Italian Society for the Study of Diabetes (SID)/Italian Endocrinological Society (SIE) guidelines on the treatment of hyperglycemia in Cushing’s syndrome and acromegaly
Abstract
Hyperglycemia is a common feature associated with states of increased growth hormone secretion and glucocorticoid levels. The purpose of these guidelines is to assist clinicians and other health care providers to take evidence-based therapeutic decisions for the treatment of hyperglycemia in patients with growth hormone and corticosteroid excess. Both the SID and SIE appointed members to represent each society and to collaborate in Guidelines writing. Members were chosen for their specific knowledge in the field. Each member agreed to produce-and regularly update-conflicts of interest. The authors of these guidelines prepared their contributions following the recommendations for the development of Guidelines, using the standard classes of recommendation shown below. All members of the writing committee provided editing and systematic review of each part of the manuscript, and discussed the grading of evidence. Consensus was guided by a systematic review of all available trials and by interactive discussions.
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Controlling hypercortisolism is the first step toward improving glucose metabolism in endogenous Cushing syndrome, but different treatments may affect diabetes outcome regardless of how well cortisol excess is corrected.
“Controlling hypercortisolism is the first step toward improving glucose metabolism in patients with endogenous CS, but different treatments for hypercortisolism may affect the outcome of diabetes, regardless of how well cortisol excess is corrected (, , , , , , ).”
From Glucose Metabolism Abnormalities in Cushing Syndrome: From Molecular Basis to Clinical Management (2017) · cites this paper as [264]
No studies have specifically investigated the role of antidiabetic therapy in treating hyperglycemia in patients with endogenous Cushing syndrome.
“Although GCs are well known to induce DM, no studies have specifically investigated the role of antidiabetic therapy in the treatment of hyperglycemia in patients with endogenous CS, and few studies have reported the effects of some antidiabetic agents in exogenous GC-induced hyperglycemia.”
From Glucose Metabolism Abnormalities in Cushing Syndrome: From Molecular Basis to Clinical Management (2017) · cites this paper as [264]
Few studies have reported the effects of some antidiabetic agents in exogenous glucocorticoid-induced hyperglycemia.
“Although GCs are well known to induce DM, no studies have specifically investigated the role of antidiabetic therapy in the treatment of hyperglycemia in patients with endogenous CS, and few studies have reported the effects of some antidiabetic agents in exogenous GC-induced hyperglycemia.”
From Glucose Metabolism Abnormalities in Cushing Syndrome: From Molecular Basis to Clinical Management (2017) · cites this paper as [264]
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Glucose Metabolism Abnormalities in Cushing Syndrome: From Molecular Basis to Clinical Management
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- Authors
- Baroni, M. G., Giorgino, F., Pezzino, V., Scaroni, C., & Avogaro, A.
- Affiliations
- Sapienza University of Rome (IT)
- University of Bari Aldo Moro (IT)
- University of Catania (IT)
- University of Padua (IT)
- Corresponding author
- Avogaro, A.
- Venue
- Journal of Endocrinological Investigation
- Published
- 2015-12-30
- Volume
- 39
- Issue
- 2
- Pages
- 235-255
- ISSN
- 0391-4097 (ISSN-L)
- 1720-8386
- OpenAlex
- W2277055097
- Cited by
- 41
- References
- 184
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 1 · 2023: 8 · 2022: 2 · 2021: 3 · 2020: 6 · 2019: 3 · 2018: 5 · 2017: 5 · 2016: 4 · 2015: 1
- FWCI
- 4.35
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Journal of Endocrinological Investigation (publishedVersion)
- PubMed (publishedVersion)
- IRIS Research product catalog (Sapienza University of Rome) (submittedVersion)
- CINECA IRIS Institutional Research Information System (University of Bari Aldo Moro) (submittedVersion)
- Archivio Istituzionale della Ricerca - Università degli Studi dell Aquila (submittedVersion)
- Padua Research Archive (University of Padova) (submittedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pituitary Gland Disorders and Treatments
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Keywords
- hyperglycemia, Cushing's syndrome, acromegaly, growth hormone excess, glucocorticoid excess, diabetes treatment, corticosteroid excess, evidence-based care
- MeSH terms
- Acromegaly, Combined Modality Therapy, Cushing Syndrome, Diabetes Mellitus, Endocrinology, Glucocorticoids, Humans, Hyperglycemia, Italy, Societies, Scientific, Evidence-Based Medicine, Human Growth Hormone, Consensus, Precision Medicine
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