The diagnostic role of serum inflammatory and soluble proteins on dementia subtypes: Correlation with cognitive and functional decline
Open accessAbstract
In the past years, the possible involvement of inflammation in the pathogenesis of dementia has been the subject of several investigations. However there are restricted data about the profile of the inflammatory and soluble proteins in well evaluated Alzheimer's disease (AD), vascular dementia (VD), mild cognitive impairment (MCI) and healthy controls. There are also no reliable data regarding the relationship between the overlapping protein levels and cognitive or functional decline. We measured levels of IL-1beta, IL-2, IL-6, IL-18, TNF-alpha, beta-Amlyloid 1-40 and alpha1-antichymotrypsin levels in plasma in groups of total 82 subjects with AD, MCI, VD and controls using enzyme-linked immunosorbent assay (ELISA) method. Our study samples showed high levels of proinflammatory cytokine levels (especially IL-18) in all patient groups but only high levels of alpha1-antichymotrypsine in VD patients compared to controls. There is no significant correlation between the laboratory and clinical variables except for a link between IL-1beta and NPI scores of AD. In conclusion, this study yielded evidence of some shared mechanisms underlying AD and VD and thus motivates further studies of inflammatory markers in various types of dementia and MCI.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Higher expression of IL-1β and IL-18 has been reported in microglia, astrocytes, and neurons surrounding Aβ plaques or in plasma of AD patients.
“Inflammasome and its products have been implicated in AD pathogenesis since a higher expression of IL-1β and IL-18 has been reported in the microglia, astrocytes, and neurons that surround Aβ plaques or in the plasma of AD patients (221–225).”
From The gut-brain axis: how microbiota and host inflammasome influence brain physiology and pathology (2020) · cites this paper as [225]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
McKhann, G., Drachman, D., Folstein, M., Katzman, R., Price, D., & Stadlan, E. M. (1984) · Neurology · doi:10.1212/wnl.34.7.939 · Cited by 27,915 · see citing works
Assessment of Older People: Self-Maintaining and Instrumental Activities of Daily Living
Lawton, M. P., & Brody, E. M. (1969) · The Gerontologist · doi:10.1093/geront/9.3_part_1.179 · Cited by 18,540 · see citing works
McKhann, G., Drachman, D., Folstein, M., Katzman, R., Price, D. L., & Stadlan, E. (2011) · Neurology · doi:10.1212/01.wnl.0000400650.92875.cf · Cited by 9,882 · see citing works
A New Clinical Scale for the Staging of Dementia
Hughes, C. P., Berg, L., Danziger, W., Coben, L. A., & Martin, R. L. (1982) · British Journal of Psychiatry · doi:10.1192/bjp.140.6.566 · Cited by 7,056 · see citing works
Román, G. C., Tatemichi, T. K., Erkinjuntti, T., Cummings, J. L., Masdeu, J. C., Garcia, J. H., Amaducci, L., Orgogozo, J.-M., Brun, A., Hofman, A., et al. (1993) · Neurology · doi:10.1212/wnl.43.2.250 · Cited by 4,921 · see citing works
Inflammation and Alzheimer’s disease
Akiyama, H. (2000) · Neurobiology of Aging · doi:10.1016/s0197-4580(00)00124-x · Cited by 4,514 · see citing works
Cloning of a new cytokine that induces IFN-γ production by T cells
Okamura, H., Tsutsui, H., Komatsu, T., Yutsudo, M., Hakura, A., Tanimoto, T., Torigoe, K., Okura, T., Nukada, Y., Hattori, K., et al. (1995) · Nature · doi:10.1038/378088a0 · Cited by 2,602 · see citing works
Petersen, R. C., Stevens, J. C., Ganguli, M., Tangalos, E. G., Cummings, J. L., & DeKosky, S. T. (2001) · Neurology · doi:10.1212/wnl.56.9.1133 · Cited by 2,065 · see citing works
Deciphering the Molecular Basis of Memory Failure in Alzheimer's Disease
Walsh, D. M., & Selkoe, D. J. (2004) · Neuron · doi:10.1016/j.neuron.2004.09.010 · Cited by 1,207 · see citing works
Abraham, C. R., Selkoe, D. J., & Potter, H. (1988) · Cell · doi:10.1016/0092-8674(88)90462-x · Cited by 893 · see citing works
Dickson, D. W., Lee, S. C., Mattiace, L. A., Yen, S.-H. C., & Brosnan, C. F. (1993) · Glia · doi:10.1002/glia.440070113 · Cited by 821 · see citing works
Blum-Degena, D., Müller, T., Kuhn, W., Gerlach, M., Przuntek, H., & Riederer, P. (1995) · Neuroscience Letters · doi:10.1016/0304-3940(95)12192-7 · Cited by 801 · see citing works
Griffin, W., Sheng, J. G., Royston, M., Gentleman, S., McKenzie, J., Graham, D. I., Roberts, G., & Mrak, R. (1998) · Brain Pathology · doi:10.1111/j.1750-3639.1998.tb00136.x · Cited by 751 · see citing works
The role of inflammation in Alzheimer’s disease
Tuppo, E. E., & Arias, H. R. (2005) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2004.07.009 · Cited by 734 · see citing works
Proinflammatory Cytokines and Early Neurological Worsening in Ischemic Stroke
Vila, N., Castillo, J., Dávalos, A., & Chamorro, Á. (2000) · Stroke · doi:10.1161/01.str.31.10.2325 · Cited by 676 · see citing works
del Zoppo, G., Ginis, I., Hallenbeck, J. M., Iadecola, C., Wang, X., & Feuerstein, G. Z. (2000) · Brain Pathology · doi:10.1111/j.1750-3639.2000.tb00247.x · Cited by 660 · see citing works
(1991) · American Journal of Psychiatry · doi:10.1176/ajp.148.1.102 · Cited by 647 · see citing works
Cytokines and cognition–the case for a head-to-toe inflammatory paradigm.
