Nutrient secretagogues induce bimodal early changes in cytoplasmic calcium of insulin-releasing ob/ob mouse beta-cells.
Open accessAbstract
The cytoplasmic calcium concentration (Ca2+i) was measured in suspensions of fura-2 loaded mouse pancreatic beta-cells by continuously recording the 340/380 nm fluorescence excitation ratio. When the glucose concentration was raised from 3 to 20 mM, there was an initial lowering of Ca2+i followed by a sustained increase. Whereas the reduction in Ca2+i was related to the extracellular glucose concentration in a hyperbolic manner, the increasing component exhibited a sigmoidal dose-response relationship. Both effects became maximal at 15-20 mM of the sugar. Qualitatively similar bimodal Ca2+i responses were obtained with 30 mM mannose, 2 mM alpha-ketoisocaproic acid, 10 mM leucine, and 10 mM metabolism-stimulating leucine analogue beta-2-aminobicyclo-(2,2,1)-heptane-2-carboxylic acid. Fructose (30 mM) had virtually no effect on Ca2+i in the presence of extracellular Ca2+, and 10 mM arginine induced only a rise. The results indicate that nutrient secretagogues stimulate both the entry of Ca2+ into the beta-cells and its elimination from the cytoplasm by processes like organelle sequestration and outward transport. Consequently, the Ca2+i level determining insulin secretion results from the balance between two opposing actions.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
These data are consistent with stimulated sequestration and outward transport of Ca2+ being saturated at lower glucose concentrations in alpha-cells than in beta-cells.
“These data are consistent with stimulated sequestration and outward transport of Ca 2ϩ (14,20,21) being saturated at lower glucose concentrations in ␣-cells (14) than in -cells (21).”
From Paradoxical Stimulation of Glucagon Secretion by High Glucose Concentrations (2006) · cites this paper as [21]
Cites
A new generation of Ca2+ indicators with greatly improved fluorescence properties.
Grynkiewicz, G., Poenie, M., & Tsien, R. Y. (1985) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)83641-4 · Cited by 21,722 · see citing works
Intracellular ATP directly blocks K+ channels in pancreatic B-cells
Cook, D. L., & Hales, N. (1984) · Nature · doi:10.1038/311271a0 · Cited by 1,208 · see citing works
Regulation of insulin release by calcium.
Wollheim, C. B., & Sharp, G. W. (1981) · Physiological Reviews · doi:10.1152/physrev.1981.61.4.914 · Cited by 849 · see citing works
Ca2+, cAMP, and phospholipid-derived messengers in coupling mechanisms of insulin secretion
Prentki, M., & Matschinsky, F. M. (1987) · Physiological Reviews · doi:10.1152/physrev.1987.67.4.1185 · Cited by 777 · see citing works
STUDIES IN OBESE‐HYPERGLYCEMIC MICE*
Hellman, B. (1965) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1965.tb34819.x · Cited by 373 · see citing works
The preparation of, and studies on, free cell suspensions from mouse pancreatic islets
Lernmark, Å. (1974) · Diabetologia · doi:10.1007/bf01221634 · Cited by 360 · see citing works
L-leucine and a nonmetabolized analogue activate pancreatic islet glutamate dehydrogenase
Sener, A., & Malaisse, W. J. (1980) · Nature · doi:10.1038/288187a0 · Cited by 354 · see citing works
Insulin release: The fuel hypothesis
Malaisse, W. J., Sener, A., Herchuelz, A., & HUTTON, J. C. (1979) · Metabolism · doi:10.1016/0026-0495(79)90111-2 · Cited by 342 · see citing works
A versatile time-sharing multichannel spectrophotometer, reflectometer, and fluorometer
Chance, B., Legallais, V., Sorge, J., & Graham, N. (1975) · Analytical Biochemistry · doi:10.1016/0003-2697(75)90617-x · Cited by 240 · see citing works
The role of calcium in biological systems
(1991) · Comparative Biochemistry and Physiology Part A Physiology · doi:10.1016/0300-9629(91)90038-e · Cited by 221 · see citing works
Correlation between cytosolic free Ca2+ and insulin release in an insulin-secreting cell line.
