High fat diet, gut microbiome and gastrointestinal cancer
Open accessAbstract
Gastrointestinal cancer is currently one of the main causes of cancer death, with a large number of cases and a wide range of lesioned sites. A high fat diet, as a public health problem, has been shown to be correlated with various digestive system diseases and tumors, and can accelerate the occurrence of cancer due to inflammation and altered metabolism. The gut microbiome has been the focus of research in recent years, and associated with cell damage or tumor immune microenvironment changes via direct or extra-intestinal effects; this may facilitate the occurrence and development of gastrointestinal tumors. Based on research showing that both a high fat diet and gut microbes can promote the occurrence of gastrointestinal tumors, and that a high fat diet imbalances intestinal microbes, we propose that a high fat diet drives gastrointestinal tumors by changing the composition of intestinal microbes.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Lack of a "healthy" microbiota is associated with many forms of disease, including metabolic diseases, gastrointestinal cancer, inflammatory bowel disease, renal disease, and neurodegenerative diseases associated with aging.
“Lack of a “healthy” microbiota is associated with many forms of disease (19–24), such as metabolic diseases (obesity, type 2 diabetes), gastrointestinal cancer, inflammatory bowel disease, and renal disease, as well as neurodegenerative diseases (NDs) associated with aging, in which the activity and composition of the gut microbiota change during the life cycle.”
From Modulation of the gut–brain axis via the gut microbiota: a new era in treatment of amyotrophic lateral sclerosis (2023) · cites this paper as [21]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
2 retracted
Maret‐Ouda, J., Wahlin, K., Artama, M., Brusselaers, N., Färkkilä, M. A., Lynge, E., Mattsson, F., Pukkala, ., Romundstad, P., Tryggvadóttír, L., et al. (2018) · JAMA Oncology · doi:10.1001/jamaoncol.2018.3054 · Cited by 17 · see citing works
RetractedPimentel, G. D., Pichard, C., Laviano, A., & Fernandes, R. C. (2020) · Clinical Nutrition · doi:10.1016/j.clnu.2020.08.028 · Cited by 14 · see citing works
RetractedSiegel, R. L., Miller, K. D., & Jemal, A. (2020) · CA: A Cancer Journal for Clinicians · doi:10.3322/caac.21590 · Cited by 20,444 · see citing works
Diet rapidly and reproducibly alters the human gut microbiome
David, L. A., Maurice, C. F., Carmody, R. N., Gootenberg, D. B., Button, J. E., Wolfe, B. E., Ling, A. V., Devlin, A. S., Varma, Y., Fischbach, M. A., et al. (2014) · Nature · doi:10.1038/nature12820 · Cited by 10,100 · see citing works
Enterotypes of the human gut microbiome
MetaHIT Consortium (additional members), Arumugam, M., Raes, J., Pelletier, E., Le Paslier, D., Yamada, T., Mende, D. R., Fernandes, G. R., Tap, J., Bruls, T., et al. (2011) · Nature · doi:10.1038/nature09944 · Cited by 7,548 · see citing works
From Dietary Fiber to Host Physiology: Short-Chain Fatty Acids as Key Bacterial Metabolites
Koh, A., De Vadder, F., Kovatcheva-Datchary, P., & Bäckhed, F. (2016) · Cell · doi:10.1016/j.cell.2016.05.041 · Cited by 7,070 · see citing works
Linking long-term dietary patterns with gut microbial enterotypes
Wu, G. D., Chen, J., Hoffmann, C., Bittinger, K., Chen, Y.-Y., Keilbaugh, S. A., Bewtra, M., Knights, D., Walters, W. A., Knight, R., et al. (2011) · Science · doi:10.1126/science.1208344 · Cited by 6,513 · see citing works
De Filippo, C., Cavalieri, D., Di Paola, M., Ramazzotti, M., Poullet, J. B., Massart, S., Collini, S., Pieraccini, G., & Lionetti, P. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1005963107 · Cited by 5,579 · see citing works
Commensal <i>Bifidobacterium</i> promotes antitumor immunity and facilitates anti–PD-L1 efficacy
Sivan, A., Corrales, L., Hubert, N., Williams, J. B., Aquino-Michaels, K., Earley, Z. M., Benyamin, F. W., Man Lei, Y., Jabri, B., Alegre, M.-L., et al. (2015) · Science · doi:10.1126/science.aac4255 · Cited by 3,888 · see citing works
Mutation of the mouse klotho gene leads to a syndrome resembling ageing
Kuro-o, M., Matsumura, Y., Aizawa, H., Kawaguchi, H., Suga, T., Utsugi, T., Ohyama, Y., Kurabayashi, M., Kaname, T., Kume, E., et al. (1997) · Nature · doi:10.1038/36285 · Cited by 3,837 · see citing works
A central role for JNK in obesity and insulin resistance
Hirosumi, J., Tuncman, G., Chang, L., Görgün, C. Z., Uysal, K. T., Maeda, K., Karin, M., & Hotamisligil, G. S. (2002) · Nature · doi:10.1038/nature01137 · Cited by 3,359 · see citing works
Functional Polarization of Tumour-Associated Macrophages by Tumour-Derived Lactic Acid
Colegio, O. R., Chu, N.-Q., Szabo, A. L., Chu, T., Rhebergen, A. M., Jairam, V., Cyrus, N., Brokowski, C. E., Eisenbarth, S. C., Phillips, G. M., et al. (2014) · Nature · doi:10.1038/nature13490 · Cited by 3,046 · see citing works
Environment dominates over host genetics in shaping human gut microbiota
Rothschild, D., Weissbrod, O., Barkan, E., Kurilshikov, A., Korem, T., Zeevi, D., Costea, P. I., Godneva, A., Kalka, I. N., Bar, N., et al. (2018) · Nature · doi:10.1038/nature25973 · Cited by 2,859 · see citing works
Bile salt biotransformations by human intestinal bacteria
Ridlon, J. M., Kang, D.-J., & Hylemon, P. B. (2006) · Journal of Lipid Research · doi:10.1194/jlr.r500013-jlr200 · Cited by 2,829 · see citing works
Kostic, A. D., Chun, E., Robertson, L., Glickman, J. N., Gallini, C. A., Michaud, M., Clancy, T. E., Chung, D. C., Lochhead, P., Hold, G. L., et al. (2013) · Cell Host & Microbe · doi:10.1016/j.chom.2013.07.007 · Cited by 2,718 · see citing works
Obesity-induced gut microbial metabolite promotes liver cancer through senescence secretome
Yoshimoto, S., Loo, T. M., Atarashi, K., Kanda, H., Sato, S., Oyadomari, S., Iwakura, Y., Oshima, K., Morita, H., Hattori, M., et al. (2013) · Nature · doi:10.1038/nature12347 · Cited by 2,219 · see citing works
Geller, L. T., Barzily-Rokni, M., Danino, T., Jonas, O. H., Shental, N., Nejman, D., Gavert, N., Zwang, Y., Cooper, Z. A., Shee, K., et al. (2017) · Science · doi:10.1126/science.aah5043 · Cited by 1,817 · see citing works
Tumor Microbiome Diversity and Composition Influence Pancreatic Cancer Outcomes
Riquelme, E., Zhang, Y., Zhang, L., Montiel, M., Zoltan, M., Dong, W., Quesada, P., Sahin, I., Chandra, V., San Lucas, A., et al. (2019) · Cell · doi:10.1016/j.cell.2019.07.008 · Cited by 1,577 · see citing works
Analysis of <i>Fusobacterium</i> persistence and antibiotic response in colorectal cancer
Bullman, S., Pedamallu, C. S., Sicinska, E., Clancy, T. E., Zhang, X., Cai, D., Neuberg, D., Huang, K., Guevara, F., Nelson, T., et al. (2017) · Science · doi:10.1126/science.aal5240 · Cited by 1,574 · see citing works
Noncanonical Inflammasome Activation by Intracellular LPS Independent of TLR4
Kayagaki, N., Wong, M. T., Stowe, I. B., Ramani, S. R., Gonzalez, L. C., Akashi‐Takamura, S., Miyake, K., Zhang, J., Lee, W. P., Muszyński, A., et al. (2013) · Science · doi:10.1126/science.1240248 · Cited by 1,545 · see citing works
Gut microbiome–mediated bile acid metabolism regulates liver cancer via NKT cells
Ma, C., Han, M., Heinrich, B., Fu, Q., Zhang, Q., Sandhu, M., Agdashian, D., Terabe, M., Berzofsky, J. A., Fako, V., et al. (2018) · Science · doi:10.1126/science.aan5931 · Cited by 1,508 · see citing works
Gur, C., Ibrahim, Y., Isaacson, B., Yamin, R., Abed, J., Gamliel, M., Enk, J., Bar-On, Y., Stanietsky-Kaynan, N., Coppenhagen-Glazer, S., et al. (2015) · Immunity · doi:10.1016/j.immuni.2015.01.010 · Cited by 1,490 · see citing works
The gut-liver axis and the intersection with the microbiome
Tripathi, A., Debelius, J., Brenner, D. A., Karin, M., Loomba, R., Schnabl, B., & Knight, R. (2018) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-018-0011-z · Cited by 1,480 · see citing works
Pushalkar, S., Hundeyin, M., Daley, D., Zambirinis, C. P., Kurz, E., Mishra, A., Mohan, N., Aykut, B., Usyk, M., Torres, L. E., et al. (2018) · Cancer Discovery · doi:10.1158/2159-8290.cd-17-1134 · Cited by 1,400 · see citing works
Gut microbiota in colorectal cancer: mechanisms of action and clinical applications
Wong, S. H., & Yu, J. (2019) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-019-0209-8 · Cited by 1,355 · see citing works
Yu, J. Q., Feng, Q., Wong, S. H., Zhang, D., Liang, Q. Y., Qin, Y., Tang, L., Zhao, H., Stenvang, J., Li, Y., et al. (2015) · Gut · doi:10.1136/gutjnl-2015-309800 · Cited by 1,247 · see citing works
Self-citationMutational signature in colorectal cancer caused by genotoxic pks+ E. coli
Pleguezuelos-Manzano, C., Puschhof, J., Rosendahl Huber, A., van Hoeck, A., Wood, H. M., Nomburg, J., Gurjao, C., Manders, F., Dalmasso, G., Stege, P. B., et al. (2020) · Nature · doi:10.1038/s41586-020-2080-8 · Cited by 1,208 · see citing works
Kim, K., Gu, W., Lee, I., Joh, E., & Kim, D. (2012) · PLoS ONE · doi:10.1371/journal.pone.0047713 · Cited by 1,184 · see citing works
Molecular mechanisms of alcohol-mediated carcinogenesis
Seitz, H. K., & Stickel, F. (2007) · Nature reviews. Cancer · doi:10.1038/nrc2191 · Cited by 1,142 · see citing works
Patients with familial adenomatous polyposis harbor colonic biofilms containing tumorigenic bacteria
Dejea, C. M., Fathi, P., Craig, J. M., Boleij, A., Taddese, R., Geis, A. L., Wu, X., DeStefano Shields, C. E., Hechenbleikner, E. M., Huso, D. L., et al. (2018) · Science · doi:10.1126/science.aah3648 · Cited by 1,105 · cited 1× · see citing works
“coli, promoting colibactin-induced DNA damage to colonic epithelial cells [143].”