Wilson, C. J., Finch, C. E., & Cohen, H. J. (2002) · Journal of the American Geriatrics Society · doi:10.1046/j.1532-5415.2002.50619.x · Cited by 637 · see citing works
Plasma and Cerebrospinal Fluid Levels of Amyloid β Proteins 1-40 and 1-42 in Alzheimer Disease
Mehta, P. D., Pirttilä, T., Mehta, S. P., Sersen, E. A., Aisen, P. S., & Wisniewski, H. M. (2000) · Archives of Neurology · doi:10.1001/archneur.57.1.100 · Cited by 582 · see citing works
DeMattos, R. B., Bales, K. R., Cummins, D. J., Paul, S. M., & Holtzman, D. M. (2002) · Science · doi:10.1126/science.1067568 · Cited by 563 · see citing works
Interleukin-6 and risk of cognitive decline: MacArthur Studies of Successful Aging
Weaver, J. D., Huang, M.-H., Albert, M., Harris, T., Rowe, J. W., & Seeman, T. E. (2002) · Neurology · doi:10.1212/wnl.59.3.371 · Cited by 536 · see citing works
Intrathecal inflammation precedes development of Alzheimer's disease
Tarkowski, E. (2003) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.74.9.1200 · Cited by 501 · see citing works
Microglia in degenerative neurological disease
McGeer, P. L., Kawamata, T., Walker, D. G., Akiyama, H., Tooyama, I., & McGeer, E. G. (1993) · Glia · doi:10.1002/glia.440070114 · Cited by 500 · see citing works
Molloy, D., Alemayehu, E., & Roberts, R. E. (1991) · Alzheimer Disease & Associated Disorders · doi:10.1097/00002093-199100530-00020 · Cited by 488 · see citing works
Inflammatory processes in Alzheimer's disease
McGeer, E. G., & McGeer, P. L. (2003) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/s0278-5846(03)00124-6 · Cited by 473 · see citing works
Licastro, F., Pedrini, S., Caputo, L., Annoni, G., Davis, L. J., Ferri, C., Casadei, V. M., & Grimaldi, L. M. E. (2000) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(99)00226-x · Cited by 400 · see citing works
Microglial Activation Resulting from CD40-CD40L Interaction After β-Amyloid Stimulation
Tan, J., Town, T., Paris, D., Mori, T., Suo, Z., Crawford, F., Mattson, M. P., Flavell, R. A., & MULLAN, M. J. (1999) · Science · doi:10.1126/science.286.5448.2352 · Cited by 352 · see citing works
Tarkowski, E., Blennow, K., Wallin, A., & Tarkowski, A. (1999) · Journal of Clinical Immunology · doi:10.1023/a:1020568013953 · Cited by 349 · see citing works
A4POE*4-associated Alzheimer's disease risk is modified by α1–antichymotrypsin polymorphism
Kamboh, M. I., Sanghera, D. K., Ferrell, R. E., & DeKosky, S. T. (1995) · Nature Genetics · doi:10.1038/ng0895-486 · Cited by 336 · see citing works
Up-Regulated Production and Activation of the Complement System in Alzheimer's Disease Brain
Yasojima, K., Schwab, C., McGeer, E. G., & McGeer, P. L. (1999) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)65340-0 · Cited by 328 · see citing works
Standardization of measurement of β-amyloid<sub>(1-42)</sub>in cerebrospinal fluid and plasma
Vanderstichele, H., Kerschaver, E. V., Hesse, C., Davidsson, P., Buyse, M.-A., Andreasen, N., Minthon, L., Wallin, A., Blennow, K., & Vanmechelen, E. (2000) · Amyloid · doi:10.3109/13506120009146438 · Cited by 301 · see citing works
