karaki, S.-I., Kato, I., Fukami, Y., TERASAKI, M., & Kuwahara, A. (2009) · Biomedical Research · doi:10.2220/biomedres.30.149 · Cited by 333 · see citing works
The Gut Microbiota Regulates Intestinal CD4 T Cells Expressing RORγt and Controls Metabolic Disease
Garidou, L., Pomié, C., Klopp, P., Waget, A., Charpentier, J., Aloulou, M., Giry, A., Serino, M., Stenman, L., Lahtinen, S., et al. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.06.001 · Cited by 303 · see citing works
Rajkumar, H., Mahmood, N., Kumar, M., Varikuti, S. R., Challa, H. R., & Myakala, S. P. (2014) · Mediators of Inflammation · doi:10.1155/2014/348959 · Cited by 301 · see citing works
Multi-time-step explicit-implicit method for non-linear structural dynamics
Gravouil, A., & Combescure, A. (2000) · International Journal for Numerical Methods in Engineering · doi:10.1002/1097-0207(20010110)50:1 · Cited by 292 · see citing works
Adipokine inflammation and insulin resistance: the role of glucose, lipids and endotoxin
Piya, M. K., McTernan, P. G., & Kumar, S. (2012) · Journal of Endocrinology · doi:10.1530/joe-12-0498 · Cited by 262 · see citing works
Effect of the Normal Microbial Flora on Gastrointestinal Motility.
Abrams, G. D., & Bishop, J. E. (1967) · Experimental Biology and Medicine · doi:10.3181/00379727-126-32430 · Cited by 242 · see citing works
Implication of inflammatory signaling pathways in obesity-induced insulin resistance
Tanti, J., Ceppo, F., Jager, J., & Berthou, F. (2013) · Frontiers in Endocrinology · doi:10.3389/fendo.2012.00181 · Cited by 242 · see citing works
Harte, A. L., Varma, M. C., Tripathi, G., McGee, K. C., Al‐Daghri, N. M., Al-Attas, O. S., Sabico, S., O’Hare, J. P., Ceriello, A., Saravanan, P., et al. (2011) · Diabetes Care · doi:10.2337/dc11-1593 · Cited by 236 · see citing works
Effects of fructans-type prebiotics on lipid metabolism
Delzenne, N. M., & Kok, N. N. (2001) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/73.2.456s · Cited by 225 · see citing works
Delzenne, N., Cani, P. D., & Neyrinck, A. (2007) · Journal of NutriLife · doi:10.1093/jn/137.11.2547s · Cited by 208 · see citing works
Mosqueda, G., Whittaker, A. S., & Fenves, G. L. (2004) · Journal of Structural Engineering · doi:10.1061/(asce)0733-9445(2004)130:3(433 · Cited by 207 · see citing works
Lipopolysaccharide (LPS)-Binding Protein Mediates LPS Detoxification by Chylomicrons
Vreugdenhil, A. C. E., Rousseau, C. H., Härtung, T., Greve, J. W. M., Veer, C. V. ′., & Buurman, W. A. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.170.3.1399 · Cited by 206 · see citing works
van Hoffen, E., Ruiter, B., Faber, J., M’Rabet, L., Knol, E. F., Stahl, B., Arslanoğlu, S., Moro, G. E., Boehm, G., & Garssen, J. (2008) · Allergy · doi:10.1111/j.1398-9995.2008.01765.x · Cited by 200 · see citing works
Noga, A. A., & Vance, D. E. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m301982200 · Cited by 200 · see citing works
Mechanisms of disease: inflammasome activation and the development of type 2 diabetes
Grant, R. W., & Dixit, V. D. (2013) · Frontiers in Immunology · doi:10.3389/fimmu.2013.00050 · Cited by 200 · see citing works
Frictional Behavior of Steel-PTFE Interfaces for Seismic Isolation
Dolce, M., Cardone, D., & Croatto, F. (2005) · Bulletin of Earthquake Engineering · doi:10.1007/s10518-005-0187-9 · Cited by 198 · see citing works
Inflammation links excess fat to insulin resistance: the role of the interleukin‐1 family
Tack, C. J., Stienstra, R., Joosten, L. A. B., & Netea, M. G. (2012) · Immunological Reviews · doi:10.1111/j.1600-065x.2012.01145.x · Cited by 192 · see citing works
Characterizing friction in sliding isolation bearings
Kumar, M., Whittaker, A. S., & Constantinou, M. C. (2014) · Earthquake Engineering & Structural Dynamics · doi:10.1002/eqe.2524 · Cited by 190 · see citing works
Peptide YY and Proglucagon mRNA Expression Patterns and Regulation in the Gut
