The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Neurotoxins Affecting Neuroexocytosis
Abstract
Nerve terminals are specific sites of action of a very large number of toxins produced by many different organisms. The mechanism of action of three groups of presynaptic neurotoxins that interfere directly with the process of neurotransmitter release is reviewed, whereas presynaptic neurotoxins acting on ion channels are not dealt with here. These neurotoxins can be grouped in three large families: 1) the clostridial neurotoxins that act inside nerves and block neurotransmitter release via their metalloproteolytic activity directed specifically on SNARE proteins; 2) the snake presynaptic neurotoxins with phospholipase A 2 activity, whose site of action is still undefined and which induce the release of acethylcholine followed by impairment of synaptic functions; and 3) the excitatory latrotoxin-like neurotoxins that induce a massive release of neurotransmitter at peripheral and central synapses. Their modes of binding, sites of action, and biochemical activities are discussed in relation to the symptoms of the diseases they cause. The use of these toxins in cell biology and neuroscience is considered as well as the therapeutic utilization of the botulinum neurotoxins in human diseases characterized by hyperfunction of cholinergic terminals.
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Cites
Crystal structure of a SNARE complex involved in synaptic exocytosis at 2.4 Å resolution
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Structure of influenza haemagglutinin at the pH of membrane fusion
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Cited by
Genetic ablation of the t-SNARE SNAP-25 distinguishes mechanisms of neuroexocytosis
Washbourne, P., Thompson, P. M., Carta, M., Costa, E. T., Mathews, J. R., Lopez-Benditó, G., Molnár, Z., Becher, M. W., Valenzuela, C. F., Partridge, L. D., et al. (2002) · Nature Neuroscience · doi:10.1038/nn783 · Cited by 543
Mechanisms of Degranulation in Neutrophils
Lacy, P. (2006) · Allergy, Asthma & Clinical Immunology · doi:10.1186/1710-1492-2-3-98 · Cited by 473
Regulated Exocytosis Contributes to Protein Kinase C Potentiation of Vanilloid Receptor Activity
Morenilla-Palao, C., Planells-Cases, R., García-Sanz, N., & Ferrer-Montiel, A. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m311515200 · Cited by 425
Quantitative analysis of the native presynaptic cytomatrix by cryoelectron tomography
Fernández-Busnadiego, R., Zuber, B., Maurer, U. E., Cyrklaff, M., Baumeister, W., & Lučić, V. (2010) · Journal of Cell Biology · doi:10.1083/jcb.200908082 · Cited by 267
Operation of a homeostatic sleep switch
Pimentel, D., Donlea, J. M., Talbot, C. B., Song, S. M., Thurston, A. J. F., & Miesenböck, G. (2016) · Nature · doi:10.1038/nature19055 · Cited by 265
Metadata
- Authors
- Schiavo, G., Matteoli, M., & Montecucco, C.
- Venue
- Physiological Reviews
- Publisher
- American Physiological Society
- Published
- 2000-01-04
- Volume
- 80
- Issue
- 2
- Pages
- 717-766
- ISSN
- 0031-9333 (ISSN-L)
- 1522-1210
- OpenAlex
- W2122977798
- Cited by
- 1,269
- References
- 6
- FWCI
- 6.01
- Type
- journal article
- Language
- en
- Open access
- closed
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