Shimura, H., Hattori, N., Kubo, S., Yoshikawa, M., Kitada, T., Matsumine, H., Asakawa, S., Minoshima, S., Yamamura, Y., Shimizu, N., et al. (1999) · Annals of Neurology · doi:10.1002/1531-8249(199905)45:5 · Cited by 282 · see citing works
Biomarkers of Alzheimer disease in plasma
Irizarry, M. C. (2004) · NeuroRx · doi:10.1602/neurorx.1.2.226 · Cited by 269 · see citing works
Chemokines/chemokine receptors in the central nervous system and Alzheimer's disease
Xia, M., & Hyman, B. T. (1999) · Journal of NeuroVirology · doi:10.3109/13550289909029743 · Cited by 269 · see citing works
Age but Not Diagnosis Is the Main Predictor of Plasma Amyloid β-Protein Levels
Fukumoto, H., Tennis, M. K., Locascio, J. J., Hyman, B. T., Growdon, J. H., & Irizarry, M. C. (2003) · Archives of Neurology · doi:10.1001/archneur.60.7.958 · Cited by 258 · see citing works
Inflammation and therapeutic vaccination in CNS diseases
Weiner, H. L., & Selkoe, D. J. (2002) · Nature · doi:10.1038/nature01325 · Cited by 253 · see citing works
Morphologic association between microglia and senile plaque amyloid in Alzheimer's disease
Perlmutter, L. S., Barron, E., & Chui, H. C. (1990) · Neuroscience Letters · doi:10.1016/0304-3940(90)90748-x · Cited by 240 · see citing works
Mehta, P. D., Pirttilä, T., Patrick, B. A., Barshatzky, M., & Mehta, S. P. (2001) · Neuroscience Letters · doi:10.1016/s0304-3940(01)01754-2 · Cited by 230 · see citing works
Fiala, M., Zhang, L., Gan, X.-H., Sherry, B. A., Taub, D. D., Graves, M. C., Hama, S., Way, D., Weinand, M. E., Witte, M. H., et al. (1998) · PubMed Central · Cited by 229 · see citing works
Mrak, R. E., Sheng, J. G., & Griffin, W. S. T. (1996) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-199603000-00002 · Cited by 224 · see citing works
Diagnostic evaluation of degenerative and vascular dementia.
Loeb, C., & Gandolfo, C. (1983) · Stroke · doi:10.1161/01.str.14.3.399 · Cited by 222 · see citing works
Brain Inflammation in Alzheimer Disease and the Therapeutic Implications
McGeer, E. G., & McGeer, P. L. (1999) · Current Pharmaceutical Design · doi:10.2174/1381612805666230111212056 · Cited by 198 · see citing works
Polymorphisms in Inflammatory Genes and the Risk of Alzheimer Disease
McGeer, P. L. (2001) · Archives of Neurology · doi:10.1001/archneur.58.11.1790 · Cited by 192 · see citing works
Nitric Oxide Synthase in Reactive Astrocytes Adjacent to β-Amyloid Plaques
Wallace, M. N., Geddes, J. G., Farquhar, D. A., & Masson, M. R. (1997) · Experimental Neurology · doi:10.1006/exnr.1996.6373 · Cited by 183 · see citing works
Yatsiv, I., Morganti-Kossmann, M. C., Perez, D. R., Dinarello, C. A., Novick, D., Rubinstein, M., Otto, V. I., Rancan, M., Kossmann, T., Redaelli, C., et al. (2002) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/00004647-200208000-00008 · Cited by 183 · see citing works
Brain interleukin-1 beta in Alzheimer's disease and vascular dementia.
