Intestinal transport and metabolism of bile acids

Diet rapidly and reproducibly alters the human gut microbiome

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Host-gut microbiota metabolic interactions

Nicholson, J. K., Holmes, E., Kinross, J., Burcelin, R., Gibson, G., Jia, W., & Pettersson, S. (2012) · Science · doi:10.1126/science.1223813 · Cited by 4,760 · see citing works

Gut Microbiota from Twins Discordant for Obesity Modulate Metabolism in Mice

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Bile salt biotransformations by human intestinal bacteria

Ridlon, J. M., Kang, D.-J., & Hylemon, P. B. (2006) · Journal of Lipid Research · doi:10.1194/jlr.r500013-jlr200 · Cited by 2,829 · see citing works

Gut microbiota regulates bile acid metabolism by reducing the levels of tauro-beta-muricholic acid, a naturally occurring FXR antagonist

Sayin, S. I., Wahlström, A., Felin, J., Jäntti, S., Marschall, H.-U., Bamberg, K., Angelin, B., Hyötyläinen, T., Orešič, M., & Bäckhed, F. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.01.003 · Cited by 2,331 · see citing works

The Enzymes, Regulation, and Genetics of Bile Acid Synthesis

Russell, D. W. (2003) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.72.121801.161712 · Cited by 2,069 · see citing works

Dietary-fat-induced taurocholic acid promotes pathobiont expansion and colitis in Il10-/- mice

Devkota, S., Wang, Y., Musch, M. W., Leone, V., Fehlner-Peach, H., Nadimpalli, A., Antonopoulos, D. A., Jabri, B., & Chang, E. B. (2012) · Nature · doi:10.1038/nature11225 · Cited by 1,904 · see citing works

The interaction between bacteria and bile

Begley, M., Gahan, C. G. M., & Hill, C. (2004) · FEMS Microbiology Reviews · doi:10.1016/j.femsre.2004.09.003 · Cited by 1,793 · see citing works

The microbiome and cancer

Schwabe, R. F., & Jobin, C. (2013) · Nature Reviews Cancer · doi:10.1038/nrc3610 · Cited by 1,689 · see citing works

Targeting bile‐acid signalling for metabolic diseases

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Bile Acid Metabolism and Signaling

Chiang, J. Y. L. (2013) · Comprehensive physiology · doi:10.1002/cphy.c120023 · Cited by 1,390 · see citing works

Bile acids and the gut microbiome

Ridlon, J. M., Kang, D. J., Hylemon, P. B., & Bajaj, J. S. (2014) · Current Opinion in Gastroenterology · doi:10.1097/mog.0000000000000057 · Cited by 1,329 · see citing works

Pleiotropic Roles of Bile Acids in Metabolism

de Aguiar Vallim, T. Q., Tarling, E. J., & Edwards, P. A. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.03.013 · Cited by 1,209 · see citing works

Regulation of antibacterial defense in the small intestine by the nuclear bile acid receptor

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Functional and comparative metagenomic analysis of bile salt hydrolase activity in the human gut microbiome

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A gene encoding a liver-specific ABC transporter is mutated in progressive familial intrahepatic cholestasis

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Interactions Between the Intestinal Microbiome and Liver Diseases

Schnabl, B., & Brenner, D. A. (2014) · Gastroenterology · doi:10.1053/j.gastro.2014.01.020 · Cited by 971 · see citing works

The Sister of P-glycoprotein Represents the Canalicular Bile Salt Export Pump of Mammalian Liver

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Bile acid signaling in metabolic disease and drug therapy

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Connecting dysbiosis, bile-acid dysmetabolism and gut inflammation in inflammatory bowel diseases

Duboc, H., Rajca, S., Rainteau, D., Benarous, D., Maubert, M.-A., Quervain, E., Thomas, G., Barbu, V., Humbert, L., Despras, G., et al. (2013) · Gut · doi:10.1136/gutjnl-2012-302578 · Cited by 930 · see citing works

Bile Acids: Chemistry, Pathochemistry, Biology, Pathobiology, and Therapeutics

Hofmann, A. F., & Hagey, L. R. (2008) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-008-7568-6 · Cited by 858 · see citing works

Microbes, Microbiota, and Colon Cancer

Sears, C. L., & Garrett, W. S. (2014) · Cell Host & Microbe · doi:10.1016/j.chom.2014.02.007 · Cited by 820 · see citing works