BackgroundMarques, F. Z., Nelson, E., Chu, P.-Y., Horlock, D., Fiedler, A., Ziemann, M., Tan, J. K., Kuruppu, S., Rajapakse, N. W., El-Osta, A., et al. (2017) · Circulation · doi:10.1161/circulationaha.116.024545 · Cited by 1,065 · see citing works
The gut microbiota at the intersection of diet and human health
Gentile, C. L., & Weir, T. L. (2018) · Science · doi:10.1126/science.aau5812 · Cited by 1,049 · see citing works
Genetic determinants of the gut microbiome in UK twins
Goodrich, J. K., Davenport, E. R., Beaumont, M., Jackson, M. A., Knight, R., Ober, C., Spector, T. D., Bell, J. T., Clark, A. G., & Ley, R. E. (2016) · Cell Host & Microbe · doi:10.1016/j.chom.2016.04.017 · Cited by 1,048 · see citing works
Zhang, C., Zhang, M., Wang, S., Han, R., Cao, Y., Hua, W., Mao, Y., Zhang, X., Pang, X., Wei, C., et al. (2010) · The ISME Journal · doi:10.1038/ismej.2009.112 · Cited by 1,024 · see citing works
Yang, Y. P., Weng, W., Peng, J., Hong, L., Yang, L., Toiyama, Y., Gao, R., Liu, M., Yin, M., Pan, C., et al. (2016) · Gastroenterology · doi:10.1053/j.gastro.2016.11.018 · Cited by 1,015 · see citing works
Abed, J., Emgård, J. E. M., Zamir, G., Faroja, M., Almogy, G., Grenov, A., Sol, A., Naor, R., Pikarsky, E., Atlan, K. A., et al. (2016) · Cell Host & Microbe · doi:10.1016/j.chom.2016.07.006 · Cited by 888 · see citing works
The fungal mycobiome promotes pancreatic oncogenesis via activation of MBL
Aykut, B., Pushalkar, S., Chen, R., Li, Q., Abengozar, R., Kim, J. I., Shadaloey, S. A., Wu, D., Preiss, P., Verma, N., et al. (2019) · Nature · doi:10.1038/s41586-019-1608-2 · Cited by 883 · see citing works
Diet-microbiota interactions and personalized nutrition
Kolodziejczyk, A. A., Zheng, D., & Elinav, E. (2019) · Nature Reviews Microbiology · doi:10.1038/s41579-019-0256-8 · Cited by 879 · see citing works
Cuevas-Ramos, G., Petit, C. R., Marcq, I., Boury, M., Oswald, E., & Nougayrède, J.-P. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1001261107 · Cited by 855 · see citing works
The Human Gut Microbiome: From Association to Modulation
Schmidt, T. S. B., Raes, J., & Bork, P. (2018) · Cell · doi:10.1016/j.cell.2018.02.044 · Cited by 845 · see citing works
Dietary quality among men and women in 187 countries in 1990 and 2010: a systematic assessment
Imamura, F., Micha, R., Khatibzadeh, S., Fahimi, S., Shi, P., Powles, J., & Mozaffarian, D. (2015) · The Lancet Global Health · doi:10.1016/s2214-109x(14)70381-x · Cited by 834 · see citing works
The effect of host genetics on the gut microbiome
Bonder, M. J., Kurilshikov, A., Tigchelaar, E. F., Mujagic, Z., Imhann, F., Vila, A. V., Deelen, P., Vatanen, T., Schirmer, M., Smeekens, S. P., et al. (2016) · Nature Genetics · doi:10.1038/ng.3663 · Cited by 819 · see citing works
Tumour-associated and non-tumour-associated microbiota in colorectal cancer
Flemer, B., Lynch, D. B., Brown, J. M. R., Jeffery, I. B., Ryan, F. J., Claesson, M. J., O'Riordain, M., Shanahan, F., & O'Toole, P. W. (2017) · Gut · doi:10.1136/gutjnl-2015-309595 · Cited by 804 · see citing works
Plottel, C. S., & Blaser, M. J. (2011) · Cell Host & Microbe · doi:10.1016/j.chom.2011.10.003 · Cited by 743 · see citing works
The lactic acid bacteria: A literature survey
Carr, F. J., Chill, D., & Maida, N. (2002) · Critical Reviews in Microbiology · doi:10.1080/1040-840291046759 · Cited by 724 · see citing works
Carcinogenesis of Helicobacter pylori
Correa, P., & Houghton, J. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.06.026 · Cited by 708 · see citing works
Gastric microbial community profiling reveals a dysbiotic cancer-associated microbiota
Ferreira, R. M., Pereira-Marques, J., Pinto-Ribeiro, I., Costa, J. L., Carneiro, F., Machado, J. C., & Figueiredo, C. (2018) · Gut · doi:10.1136/gutjnl-2017-314205 · Cited by 697 · see citing works
<i>Fusobacterium nucleatum</i> and T Cells in Colorectal Carcinoma
Mima, K., Sukawa, Y., Nishihara, R., Qian, Z. R., Yamauchi, M., Inamura, K., Kim, S. A., Masuda, A., Nowak, J. A., Nosho, K., et al. (2015) · JAMA Oncology · doi:10.1001/jamaoncol.2015.1377 · Cited by 669 · see citing works
Chung, L., Orberg, E. T., Geis, A. L., Chan, J. L., Fu, K., Shields, C. E. D., Dejea, C. M., Fathi, P., Chen, J., Finard, B. B., et al. (2018) · Cell Host & Microbe · doi:10.1016/j.chom.2018.01.007 · Cited by 657 · see citing works
Gene-microbiota interactions contribute to the pathogenesis of inflammatory bowel disease
Chu, H., Khosravi, A., Kusumawardhani, I. P., Kwon, A. H. K., Vasconcelos, A. C., Cunha, L. D., Mayer, A. E., Shen, Y., Wu, W.-L., Kambal, A., et al. (2016) · Science · doi:10.1126/science.aad9948 · Cited by 647 · see citing works
Goodwin, A. C., Shields, C. E. D., Wu, S., Huso, D. L., Wu, X., Murray-Stewart, T. R., Hacker-Prietz, A., Rabizadeh, S., Woster, P. M., Sears, C. L., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1010203108 · Cited by 612 · see citing works
San-Millán, I., & Brooks, G. A. (2016) · Carcinogenesis · doi:10.1093/carcin/bgw127 · Cited by 612 · see citing works
Wan, Y., Wang, F., Yuan, J., Li, J., Jiang, D., Zhang, J., Li, H., Wang, R., Tang, J., Huang, T., et al. (2019) · Gut · doi:10.1136/gutjnl-2018-317609 · Cited by 598 · see citing works
Self-citationHelicobacter pylori VacA, a paradigm for toxin multifunctionality
Cover, T. L., & Blanke, S. R. (2005) · Nature Reviews Microbiology · doi:10.1038/nrmicro1095 · Cited by 569 · see citing works
Selective inhibition of IDO1 effectively regulates mediators of antitumor immunity
Liu, X., Shin, N., Koblish, H. K., Yang, G., Wang, Q., Wang, K., Leffet, L., Hansbury, M., Thomas, B. A., Rupar, M. J., et al. (2010) · Blood · doi:10.1182/blood-2009-09-246124 · Cited by 549 · see citing works
Self-citationBilophila wadsworthia aggravates high fat diet induced metabolic dysfunctions in mice
Natividad, J. M., Lamas, B., Pham, H., Michel, M., Rainteau, D. P., Bridonneau, C., Costa, G. D., Vlieg, J. V. H., Sovran, B., Chamignon, C., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-05249-7 · Cited by 547 · see citing works
A high-fat diet is associated with endotoxemia that originates from the gut
Pendyala, S., Walker, J. M., & Holt, P. R. (2012) · Gastroenterology · doi:10.1053/j.gastro.2012.01.034 · Cited by 546 · see citing works
Brandt, S., Kwok, T., Hartig, R., König, W., & Backert, S. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0409873102 · Cited by 535 · see citing works
Dysregulated Microbial Fermentation of Soluble Fiber Induces Cholestatic Liver Cancer
Singh, V., Yeoh, B. S., Chassaing, B., Xiao, X., Saha, P., Aguilera Olvera, R., Lapek, J. D., Zhang, L., Wang, W.-B., Hao, S., et al. (2018) · Cell · doi:10.1016/j.cell.2018.09.004 · Cited by 532 · see citing works
Fusobacterium nucleatum promotes colorectal cancer by inducing Wnt/β‐catenin modulator Annexin A1
Rubinstein, M. R., Baik, J. E., Lagana, S. M., Han, R. P., Raab, W. J., Sahoo, D., Dalerba, P. D., Wang, T. C., & Han, Y. W. (2019) · EMBO Reports · doi:10.15252/embr.201847638 · Cited by 525 · see citing works
Cougnoux, A., Dalmasso, G., Martinez, R., Buc, E., Delmas, J., Gibold, L., Sauvanet, P., Darcha, C., Déchelotte, P., Bonnet, M., et al. (2014) · Gut · doi:10.1136/gutjnl-2013-305257 · Cited by 486 · see citing works
Quante, M., Bhagat, G., Abrams, J. A., Marache, F., Good, P., Lee, M. D., Lee, Y., Friedman, R. A., Asfaha, S., Dubeykovskaya, Z. A., et al. (2012) · Cancer Cell · doi:10.1016/j.ccell.2026.07.005 · Cited by 485 · see citing works
Zeng, H., Umar, S., Rust, B., Lazarova, D., & Bordonaro, M. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20051214 · Cited by 480 · see citing works