Cacabelos, R., Alvarez, X. A., Fernández‐Novoa, L., Franco, A., Mangues, R., Pellicer, À., & Nishimura, T. (1994) · PubMed · Cited by 182 · see citing works
Lanzrein, A.-S., Johnston, C., Perry, V. H., Jobst, K. A., King, E. M., & Smith, A. D. (1998) · Alzheimer Disease & Associated Disorders · doi:10.1097/00002093-199809000-00016 · Cited by 178 · see citing works
Interleukin-6 Production Does Not Increase With Age
Beharka, A. A., Meydani, M., Wu, D., Leka, L. S., Meydani, A., & Meydani, S. N. (2001) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/56.2.b81 · Cited by 169 · see citing works
Biochemical markers related to Alzheimer’s dementia in serum and cerebrospinal fluid
Teunissen, C. E., de Vente, J., Steinbusch, H. W. M., & Bruijn, C. D. (2002) · Neurobiology of Aging · doi:10.1016/s0197-4580(01)00328-1 · Cited by 167 · see citing works
Kalman, J. L., Juhász, A., Laird, G., Dickens, P., Járdánházy, T., Rimanóczy, Á., Boncz, I., Parry-Jones, W. L., & Janka, Z. (2009) · Acta Neurologica Scandinavica · doi:10.1111/j.1600-0404.1997.tb00275.x · Cited by 167 · see citing works
Circulating cytokines in Alzheimer's disease
Singh, V. K., & Guthikonda, P. (1997) · Journal of Psychiatric Research · doi:10.1016/s0022-3956(97)00023-x · Cited by 163 · see citing works
Neuroinflammation and anti-inflammatory therapy for Alzheimer’s disease
Moore, A. H., & O’Banion, M. K. (2002) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(02)00162-x · Cited by 146 · see citing works
Astrocytes in Alzheimer's disease gray matter express alpha 1-antichymotrypsin mRNA.
Pasternack, J. M., Abraham, C. R., Dyke, B. J. V., Potter, H., & Younkin, S. G. (1989) · PubMed Central · Cited by 140 · see citing works
Inflammation and Alzheimer’s Disease: Mechanisms and Therapeutic Strategies
Aisen, P. S. S. (2009) · Gerontology · doi:10.1159/000213842 · Cited by 134 · see citing works
Alterations in Glia and Axons in the Brains of Binswanger’s Disease Patients
Akiguchi, I., Tomimoto, H., Suenaga, T., Wakita, H., & Budka, H. (1997) · Stroke · doi:10.1161/01.str.28.7.1423 · Cited by 130 · see citing works
Paganelli, R., Iorio, A. D., Patricelli, L., Ripani, F., Sparvieri, E., Faricelli, R., Iarlori, C., Porreca, E., Gioacchino, M. D., & Abate, G. (2002) · Experimental Gerontology · doi:10.1016/s0531-5565(01)00191-7 · Cited by 128 · see citing works
Li, H., Kostulas, N., Huang, Y.-M., Xiao, B.-G., van der Meide, P. H., Kostulas, V., Giedraitas, V., & Link, H. (2001) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(01)00264-8 · Cited by 109 · see citing works
Jia, J., Meng, R., Sun, Y., Sun, W., Ji, X., & Jia, L. (2005) · Neuroscience Letters · doi:10.1016/j.neulet.2005.03.051 · Cited by 96 · see citing works
Decline of immune responsiveness: A pathogenetic factor in Alzheimer’s disease?
Richartz, E., Stransky, E., Batra, A., Simon, P. D., Lewczuk, P., Buchkremer, G., BARTELS, M., & Schott, K. J. (2005) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2004.12.005 · Cited by 95 · see citing works
Local and systemic GM-CSF increase in Alzheimer's disease and vascular dementia
Tarkowski, E., Wallin, A., Regland, B., Blennow, K., & Tarkowski, A. (2001) · Acta Neurologica Scandinavica · doi:10.1034/j.1600-0404.2001.103003166.x · Cited by 91 · see citing works
Reactive astrocytes and α1-antichymotrypsin in Alzheimer's disease
Abraham, C. R. (2001) · Neurobiology of Aging · doi:10.1016/s0197-4580(01)00302-5 · Cited by 87 · see citing works
Inflammatory markers in Alzheimer's disease and multi-infarct dementia
Luigi, A. D., Fragiacomo, C., Lucca, U., Quadri, P., Tettamanti, M., & Simoni, M. G. D. (2001) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(01)00313-x · Cited by 85 · see citing works
Serum interleukin-6 and interleukin-6 soluble receptor in Alzheimer's disease
Angelis-Stoforidis, P., Scharf, S., Mander, A. G., Vajda, F. J. E., & Christophidis, N. (1998) · Neuroscience Letters · doi:10.1016/s0304-3940(98)00136-0 · Cited by 81 · see citing works
Insights into oxidative stress and potential novel therapeutic targets for Alzheimer disease.
