Cited by 58Neuroscience and Neuropharmacology ResearchConnexins and lens biologyBarrier Structure and Function Studies

Fluxes of lactate into, from, and among gap junction-coupled astrocytes and their interaction with noradrenaline

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Hertz, Leif, Gibbs, Marie E., Dienel, Gerald A.·2014·Frontiers in Neuroscience

Abstract

Lactate is a versatile metabolite with important roles in modulation of brain glucose utilization rate (CMRglc), diagnosis of brain-injured patients, redox- and receptor-mediated signaling, memory, and alteration of gene transcription. Neurons and astrocytes release and accumulate lactate using equilibrative monocarboxylate transporters that carry out net transmembrane transport of lactate only until intra- and extracellular levels reach equilibrium. Astrocytes have much faster lactate uptake than neurons and shuttle more lactate among gap junction-coupled astrocytes than to nearby neurons. Lactate diffusion within syncytia can provide precursors for oxidative metabolism and glutamate synthesis and facilitate its release from endfeet to perivascular space to stimulate blood flow. Lactate efflux from brain during activation underlies the large underestimation of CMRglc with labeled glucose and fall in CMRO2/CMRglc ratio. Receptor-mediated effects of lactate on locus coeruleus neurons include noradrenaline release in cerebral cortex and c-AMP-mediated stimulation of astrocytic gap junctional coupling, thereby enhancing its dispersal and release from brain. Lactate transport is essential for its multifunctional roles.

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Authors
Hertz, L., Gibbs, M. E., & Dienel, G. A.
Affiliations
  • China Medical University (CN)
  • Monash University (AU)
  • University of Arkansas for Medical Sciences (US)
Corresponding author
Dienel, Gerald A.
Venue
Frontiers in Neuroscience
Published
2014-09-09
Volume
8
Pages
261-261
ISSN
1662-453X (ISSN-L)
OpenAlex
W2162720163
Cited by
58
References
115
Citations by year
2026: 3 · 2025: 3 · 2024: 1 · 2023: 6 · 2022: 2 · 2021: 6 · 2019: 4 · 2018: 8 · 2017: 6 · 2016: 4 · 2015: 12 · 2014: 3
FWCI
0.95
Type
journal article
Language
en
Open access
Licence
cc-by
Locations
  • Frontiers in Neuroscience (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Connexins and lens biology
  • Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
Keywords
lactate, astrocytes, electrical coupling, norepinephrine, lactate transport, monocarboxylate transporters, cerebral metabolic rate of glucose, syncytia, glutamate release, blood flow, locus coeruleus, cAMP signaling, brain energy metabolism

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