Modulation of the fecal bile acid profile by gut microbiota in cirrhosis

Kakiyama, G., Pandak, W. M., Gillevet, P. M., Hylemon, P. B., Heuman, D. M., Daita, K., Takei, H., Muto, A., Nittono, H., Ridlon, J. M., et al. (2013) · Journal of Hepatology · doi:10.1016/j.jhep.2013.01.003 · Cited by 782 · see citing works

Systemic gut microbial modulation of bile acid metabolism in host tissue compartments

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Organic anion-transporting polypeptide B (OATP-B) and its functional comparison with three other OATPs of human liver

Kullak-Ublick, G. A., Ismair, M. G., Stieger, B., Landmann, L., Huber, R., Pizzagalli, F., Fattinger, K. E., Meier, P. J., & Hagenbuch, B. (2001) · Gastroenterology · doi:10.1053/gast.2001.21176 · Cited by 718 · see citing works

Microbiome remodelling leads to inhibition of intestinal farnesoid X receptor signalling and decreased obesity

Li, F., Jiang, C., Krausz, K. W., Li, Y., Albert, I., Hao, H., Fabre, K. M., Mitchell, J. B., Patterson, A. D., & Gonzalez, F. J. (2013) · Nature Communications · doi:10.1038/ncomms3384 · Cited by 705 · see citing works

Bile acid receptors as targets for drug development

Schaap, F. G., Trauner, M., & Jansen, P. L. M. (2014) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2013.151 · Cited by 696 · see citing works

Bile acids as regulatory molecules

Hylemon, P. B., Zhou, H., Pandak, W. M., Ren, S., Gil, G., & Dent, P. (2009) · Journal of Lipid Research · doi:10.1194/jlr.r900007-jlr200 · Cited by 694 · see citing works

Bile acid transporters

Dawson, P. A., Lan, T., & Rao, A. (2009) · Journal of Lipid Research · doi:10.1194/jlr.r900012-jlr200 · Cited by 683 · see citing works

The MRP family of drug efflux pumps

Kruh, G. D., & Belinsky, M. G. (2003) · Oncogene · doi:10.1038/sj.onc.1206953 · Cited by 615 · see citing works

Bile resistance mechanisms in Lactobacillus and Bifidobacterium

Ruiz, L., Margolles, A., & Sánchez, B. (2013) · Frontiers in Microbiology · doi:10.3389/fmicb.2013.00396 · Cited by 548 · see citing works

Physical-chemical behavior of dietary and biliary lipids during intestinal digestion and absorption. 2. Phase analysis and aggregation states of luminal lipids during duodenal fat digestion in healthy adult human beings

Hernell, O., Staggers, J. E., & Carey, M. C. (1990) · Biochemistry · doi:10.1021/bi00460a012 · Cited by 495 · see citing works

The human fatty acid-binding protein family: Evolutionary divergences and functions

Smathers, R. L., & Petersen, D. R. (2011) · Human Genomics · doi:10.1186/1479-7364-5-3-170 · Cited by 493 · see citing works

Role of bile acid malabsorption in pathogenesis of diarrhea and steatorrhea in patients with ileal resection. I. Response to cholestyramine or replacement of dietary long chain triglyceride by medium chain triglyceride.

Hofmann, A. F., & Poley, J. R. (1972) · PubMed · Cited by 477 · see citing works

Role of Bile Acid Malabsorption in Pathogenesis of Diarrhea and Steatorrhea in Patients with Ileal Resection

Hofmann, A. F., & Poley, J. R. (1972) · Gastroenterology · doi:10.1016/s0016-5085(72)80109-4 · Cited by 474 · see citing works

Active efflux of bile salts by Escherichia coli

Thanassi, D. G., Cheng, L. W., & Nikaido, H. (1997) · Journal of Bacteriology · doi:10.1128/jb.179.8.2512-2518.1997 · Cited by 471 · see citing works

The role of the gut microbiota in nonalcoholic fatty liver disease

Abu-Shanab, A., & Quigley, E. M. M. (2010) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2010.172 · Cited by 457 · see citing works

Beyond intestinal soap—bile acids in metabolic control

Kuipers, F., Bloks, V. W., & Groen, A. K. (2014) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2014.60 · Cited by 453 · see citing works

The Intraluminal Phase of Fat Digestion in Man: The Lipid Content of the Micellar and Oil Phases of Intestinal Content Obtained during Fat Digestion and Absorption*

Hofmann, A. F., & Borgström, B. (1964) · Journal of Clinical Investigation · doi:10.1172/jci104909 · Cited by 444 · see citing works