Zhou, J. F., Hegsted, M., McCutcheon, K. L., Keenan, M. J., Xi, X., Raggio, A. M., & Martin, R. J. (2006) · Obesity · doi:10.1038/oby.2006.77 · Cited by 187 · see citing works
Epithelia Under Metabolic Stress Perceive Commensal Bacteria as a Threat
Nazli, A., Yang, P., Jury, J., Howe, K. L., Watson, J. L., Söderholm, J. D., Sherman, P. M., Perdue, M. H., & McKay, D. M. (2004) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)63182-3 · Cited by 183 · see citing works
DYNAMIC DESTRUCTIVE TEST OF A CANTILEVER BEAM, CONTROLLED BY AN ANALOG-COMPUTER
Hakuno, M., Shidawara, M., & Hara, T. (1969) · Proceedings of the Japan Society of Civil Engineers · doi:10.2208/jscej1969.1969.171_1 · Cited by 165 · see citing works
Li, Y., Cai, H., Wang, Z.-H., Xu, J., & Fang, J. (2015) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.13492 · Cited by 156 · see citing works
Role of the aryl hydrocarbon receptor in drug metabolism
Ramadoss, P., Marcus, C. B., & Perdew, G. H. (2005) · Expert Opinion on Drug Metabolism & Toxicology · doi:10.1517/17425255.1.1.9 · Cited by 144 · see citing works
Bellahcene, M., O’Dowd, J. F., Wargent, E. T., Zaibi, M. S., Hislop, D. C., Ngala, R. A., Smith, D. M., Cawthorne, M. A., Stocker, C. J., & Arch, J. R. S. (2012) · British Journal Of Nutrition · doi:10.1017/s0007114512003923 · Cited by 132 · see citing works
Goat Milk Oligosaccharides Are Anti-Inflammatory in Rats with Hapten-Induced Colitis
Daddaoua, A., Puerta, V., Requena, P., Martinez-Ferez, A., Guadix, E. M., de Medina, F. S., Zarzuelo, A., Suárez, M. D., Bozá, J., & Martínez‐Augustin, O. (2006) · Journal of Nutrition · doi:10.1093/jn/136.3.672 · Cited by 127 · see citing works
Tryptophanase in Diverse Bacterial Species
Demoss, R. D., & Moser, K. W. (1969) · Journal of Bacteriology · doi:10.1128/jb.98.1.167-171.1969 · Cited by 114 · see citing works
Numerical Assessment of Frictional Heating in Sliding Bearings for Seismic Isolation
Quaglini, V., Bocciarelli, M., Gandelli, E., et al. (2014) · Journal of Earthquake Engineering · doi:10.1080/13632469.2014.924890 · Cited by 101 · see citing works
DOMENICO, D. D., Ricciardi, G., & Benzoni, G. (2017) · Soil Dynamics and Earthquake Engineering · doi:10.1016/j.soildyn.2017.12.019 · Cited by 88 · see citing works
Ivey, K. L., Hodgson, J. M., Kerr, D. A., Lewis, J. R., Thompson, P. L., & Prince, R. (2014) · European Journal of Clinical Nutrition · doi:10.1038/ejcn.2013.294 · Cited by 87 · see citing works
Impact of prebiotics on human health
Bruzzese, E., Volpicelli, M., Squaglia, M., et al. (2006) · Digestive and Liver Disease · doi:10.1016/s1590-8658(07)60011-5 · Cited by 85 · see citing works
Saito, I. (2012) · Circulation Journal · doi:10.1253/circj.cj-11-1519 · Cited by 81 · see citing works
Finite element model updating for structures with parametric constraints
Zhang, Q. W., Chang, C. C., & Chang, T. Y. (2000) · Earthquake Engineering & Structural Dynamics · doi:10.1002/1096-9845(200007)29:7 · Cited by 79 · see citing works
Furinghetti, M., Pavese, A., Quaglini, V., et al. (2018) · Soil Dynamics and Earthquake Engineering · doi:10.1016/j.soildyn.2018.11.020 · Cited by 73 · see citing works
Effect of non-digestible fermentable carbohydrates on hepatic fatty acid metabolism
Delzenne, N. M., & Kok, N. N. (1998) · Biochemical Society Transactions · doi:10.1042/bst0260228 · Cited by 53 · see citing works
Bonelli, A., Bursi, O. S., He, L., et al. (2008) · International Journal for Numerical Methods in Engineering · doi:10.1002/nme.2285 · Cited by 46 · see citing works
Vergès, B. L., Duvillard, L., Lagrost, L., et al. (2014) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2013-3463 · Cited by 42 · see citing works
The microbiome and its pharmacological targets: therapeutic avenues in cardiometabolic diseases
Neves, A. L., Chilloux, J., Sarafian, M. H., Rahim, M. B. H. A., Boulangé, C. L., & Dumas, M. (2015) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2015.09.013 · Cited by 36 · see citing works
Self-citationHas provoking microbiota aggression driven the obesity epidemic?
