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Role of Apolipoprotein E in Anxiety
Abstract
Anxiety is most common among Alzheimer's disease (AD) patients with an age at onset under age 65. Apolipoprotein E4 (apoE4) is a risk factor for developing AD at an earlier age and might contribute to this effect. In mice, apoE plays a role in the regulation of anxiety, which might involve histamine receptor-mediated signaling and steroidogenesis in the adrenal gland. In addition, human apoE isoforms have differential effects on anxiety in adult mice lacking apoE and probable AD patients. Compared to wild-type mice, mice lacking apoE and apoE4 mice showed pathological alterations in the central nucleus of the amygdala, which is involved in regulation of anxiety. ApoE4, but not mice lacking apoE, or apoE3 mice showed impaired dexamethasone suppression of plasma corticosterone. Understanding how apoE modulates measures of anxiety might help the developments of therapeutic targets to reduce or even prevent measures of anxiety in health and in dementing illnesses.
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APOE genotype modulates anxiety and anxiety-like behavior in humans and in mice.
“APOE genotype has been shown to modulate anxiety and anxiety-like behavior in humans and in mice (Raber et al., 2007).”
From Apolipoprotein E–low density lipoprotein receptor interaction affects spatial memory retention and brain ApoE levels in an isoform-dependent manner (2014) · cites this paper as Raber et al., 2007
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Jeremic, D., Jiménez-Díaz, L., & Navarro-López, J. D. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101496 · Cited by 306
Does Anxiety Affect Risk of Dementia? Findings From the Caerphilly Prospective Study
Gallacher, J., Bayer, A., Fish, M., Pickering, J., Pedro, S., Dunstan, F., Ebrahim, S., & Ben-Shlomo, Y. (2009) · Psychosomatic Medicine · doi:10.1097/psy.0b013e3181a6177c · Cited by 137
Johnson, L. A., Olsen, R. H. J., Merkens, L. S., DeBarber, A., Steiner, R. D., Sullivan, P. M., Maeda, N., & Raber, J. (2014) · Neurobiology of Disease · doi:10.1016/j.nbd.2013.12.016 · Cited by 107
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Metadata
- Authors
- Raber, J.
- Venue
- Neural Plasticity
- Publisher
- Wiley
- Published
- 2007
- Volume
- 2007
- Pages
- 1-7
- ISSN
- 2090-5904
- 1687-5443
- PMC
- PMC1940061
- Cited by
- 44
- References
- 2
- Language
- en
- Funders
- Ellison Medical Foundation (AG-NS-0201, R01 AG20904, M01 RR000334, P30 AG08017)
- National Institutes of Health (AG-NS-0201, R01 AG20904, M01 RR000334, P30 AG08017)
- Alzheimer’s Disease Center (AG-NS-0201, R01 AG20904, M01 RR000334, P30 AG08017)
- National Institute on Aging (AG-NS-0201, R01 AG20904, M01 RR000334, P30 AG08017)
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