Peripheral Chemo-Cytokine Profiles in Alzheimers and Parkinsons Diseases

Parkinsonism: onset, progression, and mortality

Hoehn, M. M., & Yahr, M. D. (1967) · Neurology · doi:10.1212/wnl.17.5.427 · Cited by 12,107 · see citing works

Accuracy of clinical diagnosis of idiopathic Parkinson's disease: a clinico-pathological study of 100 cases.

Hughes, A. J., Daniel, S. E., Kilford, L., & Lees, A. J. (1992) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.55.3.181 · Cited by 10,378 · see citing works

Overdependence on degraded gist memory in Alzheimer's disease.

Gallo, D. A., Shahid, K. R., Olson, M. A., Solomon, T. M., Schacter, D. L., & Budson, A. E. (2006) · Neuropsychology · doi:10.1037/0894-4105.20.6.625 · Cited by 4,756 · see citing works

Microglia: a sensor for pathological events in the CNS

Kreutzberg, G. W. (1996) · Trends in Neurosciences · doi:10.1016/0166-2236(96)10049-7 · Cited by 4,396 · see citing works

Systemic LPS causes chronic neuroinflammation and progressive neurodegeneration

Qin, L., Wu, X., Block, M. L., Liu, Y., Breese, G. R., Hong, J., Knapp, D. J., & Crews, F. T. (2007) · Glia · doi:10.1002/glia.20467 · Cited by 2,144 · see citing works

ETIOLOGY AND PATHOGENESIS OF PARKINSON'S DISEASE

Olanow, C. W., & Tatton, W. G. (1999) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.22.1.123 · Cited by 1,394 · see citing works

Microglia and neuroinflammation: a pathological perspective

Streit (2004) · Journal of Neuroinflammation · doi:10.1186/1742-2094-1-14 · Cited by 1,039 · see citing works

Soluble oligomers of the amyloid β-protein impair synaptic plasticity and behavior

Selkoe, D. J. (2008) · Behavioural Brain Research · doi:10.1016/j.bbr.2008.02.016 · Cited by 1,038 · see citing works

Tumor necrosis factor-α (TNF-α) increases both in the brain and in the cerebrospinal fluid from parkinsonian patients

Mogi, M., Harada, M., Riederer, P., Narabayashi, H., Fujita, K., & Nagatsu, T. (1994) · Neuroscience Letters · doi:10.1016/0304-3940(94)90746-3 · Cited by 986 · see citing works

Central and Systemic Endotoxin Challenges Exacerbate the Local Inflammatory Response and Increase Neuronal Death during Chronic Neurodegeneration

Cunningham, C., Wilcockson, D. C., Campion, S., Lunnon, K., & Perry, V. H. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.2614-05.2005 · Cited by 768 · see citing works

Glial‐Neuronal Interactions in Alzheimer's Disease: The Potential Role of a ‘Cytokine Cycle’ in Disease Progression

Griffin, W., Sheng, J. G., Royston, M., Gentleman, S., McKenzie, J., Graham, D. I., Roberts, G., & Mrak, R. (1998) · Brain Pathology · doi:10.1111/j.1750-3639.1998.tb00136.x · Cited by 751 · see citing works

Inflammatory markers and cognition in well-functioning African-American and white elders

Yaffe, K., Lindquist, K., Penninx, B. W., Simonsick, E. M., Pahor, M., Kritchevsky, S., Launer, L., Kuller, L., Rubin, S., & Harris, T. (2003) · Neurology · doi:10.1212/01.wnl.0000073620.42047.d7 · Cited by 706 · see citing works

Neurotactin, a membrane-anchored chemokine upregulated in brain inflammation

Pan, Y., Lloyd, C. M., Zhou, H., Dolich, S., Deeds, J., Gonzalo, J.-Á., Vath, J., Gosselin, M., Ma, J., Dussault, B. J., et al. (1997) · Nature · doi:10.1038/42491 · Cited by 643 · see citing works

Inflammation as a causative factor in the aetiology of Parkinson's disease

Whitton, P. S. (2007) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0707167 · Cited by 625 · see citing works

TGF-β1 promotes microglial amyloid-β clearance and reduces plaque burden in transgenic mice

Wyss-Coray, T., Lin, C., Yan, F., Yu, G.-Q., Rohde, M., McConlogue, L., Masliah, E., & Mucke, L. (2001) · Nature Medicine · doi:10.1038/87945 · Cited by 587 · see citing works

The influence of systemic inflammation on inflammation in the brain: implications for chronic neurodegenerative disease

Perry, V. H. (2004) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2004.01.004 · Cited by 560 · see citing works

Peripheral cytokines profile in parkinson’s disease

Reale, M., Iarlori, C., Thomas, A., Gambi, D., Perfetti, B., Di Nicola, M., & Onofrj, M. (2009) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2008.07.003 · Cited by 547 · see citing works

Interleukin-1 Expression in Different Plaque Types in Alzheimerʼs Disease

Griffin, W. S. T., Sheng, J. G., Roberts, G. W., & Mrak, R. E. (1995) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-199503000-00014 · Cited by 546 · see citing works

Interleukin (IL)-1β, IL-2, IL-4, IL-6 and transforming growth factor-α levels are elevated in ventricular cerebrospinal fluid in juvenile parkinsonism and Parkinson's disease

Mogi, M., Harada, M., Narabayashi, H., Inagaki, H., Minami, M., & Nagatsu, T. (1996) · Neuroscience Letters · doi:10.1016/0304-3940(96)12706-3 · Cited by 545 · see citing works

Occurrence of T cells in the brain of Alzheimer's disease and other neurological diseases

Togo, T., Akiyama, H., Iseki, E., Kondo, H., Ikeda, K., Kato, M., Oda, T., Tsuchiya, K., & Kosaka, K. (2002) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(01)00496-9 · Cited by 481 · see citing works

