Cited by 183Gut microbiota and healthLiver physiology and pathologyLiver Disease and Transplantation

Contribution of Gut Bacteria to Liver Pathobiology

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Son, Gakuhei, Kremer, Michael, Hines, Ian N.·2010·Gastroenterology Research and Practice

Abstract

Emerging evidence suggests a strong interaction between the gut microbiota and health and disease. The interactions of the gut microbiota and the liver have only recently been investigated in detail. Receiving approximately 70% of its blood supply from the intestinal venous outflow, the liver represents the first line of defense against gut-derived antigens and is equipped with a broad array of immune cells (i.e., macrophages, lymphocytes, natural killer cells, and dendritic cells) to accomplish this function. In the setting of tissue injury, whereby the liver is otherwise damaged (e.g., viral infection, toxin exposure, ischemic tissue damage, etc.), these same immune cell populations and their interactions with the infiltrating gut bacteria likely contribute to and promote these pathologies. The following paper will highlight recent studies investigating the relationship between the gut microbiota, liver biology, and pathobiology. Defining these connections will likely provide new targets for therapy or prevention of a wide variety of acute and chronic liver pathologies.

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Crossref · 10.1155/2010/453563

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  • It is now recognised that the gut microbiota and chronic liver diseases are closely linked.

    “It is now recognised that the gut microbiota and chronic liver diseases are closely linked.”

    From The gut microbiota and host health: a new clinical frontier (2016) · cites this paper as [37]

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  1. [34]Martin HM Campbell BJ Hart CA Enhanced Escherichia coli adherence and invasion in Crohn’s disease and colon cancer Gastroenterology 2004 127 1 80 93 15236175

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Authors
Son, G., Kremer, M., & Hines, I. N.
Affiliations
  • University of North Carolina at Chapel Hill (US)
  • Heidelberg University (DE)
Corresponding author
Hines, Ian N.
Venue
Gastroenterology Research and Practice
Publisher
Wiley
Published
2010
Volume
2010
Pages
1-13
ISSN
  • 1687-6121 (ISSN-L)
  • 1687-630X
OpenAlex
W2154553379
Cited by
183
References
133
Citations by year
2026: 4 · 2025: 9 · 2024: 10 · 2023: 10 · 2022: 13 · 2021: 34 · 2020: 11 · 2019: 12 · 2018: 13 · 2017: 6 · 2016: 17 · 2015: 12 · 2014: 11 · 2013: 6 · 2012: 10
FWCI
2.73
Type
journal article
Language
en
Open access
Locations
  • Gastroenterology Research and Practice (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Carolina Digital Repository (University of North Carolina at Chapel Hill) (submittedVersion)
  • The Scholarship East Carolina University's Institutional Repository (East Carolina University) (submittedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • UNC Libraries
Funders
  • National Institute on Alcohol Abuse and Alcoholism (AA016563, P30 DK034987)
  • National Institute on Diabetes, Digestive, and Kidney Diseases (AA016563, P30 DK034987)
  • University of North Carolina (AA016563, P30 DK034987)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
  • Health Sciences › Medicine › Hepatology › Liver physiology and pathology
  • Health Sciences › Medicine › Hepatology › Liver Disease and Transplantation
Keywords
gut microbiota, liver, gut-liver axis, liver injury, macrophages, natural killer cells, dendritic cells, viral hepatitis, toxin-induced liver injury, ischemic liver injury, chronic liver disease, therapeutic target

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