Intracellular pH.
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Nicotine accumulates within cells, so that the apparent intracellular volume occupied by nicotine is six- to eightfold greater than the total intracellular volume measured, for instance, by inulin exclusion.
“Nicotine accumulates within cells, so that the apparent “intracellular volume” occupied by nicotine is six- to eightfold greater than the total intracellular volume measured, for instance, by inulin exclusion.”
From Nicotine is a selective pharmacological chaperone of acetylcholine receptor number and stoichiometry. Implications for drug discovery (2009) · cites this paper as [78]
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Tumor pH controls the <i>in vivo</i> efficacy of weak acid and base chemotherapeutics
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Hackam, D. J., Rotstein, O. D., Zhang, W.-J., Gruenheid, S., Gros, P., & Grinstein, S. (1998) · The Journal of Experimental Medicine · doi:10.1084/jem.188.2.351 · Cited by 202 · see citing works
Wallimann, T., Schlösser, T., & Eppenberger, H. M. (1984) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)42981-4 · Cited by 202 · see citing works
Motoneuron activity patterns related to the earliest behavior of the zebrafish embryo
Saint-Amant, L., & Drapeau, P. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-11-03964.2000 · Cited by 200 · see citing works
CO2 in large-scale and high-density CHO cell perfusion culture
Gray, D. R., Chen, S., Howarth, W., Inlow, D., & Maiorella, B. L. (1996) · Cytotechnology · doi:10.1007/bf00353925 · Cited by 176 · see citing works
Stoichiometry and Ion Dependencies of the Intracellular-pH-Regulating Mechanism in Squid Giant Axons
Boron, W. F., & Russell, J. M. (1983) · The Journal of general physiology · doi:10.1085/jgp.81.3.373 · Cited by 169 · see citing works
Self-citationLester, H. A., Xiao, C., Srinivasan, R., Son, C. D., Miwa, J., Pantoja, R., Banghart, M. R., Dougherty, D. A., Goate, A. M., & Wang, J. C. (2009) · The AAPS Journal · doi:10.1208/s12248-009-9090-7 · Cited by 163 · see citing works
Clement, D. L., Mally, S., Stock, C., Lethan, M., Satir, P., Schwab, A., Pedersen, S. F., & Christensen, S. T. (2012) · Journal of Cell Science · doi:10.1242/jcs.116426 · Cited by 94 · see citing works
Kinetic Analysis of Intracellular Concentrations of Reactive Nitrogen Species
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Boron, W. F. (1987) · Membrane Transport Processes in Organized Systems · doi:10.1007/978-1-4684-5404-8_3 · Cited by 60 · see citing works
Self-citationHertz, L., Gibbs, M. E., & Dienel, G. A. (2014) · Frontiers in Neuroscience · doi:10.3389/fnins.2014.00261 · Cited by 58 · see citing works
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- Authors
- Roos, A., & Boron, W. F.
- ORCID
- Boron, W F
- Venue
- Physiological Reviews
- Publisher
- American Physiological Society
- Published
- 1981-04
- Volume
- 61
- Issue
- 2
- Pages
- 296-434
- ISSN
- 0031-9333 (ISSN-L)
- 1522-1210
- OpenAlex
- W4238605098
- Cited by
- 2,511
- References
- 0
- Citations by year
- 2026: 13 · 2025: 27 · 2024: 23 · 2023: 26 · 2022: 29 · 2021: 35 · 2020: 42 · 2019: 29 · 2018: 18 · 2017: 34 · 2016: 34 · 2015: 42 · 2014: 46 · 2013: 45 · 2012: 44
- FWCI
- 32.76
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Physiological Reviews (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion Transport and Channel Regulation
- Life Sciences › Neuroscience › Sensory Systems › Ion Channels and Receptors
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion channel regulation and function
- Keywords
- intracellular pH, acid-base balance, proton transport, pH control
- MeSH terms
- Acids, Animals, Biological Transport, Body Fluids, Buffers, Cell Membrane Permeability, Chemistry, Humans, Hydrogen-Ion Concentration, Intracellular Fluid, Intracellular Membranes, Microchemistry, Microelectrodes, Reference Values, Temperature, Chemical Phenomena
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
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