A High Plasma Concentration of TNF- Is Associated With Dementia in Centenarians

Brüünsgaard, H., Andersen‐Ranberg, K., Jeune, B., Pedersen, B. K., Skinhøj, P., & Pedersen, B. K. (1999) · The Journals of Gerontology Series A · doi:10.1093/gerona/54.7.m357 · Cited by 458 · see citing works

Inflammatory markers and the risk of Alzheimer disease: The Framingham Study

Tan, Z. S., Beiser, A. S., Vasan, R. S., Roubenoff, R., Dinarello, C. A., Harris, T. B., Benjamin, E. J., Au, R., Kiel, D. P., Wolf, P. A., et al. (2007) · Neurology · doi:10.1212/01.wnl.0000263217.36439.da · Cited by 440 · see citing works

Lewy bodies are ubiquitinated

Kuzuhara, S., Mori, H., Izumiyama, N., Yoshimura, M., & Ihara, Y. (1988) · Acta Neuropathologica · doi:10.1007/bf00687787 · Cited by 409 · see citing works

Increased plasma levels of interleukin-1, interleukin-6 and α-1-antichymotrypsin in patients with Alzheimer's disease: peripheral inflammation or signals from the brain?

Licastro, F., Pedrini, S., Caputo, L., Annoni, G., Davis, L. J., Ferri, C., Casadei, V. M., & Grimaldi, L. M. E. (2000) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(99)00226-x · Cited by 400 · see citing works

Pathology and Biology of the Lewy Body

Pollanen, M. S., Dickson, D. W., & Bergeron, C. (1993) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-199305000-00001 · Cited by 396 · see citing works

Lipopolysaccharide-induced-neuroinflammation increases intracellular accumulation of amyloid precursor protein and amyloid β peptide in APPswe transgenic mice

Sheng, J. (2003) · Neurobiology of Disease · doi:10.1016/s0969-9961(03)00069-x · Cited by 388 · see citing works

Expression of chemokine receptors by subsets of neurons in the central nervous system

Horuk, R., Martin, A. W., Wang, Z., Schweitzer, L., Gerassimides, A., Guo, H.-D., Lu, Z., Hesselgesser, J., Perez, H. D., Kim, J., et al. (1997) · The Journal of Immunology · doi:10.4049/jimmunol.158.6.2882 · Cited by 385 · see citing works

Activation of microglia by aggregated β-amyloid or lipopolysaccharide impairs MHC-II expression and renders them cytotoxic whereas IFN-γ and IL-4 render them protective

Butovsky, O., Talpalar, A. E., Ben‐Yaakov, K., & Schwartz, M. (2005) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2005.03.005 · Cited by 368 · see citing works

Neuroinflammation: Implications for the Pathogenesis and Molecular Diagnosis of Alzheimer's Disease

Rojo, L. E., Fernández, J. A., Maccioni, A. A., Jimenez, J. M., & Maccioni, R. B. (2008) · Archives of Medical Research · doi:10.1016/j.arcmed.2007.10.001 · Cited by 351 · see citing works

Chronic neuroinflammation in rats reproduces components of the neurobiology of Alzheimer's disease

Hauss‐Wegrzyniak, B., Dobrzański, P., Stoehr, J. D., & Wenk, G. L. (1998) · Brain Research · doi:10.1016/s0006-8993(97)01215-8 · Cited by 337 · see citing works

Systemic Inflammatory Stimulus Potentiates the Acute Phase and CXC Chemokine Responses to Experimental Stroke and Exacerbates Brain Damage via Interleukin-1- and Neutrophil-Dependent Mechanisms

McColl, B. W., Rothwell, N. J., & Allan, S. M. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.5376-06.2007 · Cited by 337 · see citing works

Central and systemic IL-1 exacerbates neurodegeneration and motor symptoms in a model of Parkinson’s disease

Pott Godoy, M. C., Tarelli, R., Ferrari, C. C., Sarchi, M. I., & Pitossi, F. J. (2008) · Brain · doi:10.1093/brain/awn101 · Cited by 335 · see citing works

Association of circulating TNF-α and IL-6 with ageing and parkinsonism

Dobbs, R. J., Charlett, A., Purkiss, A. G., Dobbs, S. M., Weller, C., & Peterson, D. W. (1999) · Acta Neurologica Scandinavica · doi:10.1111/j.1600-0404.1999.tb00721.x · Cited by 324 · see citing works

Peripheral Inflammatory Biomarkers and Risk of Parkinson's Disease

Chen, H., O'Reilly, E. J., Schwarzschild, M. A., & Ascherio, A. (2007) · American Journal of Epidemiology · doi:10.1093/aje/kwm260 · Cited by 317 · see citing works

A central role for astrocytes in the inflammatory response to β-amyloid; chemokines, cytokines and reactive oxygen species are produced

Johnstone, M., Gearing, A. J. H., & Miller, K. (1999) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(98)00226-4 · Cited by 313 · see citing works

TRANSFORMING GROWTH FACTOR-βS IN NEURODEGENERATIVE DISEASE

FLANDERS, K. (1998) · Progress in Neurobiology · doi:10.1016/s0301-0082(97)00066-x · Cited by 310 · see citing works

Serum TNF-alpha levels are increased and correlate negatively with free IGF-I in Alzheimer disease

Álvarez, A., Cacabelos, R., Sanpedro, C., García-Fantini, M., & Aleixandre, M. (2006) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2006.02.012 · Cited by 278 · see citing works

Inflammation and Infection in Clinical Stroke

Emsley, H. C. A., & Tyrrell, P. J. (2002) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/01.wcb.0000037880.62590.28 · Cited by 277 · see citing works

