Hormonal regulation of hepatic gluconeogenesis.

Kraus-Friedmann, N

doi:10.1152/physrev.1984.64.1.170

Cited by 277Metabolism, Diabetes, and CancerGrowth Hormone and Insulin-like Growth FactorsPancreatic function and diabetes

Hormonal regulation of hepatic gluconeogenesis.

Kraus-Friedmann, N·1984·Physiological Reviews

DOI 10.1152/physrev.1984.64.1.170

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Angiotensin II, a major hormone of the RAAS, supports re-allocation of energy-rich fuels and calcium/phosphorus to an activated immune system.
“Thus, similar to the SNS with its major neurotransmitters noradrenaline/adrenaline, angiotensin II, a major hormone of the RAAS, supports re-allocation of energy-rich fuels and calcium/phosphorus to an activated immune system.”
From Interaction of the endocrine system with inflammation: a function of energy and volume regulation (2014) · cites this paper as [74]

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“In the liver, GC excess increases glucose production directly, through the activation of enzymes for gluconeogenesis, together with the stimulation of lipolysis and proteolysis, with a parallel increase of substrates for gluconeogenesis [33].”
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Thiol Oxidation and Cytochrome P450-Dependent Metabolism of CCl4 Triggers Ca2+ Release from Liver Microsomes
Stoyanovsky, D. A., & Cederbaum, A. I. (1996) · Biochemistry · doi:10.1021/bi961295p · Cited by 40 · see citing works
Time course of changes in gluconeogenic enzyme activities during exercise and recovery
Dohm, G. L., Kasperek, G. J., & Barakat, H. A. (1985) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1985.249.1.e6 · Cited by 40 · see citing works
Prevention and management of neonatal hypoglycaemia.
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The role of the matrix calcium level in the enhancement of mitochondrial pyruvate carboxylation by glucagon pretreatment.
Walajtys-Rhode, E., Zapatero, J., Moehren, G., et al. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)48504-3 · Cited by 39 · see citing works
Glycogen synthesis from lactate in skeletal muscle of the lizardDipsosaurus dorsalis
Gleeson, T. T. (1985) · Journal of Comparative Physiology B · doi:10.1007/bf00695783 · Cited by 39 · see citing works
The effect of chronic cortisol elevation on urea metabolism and excretion in the rainbow trout ( Oncorhynchus mykiss )
McDonald, M. D., & Wood, C. M. (2004) · Journal of Comparative Physiology B · doi:10.1007/s00360-003-0390-4 · Cited by 38 · see citing works
“…has for decades been associated with an increased urea production, the primary nitrogenous waste in mammals, and elevated urea excretion has been used as an indicator of protein breakdown in response to glucocorticoids (Ingle 1952; Christowitz et al. 1981; reviewed by Kraus-Friedmann 1984).”
Background
Changes in Hepatic Key Enzymes of Dairy Calves in Early Weaning Production Systems
Haga, S., Fujimoto, S., Yonezawa, T., et al. (2008) · Journal of Dairy Science · doi:10.3168/jds.2007-0853 · Cited by 36 · see citing works
“It is known that hepatic PC and PEPCK activities are stimulated by glucocorticoids (Kraus-Friedmann, 1984; Pilkis and Granner, 1992; Jitrapakdee and Wallace, 1999).”
Background
Metabolic responses induced by fasting in the common vampire bat Desmodus rotundus
Freitas, M. B., Welker, A. F., Millán, S., & Pinheiro, E. C. (2003) · Journal of Comparative Physiology B · doi:10.1007/s00360-003-0383-3 · Cited by 37 · see citing works
“The breakdown of liver glycogen and hepatic production of glucose especially from alanine, have been reported as the main metabolic responses of mammals to food shortages (Kraus-Friedmann 1984).”
Background
Regulation of forkhead box O1 (FOXO1) by protein kinase B and glucocorticoids: different mechanisms of induction of beta cell death in vitro
Kaiser, G., Gerst, F., Michael, D., Berchtold, S., Friedrich, B., Strutz‐Seebohm, N., Lang, F. J. W., Häring, H., & Ullrich, S. (2013) · Diabetologia · doi:10.1007/s00125-013-2863-7 · Cited by 36 · see citing works
“Glucocorticoids regulate physiological blood glucose concentration by mobilising glucose from hepatocytes [40].”
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Effects of chronic environmental acidification and a summer global warming scenario: protein synthesis in juvenile rainbow trout (Oncorhynchus mykiss)
Reid, S. D., Dockray, J. J., Linton, T. K., et al. (1997) · Canadian Journal of Fisheries and Aquatic Sciences · doi:10.1139/f97-109 · Cited by 36 · see citing works