Bile salts of vertebrates: structural variation and possible evolutionary significance

Hofmann, A. F., Hagey, L. R., & Krasowski, M. D. (2009) · Journal of Lipid Research · doi:10.1194/jlr.r000042 · Cited by 423 · see citing works

Role of the Microbiome in Energy Regulation and Metabolism

Nieuwdorp, M., Gilijamse, P. W., Pai, N., & Kaplan, L. M. (2014) · Gastroenterology · doi:10.1053/j.gastro.2014.02.008 · Cited by 421 · see citing works

Bile acid transporters and regulatory nuclear receptors in the liver and beyond

Halilbasic, E., Claudel, T., & Trauner, M. A. (2012) · Journal of Hepatology · doi:10.1016/j.jhep.2012.08.002 · Cited by 397 · see citing works

Bile Acid Sulfation: A Pathway of Bile Acid Elimination and Detoxification

Alnouti, Y. (2009) · Toxicological Sciences · doi:10.1093/toxsci/kfn268 · Cited by 389 · see citing works

Primary bile acid malabsorption caused by mutations in the ileal sodium-dependent bile acid transporter gene (SLC10A2).

Oelkers, P. M., Kirby, L. C., Heubi, J. E., & Dawson, P. A. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119355 · Cited by 379 · see citing works

Mechanism of growth inhibition by free bile acids in lactobacilli and bifidobacteria

Kurdi, P., Kawanishi, K., Mizutani, K., & Yokota, A. (2006) · Journal of Bacteriology · doi:10.1128/jb.188.5.1979-1986.2006 · Cited by 364 · see citing works

Key discoveries in bile acid chemistry and biology and their clinical applications: history of the last eight decades

Hofmann, A. F., & Hagey, L. R. (2014) · Journal of Lipid Research · doi:10.1194/jlr.r049437 · Cited by 359 · see citing works

Microbiota Modification with Probiotics Induces Hepatic Bile Acid Synthesis via Downregulation of the Fxr-Fgf15 Axis in Mice

Degirolamo, C., Rainaldi, S., Bovenga, F., Murzilli, S., & Moschetta, A. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.02.032 · Cited by 356 · see citing works

Functional Characterization of pH-Sensitive Organic Anion Transporting Polypeptide OATP-B in Human

Nozawa, T., Imai, K., Nezu, J., Tsuji, A., & Tamai, I. (2004) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.103.060194 · Cited by 351 · see citing works

Targeted Deletion of the Ileal Bile Acid Transporter Eliminates Enterohepatic Cycling of Bile Acids in Mice

Dawson, P. A., Haywood, J., Craddock, A. L., Wilson, M. D., Tietjen, M., Kluckman, K. D., Maeda, N., & Parks, J. S. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m306370200 · Cited by 338 · see citing works

Cirrhosis, bile acids and gut microbiota: Unraveling a complex relationship

Ridlon, J. M., Alves, J. M., Hylemon, P. B., & Bajaj, J. S. (2013) · Gut Microbes · doi:10.4161/gmic.25723 · Cited by 336 · see citing works

OSTα‐OSTβ

Ballatori, N., Christian, W. V., Lee, J., Dawson, P. A., Soroka, C. J., Boyer, J. L., Madejczyk, M. S., & Li, N. (2005) · Hepatology · doi:10.1002/hep.20961 · Cited by 336 · see citing works

Targeted inactivation of sister of P-glycoprotein gene ( spgp ) in mice results in nonprogressive but persistent intrahepatic cholestasis

Wang, R., Salem, M., Yousef, I. M., Tuchweber, B., Lam, P., Childs, S. J., Helgason, C. D., Ackerley, C. A., Phillips, M. J., & Ling, V. W. T. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.98.4.2011 · Cited by 333 · see citing works

Inhibiting the Initiation of <i>Clostridium difficile</i> Spore Germination using Analogs of Chenodeoxycholic Acid, a Bile Acid

Sorg, J. A., & Sonenshein, A. L. (2010) · Journal of Bacteriology · doi:10.1128/jb.00610-10 · Cited by 332 · see citing works

Oral bile acids reduce bacterial overgrowth, bacterial translocation, and endotoxemia in cirrhotic rats

Lorenzo-Zúñiga, V., Bartolí, R., Planas, R., Hofmann, A. F., Viñado, B., Hagey, L. R., Hernández, J. M., Mañé, J., Alvarez, M. A., Ausina, V., et al. (2003) · Hepatology · doi:10.1053/jhep.2003.50116 · Cited by 321 · see citing works

