Contribution of Gut Bacteria to Liver Pathobiology
Open accessAbstract
Emerging evidence suggests a strong interaction between the gut microbiota and health and disease. The interactions of the gut microbiota and the liver have only recently been investigated in detail. Receiving approximately 70% of its blood supply from the intestinal venous outflow, the liver represents the first line of defense against gut-derived antigens and is equipped with a broad array of immune cells (i.e., macrophages, lymphocytes, natural killer cells, and dendritic cells) to accomplish this function. In the setting of tissue injury, whereby the liver is otherwise damaged (e.g., viral infection, toxin exposure, ischemic tissue damage, etc.), these same immune cell populations and their interactions with the infiltrating gut bacteria likely contribute to and promote these pathologies. The following paper will highlight recent studies investigating the relationship between the gut microbiota, liver biology, and pathobiology. Defining these connections will likely provide new targets for therapy or prevention of a wide variety of acute and chronic liver pathologies.
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It is now recognised that the gut microbiota and chronic liver diseases are closely linked.
“It is now recognised that the gut microbiota and chronic liver diseases are closely linked.”
From The gut microbiota and host health: a new clinical frontier (2016) · cites this paper as [37]
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“37 Furthermore the fi eld of bile acid signalling has thrown open the concept of the gut:liver axis as being active and highly regulated.”
BackgroundImmune surveillance by the liver
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- Authors
- Son, G., Kremer, M., & Hines, I. N.
- Affiliations
- University of North Carolina at Chapel Hill (US)
- Heidelberg University (DE)
- Corresponding author
- Hines, Ian N.
- Venue
- Gastroenterology Research and Practice
- Publisher
- Wiley
- Published
- 2010
- Volume
- 2010
- Pages
- 1-13
- ISSN
- 1687-6121 (ISSN-L)
- 1687-630X
- PMC
- PMC2913801
- OpenAlex
- W2154553379
- Cited by
- 183
- References
- 133
- Citations by year
- 2026: 4 · 2025: 9 · 2024: 10 · 2023: 10 · 2022: 13 · 2021: 34 · 2020: 11 · 2019: 12 · 2018: 13 · 2017: 6 · 2016: 17 · 2015: 12 · 2014: 11 · 2013: 6 · 2012: 10
- FWCI
- 2.73
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Gastroenterology Research and Practice (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Carolina Digital Repository (University of North Carolina at Chapel Hill) (submittedVersion)
- The Scholarship East Carolina University's Institutional Repository (East Carolina University) (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- UNC Libraries
- Funders
- National Institute on Alcohol Abuse and Alcoholism (AA016563, P30 DK034987)
- National Institute on Diabetes, Digestive, and Kidney Diseases (AA016563, P30 DK034987)
- University of North Carolina (AA016563, P30 DK034987)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Health Sciences › Medicine › Hepatology › Liver Disease and Transplantation
- Keywords
- gut microbiota, liver, gut-liver axis, liver injury, macrophages, natural killer cells, dendritic cells, viral hepatitis, toxin-induced liver injury, ischemic liver injury, chronic liver disease, therapeutic target
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
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