Chemokines/chemokine receptors in the central nervous system and Alzheimer's disease

Xia, M., & Hyman, B. T. (1999) · Journal of NeuroVirology · doi:10.3109/13550289909029743 · Cited by 269 · see citing works

Immunohistochemical Study of the β-Chemokine Receptors CCR3 and CCR5 and Their Ligands in Normal and Alzheimer's Disease Brains

Xia, M., Qin, S., Wu, L.-J., Mackay, C., & Hyman, B. (1998) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)65542-3 · Cited by 267 · see citing works

Neurobiology and treatment of Parkinson's disease

Schapira, A. H. V. (2008) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2008.10.005 · Cited by 252 · see citing works

Cytokines in Neuroinflammation and Alzheimers Disease

Cacquevel, M., Lebeurrier, N., Chéenne, S., & Vivien, D. (2004) · Current Drug Targets · doi:10.2174/1389450043345308 · Cited by 245 · see citing works

IL-4, IL-10 and IL-13 modulate Aβ(1–42)-induced cytokine and chemokine production in primary murine microglia and a human monocyte cell line

Szczepanik, A. M. (2001) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(00)00404-5 · Cited by 243 · see citing works

p53 protein, interferon-γ, and NF-κB levels are elevated in the parkinsonian brain

Mogi, M., Kondo, T., Mizuno, Y., & Nagatsu, T. (2006) · Neuroscience Letters · doi:10.1016/j.neulet.2006.12.003 · Cited by 242 · see citing works

IL-18: a key player in neuroinflammation and neurodegeneration?

Felderhoff‐Mueser, U., Schmidt, O. I., Oberholzer, A., Bührer, C., & Stahel, P. F. (2005) · Trends in Neurosciences · doi:10.1016/j.tins.2005.06.008 · Cited by 242 · see citing works

Trophic effects of interleukin-4, -7 and -8 on hippocampal neuronal cultures: potential involvement of glial-derived factors

Araujo, D. M., & Cotman, C. W. (1993) · Brain Research · doi:10.1016/0006-8993(93)90400-h · Cited by 237 · see citing works

Microglial activation with atypical proinflammatory cytokine expression in a rat model of Parkinson's disease

Depino, A. M., Earl, C. D., Kaczmarczyk, E., Ferrari, C. C., Besedovsky, H. O., del Rey, A., Pitossi, F. J., & Oertel, W. H. (2003) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2003.03014.x · Cited by 237 · see citing works

Plasma cytokines profile in older subjects with late onset Alzheimer’s disease or vascular dementia

Zuliani, G., Ranzini, M., Guerra, G., Rossi, L., Munari, M. R., Zurlo, A., Volpato, S., Atti, A. R., Blè, A., & Fellin, R. (2006) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2006.02.008 · Cited by 234 · see citing works

Chemokines and chemokine receptors in inflammation of the nervous system: manifold roles and exquisite regulation

Huang, D., Han, Y., Rani, M. R. S., Glabinski, A. R., Trebst, C., Sørensen, T. L., Tani, M., Wang, J., Chien, P., O'Bryan, S., et al. (2000) · Immunological Reviews · doi:10.1034/j.1600-065x.2000.17709.x · Cited by 233 · see citing works

Lymphocyte oxidative DNA damage and plasma antioxidants in Alzheimer disease

Mecocci, P. (2002) · Archives of Neurology · doi:10.1001/archneur.59.5.794 · Cited by 229 · see citing works

α-Synuclein activates stress signaling protein kinases in THP-1 cells and microglia

Klegeris, A., Pelech, S., Giasson, B. I., Maguire, J., Zhang, H., McGeer, E. G., & McGeer, P. L. (2008) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2006.11.013 · Cited by 227 · see citing works

Neuronal–Glial Interactions Mediated by Interleukin-1 Enhance Neuronal Acetylcholinesterase Activity and mRNA Expression

Li, Y., Liu, L., Kang, J., Sheng, J. G., Barger, S. W., Mrak, R. E., & Griffin, W. S. T. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-01-00149.2000 · Cited by 209 · see citing works

Serum MCP-1 levels are increased in mild cognitive impairment and mild Alzheimer’s disease

Galimberti, D., Fenoglio, C., Lovati, C., Venturelli, E., Guidi, I., Corrà, B., Scalabrini, D., Clerici, F., Mariani, C., Bresolin, N., et al. (2006) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2005.10.007 · Cited by 209 · see citing works

Low levels of circulating inflammatory cytokines—Do they affect human brain functions?

Pollmächer, T., Haack, M., Schuld, A., Reichenberg, A., & Yirmiya, R. (2002) · Brain, Behavior, and Immunity · doi:10.1016/s0889-1591(02)00004-1 · Cited by 202 · see citing works

Amyloid β and Amylin Fibrils Induce Increases in Proinflammatory Cytokine and Chemokine Production by THP‐1 Cells and Murine Microglia

Yates, S. L., Burgess, L. H., Kocsis‐Angle, J., Antal, J. M., Dority, M. D., Embury, P. B., Piotrkowski, A. M., & Brunden, K. R. (2000) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2000.0741017.x · Cited by 202 · see citing works

TGF‐β1 is an organizer of responses to neurodgeneration

Finch, C. E., Laping, N. J., Morgan, T. E., Nichols, N. R., & Pasinetti, G. M. (1993) · Journal of Cellular Biochemistry · doi:10.1002/jcb.240530408 · Cited by 197 · see citing works

Interleukin‐6 release from the human brain during prolonged exercise

Nybo, L., Nielsen, B., Pedersen, B. K., Møller, K., & Secher, N. H. (2002) · The Journal of Physiology · doi:10.1113/jphysiol.2002.022285 · Cited by 196 · see citing works

