The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Heat Shock Proteins and Cardiovascular Pathophysiology
Abstract
In the eukaryotic cell an intrinsic mechanism is present providing the ability to defend itself against external stressors from various sources. This defense mechanism probably evolved from the presence of a group of chaperones, playing a crucial role in governing proper protein assembly, folding, and transport. Upregulation of the synthesis of a number of these proteins upon environmental stress establishes a unique defense system to maintain cellular protein homeostasis and to ensure survival of the cell. In the cardiovascular system this enhanced protein synthesis leads to a transient but powerful increase in tolerance to such endangering situations as ischemia, hypoxia, oxidative injury, and endotoxemia. These so-called heat shock proteins interfere with several physiological processes within several cell organelles and, for proper functioning, are translocated to different compartments following stress-induced synthesis. In this review we describe the physiological role of heat shock proteins and discuss their protective potential against various stress agents in the cardiovascular system.
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Levy, D., Garrison, R. J., Savage, D. D., Kannel, W. B., & Castelli, W. P. (1990) · New England Journal of Medicine · doi:10.1056/nejm199005313222203 · Cited by 5,699
Heat Shock Transcription Factors: Structure and Regulation
Wu, C. (1995) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cb.11.110195.002301 · Cited by 1,231
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Loreti, E., Poggi, A., Novi, G., Alpi, A., & Perata, P. (2005) · Plant Physiology · doi:10.1104/pp.104.057299 · Cited by 302
Nitrite as a mediator of ischemic preconditioning and cytoprotection
Murillo, D., Kamga, C., Mo, L., & Shiva, S. (2011) · Nitric Oxide · doi:10.1016/j.niox.2011.01.003 · Cited by 57
Alarmins in chronic noncommunicable diseases: Atherosclerosis, diabetes and cancer
Boteanu, R. M., Suica, V. I., Uyy, E., Ivan, L., Dima, S. O., Popescu, I., Simionescu, M., & Antohe, F. (2017) · Journal of Proteomics · doi:10.1016/j.jprot.2016.11.006 · Cited by 38
Metadata
- Authors
- Snoeckx, L. H. E. H., Cornelussen, R. N., Van Nieuwenhoven, F. A., Reneman, R. S., & Van der Vusse, G. J.
- Venue
- Physiological Reviews
- Publisher
- American Physiological Society
- Published
- 2001-01-10
- Volume
- 81
- Issue
- 4
- Pages
- 1461-1497
- ISSN
- 0031-9333 (ISSN-L)
- 1522-1210
- OpenAlex
- W2180121032
- Cited by
- 374
- References
- 2
- FWCI
- 1.13
- Type
- journal article
- Language
- en
- Open access
- closed
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- Snoeckx, L. H. E. H., Cornelussen, R. N., Van Nieuwenhoven, F. A., Reneman, R. S., & Van der Vusse, G. J. (2001). Heat Shock Proteins and Cardiovascular Pathophysiology. Physiological Reviews. https://doi.org/10.1152/physrev.2001.81.4.1461
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