Loo, T. M., Kamachi, F., Watanabe, Y., Yoshimoto, S., Kanda, H., Arai, Y., Nakajima-Takagi, Y., Iwama, A., Koga, T., Sugimoto, Y., et al. (2017) · Cancer Discovery · doi:10.1158/2159-8290.cd-16-0932 · Cited by 478 · see citing works
FXR Regulates Intestinal Cancer Stem Cell Proliferation
Fu, T., Coulter, S., Yoshihara, E., Oh, T. G., Fang, S., Cayabyab, F., Zhu, Q., Zhang, T., Leblanc, M., Liu, S., et al. (2019) · Cell · doi:10.1016/j.cell.2019.01.036 · Cited by 456 · see citing works
High-fat-diet-mediated dysbiosis promotes intestinal carcinogenesis independently of obesity
Schulz, M. D., Atay, Ç., Heringer, J., Romrig, F., Schwitalla, S., Aydın, B., Ziegler, P. K., Varga, J., Reindl, W., Pommerenke, C., et al. (2014) · Nature · doi:10.1038/nature13398 · Cited by 452 · see citing works
Do, M. H., Lee, E., Oh, M.-J., Kim, Y., & Park, H.-Y. (2018) · Nutrients · doi:10.3390/nu10060761 · Cited by 441 · see citing works
The Role of Myeloid-Derived Suppressor Cells (MDSC) in Cancer Progression
Umansky, V., Blattner, C., Gebhardt, C., & Utikal, J. S. (2016) · Vaccines · doi:10.3390/vaccines4040036 · Cited by 440 · see citing works
Meyerhardt, J. A., Niedzwiecki, D., Hollis, D. R., Saltz, L. B., Hu, F. B., Mayer, R. J., Nelson, H., Whittom, R., Hantel, A., Thomas, J. P., et al. (2007) · JAMA · doi:10.1001/jama.298.7.754 · Cited by 435 · see citing works
The MDM2-p53 pathway revisited
Nag, S. A., Jiangjiang, Q., Kalkunte, S. S., Ming-hai, W., & Zhang, R. (2013) · Journal of Biomedical Research · doi:10.7555/jbr.27.20130030 · Cited by 414 · see citing works
He, Z., Gharaibeh, R. Z., Newsome, R. C., Pope, J. L., Dougherty, M. W., Tomkovich, S., Pons, B., Mirey, G., Vignard, J., Hendrixson, D. R., et al. (2019) · Gut · doi:10.1136/gutjnl-2018-317200 · Cited by 409 · see citing works
Mitsuhashi, K., Nosho, K., Sukawa, Y., Matsunaga, Y., Ito, M., Kurihara, H., Kanno, S., Igarashi, H., Naito, T., Adachi, Y., et al. (2015) · Oncotarget · doi:10.18632/oncotarget.3109 · Cited by 404 · see citing works
Gut microbiota promotes tumor growth in mice by modulating immune response
Sethi, V., Kurtom, S., Tarique, M., Lavania, S., Malchiodi, Z., Hellmund, L., Zhang, L., Sharma, U., Giri, B., Garg, B., et al. (2018) · Gastroenterology · doi:10.1053/j.gastro.2018.04.001 · Cited by 403 · see citing works
The gut-bone axis: How bacterial metabolites bridge the distance
Zaiss, M. M., Jones, R. M., Schett, G., & Pacifici, R. (2019) · Journal of Clinical Investigation · doi:10.1172/jci128521 · Cited by 403 · see citing works
Bacterial biogeography of the human digestive tract
Stearns, J. C., Lynch, M. D. J., Senadheera, D. B., Tenenbaum, H. C., Goldberg, M. B., Cvitkovitch, D. G., Croitoru, K., Moreno‐Hagelsieb, G., & Neufeld, J. D. (2011) · Scientific Reports · doi:10.1038/srep00170 · Cited by 399 · see citing works
Incio, J., Liu, H., Suboj, P., Chin, S. M., Chen, I. X., Pinter, M., Ng, M., Nia, H., Grahovac, J., Kao, S., et al. (2016) · Cancer Discovery · doi:10.1158/2159-8290.cd-15-1177 · Cited by 397 · see citing works
van Baarlen, P., Troost, F. J., van Hemert, S., van Kraaij, C., de Vos, W. M., de Groot, P. J., Hooiveld, G. J. E. J., Brummer, R. J., & Kleerebezem, M. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0809919106 · Cited by 384 · see citing works
Melatonin reprogramming of gut microbiota improves lipid dysmetabolism in high‐fat diet‐fed mice
Yin, J., Li, Y., Han, H. L., Chen, S., Gao, J., Liu, G., Wu, X., Deng, J., Yu, Q., Huang, X., et al. (2018) · Journal of Pineal Research · doi:10.1111/jpi.12524 · Cited by 384 · see citing works
Self-citationLofgren, J. L. S., Whary, M. T., Ge, Z., Muthupalani, S., Taylor, N. S., Mobley, M. W., Potter, A. F., Varró, A., Eibach, D., Suerbaum, S., et al. (2010) · Gastroenterology · doi:10.1053/j.gastro.2010.09.048 · Cited by 380 · see citing works
Xiao, S., Fei, N., Pang, X., Shen, J., Wang, L., Zhang, B., Zhang, M. H., Zhang, X., Zhang, C., Li, M., et al. (2013) · FEMS Microbiology Ecology · doi:10.1111/1574-6941.12228 · Cited by 376 · see citing works
Metabolite-Sensing Receptor Ffar2 Regulates Colonic Group 3 Innate Lymphoid Cells and Gut Immunity
Chun, E., Lavoie, S., Fonseca-Pereira, D., Bae, S., Michaud, M., Hoveyda, H. R., Fraser, G. L., Gallini Comeau, C. A., Glickman, J. N., Fuller, M. H., et al. (2019) · Immunity · doi:10.1016/j.immuni.2019.09.014 · Cited by 336 · see citing works
Meta-Analysis Reveals Reproducible Gut Microbiome Alterations in Response to a High-Fat Diet
Bisanz, J. E., Upadhyay, V., Turnbaugh, J. A., Ly, K., & Turnbaugh, P. J. (2019) · Cell Host & Microbe · doi:10.1016/j.chom.2019.06.013 · Cited by 333 · see citing works
Microbiota-liver axis in hepatic disease
Chassaing, B., Etienne‐Mesmin, L., & Gewirtz, A. T. (2013) · Hepatology · doi:10.1002/hep.26494 · Cited by 329 · see citing works
Mehta, R. S., Nishihara, R., Cao, Y., Song, M., Mima, K., Qian, Z. R., Nowak, J. A., Kosumi, K., Hamada, T., Masugi, Y., et al. (2017) · JAMA Oncology · doi:10.1001/jamaoncol.2016.6374 · Cited by 325 · see citing works
Gäbele, E., Dostert, K., Hofmann, C., Wiest, R., Schölmerich, J., Hellerbrand, C., & Obermeier, F. (2011) · Journal of Hepatology · doi:10.1016/j.jhep.2011.02.035 · Cited by 324 · see citing works
Microbiota in pancreatic health and disease: the next frontier in microbiome research
Thomas, R. M., & Jobin, C. (2019) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-019-0242-7 · Cited by 306 · see citing works
Structure of the human gastric bacterial community in relation to Helicobacter pylori status
Maldonado‐Contreras, A., Goldfarb, K. C., Godoy‐Vitorino, F., Karaöz, U., Contreras, M., Blaser, M. J., Brodie, E., & Domínguez-Bello, M. G. (2010) · The ISME Journal · doi:10.1038/ismej.2010.149 · Cited by 301 · see citing works
Diagnostic potential and interactive dynamics of the colorectal cancer virome
Hannigan, G. D., Duhaime, M. B., Ruffin, M. T., Koumpouras, C. C., & Schloss, P. D. (2018) · mBio · doi:10.1128/mbio.02248-18 · Cited by 298 · see citing works
Miranda, P. M., Palma, G. D., Serkis, V., Lu, J., Louis-Auguste, M., McCarville, J. L., Verdu, E. F., Collins, S. M., & Berčík, P. (2018) · Microbiome · doi:10.1186/s40168-018-0433-4 · Cited by 295 · see citing works
Lertpiriyapong, K., Whary, M. T., Muthupalani, S., Lofgren, J. L. S., Gamazon, E. R., Feng, Y., Ge, Z., Wang, T. C., & Fox, J. G. (2013) · Gut · doi:10.1136/gutjnl-2013-305178 · Cited by 289 · see citing works
Hsu, R. Y., Chan, C., Spicer, J., Rousseau, M., Giannias, B., Rousseau, S., & Ferri, L. (2011) · Cancer Research · doi:10.1158/0008-5472.can-10-2833 · Cited by 270 · see citing works
Bauer, P. V., Duca, F. A., Waise, T. M. Z., Rasmussen, B. A., Abraham, M. A., Dranse, H. J., Puri, A., O’Brien, C. A., & Lam, T. K. T. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2017.09.019 · Cited by 265 · see citing works
Boursi, B., Mamtani, R., Haynes, K., & Yang, Y. (2015) · European Journal of Cancer · doi:10.1016/j.ejca.2015.08.015 · Cited by 263 · see citing works
Guglietta, S., Chiavelli, A., Zagato, E., Krieg, C., Gandini, S., Ravenda, P. S., Bazolli, B., Lu, B., Penna, G., & Rescigno, M. (2016) · Nature Communications · doi:10.1038/ncomms11037 · Cited by 257 · see citing works
Dysbiosis of the microbiome in gastric carcinogenesis
Castaño‐Rodríguez, N., Goh, K., Fock, K. M., Mitchell, H. M., & Kaakoush, N. O. (2017) · Scientific Reports · doi:10.1038/s41598-017-16289-2 · Cited by 253 · see citing works
Dysregulated hepatic bile acids collaboratively promote liver carcinogenesis
Xie, G., Wang, X., Huang, F., Zhao, A., Chen, W., Yan, J., Zhang, Y., Lei, S., Ge, K., Zheng, X., et al. (2016) · International Journal of Cancer · doi:10.1002/ijc.30219 · Cited by 252 · see citing works