Association of an interleukin 1α polymorphism with Alzheimer’s disease

Du, Y., Dodel, R. C., Eastwood, B. J., Bales, K. R., Gao, F., Lohmüller, F., Müller, U., Kurz, A., Zimmer, R., Evans, R. M., et al. (2000) · Neurology · doi:10.1212/wnl.55.4.480 · Cited by 195 · see citing works

Cytokine Gene Expression as a Function of the Clinical Progression of Alzheimer Disease Dementia

Luterman, J. D., Haroutunian, V., Yemul, S., Ho, L., Purohit, D., Aisen, P. S., Mohs, R., & Pasinetti, G. M. (2000) · Archives of Neurology · doi:10.1001/archneur.57.8.1153 · Cited by 192 · see citing works

TNF-α Inhibition as a Treatment Strategy for Neurodegenerative Disorders: New Drug Candidates and Targets

Tweedie, D., Sambamurti, K., & Greig, N. H. (2007) · Current Alzheimer Research · doi:10.2174/156720507781788873 · Cited by 188 · see citing works

The Identification and Characterization of Oxidized RNAs in Alzheimer's Disease

Shan, X., Tashiro, H., & Lin, C. G. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-12-04913.2003 · Cited by 185 · see citing works

Normal and reactive NG2+ glial cells are distinct from resting and activated microglia

Nishiyama, A., Yu, M., Drazba, J. A., & Tuohy, V. K. (1997) · Journal of Neuroscience Research · doi:10.1002/(sici)1097-4547(19970515)48:4 · Cited by 184 · see citing works

Advances in the Cellular and Molecular Biology of the Beta-Amyloid Protein in Alzheimer 's Disease

Sambamurti, K., Greig, N. H., & Lahiri, D. K. (2002) · NeuroMolecular Medicine · doi:10.1385/nmm:1:1:1 · Cited by 184 · see citing works

Inflammatory Markers in Matched Plasma and Cerebrospinal Fluid from Patients with Alzheimer’s Disease

Sun, Y., Minthon, L., Wallmark, A., Warkentin, S., Blennow, K., & Janciauskiene, S. M. (2003) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000071001 · Cited by 178 · see citing works

Longitudinal Study of Inflammatory Factors in Serum, Cerebrospinal Fluid, and Brain Tissue in Alzheimer Disease

Lanzrein, A.-S., Johnston, C., Perry, V. H., Jobst, K. A., King, E. M., & Smith, A. D. (1998) · Alzheimer Disease & Associated Disorders · doi:10.1097/00002093-199809000-00016 · Cited by 178 · see citing works

Platelet APP, ADAM 10 and BACE alterations in the early stages of Alzheimer disease

Colciaghi, F., Marcello, E. E., Borroni, B., Zimmermann, M., Caltagirone, C., Cattabeni, F., Padovani, A., & Luca, M. D. (2004) · Neurology · doi:10.1212/01.wnl.0000106953.49802.9c · Cited by 178 · see citing works

Chemokines and Chemokine Receptors in Neurological Disease: Raise, Retain, or Reduce?

Savarin-Vuaillat, C., & Ransohoff, R. M. (2007) · Neurotherapeutics · doi:10.1016/j.nurt.2007.07.004 · Cited by 177 · see citing works

Altered plasma cytokine levels in Alzheimer's disease: Correlation with the disease progression

Motta, M., Imbesi, R., Rosa, M. D., Stivala, F., & Malaguarnera, L. (2007) · Immunology Letters · doi:10.1016/j.imlet.2007.09.002 · Cited by 176 · see citing works

Biochemical markers related to Alzheimer’s dementia in serum and cerebrospinal fluid

Teunissen, C. E., de Vente, J., Steinbusch, H. W. M., & Bruijn, C. D. (2002) · Neurobiology of Aging · doi:10.1016/s0197-4580(01)00328-1 · Cited by 167 · see citing works

Circulating cytokines in Alzheimer's disease

Singh, V. K., & Guthikonda, P. (1997) · Journal of Psychiatric Research · doi:10.1016/s0022-3956(97)00023-x · Cited by 163 · see citing works

Increased production of inflammatory cytokines in mild cognitive impairment

Magaki, S., Mueller, C., DICKSON, C., & Kirsch, W. M. (2006) · Experimental Gerontology · doi:10.1016/j.exger.2006.09.015 · Cited by 156 · see citing works

Association between IL-8 cytokine and cognitive performance in an elderly general population—The MEMO-Study

Baune, B. T., Ponath, G. D., Golledge, J., Varga, G., Arolt, V., Rothermundt, M., & Berger, K. (2007) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2006.12.003 · Cited by 151 · see citing works

Metal and Inflammatory Targets for Alzheimers Disease

Rogers, J. T., & Lahiri, D. K. (2004) · Current Drug Targets · doi:10.2174/1389450043345272 · Cited by 149 · see citing works

Altered expression of transforming growth factor-beta in Alzheimer's disease

Flanders, K. C., Lippa, C. F., Smith, T. W., Pollen, D. A., & Sporn, M. B. (1995) · Neurology · doi:10.1212/wnl.45.8.1561 · Cited by 147 · see citing works

Peripheral Inflammatory Cytokines as Biomarkers in Alzheimer’s Disease and Mild Cognitive Impairment

Guerreiro, R. J., Santana, I. J., Brás, J., Santiago, B., Paiva, A. A., & Oliveira, C. R. (2007) · Neurodegenerative Diseases · doi:10.1159/000107700 · Cited by 147 · see citing works

Inflammatory Cytokine Gene Polymorphisms and Increased Risk of Parkinson Disease

Wahner, A. D., Sinsheimer, J. S., Bronstein, J. M., & Ritz, B. R. (2007) · Archives of Neurology · doi:10.1001/archneur.64.6.836 · Cited by 143 · see citing works

Intracerebroventricular injection of interleukin 1 induces high circulating levels of interleukin 6.

