Regulation of insulin release by calcium.
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An increase in the cytoplasmic Ca2+ concentration is essential to trigger insulin release.
“An increase in the cytoplasmic Ca2+ concentration is essential to trigger insulin release (732).”
From Pancreatic β-Cell Electrical Activity and Insulin Secretion: Of Mice and Men (2018) · cites this paper as [732]
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Pancreatic β-Cell Electrical Activity and Insulin Secretion: Of Mice and Men
Rorsman, P., & Ashcroft, F. M. (2018) · Physiological Reviews · doi:10.1152/physrev.00008.2017 · Cited by 793 · see citing works
Regulation of ATP production by mitochondrial Ca2+
Tarasov, A. I., Griffiths, E. J., & Rutter, G. A. (2012) · Cell Calcium · doi:10.1016/j.ceca.2012.03.003 · Cited by 319 · see citing works
Fast insulin secretion reflects exocytosis of docked granules in mouse pancreatic B-cells
Olofsson, C. S., Göpel, S. O., Barg, S., Galvanovskis, J., Ma, X., Salehi, A., Rorsman, P., & Eliasson, L. (2002) · Pflügers Archiv · doi:10.1007/s00424-002-0781-5 · Cited by 290 · see citing works
Holz, G. G., Leech, C. A., Heller, R. S., Castonguay, M., & Habener, J. F. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.20.14147 · Cited by 220 · see citing works
The dynamic plasticity of insulin production in β-cells
Boland, B. B., Rhodes, C. J., & Grimsby, J. S. (2017) · Molecular Metabolism · doi:10.1016/j.molmet.2017.04.010 · Cited by 194 · see citing works
Holz, G. G., Leech, C. A., & Habener, J. F. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.30.17749 · Cited by 188 · see citing works
Model for synchronization of pancreatic beta-cells by gap junction coupling
Sherman, A., & Rinzel, J. (1991) · Biophysical Journal · doi:10.1016/s0006-3495(91)82271-8 · Cited by 181 · see citing works
Connexins: Key Mediators of Endocrine Function
Bosco, D., Haefliger, J.-A., & Meda, P. (2011) · Physiological Reviews · doi:10.1152/physrev.00027.2010 · Cited by 169 · see citing works
The role of Ca<sup>2+</sup> in the pathophysiology of pancreatitis
Gerasimenko, J. V., Gerasimenko, O. V., & Petersen, O. H. (2014) · The Journal of Physiology · doi:10.1113/jphysiol.2013.261784 · Cited by 143 · see citing works
Mitochondrial signals drive insulin secretion in the pancreatic β-cell
Wiederkehr, A., & Wollheim, C. B. (2012) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2011.07.016 · Cited by 133 · see citing works
Self-citationPatterson, J. N., Cousteils, K., Lou, J. W., Manning Fox, J. E., MacDonald, P. E., & Joseph, J. W. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.521666 · Cited by 98 · see citing works
Gylfe, E. (1988) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)68305-x · Cited by 61 · see citing works
Neuropeptide Y and somatostatin inhibit insulin secretion through different mechanisms
Schwetz, T. A., Ustione, A., & Piston, D. W. (2013) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00374.2012 · Cited by 40 · see citing works
Richmond, J. E., Codignola, A., Cooke, I. M., & Sher, E. (1996) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s004240050132 · Cited by 36 · see citing works
- Authors
- Wollheim, C. B., & Sharp, G. W.
- ORCID
- Wollheim, C B
- Venue
- Physiological Reviews
- Publisher
- American Physiological Society
- Published
- 1981-10
- Volume
- 61
- Issue
- 4
- Pages
- 914-973
- ISSN
- 0031-9333 (ISSN-L)
- 1522-1210
- OpenAlex
- W2176847545
- Cited by
- 849
- References
- 0
- Citations by year
- 2026: 3 · 2025: 5 · 2024: 2 · 2023: 6 · 2022: 10 · 2021: 13 · 2020: 8 · 2019: 14 · 2018: 6 · 2017: 9 · 2016: 6 · 2015: 14 · 2014: 13 · 2013: 11 · 2012: 16
- FWCI
- 63.02
- Type
- journal article
- Language
- en
- Open access
- Licence
- cc-by
- Locations
- Physiological Reviews (publishedVersion)
- PubMed (publishedVersion)
- Archive ouverte UNIGE (University of Geneva) (submittedVersion, cc-by)
- Topics
- Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion channel regulation and function
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Calcium signaling and nucleotide metabolism
- Keywords
- insulin secretion, calcium, calcium signaling, pancreatic beta cells, calcium channels
- MeSH terms
- Insulin Secretion, Acetylcholine, Cyclic AMP, Adenylyl Cyclases, Animals, Arginine, Biomechanical Phenomena, Calcium, Calmodulin, Cattle, Cell Membrane, Cricetulus, Diabetes Mellitus, Dogs, Electrophysiology, Epinephrine, Extracellular Space, Chemical Fractionation, Glucose, Cricetinae, Histocytochemistry, Humans, Hypocalcemia, Insulin, Ionophores, Islets of Langerhans, Leucine, Mice, Inbred C57BL, Mice, Mutant Strains, Mutation, Somatostatin, Swine, Mice, Rats
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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