Chassaing, B., & Gewirtz, A. T. (2016) · BioEssays · doi:10.1002/bies.201500116 · Cited by 36 · see citing works
Calabrese, A., Strano, S., & Terzo, M. (2014) · Structural Control and Health Monitoring · doi:10.1002/stc.1687 · Cited by 33 · see citing works
Pavese, A., Furinghetti, M., & Casarotti, C. (2017) · Journal of Earthquake Engineering · doi:10.1080/13632469.2017.1323046 · Cited by 29 · see citing works
Bursi, O. S., He, L., Bonelli, A., et al. (2009) · Journal of Computational and Applied Mathematics · doi:10.1016/j.cam.2009.08.082 · Cited by 26 · see citing works
Furinghetti, M., & Pavese, A. (2017) · Mechanics Based Design of Structures and Machines · doi:10.1080/15397734.2017.1281145 · Cited by 23 · see citing works
Eucentre TREES Lab: Laboratory for Training and Research in Earthquake Engineering and Seismology
Peloso, S., Pavese, A., & Casarotti, C. (2011) · Geotechnical, geological and earthquake engineering · doi:10.1007/978-94-007-1977-4_4 · Cited by 22 · see citing works
Bursi, O. S., Abbiati, G., Cazzador, E., et al. (2017) · International Journal for Numerical Methods in Engineering · doi:10.1002/nme.5556 · Cited by 22 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Chiu, C. Y., & Miller, S. A. (2019) · Nature Reviews Genetics · doi:10.1038/s41576-019-0113-7 · Cited by 1,620 · see citing works
Pinto-Sanchez, M. I., Hall, G. B., Ghajar, K., Nardelli, A., Bolino, C., Lau, J. T., Martin, F.-P., Cominetti, O., Welsh, C., Rieder, A., et al. (2017) · Gastroenterology · doi:10.1053/j.gastro.2017.05.003 · Cited by 821 · see citing works
Obesity and type 2 diabetes mellitus: connections in epidemiology, pathogenesis, and treatments
Ruze, R., Liu, T., Zou, X., Song, J., Chen, Y., Xu, R., Yin, X., & Xu, Q. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1161521 · Cited by 799 · see citing works
Ultra-processed food consumption and excess weight among US adults
Juul, F., Martinez-Steele, E., Parekh, N., Monteiro, C. A., & Chang, V. W. (2018) · British Journal Of Nutrition · doi:10.1017/s0007114518001046 · Cited by 475 · see citing works
Obesity pandemic: causes, consequences, and solutions—but do we have the will?