Philip, B., Roland, C. L., Daniluk, J., Liu, Y., Chatterjee, D., Gomez, S., Ji, B., Huang, H., Wang, H., Fleming, J. B., et al. (2013) · Gastroenterology · doi:10.1053/j.gastro.2013.08.018 · Cited by 249 · see citing works
Cantorna, M. T., Snyder, L. M., & Arora, J. (2019) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.1080/10409238.2019.1611734 · Cited by 244 · see citing works
Mueller, D., Tegtmeyer, N., Brandt, S., Yamaoka, Y., Poire, E. D., Sgouras, D. N., Weßler, S., Torres, J., Smolka, A. J., & Backert, S. (2012) · Journal of Clinical Investigation · doi:10.1172/jci61143 · Cited by 240 · see citing works
Diet, genetics, and the gut microbiome drive dynamic changes in plasma metabolites
Fujisaka, S., Avila-Pacheco, J., Soto, M., Kostic, A., Dreyfuss, J. M., Pan, H., Ussar, S., Altindis, E., Li, N., Bry, L., et al. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.02.060 · Cited by 231 · see citing works
The gut microbiota in conventional and serrated precursors of colorectal cancer
Peters, B. A., Dominianni, C., Shapiro, J. A., Church, T. R., Wu, J., Miller, G., Yuen, E., Freiman, H. J., Lustbader, I., Salik, J., et al. (2016) · Microbiome · doi:10.1186/s40168-016-0218-6 · Cited by 230 · see citing works
Gut microbial profile analysis by MiSeq sequencing of pancreatic carcinoma patients in China
Ren, Z., Jiang, J., Xie, H., Li, A., Lu, H., Xu, S., Zhou, L., Zhang, H., Cui, G., Chen, X., et al. (2017) · Oncotarget · doi:10.18632/oncotarget.18820 · Cited by 228 · see citing works
Enrichment of oral microbiota in early cystic precursors to invasive pancreatic cancer
Gaiser, R. A., Halimi, A., Alkharaan, H., Lu, L., Davanian, H., Healy, K., Hugerth, L. W., Ateeb, Z., Valente, R., Fernández Moro, C., et al. (2019) · Gut · doi:10.1136/gutjnl-2018-317458 · Cited by 227 · see citing works
Intestinal microbiota enhances pancreatic carcinogenesis in preclinical models
Thomas, R. M., Gharaibeh, R. Z., Gauthier, J., Beveridge, M. J., Pope, J. L., Guijarro, M. V., Yu, Q., He, Z., Ohland, C., Newsome, R. C., et al. (2018) · Carcinogenesis · doi:10.1093/carcin/bgy073 · Cited by 224 · see citing works
Bier, A., Braun, T., Khasbab, R., Segni, A. D., Grossman, E., Haberman, Y., & Leibowitz, A. (2018) · Nutrients · doi:10.3390/nu10091154 · Cited by 224 · see citing works
Kon, S., Ishibashi, K., Katoh, H., Kitamoto, S., Shirai, T., Tanaka, S., Kajita, M., Ishikawa, S., Yamauchi, H., Yako, Y., et al. (2017) · Nature Cell Biology · doi:10.1038/ncb3509 · Cited by 223 · see citing works
Orberg, E. T., Fan, H., Tam, A. J., Dejea, C. M., Shields, C. E. D., Wu, S., Chung, L., Finard, B. B., Wu, X., Fathi, P., et al. (2016) · Mucosal Immunology · doi:10.1038/mi.2016.53 · Cited by 222 · see citing works
Fujiwara, N., Nakagawa, H., Enooku, K., Kudo, Y., Hayata, Y., Nakatsuka, T., Tanaka, Y., Tateishi, R., Hikiba, Y., Misumi, K., et al. (2018) · Gut · doi:10.1136/gutjnl-2017-315193 · Cited by 221 · see citing works
Distinctly altered gut microbiota in the progression of liver disease
Xie, G., Wang, X., Liu, P., Wei, R., Chen, W., Rajani, C., Hernandez, B. Y., Alegado, R., Dong, B., Li, D., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.8466 · Cited by 219 · see citing works
Bacterial overgrowth and diversification of microbiota in gastric cancer
Wang, L., Zhou, J., Xin, Y., Geng, C.-X., Tian, Z., Yu, X., & Dong, Q. (2015) · European Journal of Gastroenterology & Hepatology · doi:10.1097/meg.0000000000000542 · Cited by 215 · see citing works
Spermine oxidase mediates the gastric cancer risk associated with Helicobacter pylori CagA
Chaturvedi, R., Asim, M., Romero–Gallo, J., Barry, D. P., Hoge, S., de Sablet, T., Delgado, A. G., Wroblewski, L. E., Piazuelo, M. B., Yan, F., et al. (2011) · Gastroenterology · doi:10.1053/j.gastro.2011.07.045 · Cited by 208 · see citing works
Lithocholic acid, a bacterial metabolite reduces breast cancer cell proliferation and aggressiveness
Mikó, E., Vida, A., Kovàcs, T., Ujlaki, G., Trencsényi, G., Márton, J., Sári, Z., Kovács, P., Boratkó, A., Hujber, Z., et al. (2018) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2018.04.002 · Cited by 207 · see citing works
Gut-associated IgA+ immune cells regulate obesity-related insulin resistance
Luck, H., Khan, S. M., Kim, J. H., Copeland, J. K., Revelo, X. S., Tsai, S. J., Chakraborty, M., Cheng, K., Chan, Y. T., Nøhr, M. K., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-11370-y · Cited by 204 · see citing works
Wang, T., Fan, C., Yao, A., Xu, X., Zheng, G., You, Y., Jiang, C., Zhao, X., Hou, Y., Hung, M., et al. (2018) · Immunity · doi:10.1016/j.immuni.2018.08.018 · Cited by 203 · see citing works
Cohen, L. J., Cho, J. H., Gevers, D., & Chu, H. (2019) · Gastroenterology · doi:10.1053/j.gastro.2019.03.017 · Cited by 201 · see citing works
Vadrevu, S. K., Chintala, N. K., Sharma, S., Sharma, P., Cleveland, C., Riediger, L., Manne, S., Fairlie, D. P., Gorczyca, W., Almanza, O., et al. (2014) · Cancer Research · doi:10.1158/0008-5472.can-14-0157 · Cited by 200 · see citing works
Role of SCFAs in gut microbiome and glycolysis for colorectal cancer therapy
Wang, G., Yu, Y., Wang, Y., Wang, J., Guan, R., Sun, Y., Shi, F., Gao, J., & Fu, X. (2019) · Journal of Cellular Physiology · doi:10.1002/jcp.28436 · Cited by 199 · see citing works
Self-citationRosean, C. B., Bostic, R. R., Ferey, J. C. M., Feng, T.-Y., Azar, F. N., Tung, K. S. K., Dozmorov, M. G., Smirnova, E., Bos, P. D., & Rutkowski, M. R. (2019) · Cancer Research · doi:10.1158/0008-5472.can-18-3464 · Cited by 199 · see citing works
Inflammation, Immunity, and Cancer
Singh, R., Mishra, M. K., & Aggarwal, H. (2017) · Mediators of Inflammation · doi:10.1155/2017/6027305 · Cited by 198 · see citing works
Malik, A., Sharma, D., Malireddi, R. K. S., Guy, C. S., Chang, T., Olsen, S. R., Neale, G. A. M., Vogel, P., & Kanneganti, T. (2018) · Immunity · doi:10.1016/j.immuni.2018.08.024 · Cited by 198 · see citing works
Fiber Intake and Survival After Colorectal Cancer Diagnosis
Song, M., Wu, K., Meyerhardt, J. A., Ogino, S., Wang, M., Fuchs, C. S., Giovannucci, E. L., & Chan, A. T. (2018) · JAMA Oncology · doi:10.1001/jamaoncol.2017.3684 · Cited by 197 · see citing works
Long-term use of antibiotics and risk of colorectal adenoma
Cao, Y., Wu, K., Mehta, R. S., Drew, D. A., Song, M., Lochhead, P. J., Nguyen, L. H., Izard, J., Fuchs, C. S., Garrett, W. S., et al. (2017) · Gut · doi:10.1136/gutjnl-2016-313413 · Cited by 196 · see citing works
Microbial regulation of host hydrogen sulfide bioavailability and metabolism
Shen, X., Carlström, M., Borniquel, S., Jädert, C., Kevil, C. G., & Lundberg, J. O. (2013) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2013.02.024 · Cited by 194 · see citing works
Adiposity and gastrointestinal cancers: epidemiology, mechanisms and future directions
Murphy, N., Jenab, M., & Gunter, M. J. (2018) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-018-0038-1 · Cited by 194 · see citing works
Song, W., Tiruthani, K., Wang, Y., Shen, L., Hu, M., Dorosheva, O., Qiu, K., Kinghorn, K., Liu, R., & Huang, L. (2018) · Advanced Materials · doi:10.1002/adma.201805007 · Cited by 194 · see citing works
Self-citationOf inflammasomes and pathogens – sensing of microbes by the inflammasome
Bauernfeind, F. G., & Hornung, V. (2013) · EMBO Molecular Medicine · doi:10.1002/emmm.201201771 · Cited by 191 · see citing works
The Impact of Dietary Transition Metals on Host-Bacterial Interactions
Lopez, C. A., & Skaar, E. P. (2018) · Cell Host & Microbe · doi:10.1016/j.chom.2018.05.008 · Cited by 190 · cited 1× · see citing works
“Meanwhile, some micronutrients such as vitamins and zinc can also affect the composition of intestinal microbes [219, 220].”