Maiese, K., & Chong, Z. Z. (2004) · PubMed · Cited by 79 · see citing works
Inflammation and Alzheimer's disease
Jones, R. W. (2001) · The Lancet · doi:10.1016/s0140-6736(01)05667-7 · Cited by 73 · see citing works
Peripheral cytokine release in Alzheimer patients: correlation with disease severity
Sala, G., Galimberti, G., Canevari, C., Raggi, M. E., Isella, V., Facheris, M., Appollonio, I. M., & Ferrarese, C. (2003) · Neurobiology of Aging · doi:10.1016/s0197-4580(03)00010-1 · Cited by 71 · see citing works
Elevated interleukin-6 levels in cerebrospinal fluid of vascular dementia patients
Wada‐Isoe, K., Wakutani, Y., Urakami, K., & Nakashima, K. (2004) · Acta Neurologica Scandinavica · doi:10.1111/j.1600-0404.2004.00286.x · Cited by 69 · see citing works
Bonaccorso, S., Lin, A., Song, C., Verkerk, R. M., Kenis, G., Bosmans, E., Scharpé, S., Vandewoude, M. F. J., Dossche, A., & Maes, M. H. J. (1998) · Aging Clinical and Experimental Research · doi:10.1007/bf03339794 · Cited by 62 · see citing works
Yücesoy, B., Peila, R., White, L. R., Wu, K., Johnson, V. J., Kashon, M. L., LUSTER, M., & Launer, L. J. (2005) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2005.01.013 · Cited by 61 · see citing works
Assessment of Behavioural and Psychological Symptoms Associated with Dementia
Conn, D. K., & Thorpe, L. U. (2007) · Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques · doi:10.1017/s0317167100005606 · Cited by 59 · see citing works
Lindberg, C., Chromek, M., Ahrengart, L., Brauner, A., Schultzberg, M., & Garlind, A. (2005) · Neurochemistry International · doi:10.1016/j.neuint.2005.01.004 · Cited by 57 · see citing works
Bagli, M., Papassotiropoulos, A., Becker, K., Jessen, F., rger, K. B. ⁄., Ptok, U., Rao, M. L., M�ller, H.-J., Maier, W., Heun, R., et al. (2003) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-003-0405-x · Cited by 35 · see citing works
Proteoglycans and the acute-phase response in Alzheimer's disease brain
Leveugle, B., & Fillit, H. M. (1994) · Molecular Neurobiology · doi:10.1007/bf02816102 · Cited by 31 · see citing works
Nilsson, L. N. G., Das, S., & Potter, H. (2001) · Neurochemistry International · doi:10.1016/s0197-0186(01)00043-2 · Cited by 28 · see citing works
Serum interleukin-2 levels in patients with dementia of the Alzheimer type
Esumi, E., Araga, S., & Takahashi, K. (1991) · Acta Neurologica Scandinavica · doi:10.1111/j.1600-0404.1991.tb04905.x · Cited by 19 · see citing works
Biomarkers of Alzheimer disease in plasma
Irizarry, M. C. (2004) · Neurotherapeutics · doi:10.1007/bf03206606 · Cited by 17 · see citing works
Dinsmore, S. T. (1999) · Journal of Osteopathic Medicine · doi:10.7556/jaoa.1999.99.9.s1 · Cited by 11 · see citing works
Kordower (1999) · doi:10.1002/1531-8249(199909)46:3
Flagged first, then by citations
Research works printed but not linked: 6
- R. Mayeux, M.X. Tang, D.M. Jacobs, J. Manly, K. Bell, C. Merchant et al., Plasma amyloid β-peptide 1-42 and incipient Alzheimer's disease, Ann Neurol 46 (1999), 412-416.
- A. Papassotiropoulos, M. Bagli, F. Jessen, T.A. Nayer, W. Maier, M.L. Rao and R. Heun, A genetic variation of the inflammatory cytokine interleukin-6 delays the initial onset and reduces the risk for sporadic Alzheimer's disease, Ann Neurol 45 (1999), 666-668.
- J.M. Pasternack, C.R. Abraham, B.J. Van Dyke, H. Potter and S.G. Younkin, Astrocytes in Alzheimer's disease gray matter express alpha1-antichymotrypsinmRNA, American Journal of Pathology 125 (1989), 827-834.
- A.C. Petersen, J.C. Stevens, M. Ganguli et al., Practice pa- rameter: early detection of dementia: mild cognitive impair- ment (an-evidence based review). Report of the Quality Stan- dards Subcommittee of the America Academy of Neurology 56 (2001), 1133-1142.
- B. Reisberg, S.H. Ferris, M.J. de Leon and T. Crook, The global Deterioration Scale (GDS) for assessment of primary degenerative dementia, American Journal of Psychiatry 139 (1982), 1136-1139.
- N. Vila, J. Castillo, A. Davalos and A. Chamorro, Proin- flammatory cytokines and early neurological worsening in is- chemic stroke, Stroke 31 (2000), 2325-2329.