Meldrum, D. R., Morris, M. A., & Gambone, J. C. (2017) · Fertility and Sterility · doi:10.1016/j.fertnstert.2017.02.104 · Cited by 457 · see citing works
Do, M. H., Lee, E., Oh, M.-J., Kim, Y., & Park, H.-Y. (2018) · Nutrients · doi:10.3390/nu10060761 · Cited by 441 · see citing works
Role of the gut microbiota in type 2 diabetes and related diseases
Yang, G., Wei, J., Liu, P., Zhang, Q., Tian, Y., Hou, G., Meng, L., Xin, Y., & Jiang, X. (2021) · Metabolism · doi:10.1016/j.metabol.2021.154712 · Cited by 418 · see citing works
Signalling cognition: The gut microbiota and hypothalamic-pituitary-adrenal axis
Rusch, J. A., Layden, B. T., & Dugas, L. R. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1130689 · Cited by 415 · see citing works
Probiotics, prebiotics and amelioration of diseases
Tsai, Y.-L., Lin, T.-L., Chang, C.-J., Wu, T.-R., Lai, W.-F., Lu, C.-C., & Lai, H.-C. (2019) · Journal of Biomedical Science · doi:10.1186/s12929-018-0493-6 · Cited by 388 · see citing works
Ultra-processed Foods and Cardiovascular Diseases: Potential Mechanisms of Action
Juul, F., Vaidean, G., & Parekh, N. (2021) · Advances in Nutrition · doi:10.1093/advances/nmab049 · Cited by 374 · see citing works
Parker, A., Romano, S., Ansorge, R., Aboelnour, A., Le Gall, G., Savva, G. M., Pontifex, M. G., Telatin, A., Baker, D., Jones, E., et al. (2022) · Microbiome · doi:10.1186/s40168-022-01243-w · Cited by 368 · see citing works
Total Lipopolysaccharide from the Human Gut Microbiome Silences Toll-Like Receptor Signaling
d’Hennezel, E., Abubucker, S., Murphy, L. O., & Cullen, T. W. (2017) · mSystems · doi:10.1128/msystems.00046-17 · Cited by 324 · see citing works
Effects of Synbiotic Supplement on Human Gut Microbiota, Body Composition and Weight Loss in Obesity
Sergeev, I. N., Aljutaily, T., Walton, G., & Huarte, E. (2020) · Nutrients · doi:10.3390/nu12010222 · Cited by 331 · see citing works
Forbes, J. D., Azad, M. B., Vehling, L., Tun, H. M., Konya, T. B., Guttman, D. S., Field, C. J., Lefebvre, D., Sears, M. R., Becker, A. B., et al. (2018) · JAMA Pediatrics · doi:10.1001/jamapediatrics.2018.1161 · Cited by 285 · see citing works
Lee, D. M., Battson, M. L., Jarrell, D. K., Hou, S., Ecton, K. E., Weir, T. L., & Gentile, C. L. (2018) · Cardiovascular Diabetology · doi:10.1186/s12933-018-0708-x · Cited by 246 · see citing works
“The gut microbiota has emerged as a critical regular of human physiology and disease processes [22], and data from our laboratory [23] and elsewhere [24] indicate that the gut microbiota is an important regulator of vascular function.”
BackgroundSung, M. M., Kim, T. T., Denou, E., Soltys, C.-L. M., Hamza, S. M., Byrne, N. J., Masson, G., Park, H., Wishart, D. S., Madsen, K. L., et al. (2017) · Diabetes · doi:10.2337/db16-0680 · Cited by 204 · see citing works
Patterns of Oral Microbiota Diversity in Adults and Children: A Crowdsourced Population Study
Burcham, Z. M., Garneau, N. L., Comstock, S. S., Tucker, R. M., Knight, R., Metcalf, J. L., Scientists, G. O. T. L. C., Miranda, A., Reinhart, B., Meyers, D., et al. (2020) · Scientific Reports · doi:10.1038/s41598-020-59016-0 · Cited by 183 · see citing works
Kim, J., Yun, J. M., Kim, M. K., Kwon, O., & Cho, B. (2018) · Journal of Medicinal Food · doi:10.1089/jmf.2017.3937 · Cited by 182 · see citing works
Microbiota-gut brain axis involvement in neuropsychiatric disorders
