Salivary Glucose Concentration and Excretion in Normal and Diabetic Subjects
Open accessAbstract
The present report aims mainly at a reevaluation of salivary glucose concentration and excretion in unstimulated and mechanically stimulated saliva in both normal and diabetic subjects. In normal subjects, a decrease in saliva glucose concentration, an increase in salivary flow, but an unchanged glucose excretion rate were recorded when comparing stimulated saliva to unstimulated saliva. In diabetic patients, an increase in salivary flow with unchanged salivary glucose concentration and glucose excretion rate were observed under the same experimental conditions. Salivary glucose concentration and excretion were much higher in diabetic patients than in control subjects, whether in unstimulated or stimulated saliva. No significant correlation between glycemia and either glucose concentration or glucose excretion rate was found in the diabetic patients, whether in unstimulated or stimulated saliva. In the latter patients, as compared to control subjects, the relative magnitude of the increase in saliva glucose concentration was comparable, however, to that of blood glucose concentration. The relationship between these two variables was also documented in normal subjects and diabetic patients undergoing an oral glucose tolerance test.
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Salivary glucose can offer an alternative painless screening route for diabetic patients.
“Salivary glucose can thus offer an alternative painless screening route for diabetic patients149-154.”
From Wearable biosensors for healthcare monitoring (2019) · cites this paper as [152]
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Research works printed but not linked: 1
- [25]Heintze U Birkhed D Björn H Secretion rate and buffer effect of resting and stimulated whole saliva as a function of age and sex Swedish Dental Journal 1983 7 6 227 238 6583873
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- Authors
- Jurysta, C., Bulur, N., Oguzhan, B., Satman, I., Yilmaz, T. M., Malaisse, W. J., & Sener, A.
- Affiliations
- Université Libre de Bruxelles (BE)
- Istanbul University (TR)
- Corresponding author
- Sener, Abdullah
- Venue
- BioMed Research International
- Publisher
- Wiley
- Published
- 2009-01
- Volume
- 2009
- Issue
- 1
- Pages
- 430426-430426
- ISSN
- 1110-7243 (ISSN-L)
- 2314-6133
- 2314-6141
- PMC
- PMC2686806
- OpenAlex
- W2164780344
- Cited by
- 198
- References
- 31
- Citations by year
- 2026: 2 · 2025: 15 · 2024: 13 · 2023: 15 · 2022: 11 · 2021: 13 · 2020: 11 · 2019: 14 · 2018: 13 · 2017: 14 · 2016: 12 · 2015: 20 · 2014: 15 · 2013: 9 · 2012: 10
- FWCI
- 4.65
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- BioMed Research International (publishedVersion, cc-by)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Dépôt institutionnel de l'Université libre de Bruxelles (Université Libre de Bruxelles) (submittedVersion, other-oa)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Belgian Foundation for Scientific Medical Research (3.4520.07)
- Topics
- Health Sciences › Medicine › Physiology › Salivary Gland Disorders and Functions
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › HIV/AIDS oral health manifestations
- Keywords
- salivary glucose, diabetes mellitus, salivary flow, unstimulated saliva, stimulated saliva, oral glucose tolerance test, glycemia, blood glucose
- MeSH terms
- Adult, Blood Glucose, Data Interpretation, Statistical, Diabetes Mellitus, Female, Glucose, Humans, Male, Middle Aged, Saliva, Secretory Rate
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