Simoni, M. G. D., Sironi, M., Luigi, A. D., Manfridi, A., Mantovani, A., & Ghezzi, P. (1990) · The Journal of Experimental Medicine · doi:10.1084/jem.171.5.1773 · Cited by 141 · see citing works

Blood levels of histamine, IL-1β, and TNF-α in patients with mild to moderate alzheimer disease

Alvarez, X. A., Franco, A., Fernández-Novoa, L., & Cacabelos, R. (1996) · Molecular and Chemical Neuropathology · doi:10.1007/bf02815005 · Cited by 139 · see citing works

Overexpression of Monocyte Chemotactic Protein-1/CCL2 in β-Amyloid Precursor Protein Transgenic Mice Show Accelerated Diffuse β-Amyloid Deposition

Yamamoto, M., Horiba, M., Buescher, J. L., Huang, D., Gendelman, H. E., Ransohoff, R. M., & Ikezu, T. (2005) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)62364-4 · Cited by 137 · see citing works

Evaluation of Interleukins, ACTH, Cortisol and Prolactin Concentrations in the Blood of Patients with Parkinson's Disease

Stypuła, G., Radek, M., Stepien, H., Żylińska, K., & Pawlikowski, M. (1996) · NeuroImmunoModulation · doi:10.1159/000097237 · Cited by 134 · see citing works

Increase in Peripheral CD4 Bright+ CD8 Dull+ T Cells in Parkinson Disease

Hisanaga, K., 浅黄美沙, Itoyama, Y., & Iwasaki, Y. (2001) · Archives of Neurology · doi:10.1001/archneur.58.10.1580 · Cited by 131 · see citing works

Proinflammatory cytokines in sera of elderly patients with dementia: levels in vascular injury are higher than those of mild–moderate Alzheimer's disease patients

Paganelli, R., Iorio, A. D., Patricelli, L., Ripani, F., Sparvieri, E., Faricelli, R., Iarlori, C., Porreca, E., Gioacchino, M. D., & Abate, G. (2002) · Experimental Gerontology · doi:10.1016/s0531-5565(01)00191-7 · Cited by 128 · see citing works

Increased intrathecal TGF-β1, but not IL-12, IFN-γ and IL-10 levels in Alzheimer’s disease patients

Rota, E., Bellone, G., Rocca, P., Bergamasco, B., Emanuelli, G., & Ferrero, P. (2006) · Neurological Sciences · doi:10.1007/s10072-006-0562-6 · Cited by 125 · see citing works

Peripheral T cells overexpress MIP-1α to enhance its transendothelial migration in Alzheimer's disease

Man, S., Ma, Y., Shang, D., Zhao, W., Li, B., Guo, D., Fang, W., Zhu, L., & Chen, Y. (2006) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2006.02.013 · Cited by 122 · see citing works

Increase in Circulating Levels of Monocyte Chemoattractant Protein-1 with Aging

Inadera, H., Egashira, K., Takemoto, M., Ouchi, Y., & Matsushima, K. (1999) · Journal of Interferon & Cytokine Research · doi:10.1089/107999099313127 · Cited by 120 · see citing works

Circulating interleukin-15 and RANTES chemokine in Parkinson’s disease

Rentzos, M., Nikolaou, C., Andreadou, E., Paraskevas, G. P., Rombos, A., Zoga, M., Tsoutsou, A., Boufidou, F., Kapaki, E., & Vassilopoulos, D. (2007) · Acta Neurologica Scandinavica · doi:10.1111/j.1600-0404.2007.00894.x · Cited by 119 · see citing works

Chemokines in serum and cerebrospinal fluid of Alzheimer's disease patients

Galimberti, D., Schoonenboom, N. S. M., Scarpini, E. A., & Scheltens, P. (2003) · Annals of Neurology · doi:10.1002/ana.10531 · Cited by 116 · see citing works

Interleukin-18 produced by peripheral blood cells is increased in Alzheimer’s disease and correlates with cognitive impairment

Bossù, P., Ciaramella, A., Salani, F., Bizzoni, F., Varsi, E., Di Iulio, F., Giubilei, F., Gianni, W., Trequattrini, A., Moro, M. L., et al. (2008) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2007.10.001 · Cited by 116 · see citing works

Nuanced roles of cytokines in three major human brain disorders

Steinman, L. (2008) · Journal of Clinical Investigation · doi:10.1172/jci36532 · Cited by 109 · see citing works

Acetylcholinesterase inhibitors reduce brain and blood interleukin‐1β production

Pollak, Y., Gilboa-Geffen, A., Menachem-Zidon, O. B., Ben‐Hur, T., Soreq, H., & Yirmiya, R. (2005) · Annals of Neurology · doi:10.1002/ana.20454 · Cited by 105 · see citing works

Beta-amyloid (25-35) peptide and IFN-γ synergistically induce the production of the chemotactic cytokine MCP-1/JE in monocytes and microglial cells

Meda, L., Bernasconi, S., Bonaiuto, C., Sozzani, S., Zhou, D., Otvos, L. P., Mantovani, A., Rossi, F., & Cassatella, M. A. (1996) · The Journal of Immunology · doi:10.4049/jimmunol.157.3.1213 · Cited by 104 · see citing works

Transforming growth factor beta in Alzheimer's disease

Chao, C. C., Hu, S., Frey, W. H., A, T., Tourtellotte, W. W., & Peterson, P. K. (1994) · Clinical and Diagnostic Laboratory Immunology · doi:10.1128/cdli.1.1.109-110.1994 · Cited by 103 · see citing works

Chemokines in and out of the central nervous system: much more than chemotaxis and inflammation