Wollheim, C. B., & Pozzan, T. (1984) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)43347-3 · Cited by 200 · see citing works
The Significance of Calcium for Glucose Stimulation of Insulin Release
Hellman, B. (1975) · Endocrinology · doi:10.1210/endo-97-2-392 · Cited by 195 · see citing works
The Pancreatic β-Cell Recognition of Insulin Secretagogues
Hahn, H.-J., Hellman, B., Lernmark, Å., Sehlin, J., & Täljedal, I. (1974) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)42360-0 · Cited by 179 · see citing works
Stimulation of pancreatic islet metabolism and insulin release by a nonmetabolizable amino acid.
Sener, A., MALAISSE-LAGAE, F., & Malaisse, W. J. (1981) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.78.9.5460 · Cited by 127 · see citing works
Hellman, B., Sehlin, J., & Täljedal, I. (1971) · Biochemical Journal · doi:10.1042/bj1230513 · Cited by 112 · see citing works
HUTTON, J. C., Sener, A., Herchuelz, A., Atwater, I. J., Kawazu, S., Boschero, A. C., Somers, G., Devis, G., & Malaisse, W. J. (1980) · Endocrinology · doi:10.1210/endo-106-1-203 · Cited by 99 · see citing works
Hellman, B., Idahl, L., & Danielsson, Å. (1969) · Diabetes · doi:10.2337/diab.18.8.509 · Cited by 98 · see citing works
Signal transduction in insulin secretion: comparison between fuel stimuli and receptor agonists.
Wollheim, C., & Biden, T. (1986) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1986.tb46568.x · Cited by 89 · see citing works
Gylfe, E. (1988) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)60676-3 · Cited by 83 · see citing works
Self-citationZawalich, W. S., Rognstad, R., Pagliara, A. S., & Matschinsky, F. M. (1977) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)75250-8 · Cited by 81 · see citing works
Charles, S., Tamagawa, T., & Henquin, J. (1982) · Biochemical Journal · doi:10.1042/bj2080301 · Cited by 79 · see citing works
In vitro stimulation of insulin release by non-metabolizable, transport-specific amino acids
Christensen, H. N., Hellman, B., Lernmark, Å., Sehlin, J., Tager, H. S., & Täljedal, I. (1971) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/0005-2736(71)90034-4 · Cited by 76 · see citing works
Gylfe, E. (1976) · Acta Diabetologica · doi:10.1007/bf02591577 · Cited by 74 · see citing works
Self-citationDual effect of glucose on cytoplasmic Ca2+ in single pancreatic β-cells
Grapengiesser, E., Gylfe, E., & Hellman, B. (1988) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(88)90537-2 · Cited by 72 · see citing works
Self-citationAshcroft, F. M., Ashcroft, S. J. H., & Harrison, D. E. (1987) · The Journal of Physiology · doi:10.1113/jphysiol.1987.sp016505 · Cited by 65 · see citing works
Paradoxical Inhibition of Insulin Secretion by Glucose in Human Diabetes Mellitus*
Metz, S. A., Halter, J. B., & Robertson, R. P. (1979) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-48-5-827 · Cited by 59 · see citing works
Nutrient metabolism in islet cells
Sener, A., & Malaisse, W. J. (1984) · Cellular and Molecular Life Sciences · doi:10.1007/bf01971448 · Cited by 56 · see citing works
Johansson, H., Gylfe, E., & Hellman, B. (1987) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(87)80122-5 · Cited by 51 · see citing works
Self-citationHoenig, M. E., & Sharp, G. W. G. (1986) · Endocrinology · doi:10.1210/endo-119-6-2502 · Cited by 48 · see citing works
Johansson, H. E., Larsson, R. L., Nygren, P., Lindh, E., Rastad, J., Åkerström, G., & Gylfe, E. (1987) · Bioscience Reports · doi:10.1007/bf01116863 · Cited by 42 · see citing works