Iannone, L. F., Preda, A., Blottière, H. M., Clarke, G., Albani, D., Belcastro, V., Carotenuto, M., Cattaneo, A., Citraro, R., Ferraris, C., et al. (2019) · Expert Review of Neurotherapeutics · doi:10.1080/14737175.2019.1638763 · Cited by 177 · see citing works
Chang (2018) · doi:10.3389/fmicb.2018.00983 · Cited by 152 · see citing works
Haghighatdoost, F., Bellissimo, N., Totosy de Zepetnek, J. O., & Rouhani, M. H. (2017) · Public Health Nutrition · doi:10.1017/s1368980017001768 · Cited by 153 · see citing works
Goedert, J. J., Hua, X., Bielecka, A., Okayasu, I., Milne, G. L., Jones, G. S., Fujiwara, M., Sinha, R., Wan, Y., Xu, X., et al. (2018) · British Journal of Cancer · doi:10.1038/bjc.2017.435 · Cited by 144 · see citing works
Relevance of gutmicrobiota in cognition, behaviour and Alzheimer’s disease
de J.R. De-Paula, V., Forlenza, A. S., & Forlenza, O. V. (2018) · Pharmacological Research · doi:10.1016/j.phrs.2018.07.007 · Cited by 145 · see citing works
Alderete, T. L., Jones, R. B., Chen, Z., Kim, J. S., Habre, R., Lurmann, F., Gilliland, F. D., & Goran, M. I. (2018) · Environmental Research · doi:10.1016/j.envres.2017.11.046 · Cited by 139 · see citing works
Yacoub, R., Nugent, M., Cai, W., Nadkarni, G. N., Chaves, L. D., Abyad, S., Honan, A. M., Thomas, S. A., Zheng, W., Valiyaparambil, S. A., et al. (2017) · PLOS ONE · doi:10.1371/journal.pone.0184789 · Cited by 139 · see citing works
Effects of Antidiabetic Drugs on Gut Microbiota Composition
Montandon, S., & Jornayvaz, F. (2017) · Genes · doi:10.3390/genes8100250 · Cited by 135 · see citing works
Dahiya, D., & Nigam, P. S. (2022) · Microorganisms · doi:10.3390/microorganisms10030665 · Cited by 122 · see citing works
Ji, S. K., Yan, H., Jiang, T., Guo, C. Y., Liu, J. J., Dong, S. Z., Yang, K. L., Wang, Y. J., Cao, Z. J., & Li, S. L. (2017) · Frontiers in Microbiology · doi:10.3389/fmicb.2017.01208 · Cited by 106 · see citing works
Hsu, Y.-J., Huang, W.-C., Lin, J.-S., Chen, Y.-M., Ho, S.-T., Huang, C.-C., & Tung, Y.-T. (2018) · Nutrients · doi:10.3390/nu10070862 · Cited by 116 · see citing works
Luisi, M. L. E., Lucarini, L., Biffi, B., Rafanelli, E., Pietramellara, G., Durante, M., Vidali, S., Provensi, G., Madiai, S., Gheri, C. F., et al. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.01366 · Cited by 115 · see citing works
Thomson, P., Santibañez, R., Aguirre, C., Galgani, J. E., & Garrido, D. (2019) · British Journal Of Nutrition · doi:10.1017/s0007114519001570 · Cited by 117 · see citing works
Haran, J. P., Bucci, V., Dutta, P., Ward, D., & McCormick, B. (2018) · Journal of Medical Microbiology · doi:10.1099/jmm.0.000640 · Cited by 97 · see citing works
Featured article: Structure moderation of gut microbiota in liraglutide-treated diabetic male rats
Zhang, Q., Xiao, X., Zheng, J., Li, M., Yu, M., Ping, F., Wang, T., & Wang, X. (2018) · Experimental Biology and Medicine · doi:10.1177/1535370217743765 · Cited by 101 · see citing works
Fermented Soy Products: Beneficial Potential in Neurodegenerative Diseases
Jang, C. H., Oh, J., Lim, J. S., Kim, H. J., & Kim, J.-S. (2021) · Foods · doi:10.3390/foods10030636 · Cited by 100 · see citing works
Protective Effects of Ghrelin on Fasting-Induced Muscle Atrophy in Aging Mice
Wu, C.-S., Wei, Q., Wang, H., Kim, D. M., Balderas, M., Wu, G., Lawler, J., Safe, S., Guo, S., Devaraj, S., et al. (2020) · The Journals of Gerontology: Series A · doi:10.1093/gerona/gly256 · Cited by 81 · see citing works