Cardona, A. E., Li, M., Liu, L., Savarin, C., & Ransohoff, R. M. (2008) · Journal of Leukocyte Biology · doi:10.1189/jlb.1107763 · Cited by 102 · see citing works

Acetylcholinesterase inhibitors effects on oncostatin-M, interleukin-1? and interleukin-6 release from lymphocytes of Alzheimer's disease patients

Reale, M., Iarlori, C., Gambi, F., Lucci, I., SALVATORE, M., & Gambi, D. (2005) · Experimental Gerontology · doi:10.1016/j.exger.2004.12.003 · Cited by 101 · see citing works

Increased cerebrospinal fluid levels of transforming growth factor-β1 in Alzheimer’s disease

Zetterberg, H., Andreasen, N., & Blennow, K. (2004) · Neuroscience Letters · doi:10.1016/j.neulet.2004.06.001 · Cited by 101 · see citing works

Central endotoxin induces different patterns of interleukin (IL)-1 beta and IL-6 messenger ribonucleic acid expression and IL-6 secretion in the brain and periphery

Simoni, M. G. D., Bo, R. D., Luigi, A. D., Simard, S., & Forloni, G. (1995) · Endocrinology · doi:10.1210/endo.136.3.7867598 · Cited by 100 · see citing works

Overproduction of IFN‐γ and TNF‐α from Natural Killer (NK) Cells Is Associated with Abnormal NK Reactivity and Cognitive Derangement in Alzheimer's Disease

Solerte, S. B., Cravello, L., Ferrari, E., & Fioravanti, M. (2000) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2000.tb05399.x · Cited by 99 · see citing works

Aberrant profiles of native and oxidized glycoproteins in Alzheimer plasma

Yu, H., Chertkow, H. M., Bergman, H., & Schipper, H. M. (2003) · PROTEOMICS · doi:10.1002/pmic.200300475 · Cited by 95 · see citing works

Interleukin-18 and transforming growth factor-beta 1 plasma levels in Alzheimer’s disease and vascular dementia

Malaguarnera, L., Motta, M., Di Rosa, M., Anzaldi, M., & Malaguarnera, M. (2006) · Neuropathology · doi:10.1111/j.1440-1789.2006.00701.x · Cited by 93 · see citing works

The genetics of Parkinson's disease

de Silva, H. R. (2000) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(00)00082-4 · Cited by 92 · see citing works

Human focal cerebral infarctions induce differential lesional interleukin-16 (IL-16) expression confined to infiltrating granulocytes, CD8+ T-lymphocytes and activated microglia/macrophages

Schwab, J. M., Nguyen, T. D., Meyermann, R., & Schluesener, H. J. (2001) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(00)00433-1 · Cited by 87 · see citing works

Boosting T-cell immunity as a therapeutic approach for neurodegenerative conditions: The role of innate immunity

Schwartz, M., London, A., & Shechter, R. (2008) · Neuroscience · doi:10.1016/j.neuroscience.2008.12.013 · Cited by 87 · see citing works

Serum cytokine levels in patients with Alzheimer's disease

Chao, C. C., A, T., Hu, S., Crossley, K., Sherman, R. E., Peterson, P. K., & Frey, W. H. (1994) · Clinical and Diagnostic Laboratory Immunology · doi:10.1128/cdli.1.4.433-436.1994 · Cited by 85 · see citing works

Inflammatory markers in Alzheimer's disease and multi-infarct dementia

Luigi, A. D., Fragiacomo, C., Lucca, U., Quadri, P., Tettamanti, M., & Simoni, M. G. D. (2001) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(01)00313-x · Cited by 85 · see citing works

Glucocerebrosidase gene mutations are associated with Parkinson's disease in southern Italy

Marco, E. V. D., Annesi, G., Tarantino, P., Rocca, F. E., Provenzano, G., Civitelli, D., Candiano, I. C. C., Annesi, F., Carrideo, S., Condino, F., et al. (2007) · Movement Disorders · doi:10.1002/mds.21892 · Cited by 83 · see citing works

Role of cytokines in the gene expression of amyloid β–protein precursor: Identification of a 5'-UTR-Binding nuclear factor and its implications in Alzheimer's disease

Lahiri, D. K., Chen, D., Vivien, D., Ge, Y.-W., Greig, N. H., & Rogers, J. T. (2003) · Journal of Alzheimer s Disease · doi:10.3233/jad-2003-5203 · Cited by 81 · see citing works

Serum interleukin-6 and interleukin-6 soluble receptor in Alzheimer's disease

Angelis-Stoforidis, P., Scharf, S., Mander, A. G., Vajda, F. J. E., & Christophidis, N. (1998) · Neuroscience Letters · doi:10.1016/s0304-3940(98)00136-0 · Cited by 81 · see citing works

Serum levels of interleukin-6 are not elevated in patients with Alzheimer's disease

van Duijn, C. M., Hofman, A., & Nagelkerken, L. M. (1990) · Neuroscience Letters · doi:10.1016/0304-3940(90)90666-w · Cited by 79 · see citing works

Impaired cytokine production by peripheral blood mononuclear cells and monocytes/macrophages in Parkinson's disease

Hasegawa, Y., Inagaki, T., Sawada, M., & Suzumura, A. (2000) · Acta Neurologica Scandinavica · doi:10.1034/j.1600-0404.2000.101003159.x · Cited by 78 · see citing works

The amyloid precursor protein of Alzheimer disease in human brain and blood

Li, Q., Fuller, S. J., Beyreuther, K. T., & Masters, C. L. (1999) · Journal of Leukocyte Biology · doi:10.1002/jlb.66.4.567 · Cited by 77 · see citing works

Reduced Th1 and enhanced Th2 immunity after immunization with Alzheimer's β-amyloid1–42

