The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Proximal Tubular Phosphate Reabsorption: Molecular Mechanisms
Abstract
Renal proximal tubular reabsorption of P i is a key element in overall P i homeostasis, and it involves a secondary active P i transport mechanism. Among the molecularly identified sodium-phosphate (Na/P i) cotransport systems a brush-border membrane type IIa Na-P i cotransporter is the key player in proximal tubular P i reabsorption. Physiological and pathophysiological alterations in renal P i reabsorption are related to altered brush-border membrane expression/content of the type IIa Na-P i cotransporter. Complex membrane retrieval/insertion mechanisms are involved in modulating transporter content in the brush-border membrane. In a tissue culture model (OK cells) expressing intrinsically the type IIa Na-P i cotransporter, the cellular cascades involved in “physiological/pathophysiological” control of P i reabsorption have been explored. As this cell model offers a “proximal tubular” environment, it is useful for characterization (in heterologous expression studies) of the cellular/molecular requirements for transport regulation. Finally, the oocyte expression system has permitted a thorough characterization of the transport characteristics and of structure/function relationships. Thus the cloning of the type IIa Na-P i cotransporter (in 1993) provided the tools to study renal brush-border membrane Na-P i cotransport function/regulation at the cellular/molecular level as well as at the organ level and led to an understanding of cellular mechanisms involved in control of proximal tubular P i handling and, thus, of overall P i homeostasis.
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Cites
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Self-citationAutocrine/paracrine regulation of renal Na(+)-phosphate cotransport by dopamine
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Up-regulation of FGF23 release by aldosterone
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Metadata
- Authors
- Murer, H., Hernando, N., Forster, I., & Biber, J.
- Venue
- Physiological Reviews
- Publisher
- American Physiological Society
- Published
- 2000-01-10
- Volume
- 80
- Issue
- 4
- Pages
- 1373-1409
- ISSN
- 0031-9333 (ISSN-L)
- 1522-1210
- OpenAlex
- W1948548825
- Cited by
- 491
- References
- 2
- FWCI
- 10.76
- Type
- journal article
- Language
- en
- Open access
- closed
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