Self-citationGylfe, E., & Hellman, B. (1986) · Biochemical Journal · doi:10.1042/bj2330865 · Cited by 36 · see citing works
Self-citationHellman, B., & Gylfe, E. (2008) · Pharmacology · doi:10.1159/000138178 · Cited by 35 · see citing works
Self-citationAbrahamsson, H., Gylfe, E., & Hellman, B. (1981) · The Journal of Physiology · doi:10.1113/jphysiol.1981.sp013603 · Cited by 29 · see citing works
Self-citationGlucose inhibits insulin release induced by Na+ mobilization of intracellular calcium
Hellman, B., Honkanen, T., & Gylfe, E. (1982) · FEBS Letters · doi:10.1016/0014-5793(82)80826-0 · Cited by 24 · see citing works
Self-citationPanten, U., Biermann, J., & Graen, W. (1981) · PubMed · Cited by 23 · see citing works
Hexose metabolism in pancreatic islets
Sener, A., Giroix, M.-H., & Malaisse, W. J. (1984) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1984.tb08453.x · Cited by 19 · see citing works
Hellman, B., Idahl, L., Lenzen, S., Sehlin, J., & Täljedal, I. (1978) · Endocrinology · doi:10.1210/endo-102-6-1856 · Cited by 18 · see citing works
Glucose inhibits insulin release when not promoting the entry of calcium into the β-cells
Bergsten, P., & Hellman, B. (1984) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(84)91364-0 · Cited by 18 · see citing works
PARADOXICAL HYPOINSULINÆMIA: AN ALPHA-ADRENERGIC-MEDIATED RESPONSE TO GLUCOSE
Robertson, R. P., Hazzard, W. R., Brunzell, J. D., Lerner, R. L., & Porte, D. (1972) · The Lancet · doi:10.1016/s0140-6736(72)92146-0 · Cited by 18 · see citing works
The Stimulus-Secretion Coupling of Amino Acid-Induced Insulin Release
Sener, A., Malaisse-Lagae, F., & Malaisse, W. J. (1982) · Hormone and Metabolic Research · doi:10.1055/s-2007-1019047 · Cited by 10 · see citing works
(1987) · Elsevier eBooks · doi:10.1016/c2013-0-07292-1 · Cited by 10 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Electrophysiology of the pancreatic β-cell
Ashcroft, F. M., & Rorsman, P. (1989) · Progress in Biophysics and Molecular Biology · doi:10.1016/0079-6107(89)90013-8 · Cited by 1,127 · see citing works
Pralong, W. F., Bartley, C., & Wollheim, C. B. (1990) · The EMBO Journal · doi:10.1002/j.1460-2075.1990.tb08079.x · Cited by 262 · see citing works
Gilon, P., & Henquin, J. C. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)36744-4 · Cited by 251 · see citing works
Calcium-independent phospholipases A2 and their roles in biological processes and diseases
Ramanadham, S., Ali, T., Ashley, J. W., Bone, R. N., Hancock, W. D., & Lei, X. (2015) · Journal of Lipid Research · doi:10.1194/jlr.r058701 · Cited by 195 · see citing works
Li, C., Chen, P., Palladino, A., Narayan, S. B., Russell, L. K., Sayed, S. U., Xiong, G., Chen, J., Stokes, D., Butt, Y. M., et al. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.123638 · Cited by 179 · see citing works
Hierarchy of the β‐cell signals controlling insulin secretion
Henquin, J. C., Ravier, M. A., Nenquin, M., Jonas, J., & Gilon, P. (2003) · European Journal of Clinical Investigation · doi:10.1046/j.1365-2362.2003.01207.x · Cited by 177 · see citing works
Paradoxical Stimulation of Glucagon Secretion by High Glucose Concentrations
Salehi, A., Vieira, E., & Gylfe, E. (2006) · Diabetes · doi:10.2337/db06-0080 · Cited by 159 · see citing works
“These data are consistent with stimulated sequestration and outward transport of Ca(2) (14,20,21) being saturated at lower glucose concentrations in -cells (14) than in -cells (21).”