Town, T., Vendrame, M., Patel, A., Poetter, D., DelleDonne, A., Mori, T., Smeed, R., Crawford, F., Klein, T., Tan, J., et al. (2002) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(02)00307-7 · Cited by 72 · see citing works

Gene expression profile analysis of lymphocytes from Alzheimer??s patients

K??lm??n, J., Kitajka, K., ski, M. P. K., Zvara, ?., sz, A. J. A., Vincze, G., Janka, Z., & Pusk??s, L. G. (2005) · Psychiatric Genetics · doi:10.1097/00041444-200503000-00001 · Cited by 67 · see citing works

Chemokines (RANTES and MCP-1) and chemokine-receptors (CCR2 and CCR5) gene polymorphisms in Alzheimer's and Parkinson's disease

Huerta, C., Álvarez, V., Mata, I. F., Coto, E., Ribacoba, R., Martínez, C., Estrada, M. B., Guisasola, L. M., Salvador, C., Lahoz, C. H., et al. (2004) · Neuroscience Letters · doi:10.1016/j.neulet.2004.08.016 · Cited by 67 · see citing works

Interleukin-12 is reduced in cerebrospinal fluid of patients with Alzheimer's disease and frontotemporal dementia

Rentzos, M., Paraskevas, G. P., Kapaki, E. N., Nikolaou, C., Zoga, M., Rombos, A., Tsoutsou, A., & Vassilopoulos, D. (2006) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2006.05.063 · Cited by 62 · see citing works

A Partial Failure of Membrane Protein Turnover May Cause Alzheimers Disease: A New Hypothesis

Sambamurti, K., Suram, A., Venugopal, C., Prakasam, A., Zhou, Y., Lahiri, D. K., & Greig, N. H. (2006) · Current Alzheimer Research · doi:10.2174/156720506775697142 · Cited by 62 · see citing works

Peripheral Inflammatory Response in Alzheimer's Disease and Multiinfarct Dementia

Luigi, A. D., Pizzimenti, S., Quadri, P., Lucca, U., Tettamanti, M., Fragiacomo, C., & Simoni, M. G. D. (2002) · Neurobiology of Disease · doi:10.1006/nbdi.2002.0556 · Cited by 59 · see citing works

Interleukin-6 (IL-6) is secreted from the brain after intracerebroventricular injection of IL-1 beta in rats

Romero, L. I., Kakucska, I., Lechan, R. M., & Reichlin, S. (1996) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1996.270.3.r518 · Cited by 59 · see citing works

Soluble interleukin-1 receptor type II, IL-18 and caspase-1 in mild cognitive impairment and severe Alzheimer's disease

Lindberg, C., Chromek, M., Ahrengart, L., Brauner, A., Schultzberg, M., & Garlind, A. (2005) · Neurochemistry International · doi:10.1016/j.neuint.2005.01.004 · Cited by 57 · see citing works

The Interplay between Primary and Secondary Cytokines

Mantovani, A. (1997) · Drugs · doi:10.2165/00003495-199700541-00006 · Cited by 55 · see citing works

Alzheimer Patients Treated With an AchE Inhibitor Show Higher IL-4 and Lower IL-1β Levels and Expression in Peripheral Blood Mononuclear Cells

Gambi, F., Reale, M., Iarlori, C., Salone, A., Toma, L., Paladini, C., Luca, G. D., Feliciani, C., Salvatore, M., Salerno, R. M., et al. (2004) · Journal of Clinical Psychopharmacology · doi:10.1097/01.jcp.0000125683.74595.2f · Cited by 53 · see citing works

Defective production of interleukin-2 in patients with idiopathic Parkinson's disease

Klüter, H., Vieregge, P., Stolze, H., & Kirchner, H. (1995) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(95)00180-a · Cited by 52 · see citing works

The acetylcholinesterase inhibitor, Donepezil, regulates a Th2 bias in Alzheimer's disease patients

Reale, M., Iarlori, C., Gambi, F., Feliciani, C., Lucci, I., & Gambi, D. (2006) · Neuropharmacology · doi:10.1016/j.neuropharm.2005.11.006 · Cited by 50 · see citing works

Molecular networks of brain and immunity

Goncharova, L. B., & Tarakanov, A. O. (2007) · Brain Research Reviews · doi:10.1016/j.brainresrev.2007.02.003 · Cited by 48 · see citing works

The diagnostic role of serum inflammatory and soluble proteins on dementia subtypes: Correlation with cognitive and functional decline

Öztürk, C., Özge, A., Yalın, O. Ö., Yılmaz, &. A., Delialioglu, N., Yıldız, Ç., Tesdelen, B., & Kudiaki, C. (2007) · Behavioural Neurology · doi:10.1155/2007/432190 · Cited by 46 · see citing works

The human astrocytoma cell line U373MG produces monocyte chemotactic protein (MCP)-1 upon stimulation with β-amyloid protein

Prat, E., Baron, P., Meda, L., Scarpini, E. A., Galimberti, D., Ardolino, G., Catania, A., & Scarlato, G. (2000) · Neuroscience Letters · doi:10.1016/s0304-3940(00)00966-6 · Cited by 44 · see citing works

Central β‐amyloid peptide‐induced peripheral interleukin‐6 responses in mice

Song, D., Im, Y., Jung, J., Cho, J., Suh, H., & Kim, Y. (2001) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2001.00121.x · Cited by 40 · see citing works

Impaired Production of Plasma Interleukin-6 in Patients with Parkinson's Disease

Selikhova, M. V., Кушлинский, Н. Е., Lyubimova, N. V., & Gusev, E. I. (2002) · Bulletin of Experimental Biology and Medicine · doi:10.1023/a:1015120930920 · Cited by 39 · see citing works

Influence of monocyte chemoattractant protein 1 gene polymorphism on age at onset of sporadic Parkinson's disease