Cited by
Sorted by citations
A Meta-Analysis of Cytokines in Alzheimer's Disease
Swardfager, W., Lanctôt, K., Rothenburg, L., Wong, A., Cappell, J., & Herrmann, N. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.06.012 · Cited by 1,108 · see citing works
The gut-brain axis: how microbiota and host inflammasome influence brain physiology and pathology
Rutsch, A., Kantsjö, J. B., & Ronchi, F. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.604179 · Cited by 821 · see citing works
Brosseron, F., Krauthausen, M., Kummer, M., & Heneka, M. T. (2014) · Molecular Neurobiology · doi:10.1007/s12035-014-8657-1 · Cited by 447 · see citing works
Alboni, S., Cervia, D., Sugama, S., & Conti, B. (2010) · Journal of Neuroinflammation · doi:10.1186/1742-2094-7-9 · Cited by 301 · see citing works
Dursun, E., Gezen-Ak, D., Hanağası, H., Bilgiç, B., Lohmann, E., Ertan, S., Atasoy, İ. L., Alaylıoğlu, M., Araz, Ö. S., Önal, B., et al. (2015) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2015.04.014 · Cited by 237 · see citing works
The Vitamin Nicotinamide: Translating Nutrition into Clinical Care
Maiese, K., Chong, Z. Z., Hou, J., & Shang, Y. C. (2009) · Molecules · doi:10.3390/molecules14093446 · Cited by 240 · see citing works
The role of inflammasome in Alzheimer's disease
Liu, L., & Chan, C. (2014) · Ageing Research Reviews · doi:10.1016/j.arr.2013.12.007 · Cited by 192 · see citing works
Tsai, C., Pai, M., Ukropec, J., & Ukropcová, B. (2019) · Current Alzheimer Research · doi:10.2174/1567205016666190228125429 · Cited by 160 · see citing works
Italiani, P., Puxeddu, I., Napoletano, S., Scala, E., Melillo, D., Manocchio, S., Angiolillo, A., Migliorini, P., Boraschi, D., Vitale, E., et al. (2018) · Journal of Neuroinflammation · doi:10.1186/s12974-018-1376-1 · Cited by 149 · see citing works
Association of C‐reactive protein with mild cognitive impairment
Roberts, R. O., Geda, Y. E., Knopman, D. S., Boeve, B. F., Christianson, T. J. H., Pankratz, V. S., Kullo, I. J., Tangalos, E. G., Ivnik, R. J., & Petersen, R. C. (2009) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2009.01.025 · Cited by 133 · see citing works
Blood-Based Proteomic Biomarkers of Alzheimer’s Disease Pathology
Baird, A. L., Westwood, S., & Lovestone, S. (2015) · Frontiers in Neurology · doi:10.3389/fneur.2015.00236 · Cited by 118 · see citing works
Exercise and the Aging Brain: Considerations for Sex Differences
Barha, C. K., & Liu-Ambrose, T. Y. L. (2018) · Brain Plasticity · doi:10.3233/bpl-180067 · Cited by 115 · see citing works
A Prospective Study of Albuminuria and Cognitive Function in Older Adults: The Rancho Bernardo Study
Jassal, S. K., Kritz‐Silverstein, D. C., & Barrett-Connor, E. L. (2010) · American Journal of Epidemiology · doi:10.1093/aje/kwp426 · Cited by 92 · see citing works
Interleukin-18, From Neuroinflammation to Alzheimers Disease
Bossù, P., Ciaramella, A., Salani, F., Vanni, D., Palladino, I., Caltagirone, C., & Scapigliati, G. (2010) · Current Pharmaceutical Design · doi:10.2174/138161210794519147 · Cited by 88 · see citing works
Wallin, A., Kapaki, E., Boban, M., Engelborghs, S., Hermann, D. M., Huisa, B. N., Jonsson, M. A. G., Kramberger, M. G., Lossi, L., Malojčić, B., et al. (2017) · BMC Neurology · doi:10.1186/s12883-017-0877-3 · Cited by 87 · see citing works
Peripheral Chemo-Cytokine Profiles in Alzheimers and Parkinsons Diseases
Reale, M., Greig, N., & Kamal, M. (2009) · Mini-Reviews in Medicinal Chemistry · doi:10.2174/138955709789055199 · Cited by 82 · see citing works
Kaźmierski, J., Banyś, A., Latek, J., Bourke, J. H., Jaszewski, R., Sobów, T., & Kłoszewska, I. (2014) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000357454 · Cited by 81 · see citing works