BackgroundSelf-citationIn Vivo and In Vitro Glucose-Induced Biphasic Insulin Secretion in the Mouse
Henquin, J.-C., Nenquin, M., Stiernet, P., & Ahren, B. (2006) · Diabetes · doi:10.2337/diabetes.55.02.06.db05-1051 · Cited by 166 · see citing works
DETIMARY, P., GILON, P., & HENQUIN, J.-C. (1998) · Biochemical Journal · doi:10.1042/bj3330269 · Cited by 170 · see citing works
Propagation of cytoplasmic Ca2+ oscillations in clusters of pancreatic β-cells exposed to glucose
Gylfe, E., Grapengiesser, E., & Hellman, B. (1991) · Cell Calcium · doi:10.1016/0143-4160(91)90023-8 · Cited by 136 · see citing works
Self-citationLiu, Y.-J., Vieira, E., & Gylfe, E. (2004) · Cell Calcium · doi:10.1016/j.ceca.2003.10.002 · Cited by 118 · see citing works
Self-citationCa2+ controls slow NAD(P)H oscillations in glucose‐stimulated mouse pancreatic islets
Luciani, D. S., Misler, S., & Polonsky, K. S. (2006) · The Journal of Physiology · doi:10.1113/jphysiol.2005.101766 · Cited by 114 · see citing works
“The NAD(P)H response thus coincides with the onset of the characteristic phase 0 drop in [Ca2+]c, which is in agreement with the notion that phase 0 reflects the energy-dependent buffering of basal Ca2+ by intracellular organelles via thapsigargin-sensitive uptake (Gylfe, 1988; Chow et al. 1995).”
ResultBarbosa, R. M., Silva, A. M., Tomé, Â. R., Stamford, J. A., Santos, R. M., & Rosário, L. M. (1998) · The Journal of Physiology · doi:10.1111/j.1469-7793.1998.135bz.x · Cited by 113 · see citing works
“…effect of raising glucose concentration from 3 to 11 mÒ on this signal was triphasic: there was (1) an initial [Ca¥]é depression arising from the stimulation of Ca¥ buffering mechanisms (Gylfe, 1988); (2) a rapid increase; and (3) an oscillatory pattern superimposed on an elevated plateau (Fig.”
BackgroundJohnson, D., Shepherd, R. M., Gill, D., Gorman, T., Smith, D. M., & Dunne, M. (2007) · Diabetes · doi:10.2337/db07-0026 · Cited by 80 · see citing works
“The first stage of this response is mediated by Ca(2) sequestration to cytosolic stores (46,47) and is then followed by Ca(2) influx leading to insulin release.”
BackgroundRoe, M., Mertz, R., Lancaster, M., Worley, J., & Dukes, I. (1994) · American Journal of Physiology · doi:10.1152/ajpendo.1994.266.6.e852 · Cited by 87 · see citing works
Ramanadham, S., Bohrer, A., Mueller, M., Jett, P. A., Gross, R. W., & Turk, J. (1993) · Biochemistry · doi:10.1021/bi00071a009 · Cited by 75 · see citing works
de Casteele, M. V., Kefas, B. A., Cai, Y., Heimberg, H., Scott, D. K., Henquin, J. C., PIPELEERS, D. G., & Jonas, J. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2003.11.013 · Cited by 75 · see citing works
“Thus, b-cell apoptosis was prevented by leucine and glutamine, a combination which stimulates b-cell metabolism, hence Ca2þ influx and insulin secretion, in a similar manner as a rise in glucose [25,26].”