Nishimura, M., Kuno, S., Mizuta, I., Ohta, M., Maruyama, H., Kaji, R., & Kawakami, H. (2003) · Movement Disorders · doi:10.1002/mds.10462 · Cited by 38 · see citing works

Inflammation in parkinson’s disease

Hald, A., van Beek, J., & Lotharius, J. (2007) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/1-4020-5688-5_12 · Cited by 37 · see citing works

Effect of levodopa on interleukin‐15 and RANTES circulating levels in patients affected by Parkinson′s disease

Gangemi, S., Basile, G., Merendino, R. A., et al. (2003) · Mediators of Inflammation · doi:10.1080/09629350310001599701 · Cited by 36 · see citing works

Diminished Production of Proinflammatory Cytokines in Patients with Alzheimer’s Disease

Richartz, E., Batra, A., Simon, P. D., Wormstall, H., Bartels, M., Buchkremer, G., & Schott, K. J. (2005) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000083497 · Cited by 28 · see citing works

IL-4 in vitro production is upregulated in Alzheimer's disease patients treated with acetylcholinesterase inhibitors

Lugaresi, A., Iorio, A. D., Iarlori, C., Reale, M., Luca, G. D., Sparvieri, E., Michetti, A., Conti, P., Gambi, D., Abate, G., et al. (2004) · Experimental Gerontology · doi:10.1016/j.exger.2003.08.012 · Cited by 28 · see citing works

Are Peripheral Blood Cells From Patients With Alzheimer Disease More Sensitive to Apoptotic Stimuli?

Bergman, M., Salman, H., Beloosesky, Y., Djaldetti, M., & Bessler, H. (2002) · Alzheimer Disease & Associated Disorders · doi:10.1097/00002093-200207000-00005 · Cited by 26 · see citing works

Immunization with amyloid-β using GM-CSF and IL-4 reduces amyloid burden and alters plaque morphology

Silva, K. D., Brown, M. E., Westaway, D. A., & McLaurin, J. (2006) · Neurobiology of Disease · doi:10.1016/j.nbd.2006.03.013 · Cited by 20 · see citing works

Neuroimmune axis as a basis of therapy in Alzheimer’s disease

Singh, V. K. (1990) · Birkhäuser Basel eBooks · doi:10.1007/978-3-0348-7128-0_12 · Cited by 17 · see citing works

Gene mutation detected in Parkinson's disease

Passey, S. (2005) · The Lancet Neurology · doi:10.1016/s1474-4422(05)01003-3 · Cited by 4 · see citing works

Untitled work

Zujovic (2000) · doi:10.1002/(sici)1098-1136(20000215)29:4

The many roads to mitochondrial dysfunction in neuroimmune and neuropsychiatric disorders

Morris, G., & Berk, M. (2015) · BMC Medicine · doi:10.1186/s12916-015-0310-y · Cited by 245 · see citing works

Inflammation in Parkinson’s disease: role of glucocorticoids

Herrero, M.-T., Estrada, C., Maatouk, L., & Vyas, S. (2015) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2015.00032 · Cited by 175 · see citing works

Beneficial Effects of Spirulina Consumption on Brain Health

Trotta, T., Porro, C., Cianciulli, A., & Panaro, M. A. (2022) · Nutrients · doi:10.3390/nu14030676 · Cited by 98 · see citing works

Pathways to Parkinsonism Redux: convergent pathobiological mechanisms in genetics of Parkinson's disease

Kumaran, R., & Cookson, M. R. (2015) · Human Molecular Genetics · doi:10.1093/hmg/ddv236 · Cited by 86 · see citing works

Understanding the role of SOCS signaling in neurodegenerative diseases: Current and emerging concepts

Cianciulli, A., Calvello, R., Porro, C., Trotta, T., & Panaro, M. A. (2017) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2017.07.005 · Cited by 59 · see citing works

The relationship between inflammatory markers and voxel-based gray matter volumes in nondemented older adults

Zhang, H., Sachdev, P. S., Wen, W., Crawford, J. D., Brodaty, H., Baune, B. T., Kochan, N. A., Slavin, M. J., Reppermund, S., Kang, K., et al. (2016) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2015.10.008 · Cited by 32 · see citing works

Deciphering the contributions of neuroinflammation to neurodegeneration: lessons from antibody-mediated encephalitis and coronavirus disease 2019

Shir, D., & Day, G. S. (2022) · Current Opinion in Neurology · doi:10.1097/wco.0000000000001033 · Cited by 13 · see citing works

Recent advances in the mechanisms of neuroinflammation and their roles in neurodegeneration

Niranjan, R. (2018) · Neurochemistry International · doi:10.1016/j.neuint.2018.07.003 · Cited by 112 · see citing works

Mitochondria and the Link Between Neuroinflammation and Neurodegeneration

Filippo, M. D., Chiasserini, D., Tozzi, A., Picconi, B., & Calabresi, P. (2010) · Journal of Alzheimer s Disease · doi:10.3233/jad-2010-100543 · Cited by 158 · see citing works

Lipopolysaccharide-induced neuroinflammation as a bridge to understand neurodegeneration

Batista, C. R. A., Gomes, G. F., Candelario-Jalil, E., Fiebich, B. L., & de Oliveira, A. C. P. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20092293 · Cited by 529 · see citing works

IFNγ drives neuroinflammation, demyelination, and neurodegeneration in a mouse model of multiple system atrophy

Corbin-Stein, N. J., Childers, G. M., Webster, J. M., Zane, A., Yang, Y.-T., Mudium, N., Gupta, R. K., Manfredsson, F., Kordower, J., & Harms, A. (2024) · Acta Neuropathologica Communications · doi:10.1186/s40478-023-01710-x · Cited by 20 · see citing works