Carlucci, C., Petrof, E. O., & Allen-Vercoe, E. (2016) · EBioMedicine · doi:10.1016/j.ebiom.2016.09.029 · Cited by 77 · see citing works
Evidences of a new psychobiotic formulation on body composition and anxiety
Colica, C., Avolio, E., Bollero, P., Costa de Miranda, R., Ferraro, S., Sinibaldi Salimei, P., De Lorenzo, A., & Di Renzo, L. (2017) · Mediators of Inflammation · doi:10.1155/2017/5650627 · Cited by 63 · see citing works
The microbiome and gut endocannabinoid system in the regulation of stress responses and metabolism
Srivastava, R. K., Lutz, B., & Ruiz de Azua, I. (2022) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2022.867267 · Cited by 56 · see citing works
Gorlé, N., Blaecher, C., Bauwens, E., Vandendriessche, C., Balusu, S., Vandewalle, J., Van Cauwenberghe, C., Van Wonterghem, E., Van Imschoot, G., Liu, C., et al. (2018) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2017.12.010 · Cited by 49 · see citing works
Demircan, T., Ovezmyradov, G., Yıldırım, B., Keskin, İ., İlhan, A. E., Fesçioğlu, E. C., Öztürk, G., & Yıldırım, S. (2018) · Scientific Reports · doi:10.1038/s41598-018-29373-y · Cited by 45 · see citing works
Kiosia, A., Dagbasi, A., Berkley, J. A., Wilding, J. P. H., Prendergast, A. J., Li, J. V., Swann, J., Mathers, J. C., Kerac, M., Morrison, D., et al. (2024) · Nutrition Bulletin · doi:10.1111/nbu.12670 · Cited by 43 · see citing works
Dahiya, D., & Nigam, P. S. (2022) · Microorganisms · doi:10.3390/microorganisms10091687 · Cited by 40 · see citing works
Pan, S., Guo, Y., Hong, F., Xu, P., & Zhai, Y. (2022) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2021.166281 · Cited by 37 · see citing works
Van den Abbeele, P., Duysburgh, C., Cleenwerck, I., Albers, R., Marzorati, M., & Mercenier, A. (2021) · Microorganisms · doi:10.3390/microorganisms9102142 · Cited by 31 · see citing works
Mahboobi, S., Ghasvarian, M., Ghaem, H., Alipour, H., Alipour, S., & Eftekhari, M. H. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.1018357 · Cited by 31 · see citing works
- Authors
- Boulangé, C. L., Neves, A. L., Chilloux, J., Nicholson, J. K., & Dumas, M.-E.
- Affiliations
- Imperial College London (GB)
- Corresponding author
- Nicholson, Jeremy K.
- Dumas, Marc-Emmanuel
- Venue
- Genome Medicine
- Published
- 2016-04-20
- Volume
- 8
- Issue
- 1
- Pages
- 42-42
- ISSN
- 1756-994X (ISSN-L)
- PMC
- PMC4839080
- OpenAlex
- W2339765445
- Cited by
- 1,438
- References
- 111
- Citations by year
- 2026: 89 · 2025: 153 · 2024: 169 · 2023: 146 · 2022: 156 · 2021: 202 · 2020: 156 · 2019: 150 · 2018: 126 · 2017: 74 · 2016: 14 · 2014: 1
- FWCI
- 10.96
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Genome Medicine (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Spiral (Imperial College London) (submittedVersion, cc-by)
- Funders
- Nestlé (RDLS015375)
- Portuguese Foundation for Science and Technology (SFRH/BD/52036/2012)
- Seventh Framework Programme (BE) (HEALTH-F4-2012-305312, 291840)
- Medical Research Council (GB) (MR/M501797/1)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Keywords
- gut microbiota, obesity, metabolic disorders, inflammation, energy metabolism, host-microbe interactions, immune system, lipid accumulation, microbiota-targeted therapy, dysbiosis
- MeSH terms
- Gastrointestinal Microbiome, Animals, Energy Metabolism, Homeostasis, Humans, Inflammation, Metabolic Diseases, Obesity, Metabolic Syndrome, Host-Pathogen Interactions
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