Maechler, P., Kennedy, E. D., Sebö, E., Valeva, A., Pozzan, T., & Wollheim, C. B. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.18.12583 · Cited by 68 · see citing works
Wang, J.-L., & McDaniel, M. L. (1990) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(90)90882-n · Cited by 68 · see citing works
Ramanadham, S., Wolf, M. J., Jett, P. A., Gross, R. W., & Turk, J. (1994) · Biochemistry · doi:10.1021/bi00189a052 · Cited by 64 · see citing works
Glucose Regulation of Free Ca2+ in the Endoplasmic Reticulum of Mouse Pancreatic Beta Cells
Tengholm, A., Hellman, B., & Gylfe, E. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.52.36883 · Cited by 63 · see citing works
Self-citationDyachok, O., & Gylfe, E. (2001) · Journal of Cell Science · doi:10.1242/jcs.114.11.2179 · Cited by 61 · see citing works
Self-citationRamanadham, S., Bohrer, A., Gross, R. W., & Turk, J. (1993) · Biochemistry · doi:10.1021/bi00212a015 · Cited by 65 · see citing works
Chow, R. H.-P., Lund, P.-E., Löser, S., Panten, U., & Gylfe, E. (1995) · The Journal of Physiology · doi:10.1113/jphysiol.1995.sp020756 · Cited by 60 · see citing works
Self-citationCalle, R. A., Ganesan, S., Smallwood, J. I., & Rasmussen, H. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)37021-8 · Cited by 59 · see citing works
Tian, G., Tepikin, A. V., Tengholm, A., & Gylfe, E. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.292854 · Cited by 50 · see citing works
“ER sequestration of Ca is half-maximal and maximal at about 6 and 20 mM glucose, respectively (19,47-49).”
BackgroundSelf-citationGylfe, E. (1991) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/bf00370308 · Cited by 50 · see citing works
“Disregarding the residual carbachol response in the absence of glucose, the relationship was essentially hyperbolic and in that respect similar to the glucse-indueed lowering of [Ca2+]~ [10].”
BackgroundResultSelf-citationStožer, A., Klemen, M. S., Gosak, M., Bombek, L. K., Pohorec, V., Rupnik, M. S., & Dolenšek, J. (2021) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00043.2021 · Cited by 45 · see citing works
Yada, T., Kakei, M., & Tanaka, H. (1992) · Cell Calcium · doi:10.1016/0143-4160(92)90031-m · Cited by 44 · see citing works
Mitochondrial metabolism and dynamics in pancreatic beta cell glucose sensing
Rutter, G. A., Sidarala, V., Kaufman, B. A., & Soleimanpour, S. A. (2023) · Biochemical Journal · doi:10.1042/bcj20230167 · Cited by 39 · see citing works
Sener, A. (2002) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/s0304-4165(02)00337-9 · Cited by 38 · see citing works
Qian, W., Peters, J. L., Dahlgren, G. M., Gee, K., & Kennedy, R. (2004) · BioTechniques · doi:10.2144/04376bi01 · Cited by 35 · see citing works
Pulsatile insulin release from pancreatic islets with nonoscillatory elevation of cytoplasmic Ca2+.
Westerlund, J., Gylfe, E., & Bergsten, P. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119797 · Cited by 37 · see citing works
“Moreover, glucose and other stimulators of insulin secretion induce elevation of [Ca 2 1 ] i in b cells (15), and insulin secretion from permeabilized b cells is stimulated by a rise in the external Ca 2 1 concentration (16).”