BackgroundChen, Y., Chen, Y., Zhang, J., Cao, P., Su, W., Deng, Y., Zhan, N., Fu, X., Huang, Y., & Dong, W. (2019) · Theranostics · doi:10.7150/thno.38870 · Cited by 190 · see citing works
Contribution of Gut Bacteria to Liver Pathobiology
Son, G., Kremer, M., & Hines, I. N. (2010) · Gastroenterology Research and Practice · doi:10.1155/2010/453563 · Cited by 183 · see citing works
Kovàcs, T., Mikó, E., Vida, A., Sebő, É., Tóth, J., Csonka, T., Boratkó, A., Ujlaki, G., Lente, G., Kovács, P., et al. (2019) · Scientific Reports · doi:10.1038/s41598-018-37664-7 · Cited by 183 · see citing works
Yang, Y., Zhong, Z., Wang, B., Xia, X., Yao, W., Huang, L., Wang, Y., & Ding, W. (2019) · Neuropsychopharmacology · doi:10.1038/s41386-019-0437-1 · Cited by 179 · see citing works
Self-citationColon cancer-associated B2Escherichia colicolonize gut mucosa and promote cell proliferation
Raisch, J. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i21.6560 · Cited by 174 · see citing works
Xu, L., Sharkey, D., & Cantley, L. G. (2019) · Journal of the American Society of Nephrology · doi:10.1681/asn.2019010068 · Cited by 174 · see citing works
Microbial carcinogenesis: Lactic acid bacteria in gastric cancer
Vinasco, K., Mitchell, H. M., Kaakoush, N. O., & Castaño‐Rodríguez, N. (2019) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2019.07.004 · Cited by 173 · see citing works
Zeng, H., Ishaq, S. L., Zhao, F., & Wright, A. G. (2016) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2016.05.015 · Cited by 172 · see citing works
Pancreatic Cancer, Inflammation, and Microbiome
Zambirinis, C. P., Pushalkar, S., Saxena, D. B., & Miller, G. (2014) · The Cancer Journal · doi:10.1097/ppo.0000000000000045 · Cited by 169 · see citing works
Lin, H., An, Y., Hao, F., Wang, Y., & Tang, H. (2016) · Scientific Reports · doi:10.1038/srep21618 · Cited by 169 · see citing works
Self-citationGuo, X., Li, J., Tang, R., Zhang, G., Zeng, H., Wood, R. J., & Liu, Z. (2017) · Mediators of Inflammation · doi:10.1155/2017/9474896 · Cited by 161 · see citing works
Self-citationZhao, R., Coker, O. O., Wu, J., Zhou, Y., Zhao, L., Nakatsu, G., Bian, X., Wei, H., Chan, A. W. H., Sung, J. J. �., et al. (2020) · Gastroenterology · doi:10.1053/j.gastro.2020.05.004 · Cited by 161 · see citing works
Zhang, J., Haines, C. F., Watson, A. J. M., Hart, A. R., Platt, M. J., Pardoll, D. M., Cosgrove, S. E., Gebo, K. A., & Sears, C. L. (2018) · Gut · doi:10.1136/gutjnl-2019-318593 · Cited by 158 · see citing works
Bacterial Biofilms in Colorectal Cancer Initiation and Progression
Li, S., Konstantinov, S. R., Smits, R., & Peppelenbosch, M. P. (2016) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2016.11.004 · Cited by 154 · see citing works
Fatty acid-induced CD36 expression via O-GlcNAcylation drives gastric cancer metastasis
Jiang, M., Wu, N., Xu, B., Chu, Y., Li, X., Su, S., Chen, D., Li, W., Shi, Y., Gao, X., et al. (2019) · Theranostics · doi:10.7150/thno.34024 · Cited by 154 · see citing works
Serna, G., Ruíz‐Pace, F., Hernando, J., Alonso, L., Fasani, R., Landolfi, S., Comas, R., Jimenez, J., Élez, E., Bullman, S., et al. (2020) · Annals of Oncology · doi:10.1016/j.annonc.2020.06.003 · Cited by 154 · see citing works
Münch, N. S., Fang, H., Ingermann, J., Maurer, H. C., Anand, A., Kellner, V., Sahm, V., Wiethaler, M., Baumeister, T., Wein, F., et al. (2019) · Gastroenterology · doi:10.1053/j.gastro.2019.04.013 · Cited by 153 · see citing works
Xiao, L., Sonne, S. B., Feng, Q., Chen, N., Xia, Z., Li, X., Fang, Z., Zhang, D., Fjære, E., Midtbø, L. K., et al. (2017) · Microbiome · doi:10.1186/s40168-017-0258-6 · Cited by 151 · see citing works
Self-citationInterleukin-1B Polymorphisms and Gastric Cancer Risk—A Meta-analysis
Kamangar, F., Cheng, C., Abnet, C. C., & Rabkin, C. S. (2006) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-06-0267 · Cited by 148 · see citing works
Zhang, L., Qin, Q., Liu, M., Zhang, X., He, F., & Wang, G. (2018) · Pathogens and Disease · doi:10.1093/femspd/fty028 · Cited by 147 · see citing works
Viehl, C. T., Moore, T. T., Liyanage, U. K., Frey, D. M., Ehlers, J. P., Eberlein, T. J., Goedegebuure, P. S., & Linehan, D. C. (2006) · Annals of Surgical Oncology · doi:10.1245/s10434-006-9015-y · Cited by 146 · see citing works
Yuan, X., Zhou, Y., Wang, W., Li, J., Xie, G., Zhao, Y., Xu, D., & Shen, L. (2013) · Cell Death and Disease · doi:10.1038/cddis.2013.334 · Cited by 143 · see citing works
Self-citationWroblewski, L. E., Piazuelo, M. B., Chaturvedi, R., Schumacher, M., Aihara, E., Feng, R., Noto, J. M., Delgado, A., Israel, D. A., Zavros, Y., et al. (2015) · Gut · doi:10.1136/gutjnl-2014-307650 · Cited by 143 · see citing works
Oncogenic K-Ras requires activation for enhanced activity
Huang, H., Daniluk, J., Liu, Y., Chu, J., Li, Z., Ji, B., & Logsdon, C. D. (2013) · Oncogene · doi:10.1038/onc.2012.619 · Cited by 139 · see citing works
A Low Carbohydrate, High Protein Diet Slows Tumor Growth and Prevents Cancer Initiation
Ho, V. W., Leung, K., Hsu, A., Luk, B., Lai, J., Shen, S. Y., Minchinton, A. I., Waterhouse, D., Bally, M. B., Lin, W., et al. (2011) · Cancer Research · doi:10.1158/0008-5472.can-10-3973 · Cited by 138 · see citing works
He, C., Cheng, D., Peng, C., Li, Y., Zhu, Y., & Lü, N. (2018) · Frontiers in Microbiology · doi:10.3389/fmicb.2018.00639 · Cited by 138 · see citing works
Engstler, A. J., Aumiller, T., Degen, C., Dürr, M., Weiss, E., Maier, I. B., Schattenberg, J. M., Jin, C. J., Sellmann, C., & Bergheim, I. (2015) · Gut · doi:10.1136/gutjnl-2014-308379 · Cited by 137 · see citing works
Koh, G. Y., Kane, A. V., Lee, K., Xu, Q., Wu, X., Roper, J., Mason, J. B., & Crott, J. W. (2018) · International Journal of Cancer · doi:10.1002/ijc.31559 · Cited by 137 · see citing works
Fecal microbiome signatures of pancreatic cancer patients
Half, E., Keren, N., Reshef, L., Dorfman, T., Lachter, I., Kluger, Y. S., Reshef, N., Knobler, H., Maor, Y., Stein, A., et al. (2019) · Scientific Reports · doi:10.1038/s41598-019-53041-4 · Cited by 134 · see citing works
Oshima, H., Hioki, K., Popivanova, B. K., Oguma, K., van Rooijen, N., Ishikawa, T., & Oshima, M. (2010) · Gastroenterology · doi:10.1053/j.gastro.2010.11.007 · Cited by 133 · see citing works
Effects of theabrownin on serum metabolites and gut microbiome in rats with a high-sugar diet
Yue, S., Zhao, D., Peng, C., Tan, C., Wang, Q., & Gong, J. (2019) · Food & Function · doi:10.1039/c9fo01334b · Cited by 133 · see citing works
The Gut Microbiome in Pancreatic Disease
Akshintala, V. S., Talukdar, R., Singh, V. K., & Goggins, M. (2018) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2018.08.045 · Cited by 131 · see citing works
Feng, C. W., Wang, L., Jiao, L. H., Liu, B., Zheng, S., & Xie, X. (2002) · BMC Cancer · doi:10.1186/1471-2407-2-8 · Cited by 125 · see citing works
Méndez, R., Kesh, K., Arora, N., Martino, L. D., McAllister, F. M., Merchant, N. B., Banerjee, S., & Banerjee, S. (2019) · Carcinogenesis · doi:10.1093/carcin/bgz116 · Cited by 125 · see citing works
Hale, V. L., Jeraldo, P., Chen, J., Mundy, M. B., Yao, J. Z., Priya, S., Keeney, G., Lyke, K. J., Ridlon, J. M., White, B. A., et al. (2018) · Genome Medicine · doi:10.1186/s13073-018-0586-6 · Cited by 124 · see citing works
Review of the gut microbiome and esophageal cancer: Pathogenesis and potential clinical implications
Baba, Y., Iwatsuki, M., Yoshida, N., Watanabe, M., & Baba, H. (2017) · Annals of Gastroenterological Surgery · doi:10.1002/ags3.12014 · Cited by 123 · see citing works
Hu, C.-M., Tien, S.-C., Hsieh, P.-K., Jeng, Y.-M., Chang, M.-C., Chang, Y.-T., Chen, Y.-J., Chen, Y.-J., Lee, E. Y.-H. P., & Lee, W.-H. (2019) · Cell Metabolism · doi:10.1016/j.cmet.2019.02.005 · Cited by 123 · see citing works
Leptin and mTOR: Partners in metabolism and inflammation
Maya-Monteiro, C., & Bozza, P. (2008) · Cell Cycle · doi:10.4161/cc.7.12.6157 · Cited by 121 · cited 1× · see citing works
“The leptin signaling pathway can activate mTOR [34] through downstream PI3K/Akt signaling, while mTOR indirectly activates eukaryotic initiation factor 4E, thus stimulating the translation of mRNA encoding proliferation and anti-apoptotic factors [35].”
