Cited by 170Biomarkers in Disease MechanismsVenomous Animal Envenomation and StudiesS100 Proteins and Annexins

Neuronal Pentraxin Receptor, a Novel Putative Integral Membrane Pentraxin That Interacts with Neuronal Pentraxin 1 and 2 and Taipoxin-associated Calcium-binding Protein 49

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Dodds, D'Nette C., Omeis, Ibrahim A., Cushman, Susan J., Helms, Jill A., Perin, Mark S.·1997·Journal of Biological Chemistry

Abstract

We have identified the first putative integral membrane pentraxin and named it neuronal pentraxin receptor (NPR). NPR is enriched by affinity chromatography on columns of a snake venom toxin, taipoxin, and columns of the taipoxin-binding proteins neuronal pentraxin 1 (NP1), neuronal pentraxin 2 (NP2), and taipoxin-associated calcium-binding protein 49 (TCBP49). The predominant form of NPR contains an putative NH2-terminal transmembrane domain and all forms of NPR are glycosylated. NPR has 49 and 48% amino acid identity to NP1 and NP2, respectively, and NPR message is expressed in neuronal regions that express NP1 and NP2. We suggest that NPR, NP1, NP2, and TCBP49 are involved in a pathway responsible for the transport of taipoxin into synapses and that this may represent a novel neuronal uptake pathway involved in the clearance of synaptic debris.

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Crossref · 10.1074/jbc.272.34.21488

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Authors
Dodds, D. C., Omeis, I. A., Cushman, S. J., Helms, J. A., & Perin, M. S.
Affiliations
  • Baylor College of Medicine (US)
  • University of California, San Francisco (US)
Corresponding author
Perin, Mark S.
Venue
Journal of Biological Chemistry
Publisher
Elsevier BV
Published
1997-08
Volume
272
Issue
34
Pages
21488-21494
ISSN
0021-9258 (ISSN-L)
OpenAlex
W2162193325
Cited by
170
References
26
Citations by year
2026: 5 · 2025: 3 · 2024: 6 · 2023: 1 · 2022: 5 · 2021: 6 · 2020: 18 · 2019: 2 · 2018: 5 · 2017: 4 · 2016: 3 · 2015: 5 · 2014: 7 · 2013: 5 · 2012: 3
FWCI
2.17
Type
journal article
Language
en
Open access
Locations
  • Journal of Biological Chemistry (publishedVersion, cc-by)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › Biomarkers in Disease Mechanisms
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Venomous Animal Envenomation and Studies
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › S100 Proteins and Annexins
Keywords
NPTX2, taipoxin, transmembrane domain, glycosylation, snake venom toxins, protein-protein interaction, neuronal expression
MeSH terms
Pentraxins, Amino Acid Sequence, Animals, Base Sequence, C-Reactive Protein, Calcium-Binding Proteins, Chromatography, Affinity, Elapid Venoms, Membrane Glycoproteins, Molecular Sequence Data, Molecular Weight, Nerve Tissue Proteins, Receptors, Cell Surface, RNA, Messenger, Sequence Alignment, Mannosyl-Glycoprotein Endo-beta-N-Acetylglucosaminidase, In Situ Hybridization, Rats

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