BackgroundSelf-citationSAKURADA, M., Kanatsuka, A., Saitoh, T., Makino, H., Yamamura, K., Miyazaki, J., Kikuchi, M., & Yoshida, S. (1993) · Endocrinology · doi:10.1210/en.132.6.2659 · Cited by 36 · see citing works
Ca2+ oscillations in pancreatic β‐cells exposed to leucine and arginine
Grapengiesser, E., Gylfe, E., & Hellman, B. (1989) · Acta Physiologica Scandinavica · doi:10.1111/j.1748-1716.1989.tb08636.x · Cited by 34 · see citing works
Self-citationPortha, B., Saulnier, C., & Giroix, M.-H. (1999) · Diabetologia · doi:10.1007/s001250051255 · Cited by 31 · see citing works
Grapengiesser, E., Gylfe, E., & Hellman, B. (1992) · Cell Calcium · doi:10.1016/0143-4160(92)90010-p · Cited by 30 · see citing works
Self-citationInsulin secretagogues induce Ca2+-like changes in cytoplasmic Mg2+ in pancreatic β-cells
Gylfe, E. (1990) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/0167-4889(90)90094-t · Cited by 30 · see citing works
Self-citationMetabolic regulation of intracellular calcium concentration in mouse pancreatic islets of Langerhans
Nadal, Á., Valdeolmillos, M., & Soria, B. (1994) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1994.267.5.e769 · Cited by 30 · see citing works
Turk, J., Mueller, M., Bohrer, A., & Ramanadham, S. (1992) · Biochimica et Biophysica Acta · doi:10.1016/0005-2760(92)90057-3 · Cited by 28 · see citing works
Fujitani, S., Okazaki, K., & Yada, T. (1997) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0701017 · Cited by 26 · see citing works
“…and tolbutamide evoked a rapid increase in [Ca2+]i,, whereas the elevation of the glucose concentration to 16.7 mM resulted in an initial decrease followed by a subsequent increase in [Ca2+]i, the bimodal response characteristic of the metabolized secretagogues (Gylfe, 1988; Yada et al., 1992).”
BackgroundInfluentialMetabolic amplification of insulin secretion by glucose is independent of β-cell microtubules.
Mourad, N., Nenquin, M., & Henquin, J. (2011) · American Journal of Physiology - Cell Physiology · doi:10.1152/ajpcell.00329.2010 · Cited by 24 · see citing works
Signaling Underlying Pulsatile Insulin Secretion
Gylfe, E., Ahmed, M., Bergsten, P., Dansk, H., Dyachok, O., Eberhardson, M., Grapengiesser, E., Hellman, B., Lin, J., Lin, J., et al. (2000) · Upsala Journal of Medical Sciences · doi:10.1517/03009734000000054 · Cited by 23 · see citing works
Self-citationMultiphasic Action of Glucose and -Ketoisocaproic Acid on the Cytosolic pH of Pancreatic -Cells
Salgado, A. P., Silva, A. M., Santos, R. M., & Rosário, L. M. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.15.8738 · Cited by 17 · see citing works
Tengholm, A., McClenaghan, N. H., Grapengiesser, E., Gylfe, E., & Hellman, B. (1992) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/0167-4889(92)90143-y · Cited by 17 · see citing works
Self-citationPreclinical and Clinical Studies for Sodium Tungstate: Application in Humans
Bertinat, R. (2015) · Journal of Clinical & Cellular Immunology · doi:10.4172/2155-9899.1000285 · Cited by 16 · see citing works
“In order to maintain normoglycemia, β-cells secrete insulin in response to different stimuli [87,88].”
BackgroundGlucose intolerance and pancreatic β-cell dysfunction in the anorecticanx/anxmouse
Lindfors, C., Katz, A., Selander, L., Johansen, J. E., Marconi, G., Schalling, M., Hökfelt, T. G. M., Berggren, P., Zaitsev, S. V., & Nilsson, I. A. K. (2015) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00081.2015 · Cited by 13 · see citing works
“This decrease in [Ca(2) ]i due to uptake of Ca(2) in the endoplasmic reticulum is seen under normal circumstances (15).”