BackgroundLithocholic Acid, a Metabolite of the Microbiome, Increases Oxidative Stress in Breast Cancer
Kovács, P., Csonka, T., Kovàcs, T., Sári, Z., Ujlaki, G., Sipos, A. A., Karányi, Z., Szeőcs, D., Hegedűs, C., Uray, K., et al. (2019) · Cancers · doi:10.3390/cancers11091255 · Cited by 120 · see citing works
The complement system in cancer: Ambivalence between tumour destruction and promotion
Mamidi, S., Höne, S., & Kirschfink, M. (2015) · Immunobiology · doi:10.1016/j.imbio.2015.11.008 · Cited by 117 · see citing works
Karunanithi, S., Levi, L., DeVecchio, J., Karagkounis, G., Reizes, O., Lathia, J. D., Kalady, M. F., & Noy, N. (2017) · Stem Cell Reports · doi:10.1016/j.stemcr.2017.06.002 · Cited by 116 · see citing works
A microbiota-centric view of diseases of the upper gastrointestinal tract
Nardone, G., Compare, D., & Rocco, A. (2017) · The Lancet. Gastroenterology & hepatology · doi:10.1016/s2468-1253(16)30108-x · Cited by 112 · see citing works
Propionate of a microbiota metabolite induces cell apoptosis and cell cycle arrest in lung cancer
Kim, K., Kwon, O., Ryu, T. Y., Jung, C., Kim, J., Min, J., Kim, D., Son, M., & Cho, H. (2019) · Molecular Medicine Reports · doi:10.3892/mmr.2019.10431 · Cited by 110 · see citing works
Clark, G. W. B., Smyrk, T. C., Mirvish, S. S., Anselmino, M., Yamashita, Y., Hinder, R. A., DeMeester, T. R., & Birt, D. F. (1994) · Annals of Surgical Oncology · doi:10.1007/bf02303531 · Cited by 109 · see citing works
The Prostaglandin E2 Receptor EP2 Is Required for Cyclooxygenase 2–Mediated Mammary Hyperplasia
Chang, S.-H., Ai, Y., BREYER, R. M., Lane, T. F., & Hla, T. (2005) · Cancer Research · doi:10.1158/0008-5472.can-05-0129 · Cited by 109 · see citing works
Lavoie, S., Chun, E., Bae, S., Brennan, C. A., Gallini, C. A., Lang, J. K., Michaud, M., Hoveyda, H. R., Fraser, G. L., Fuller, M. H., et al. (2020) · Gastroenterology · doi:10.1053/j.gastro.2019.12.027 · Cited by 105 · see citing works
Li, Q., Ma, L., Shen, S., Guo, Y., Cao, Q., Cai, X., Feng, J., Yan, Y., Hu, T., Luo, S., et al. (2019) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-019-1271-3 · Cited by 104 · see citing works
Mei, Q., Huang, C., Luo, S., Zhang, X., Zeng, Y., & Lu, Y. (2018) · Pancreatology · doi:10.1016/j.pan.2018.03.005 · Cited by 101 · see citing works
Raisch, J., Rolhion, N., Dubois, A., Darfeuille-Michaud, A., & Bringer, M.-A. (2015) · Laboratory Investigation · doi:10.1038/labinvest.2014.161 · Cited by 100 · see citing works
Cell Intrinsic Role of COX-2 in Pancreatic Cancer Development
Hill, R., Li, Y., Tran, L. M., Dry, S., Calvopina, J. H., Garcia, A. J., Kim, C. G., Wang, Y., Donahue, T. R., Herschman, H. R., et al. (2012) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-12-0342 · Cited by 99 · see citing works
Self-citationHe, W., Xu, J., Mu, R., Li, Q., Lv, D., Huang, Z. D., Zhang, J., Wang, C., & Dong, L. (2020) · Nature Communications · doi:10.1038/s41467-020-15524-1 · Cited by 99 · see citing works
Self-citationSánchez, B. (2018) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2018.23 · Cited by 98 · see citing works
Molecular mimicry in Helicobacter pylori infections
Chmiela, M., & Gonciarz, W. (2017) · World Journal of Gastroenterology · doi:10.3748/wjg.v23.i22.3964 · Cited by 97 · see citing works
Endogenous Hyperinsulinemia Contributes to Pancreatic Cancer Development
Zhang, A. M. Y., Magrill, J., de Winter, T. J. J., Hu, X., Skovsø, S., Schaeffer, D. F., Kopp, J. L., & Johnson, J. D. (2019) · Cell Metabolism · doi:10.1016/j.cmet.2019.07.003 · Cited by 97 · see citing works
Modelling the role of microbial p-cresol in colorectal genotoxicity
Hinai, E. A., Kullamethee, P., Rowland, I. R., Swann, J. R., Walton, G., & Commane, D. M. (2018) · Gut Microbes · doi:10.1080/19490976.2018.1534514 · Cited by 96 · see citing works
Park, H., Kim, M., Kwon, G. T., Lim, D. Y., Yu, R., Sung, M., Lee, K. W., Daily, J. W., & Park, J. H. Y. (2011) · Molecular Carcinogenesis · doi:10.1002/mc.20856 · Cited by 95 · see citing works
Altered gut microbiota composition in immune-impaired Nod2 −/− mice
Mondot, S., Barreau, F., Nabhani, Z. A., Dussaillant, M., Roux, K. L., Dore, J. M., Leclerc, M., Hugot, J., & Lepage, P. (2011) · Gut · doi:10.1136/gutjnl-2011-300478 · Cited by 94 · see citing works
Liu, T., Guo, Z., Song, X., Liu, L., Dong, W., Wang, S., Xu, M., Yang, C., Wang, B., & Cao, H. (2020) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.14984 · Cited by 94 · see citing works
Homsi, M. E., Ducroc, R. A., Claustre, J., Jourdan, G., Gertler, A., Estienne, M., Bado, A., Scoazec, J., & Plaisancié, P. (2007) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00091.2007 · Cited by 92 · see citing works
Spatial disturbances in altered mucosal and luminal gut viromes of diet‐induced obese mice
Kim, M., & Bae, J. (2015) · Environmental Microbiology · doi:10.1111/1462-2920.13182 · Cited by 92 · see citing works
Gut Microbiota-Immune System Crosstalk and Pancreatic Disorders
Pagliari, D., Saviano, A., Newton, E. E., Serricchio, M., Lago, A. D., Gasbarrini, A., & Cianci, R. (2018) · Mediators of Inflammation · doi:10.1155/2018/7946431 · Cited by 92 · see citing works
Colonic Lysine Homocysteinylation Induced by High-Fat Diet Suppresses DNA Damage Repair
Wang, D., Zhao, R., Qu, Y., Mei, X., Zhang, X., Zhou, Q., Li, Y., Yang, S., Zuo, Z., Chen, Y., et al. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.09.022 · Cited by 91 · see citing works
Impact of lactic acid bacteria on oxidative DNA damage in human derived colon cells
Koller, V. J., Marian, B., Stidl, R., Nersesyan, A. K., Winter, H., Simic, T. P., Sontag, G., & Knasmüller, S. (2007) · Food and Chemical Toxicology · doi:10.1016/j.fct.2007.09.005 · Cited by 89 · see citing works
Western Diet Deregulates Bile Acid Homeostasis, Cell Proliferation, and Tumorigenesis in Colon
Đermadi, D., Valo, S., Ollila, S., Soliymani, R., Sipari, N., Pussila, M., Sarantaus, L., Lindén, J., Baumann, M., & Nyström, M. (2017) · Cancer Research · doi:10.1158/0008-5472.can-16-2860 · Cited by 89 · see citing works
Leptin and gastro‐intestinal malignancies
Howard, J. M., Pidgeon, G. P., & Reynolds, J. V. (2010) · Obesity Reviews · doi:10.1111/j.1467-789x.2010.00718.x · Cited by 87 · see citing works
Luo, Y., Yang, Y., Liu, M., Wang, D., Wang, F., Bi, Y., Ji, J., Li, S., Liu, Y., Chen, R., et al. (2019) · Gastroenterology · doi:10.1053/j.gastro.2019.07.030 · Cited by 87 · see citing works
Linking inflammation to tumorigenesis in a mouse model of high-fat-diet-enhanced colon cancer
Day, S. D., Enos, R. T., McClellan, J. L., Steiner, J. L., Velázquez, K. T., & Murphy, E. A. (2013) · Cytokine · doi:10.1016/j.cyto.2013.04.031 · Cited by 85 · see citing works
CD74 and macrophage migration inhibitory factor as therapeutic targets in gastric cancer
Zheng, Y. (2012) · World Journal of Gastroenterology · doi:10.3748/wjg.v18.i18.2253 · Cited by 85 · see citing works
Gantuya, B., El‐Serag, H. B., Matsumoto, T., Ajami, N. J., Oyuntsetseg, K., Azzaya, D., Uchida, T., & Yamaoka, Y. (2019) · Cancers · doi:10.3390/cancers11040504 · Cited by 83 · see citing works
Tang, F., Pai, M., & Chiang, E. I. (2012) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2011.07.011 · Cited by 82 · see citing works
Dietary Fat Intake and Risk of Gastric Cancer: A Meta-Analysis of Observational Studies
Han, J. S., Jiang, Y., Liu, X., Meng, Q., Xi, Q., Zhuang, Q., Han, Y., Gao, Y., Ding, Q., & Wu, G. (2015) · PLoS ONE · doi:10.1371/journal.pone.0138580 · Cited by 80 · see citing works
Self-citationOrci, L. A., Lacotte, S., Delaune, V., Slits, F., Oldani, G., Lazarević, V., Rossetti, C., Rubbia‐Brandt, L., Morel, P., & Toso, C. (2018) · Journal of Hepatology · doi:10.1016/j.jhep.2017.12.025 · Cited by 80 · see citing works
Flagged first, then by citations
Research works printed but not linked: 5
- [229]Philip B Roland CL Daniluk J Liu Y Chatterjee D Gomez SB A high-fat diet activates oncogenic Kras and COX2 to induce development of pancreatic ductal adenocarcinoma in mice Gastroenterology 2013 145 1449 58 23958541 PMC3873752
- [230]Luo Y Yang Y Liu M Wang D Wang F Bi Y Oncogenic KRAS Reduces Expression of FGF21 in Acinar Cells to Promote Pancreatic Tumorigenesis in Mice on a High-Fat Diet Gastroenterology 2019 157 1413 28.e11 31352001 PMC6815712
- [231]Qin CJ Zhao LH Zhou X Zhang HL Wen W Tang L Inhibition of dipeptidyl peptidase IV prevents high fat diet-induced liver cancer angiogenesis by downregulating chemokine ligand 2 Cancer Lett 2018 420 26 37 29409972
- [232]Niku M Pajari AM Sarantaus L Päivärinta E Storvik M Heiman-Lindh A Western diet enhances intestinal tumorigenesis in Min/+ mice, associating with mucosal metabolic and inflammatory stress and loss of Apc heterozygosity J Nutr Biochem 2017 39 126 33 27833053
- [234]He Z Gharaibeh RZ Newsome RC Pope JL Dougherty MW Tomkovich S Campylobacter jejuni promotes colorectal tumorigenesis through the action of cytolethal distending toxin Gut 2019 68 289 300 30377189 PMC6352414