Mechanisms involved in catecholamine effect on glycogenolysis in catfish isolated hepatocytes
Brighenti, L., Puviani, A. C., Gavioli, M. E., & Ottolenghi, C. (1987) · General and Comparative Endocrinology · doi:10.1016/0016-6480(87)90239-5 · Cited by 36 · see citing works
β-cell activity and hepatic insulin extraction following dexamethasone administration in healthy subjects
Kautzky-Willer, A., Thomaseth, K., Clodi, M., Ludvik, B., Waldhäusl, W., Prager, R., & Pacini, G. (1996) · Metabolism · doi:10.1016/s0026-0495(96)90224-3 · Cited by 35 · see citing works
A study of the mechanism of glucagon-induced protein phosphorylation in isolated rat hepatocytes using (Sp)-cAMPS and (Rp)-cAMPS, the stimulatory and inhibitory diastereomers of adenosine cyclic 3',5'-phosphorothioate.
Connelly, P. A., Botelho, L. H. P., Sisk, R. B., et al. (1987) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)61351-1 · Cited by 35 · see citing works
Metabolic fate of a gastric glucose load in unrestrained rats bearing a portal vein catheter
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Insulin and the regulation of glycogen metabolism and gluconeogenesis in American eel hepatocytes
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Stimulation of the respiration rate of rat liver mitochondria by sub-micromolar concentrations of extramitochondrial Ca2+
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Effect of norepinephrine on gluconeogenesis in perfused livers of cold-exposed rats
Shiota, M., Tanaka, T., & Sugano, T. (1985) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1985.249.3.e281 · Cited by 34 · see citing works
pH dependence of hormonal regulation of gluconeogenesis and urea synthesis from glutamine in suspensions of hepatocytes.
Kashiwagura, T., Erecińska, M., & Wilson, D. F. (1985) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)89746-0 · Cited by 34 · see citing works
Hepatic gluconeogenesis and PDK3 upregulation drive cancer cachexia in flies and mice
Liu, Y., Dantas, E., Ferrer, M., Miao, T., Qadiri, M., Liu, Y., Comjean, A., Davidson, E. E., Perrier, T., Ahmed, T., et al. (2025) · Nature Metabolism · doi:10.1038/s42255-025-01265-2 · Cited by 35 · see citing works
“In animals and humans, gluconeogenesis is typically regulated by insulin and glucagon 63,84 .”
Changes in Intracellular Calcium Induced by Acute Hypothermia in Parenchymal, Endothelial, and Kupffer Cells of the Rat Liver
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Exogenous Glucocorticoids and a High-Fat Diet Cause Severe Hyperglycemia and Hyperinsulinemia and Limit Islet Glucose Responsiveness in Young Male Sprague-Dawley Rats
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The Effect of Fasting on Tissue Cyclic cAMP and Plasma Glucagon in the Obese Hyperglycemic Mouse
VINE, R. L. L., Voyles, N. R., Perrino, P. V., & Recant, L. (1975) · Endocrinology · doi:10.1210/endo-97-3-615 · Cited by 38 · see citing works
Modulation of Adipoinsular Axis in Prediabetic Zucker Diabetic Fatty Rats by Diazoxide
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Mechanisms of Impaired Growth Hormone Secretion in Genetically Obese Zucker Rats: Roles of Growth Hormone-Releasing Factor and Somatostatin*
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Growth hormone binding protein in the rat: effects of gonadal steroids
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Authors: Kraus-Friedmann, N.
Corresponding author: Kraus-Friedmann, N
Venue: Physiological Reviews
Publisher: American Physiological Society
Published: 1984-01
Volume: 64
Issue: 1
Pages: 170-259
ISSN: 0031-9333 (ISSN-L)
1522-1210
DOI: 10.1152/physrev.1984.64.1.170
OpenAlex: W2260757043
Cited by: 276
References: 0
Citations by year: 2026: 3 · 2025: 2 · 2024: 4 · 2023: 11 · 2022: 3 · 2021: 2 · 2020: 6 · 2019: 5 · 2018: 6 · 2017: 3 · 2016: 7 · 2015: 8 · 2014: 4 · 2013: 5 · 2012: 9
FWCI: 7.11
Type: journal article
Language: en
Open access: closed
Locations: Physiological Reviews (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
Keywords: hepatic gluconeogenesis, hormonal regulation, glucose metabolism, liver, insulin, glucagon, glucocorticoids, epinephrine
MeSH terms: Angiotensin II, Animals, Calcium, Catecholamines, Cell-Free System, Cells, Cultured, Cytoplasm, Cytosol, Glucagon, Glucocorticoids, Gluconeogenesis, Hormones, Insulin, Ions, Liver, Microsomes, Liver, Mitochondria, Liver, Pancreatic Hormones, Perfusion, Phosphoenolpyruvate Carboxykinase (GTP), Pyruvate Kinase, Somatostatin, Vasopressins, Rats

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