Conjugated Bile Acids Activate the Sphingosine–1–Phosphate Receptor 2 in Primary Rodent Hepatocytes

Studer, E. J., Zhou, X., Zhao, R., Wang, Y., Takabe, K., Nagahashi, M., Pandak, W. M., Dent, P., Spiegel, S., Shi, R., et al. (2011) · Hepatology · doi:10.1002/hep.24681 · Cited by 319 · see citing works

Bacterial translocation and changes in the intestinal microbiome in mouse models of liver disease

Fouts, D. E., Torralba, M., Nelson, K. E., Brenner, D. A., & Schnabl, B. (2012) · Journal of Hepatology · doi:10.1016/j.jhep.2012.01.019 · Cited by 311 · see citing works

Movement of fatty acids, fatty acid analogs, and bile acids across phospholipid bilayers

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Expression and transport properties of the human ileal and renal sodium-dependent bile acid transporter

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Significance of bile salt hydrolytic activities of lactobacilli

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Mechanisms for the intestinal absorption of bile acids

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Characterization of the kinetics of the passive and active transport mechanisms for bile acid absorption in the small intestine and colon of the rat

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Novel Potent and Selective Bile Acid Derivatives as TGR5 Agonists: Biological Screening, Structure−Activity Relationships, and Molecular Modeling Studies

Sato, H., Macchiarulo, A., Thomas, C., Gioiello, A., Une, M., Hofmann, A. F., Saladin, R., Schoonjans, K., Pellicciari, R., & Auwerx, J. H. (2008) · Journal of Medicinal Chemistry · doi:10.1021/jm7015864 · Cited by 302 · see citing works

Physical-chemical behavior of dietary and biliary lipids during intestinal digestion and absorption. 1. Phase behavior and aggregation states of model lipid systems patterned after aqueous duodenal contents of healthy adult human beings

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Bile acid receptors as targets for the treatment of dyslipidemia and cardiovascular disease

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Bile acids are nutrient signaling hormones

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Effect of bile salts on the DNA and membrane integrity of enteric bacteria

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Screening of Lactic Acid Bacteria for Bile Salt Hydrolase Activity

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Dysbiosis contributes to fibrogenesis in the course of chronic liver injury in mice

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Detoxification of Lithocholic Acid, A Toxic Bile Acid: Relevance to Drug Hepatotoxicity

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Human cecal bile acids: concentration and spectrum

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Rat cholangiocytes absorb bile acids at their apical domain via the ileal sodium-dependent bile acid transporter.

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Active and Passive Bile Acid Absorption in Man. PERFUSION STUDIES OF THE ILEUM AND JEJUNUM

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Effect of side-chain shortening on the physiologic properties of bile acids: Hepatic transport and effect on biliary secretion of 23-nor-ursodeoxycholate in rodents

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How bile acids confer gut mucosal protection against bacteria

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Transport of amphipathic anions by human multidrug resistance protein 3.

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Therapeutic Modulation of Microbiota-Host Metabolic Interactions

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Role of the Intestinal Bile Acid Transporters in Bile Acid and Drug Disposition

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Molecular mechanisms underlying bile acid‐stimulated glucagon‐like peptide‐1 secretion

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The organic solute transporter α-β, Ostα-Ostβ, is essential for intestinal bile acid transport and homeostasis

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Crypt stem cell survival in the mouse intestinal epithelium is regulated by prostaglandins synthesized through cyclooxygenase-1.

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Organic anion transporting polypeptide 1a/1b–knockout mice provide insights into hepatic handling of bilirubin, bile acids, and drugs

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Enterohepatic Circulation of Bile Salts in Farnesoid X Receptor-deficient Mice

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Sodium taurocholate cotransporting polypeptide (SLC10A1) deficiency: Conjugated hypercholanemia without a clear clinical phenotype

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Is bile acid a determinant of the gut microbiota on a high-fat diet?

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Tissue Distribution and Ontogeny of Sulfotransferase Enzymes in Mice

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Bile Acids Activate YAP to Promote Liver Carcinogenesis

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Organic Anion-Transporting Polypeptides

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Metabolism of lethocholate in healthy man. I. Biotransformation and biliary excretion of intravenously administered lithocholate, lithocholylglycine, and their sulfates.

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Characterization of bile acid transport mediated by multidrug resistance associated protein 2 and bile salt export pump

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The solute carrier family 10 (SLC10): Beyond bile acid transport

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Colonic inflammation and secondary bile acids in alcoholic cirrhosis

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