Cited by
Sorted by citations
Gut microbiota remodeling: A promising therapeutic strategy to confront hyperuricemia and gout
Wang, Z., Li, Y., Liao, W., Huang, J., Liu, Y., Li, Z., & Tang, J. (2022) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2022.935723 · Cited by 149 · see citing works
Jonscher, K. R., Chowanadisai, W., & Rucker, R. B. (2021) · Biomolecules · doi:10.3390/biom11101441 · Cited by 128 · see citing works
Lin, A., Xiong, M., Jiang, A., Huang, L., Wong, H. Z. H., Feng, S., Zhang, C., Yu, H., Chen, L., Chi, H., et al. (2025) · iMeta · doi:10.1002/imt2.70070 · Cited by 91 · see citing works
The Effects of a High-Fat Diet on Inflammatory Bowel Disease
Dang, Y., Ma, C., Chen, K., Chen, Y., Jiang, M., Hu, K., Li, L., Zeng, Z., & Zhang, H. (2023) · Biomolecules · doi:10.3390/biom13060905 · Cited by 67 · see citing works
Shao, X., Liu, L., Zhou, Y., Zhong, K., Gu, J., Hu, T., Yao, Y., Zhou, C., & Chen, W. (2023) · International Journal of Biological Sciences · doi:10.7150/ijbs.86717 · Cited by 64 · see citing works
Almanza‐Aguilera, E., Cano, A., Gil‐Lespinard, M., Burguera, N., Zamora‐Ros, R., Agudo, A., & Farràs, M. (2023) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2023.08.001 · Cited by 62 · see citing works
Flavonoids, gut microbiota, and host lipid metabolism
Zhou, M., Ma, J., Kang, M., Tang, W., Xia, S., Yin, J., & Yin, Y. (2023) · Engineering in Life Sciences · doi:10.1002/elsc.202300065 · Cited by 62 · see citing works
The effect of the intratumoral microbiome on tumor occurrence, progression, prognosis and treatment
Gao, F., Yu, B., Rao, B., Sun, Y. H., Yu, J., Wang, D., Cui, G., & Ren, Z. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1051987 · Cited by 61 · see citing works
Zou, T., Xie, F., Liang, P., Chen, J., Wang, Z., Du, ., & You, J. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.114034 · Cited by 51 · see citing works
Wang, Y., Li, Z., He, J., & Zhao, Y. (2024) · Nutrients · doi:10.3390/nu16081102 · Cited by 51 · see citing works
Self-citationThe gut microbiome, immune modulation, and cognitive decline: insights on the gut-brain axis
Zhang, R., Ding, N., Feng, X., & Liao, W. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1529958 · Cited by 56 · see citing works
Lu, G., Yu, X., Jiang, W., Luo, Q., Tong, J., Fan, S., Chai, L., Gao, D., Qiao, T., Wang, R., et al. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.893164 · Cited by 41 · see citing works
Zhu, Y., Cai, P.-J., Dai, H.-C., Xiao, Y., Jia, C., & Sun, A. (2023) · Food & Function · doi:10.1039/d3fo02177g · Cited by 42 · see citing works
Hong, D., Zhang, C., Wu, W., Lu, X., & Zhang, L. (2023) · Frontiers in Neurology · doi:10.3389/fneur.2023.1133546 · Cited by 38 · see citing works
Esophageal cancer and bacterial part of gut microbiota – A multidisciplinary point of view
Muszyński, D., Kudra, A., Sobocki, B. K., Folwarski, M., Vitale, E., Filetti, V., Dudzic, W., Kaźmierczak-Siedlecka, K., & Połom, K. (2022) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2022.1057668 · Cited by 36 · see citing works
Chen, S., Che, S., Li, S., & Ruan, Z. (2021) · Toxicology · doi:10.1016/j.tox.2021.153015 · Cited by 35 · see citing works
Zhao, H., Jin, H. Y., Xian, J., Zhang, Z., Shi, J., & Bai, X. (2022) · Nutrients · doi:10.3390/nu14194192 · Cited by 35 · see citing works
Jiang, Z., Mou, Y., Wang, H., Li, L., Jin, T., Wang, H., Liu, M., & Jin, W. (2023) · BMC Cancer · doi:10.1186/s12885-023-11493-y · Cited by 34 · see citing works
The nerve cells in gastrointestinal cancers: from molecular mechanisms to clinical intervention
Lyu, Y., Xie, F., Chen, B., Shin, W. S., Chen, W., He, Y., Leung, K. T., Tse, G. M.-K., Yu, J. Q., To, K. F., et al. (2023) · Oncogene · doi:10.1038/s41388-023-02909-x · Cited by 34 · see citing works
Su, Q., Jin, C., Bo, Z., Yang, Y., Wang, J., Wang, J., Zhou, J., Chen, Y., Zeng, H., Chen, G., et al. (2023) · Frontiers in Microbiology · doi:10.3389/fmicb.2023.1181328 · Cited by 35 · see citing works
Self-citationGut microbiome-metabolites axis: A friend or foe to colorectal cancer progression
Wu, H., Ma, W., Wang, Y., Wang, Y., Sun, X., & Zheng, Q. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.116410 · Cited by 33 · see citing works
Self-citationBacterial infection and microbiota in carcinogenesis and tumor development
Li, Q. (2023) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2023.1294082 · Cited by 31 · see citing works
Ouyang, F., Li, B., Wang, Y., Xu, L., Li, D., Li, F., & Sun‐Waterhouse, D. (2022) · Metabolites · doi:10.3390/metabo12111028 · Cited by 31 · see citing works
Self-citationManilla, V., Tommaso, N. D., Santopaolo, F., Gasbarrini, A., & Ponziani, F. R. (2023) · Microorganisms · doi:10.3390/microorganisms11020267 · Cited by 32 · see citing works
Mitochondrial sirtuins, key regulators of aging
Ji, Z., Liu, G., & Qu, J. T. (2025) · Life Medicine · doi:10.1093/lifemedi/lnaf019 · Cited by 31 · see citing works
The role of microbiomes in gastrointestinal cancers: new insights
Yarahmadi, A., & Afkhami, H. (2024) · Frontiers in Oncology · doi:10.3389/fonc.2023.1344328 · Cited by 30 · see citing works
Al-Marzooqi, S. K., Almarzooqi, F., Sadida, H. Q., Jerobin, J., Ahmed, I., Abou‐Samra, A., Fakhro, K. A., Dhawan, P., Bhat, A. A., & Akil, A. A. (2024) · Obesity Reviews · doi:10.1111/obr.13766 · Cited by 30 · see citing works
Ahmad, F., Saha, P., Singh, V., Wahid, M., Mandal, R. K., Mishra, B. N., Fagoonee, S., & Haque, S. (2022) · Food Chemistry · doi:10.1016/j.foodchem.2022.135320 · Cited by 28 · see citing works
Liu, R., Wang, C., Tao, Z., & Hu, G. (2025) · Biomedicines · doi:10.3390/biomedicines13081895 · Cited by 28 · see citing works
Self-citationTini, S., Baima, J., Pigni, S., Antoniotti, V., Caputo, M., Palma, E. D., Cerbone, L., Grosso, F., Vecchia, M. L., Bona, E., et al. (2025) · Nutrients · doi:10.3390/nu17172898 · Cited by 27 · see citing works
The role of the gut microbiome in gastrointestinal cancers
Mishra, Y., Ranjan, A., Mishra, V. K., Chattaraj, A., Aljabali, A. A. A., El‐Tanani, M., Hromić‐Jahjefendić, A., Uversky, V. N., & Tambuwala, M. M. (2023) · Cellular Signalling · doi:10.1016/j.cellsig.2023.111013 · Cited by 25 · see citing works
Zhang, Y., Men, J., Yin, K., Zhang, Y., Yang, J., Li, X., Wang, X., Diao, X., & Zhou, H. (2025) · Communications Biology · doi:10.1038/s42003-025-07641-8 · Cited by 25 · see citing works
The lactylation-macrophage interplay: implications for gastrointestinal disease therapeutics
Che, X., Zhang, Y., Chen, X., Xie, G., Li, J., Xu, C., Zhang, C., Zhu, Y., & Yang, X. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1608115 · Cited by 25 · see citing works
Self-citationAdvancing gastric cancer treatment: nanotechnology innovations and future prospects
Yang, T., & Guo, L. (2024) · Cell Biology and Toxicology · doi:10.1007/s10565-024-09943-9 · Cited by 24 · see citing works
Zhou, K., Peng, M., Deng, N., Tan, Z., & Xiao, N. (2022) · BMC Microbiology · doi:10.1186/s12866-022-02647-2 · Cited by 21 · see citing works
Gunathilake, M. N., Lee, J., Choi, I. J., Kim, Y., & Kim, J. (2021) · Nutrients · doi:10.3390/nu13082692 · Cited by 21 · see citing works
Alterations in the gastric microbiota and metabolites in gastric cancer: An update review
Lei, C., Gong, D., Zhuang, B., & Zhang, Z. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.960281 · Cited by 20 · see citing works
Guo, X., Wang, R., Chen, R., Zhang, Z., Wang, J., & Liu, X. (2024) · Clinica Chimica Acta · doi:10.1016/j.cca.2024.119732 · Cited by 20 · see citing works
Self-citationKaempferol protects gut-vascular barrier from high glucose-induced disorder via NF-κB pathway
Chu, T., Yu, R., Gu, Y., Wang, Y., Chang, H., Li, Y., Li, J., & Bian, Y. (2023) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2023.109496 · Cited by 18 · see citing works
Self-citationLi, F. N., Peng, X., & Li, W. (2025) · Food & Function · doi:10.1039/d4fo04430d · Cited by 17 · see citing works
Palmitic acid and palmitoylation in cancer: Understanding, insights, and challenges
Song, P., Jiang, Q., Wu, X., Bu, L., Xie, W., Wei, W., Xing, X., & Guo, J. (2025) · The Innovation · doi:10.1016/j.xinn.2025.100918 · Cited by 20 · see citing works
Qu, Y., Wu, Y., Cheng, W., Wang, D., Zeng, L., Wang, Y., Li, T., Zhang, L., Yang, J., Sun, L., et al. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.1079313 · Cited by 17 · see citing works
Self-citationGuo, D., Chen, Q., Wang, G., & Li, C. (2023) · Frontiers in Microbiology · doi:10.3389/fmicb.2023.1190866 · Cited by 17 · see citing works
Li, Y., Ma, B., Wang, Z., Chen, Y., & Dong, Y. (2024) · International Journal of Biological Sciences · doi:10.7150/ijbs.95316 · Cited by 17 · see citing works
Zhang, J., Xiong, Y.-W., Zhu, H.-L., Tan, L., Zhou, H., Zheng, X., Zhang, Y., Chang, W., Xu, D., Tian, W., et al. (2024) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2024.135159 · Cited by 16 · see citing works