Qian, M., Shen, X., & Wang, H. (2015) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-015-0232-4 · Cited by 69 · see citing works
Inflammasome Involvement in Alzheimer’s Disease
Olsen, I., & Singhrao, S. K. (2016) · Journal of Alzheimer s Disease · doi:10.3233/jad-160197 · Cited by 66 · see citing works
Cerebrospinal Fluid Cytokine Dynamics Differ Between Alzheimer Disease Patients and Elderly Controls
Llano, D. A., Li, J., Waring, J. F., Ellis, T. A., Devanarayan, V., Witte, D. G., & Lenz, R. A. (2011) · Alzheimer Disease & Associated Disorders · doi:10.1097/wad.0b013e31823b2728 · Cited by 49 · see citing works
Zhang, X. Y., Tang, W., Xiu, M. H., Chen, D. C., Yang, F. D., Tan, Y., Wang, Z. R., Zhang, F., Liu, J., Liu, L., et al. (2013) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2013.03.001 · Cited by 48 · see citing works
Titus, J., Bray, N. W., Kamkar, N., Camicioli, R. M., Nagamatsu, L. S., Speechley, M. R., & Montero‐Odasso, M. (2021) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2021.111431 · Cited by 48 · see citing works
Inflammation and clinical presentation in neurodegenerative disease: a volatile relationship
Bettcher, B. M., & Kramer, J. H. (2012) · Neurocase · doi:10.1080/13554794.2011.654227 · Cited by 46 · see citing works
Attia, H., Albuhayri, S., Alaraidh, S., Alotaibi, A., Yacoub, H. I., Mohamad, R. A., & Alamin, M. A. (2020) · Journal of Biochemical and Molecular Toxicology · doi:10.1002/jbt.22519 · Cited by 47 · see citing works
Interleukin 18 activates MAPKs and STAT3 but not NF-κB in hippocampal HT-22 cells
Alboni, S., Montanari, C., Benatti, C., Sánchez-Alavez, M., Rigillo, G., Blom, J. M. C., Brunello, N., Conti, B., Pariante, C. M., & Tascedda, F. (2014) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2014.02.015 · Cited by 46 · see citing works
Tsai, C., Huang, T., & Tsai, M. (2017) · Experimental Physiology · doi:10.1113/ep086624 · Cited by 40 · see citing works
Interleukin-18 modulation in autism spectrum disorders
Businaro, R., Corsi, M., Azzara, G., Raimo, T. D., Giovanni Laviola, A., Romano, E., Ricci, L., Maccarrone, M., Aronica, E., Fuso, A., et al. (2016) · Journal of Neuroinflammation · doi:10.1186/s12974-015-0466-6 · Cited by 39 · see citing works
Zhao, S., Chen, F., Wang, D., Han, W., Zhang, Y., & Yin, Q. (2020) · Neurosurgical Review · doi:10.1007/s10143-020-01387-z · Cited by 30 · see citing works
Anuradha, U., Kumar, A., & Singh, R. K. (2021) · Neurological Sciences · doi:10.1007/s10072-021-05343-7 · Cited by 24 · see citing works
Anti-inflammatory Effects of Homotaurine in Patients With Amnestic Mild Cognitive Impairment
Bossù, P., Salani, F., Ciaramella, A., Sacchinelli, E., Mosca, A., Banaj, N., Assogna, F., Orfei, M. D., Caltagirone, C., Gianni, W., et al. (2018) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2018.00285 · Cited by 22 · see citing works
Nanomedicine against Alzheimer’s and Parkinson’s Disease
Tandon, A., Singh, S. J., & Chaturvedi, R. K. (2020) · Current Pharmaceutical Design · doi:10.2174/1381612826666201021140904 · Cited by 19 · see citing works
Peripheral inflammatory markers in amnestic mild cognitive impairment
Karim, S., Hopkins, S., Purandare, N. B., Crowther, J., Morris, J., Tyrrell, P. J., & Burns, A. S. (2013) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.3988 · Cited by 18 · see citing works
Sedighi, M., Baluchnejadmojarad, T., Fallah, S., Moradi, N., Afshin‐Majd, S., & Roghani, M. (2020) · Basic and Clinical Neuroscience Journal · doi:10.32598/bcn.11.2.1747.1 · Cited by 17 · see citing works
Too, L. K., Mitchell, A. J., Yau, B., Ball, H. J., McGregor, I. S., & Hunt, N. H. (2014) · Behavioural Brain Research · doi:10.1016/j.bbr.2014.01.035 · Cited by 16 · see citing works