BackgroundShepherd, R. M., Gilon, P., & Henquin, J. C. (1996) · Endocrinology · doi:10.1210/en.137.2.677 · Cited by 12 · see citing works
Gylfe, E. (1989) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(89)92194-3 · Cited by 12 · see citing works
Self-citationGlucose Metabolism Regulates Cytosolic Ca2+ in the Pancreatic β-Cell by Three Different Mechanisms
Nadal, Á., & Soria, B. (1997) · Advances in experimental medicine and biology · doi:10.1007/978-1-4899-1819-2_33 · Cited by 10 · see citing works
Pancreatic islets cultured on extracellular matrix: An excellent preparation for microfluorometry
Arkhammar, P. O. G., Terry, B. R., Kofod, H., & Thastrup, M. (1998) · Methods in Cell Science · doi:10.1023/a:1009712630494 · Cited by 10 · see citing works
GYLFE, E. (1990) · Nature · doi:10.1038/344300b0 · Cited by 5 · see citing works
Self-citationJijakli, H., Courtois, P., Zhang, H., Sener, A., & Malaisse, W. J. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m206730200 · Cited by 4 · see citing works
Chapter 8 Calcium dysregulation, insulin release and the pathogenesis of diabetes
Bergsten, P. (2002) · Advances in cell aging and gerontology · doi:10.1016/s1566-3124(02)10020-4 · Cited by 3 · see citing works
THE SPINY MOUSE: IN SEARCH OF AN ANIMAL MODEL FOR PATHOGENESIS OF TYPE 2 DIABETES MELLITUS
Nesher, R., & Cerasi, E. (2013) · Israel Journal of Zoology · doi:10.1080/00212210.1994.10688747 · Cited by 3 · see citing works
Lebrun, P., Antoine, M.-H., Nguyễn, Q. A., Picton, S., & Malaisse, W. J. (2000) · Cell Calcium · doi:10.1054/ceca.2000.0113 · Cited by 2 · see citing works
Henquin, J., Jonas, J., Sato, Y., DETIMARY, P., & Gilon, P. (1999) · Advances in molecular and cell biology · doi:10.1016/s1569-2558(08)60096-x · Cited by 2 · see citing works
Gylfe, E. (1992) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/bf00165742 · Cited by 2 · see citing works
Self-citationDrews, G. (1996) · Springer eBooks · doi:10.1007/978-3-642-60946-6_67 · Cited by 2 · see citing works
ESTUDO DO POTENCIAL HIPOGLICEMIANTE DA WILBRANDIA EBRACTEATA EM RATOS NORMAIS E DIABÉTICOS
Folador, P. (2009) · LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas)
Malm, D., Tollersrud, O. K., Vonen, B., & Florholmen, J. R. (1996) · Scandinavian Journal of Clinical and Laboratory Investigation · doi:10.3109/00365519609088599
- Authors
- Gylfe, E.
- Affiliations
- Uppsala University (SE)
- Corresponding author
- Gylfe, E
- ORCID
- Gylfe, E
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1988-09
- Volume
- 263
- Issue
- 27
- Pages
- 13750-13754
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1576072320
- Cited by
- 61
- References
- 41
- Citations by year
- 2023: 1 · 2021: 1 · 2015: 3 · 2013: 1 · 2012: 1
- FWCI
- 4.74
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Biological Chemistry (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Calcium signaling and nucleotide metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion channel regulation and function
- Keywords
- intracellular calcium, insulin secretion, pancreatic beta cells, glucose, calcium influx, calcium efflux, leucine, alpha-ketoisocaproate, mannose, fructose, L-arginine, ob/ob mice, fura-2
- MeSH terms
- Insulin Secretion, Amino Acids, Amino Acids, Cyclic, Animals, Arginine, Calcium, Cytoplasm, Dose-Response Relationship, Drug, Glucose, Glutamine, Insulin, Islets of Langerhans, Keto Acids, Leucine, Mice, Obese, Obesity, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