Alboni, S., Tascedda, F., Uezato, A., Sugama, S., Chen, Z., Marcondes, M. C. G., & Conti, B. (2025) · Molecular Psychiatry · doi:10.1038/s41380-025-02951-z · Cited by 13 · see citing works
Fraga, V. G., Guimarães, H. C., Teixeira, A. L., Barbosa, M. T., Mateo, E. C. C., Ferriani, M. D. G. C., Caramelli, P., & Gomes, K. B. (2015) · Arquivos de Neuro-Psiquiatria · doi:10.1590/0004-282x20150137 · Cited by 10 · see citing works
Exercise and the Aging Brain: Considerations for Sex Differences
Barha, C. K., & Liu-Ambrose, T. Y. L. (2018) · Brain Plasticity · doi:10.3233/bpl-1867 · Cited by 8 · see citing works
Biomarkers of vascular cognitive impairment
Zimnitskaya, O. V., Mozheyko, E. Y., & Петрова, М. М. (2021) · CARDIOVASCULAR THERAPY AND PREVENTION · doi:10.15829/1728-8800-2021-2677 · Cited by 8 · see citing works
Dong, Y., Wang, Q., Yao, H., Xiao, Y., Wei, J., Xie, P., Hu, J., Chen, W., Tang, Y., Zhou, H., et al. (2019) · Journal of Cellular Physiology · doi:10.1002/jcp.28359 · Cited by 7 · see citing works
Khatri, A., Prakash, O., Agarwal, R., & Kushwaha, S. S. (2024) · Indian Journal of Psychiatry · doi:10.4103/indianjpsychiatry.indianjpsychiatry_975_23 · Cited by 6 · see citing works
Jung, S., Jung, E., Cui, Y., Nguyen, T. B., Ha, K.-C., Baek, H.-I., Han, S.-K., Lee, S., Chae, S., & Chung, Y. (2022) · International Journal of Pharmacology · doi:10.3923/ijp.2022.765.774 · Cited by 2 · see citing works
Ambeskovic, M., Truica, S., McCreary, J. K., Faraji, J., Fang, X., Olson, D. M., & Metz, G. A. S. (2025) · Brain Behavior and Immunity Integrative · doi:10.1016/j.bbii.2025.100104 · Cited by 2 · see citing works
The Neuroimmunology of Cortical Disease (Dementia, Epilepsy, and Autoimmune Encephalopathies)
Roth, J. L., Ott, B. R., Gaitanis, J. N., & Blum, A. S. (2011) · Humana Press eBooks · doi:10.1007/978-1-60327-860-7_15 · Cited by 2 · see citing works
Patel, B., Walker, R., Capó, M., Cusimano, N., Comas, J., Garcia, D., Cruickshank, G. S., & Ginn, C. (2023) · Medical Research Archives · doi:10.18103/mra.v11i7.2.3971 · Cited by 1 · see citing works
Maparu, K., & Singh, S. (2025) · Brain Disorders · doi:10.1016/j.dscb.2025.100244 · Cited by 1 · see citing works
- Authors
- Öztürk, C., Özge, A., Yalın, O. Ö., Yılmaz, &. A., Delialioglu, N., Yıldız, Ç., Tesdelen, B., & Kudiaki, C.
- Affiliations
- Mersin Üniversitesi (TR)
- Corresponding author
- Özge, Aynur
- Venue
- Behavioural Neurology
- Publisher
- Wiley
- Published
- 2007-01
- Volume
- 18
- Issue
- 4
- Pages
- 207-215
- ISSN
- 0953-4180 (ISSN-L)
- 1875-8584
- PMC
- PMC5469966
- OpenAlex
- W1964417277
- Cited by
- 46
- References
- 78
- Citations by year
- 2025: 3 · 2024: 1 · 2023: 1 · 2022: 1 · 2021: 3 · 2020: 5 · 2019: 2 · 2018: 4 · 2017: 2 · 2016: 2 · 2015: 4 · 2014: 5 · 2013: 3 · 2012: 1
- FWCI
- 1.41
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Behavioural Neurology (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Mersin University Scientific Research Support Foundation (365 BAPTFTTB 2006-3)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Keywords
- dementia, Alzheimer's disease, vascular dementia, mild cognitive impairment, inflammation, inflammatory cytokines, soluble protein, IL-18, IL-1β, TNF-α, interleukin-6, interleukin-2, Aβ40, alpha-1-antichymotrypsin, cognitive decline, functional decline, diagnostic biomarkers
- MeSH terms
- Acute-Phase Proteins, Aged, Analysis of Variance, Cognition Disorders, Cross-Sectional Studies, Dementia, Diagnosis, Differential, Female, Humans, Interleukins, Male, Middle Aged, Peptide Fragments, Reference Values, Severity of Illness Index, Tumor Necrosis Factor-alpha, Biomarkers, Case-Control Studies, Amyloid beta-Peptides, Matched-Pair Analysis, Statistics, Nonparametric
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