A multifactorial analysis of FAP to regulate gastrointestinal cancers progression
Cai, J., Yang, D., Sun, H., Xiao, L., Han, F., Zhang, M., Zhou, L., Jiang, M., Jiang, Q., Li, Y., et al. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1183440 · Cited by 16 · see citing works
Kumavath, R., Pavithran, H., Paul, S., Anju, V. T., Busi, S., & Dyavaiah, M. (2023) · International Journal of Oncology · doi:10.3892/ijo.2023.5592 · Cited by 16 · see citing works
Puerarin ameliorates non-alcoholic fatty liver disease by inhibiting lipid metabolism through FMO5
Li, Z., Cao, W., Zhang, Y., Lai, S., Ye, Y., Bao, J., & Fu, A. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1423634 · Cited by 16 · see citing works
Sitthideatphaiboon, P., Somlaw, N., Zungsontiporn, N., Ouwongprayoon, P., Sukswai, N., Korphaisarn, K., Poungvarin, N., Aporntewan, C., Hirankarn, N., Vinayanuwattikun, C., et al. (2024) · Scientific Reports · doi:10.1038/s41598-024-79339-6 · Cited by 16 · see citing works
Lamichhane, G., Olawale, F., Liu, J., Lee, D., Lee, S., Chaffin, N., Alake, S. E., Lucas, E. A., Zhang, G., Egan, J. M., et al. (2024) · Biology · doi:10.3390/biology13120955 · Cited by 16 · see citing works
Dietary index for gut microbiota and risk of gastrointestinal cancer: a prospective gene-diet study
Li, D.-R., Liu, B.-Q., Li, M., Qin, Y., Liu, J., Zheng, W., Gong, T., Gao, S., & Wu, Q. (2025) · Nutrition Journal · doi:10.1186/s12937-025-01151-3 · Cited by 16 · see citing works
Intestinal microbiota: A bridge between intermittent fasting and tumors
Liu, J., Shao, N., Qiu, H., Zhao, J., Chen, C., Wan, J., He, Z., Zhao, X., & Xu, L. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.115484 · Cited by 15 · see citing works
Zayeri, Z. D., Parsi, A., Shahrabi, S., Kargar, M., Davari, N., & Saki, N. (2023) · Cancer Cell International · doi:10.1186/s12935-023-03117-z · Cited by 15 · see citing works
Zhou, J., Zhang, X., Xie, Z., & Li, Z. (2024) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/s00432-023-05535-y · Cited by 15 · see citing works
Meng, Y., Sun, J. Y., & Zhang, G. (2024) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2024.104403 · Cited by 15 · see citing works
Wang, C., Liu, J., Sang, S., Ao, X., Su, M., Hu, B., & Li, H. (2022) · Computational and Mathematical Methods in Medicine · doi:10.1155/2022/9336080 · Cited by 14 · see citing works
Self-citationRetractedLópez-Plaza, B., Álvarez-Mercado, A., Arcos-Castellanos, L., Plaza-Díaz, J., Ruiz-Ojeda, F. J., Brandimonte-Hernández, M., Feliú-Batlle, J., Hummel, T., Gil, Á., & Milla, S. P. (2024) · Nutrients · doi:10.3390/nu16121905 · Cited by 5 · see citing works
The role of diet in cancer: the potential of shaping public policy and clinical outcomes in the UK
Britten, O., & Tosi, S. (2024) · Genes & Nutrition · doi:10.1186/s12263-024-00750-9 · Cited by 14 · see citing works
Exploring the gut microbiome and head and neck cancer interplay
SHETTY, V. S., & Shetty, S. S. (2024) · Pathology - Research and Practice · doi:10.1016/j.prp.2024.155603 · Cited by 14 · see citing works
Association of dietary quality indicators with gallstones in the US: NHANES 2017–2020
Wu, W., Pei, Y., Wang, J., Liang, Q., & Chen, W. (2025) · BMC Public Health · doi:10.1186/s12889-025-21783-8 · Cited by 16 · see citing works
Ye, Z., Zhang, Y., Du, M., Lu, S., Zhao, Q., & Yang, S. (2022) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2022.830081 · Cited by 13 · see citing works
A Comparative Study of Healthy Dietary Patterns for Incident and Fatal Digestive System Cancer
Kim, J., Zhang, Y., Kim, H., Zhang, Y., Zhang, X., & Giovannucci, E. L. (2023) · The American Journal of Gastroenterology · doi:10.14309/ajg.0000000000002448 · Cited by 13 · see citing works
Advances in the role of gut microbiota in the regulation of the tumor microenvironment (Review)
Xinyuan, T., Yu, L., Jianping, S., Rongwei, Z., Ruiwen, S., Ye, Z., Zhao, J., Chun-fang, T., Hongwei, C., & Haibin, G. (2023) · Oncology Reports · doi:10.3892/or.2023.8618 · Cited by 13 · see citing works
Li, J., Li, Y., Zhou, L., Li, C., Liu, J., Liu, D., Fu, Y., Wang, Y., Tang, J. H., Zhou, L., et al. (2024) · Microbiological Research · doi:10.1016/j.micres.2023.127596 · Cited by 13 · see citing works
Self-citationYu, J., Li, L., Tao, X., Chen, Y., & Dong, D. (2024) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2024.104480 · Cited by 13 · see citing works
Esdaille, A., Kuete, N., Anyaeche, V. I., Kalemoglu, E., & Kucuk, O. (2024) · Cancers · doi:10.3390/cancers16173023 · Cited by 13 · see citing works
Hu, R., Yang, X., Wang, L., Su, D., He, Z., Li, J., Gong, J., Zhang, W., Ma, S., Shi, M., et al. (2024) · Food Frontiers · doi:10.1002/fft2.484 · Cited by 13 · see citing works
Self-citationZhang, B., Qiu, J., Qu, Z., Xiao, R., Wang, L., Tian, P., Zhang, H., Chen, W., & Wang, G. (2025) · Food & Function · doi:10.1039/d4fo06449f · Cited by 13 · see citing works
The time-dependent adverse effects of a high-fat diet on sperm parameters
Qi, X., Guan, Q., Zhang, W., Huang, X., & Yu, C. (2023) · Advances in Clinical and Experimental Medicine · doi:10.17219/acem/159090 · Cited by 12 · see citing works
Jiang, H., Song, T., Li, Z., An, L., He, C., & Zheng, K. (2023) · Frontiers in Microbiology · doi:10.3389/fmicb.2023.1255650 · Cited by 12 · see citing works
Yang, L., Jiang, Z., Yang, L., Zheng, W., Chen, Y., Qu, F., Crabbe, M. J. C., Zhang, Y., Andersen, M. E., Zheng, Y., et al. (2024) · Environmental Science & Technology · doi:10.1021/acs.est.3c11009 · Cited by 12 · see citing works
Zhang, W., Zhang, H., Gao, Y., Lei, J., & Suo, C. (2025) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2025.1596688 · Cited by 12 · see citing works
Yang, Y., Teng, Y., Shi, J., Xu, J., Bao, J., Zhang, X., & Wang, Q. (2023) · European Journal of Gastroenterology & Hepatology · doi:10.1097/meg.0000000000002636 · Cited by 11 · see citing works
Yan, S., He, Y., Zhu, Y., Ye, W., Chen, Y., Zhu, C., Zhan, F., & Ma, Z. (2024) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2024.1384450 · Cited by 11 · see citing works
Diet, Gastric Microbiota, and Metabolites in Gastric Tumorigenesis
Jiang, L., Lau, H. C.-H., Zeng, R., & Yu, J. Q. (2025) · Research · doi:10.34133/research.0693 · Cited by 11 · see citing works
Pan, C., Wang, J., Mao, Z., Xue, J., Xu, Y., Zhang, Y., Chen, L., Zhang, Z.-Y., & Wang, X. (2025) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.5c05217 · Cited by 12 · see citing works
The gut-tumor connection: the role of microbiota in cancer progression and treatment strategies
Wei, Z., Gao, G., He, Q., Kwok, L., & Sun, Z. (2025) · Journal of Advanced Research · doi:10.1016/j.jare.2025.08.038 · Cited by 12 · see citing works
Li, R., He, Z., Yan, W., He, Y., Yi, X., Sha, Y., Zhang, Q., Cai, R., & Pang, W. (2023) · Food & Function · doi:10.1039/d3fo01749d · Cited by 10 · see citing works
Photodynamic Therapy and Immunological View in Gastrointestinal Tumors
Aebisher, D., Woźnicki, P., Dynarowicz, K., Kawczyk‐Krupka, A., Cieślar, G., & Bartusik‐Aebisher, D. (2023) · Cancers · doi:10.3390/cancers16010066 · Cited by 10 · see citing works
Untargeted metabolomics in gastric and colorectal cancer patients – preliminary results
Kaźmierczak-Siedlecka, K., Muszyński, D., Styburski, D., Makarewicz, J., Sobocki, B. K., Ulasiński, P., Połom, K., Stachowska, E., Skonieczna‐Żydecka, K., & Kalinowski, L. (2024) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2024.1394038 · Cited by 10 · see citing works
Shen, Y., Xi, Y., Ru, L. G. X., & Liu, H. (2025) · Langenbeck s Archives of Surgery · doi:10.1007/s00423-025-03652-5 · Cited by 10 · see citing works
Metabolism and epigenetics in cancer: toward personalized treatment
Zhang, X., Liu, D., Yin, S., Gao, Y., Li, X., & Wu, G. (2025) · Frontiers in Endocrinology · doi:10.3389/fendo.2025.1530578 · Cited by 9 · see citing works
Inflammatory factors collaboratively link Helicobacter pylori-induced gastritis to gastric cancer
Zhang, M., Su, A., Song, H., Zhang, S., Deng, Y., Jing, W., Guo, J., Zhan, W., Ma, Y., & Hu, M. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1628543 · Cited by 9 · see citing works
Mo, R., Zhang, M., Wang, H., Liu, T., Zhang, G., & Wu, Y. (2023) · Journal of Animal Science · doi:10.1093/jas/skad276 · Cited by 9 · see citing works
Chen, M., Wang, Z., Tan, D. S., Wang, X., Ye, Z., Xie, Z., Zhang, D., Wu, D., Zhao, Y., Qu, Y., et al. (2023) · Nutrients · doi:10.3390/nu16010046 · Cited by 9 · see citing works
Zhang, M., Zhou, Y., Cui, X., & Zhu, L. (2024) · Microorganisms · doi:10.3390/microorganisms12040713 · Cited by 8 · see citing works
Hu, L., Huang, L., Fang, Z., Wang, C., Luo, J., Deng, Q., Xu, D., Sun, L., & Gooneratne, R. (2024) · Microorganisms · doi:10.3390/microorganisms12061210 · Cited by 8 · see citing works
Self-citationYang, H. (2024) · Frontiers in Medicine · doi:10.3389/fmed.2024.1434582 · Cited by 8 · see citing works
Gut microbiome in non-alcoholic fatty liver disease
Mpountouridis, A., Tsigalou, C., Bezirtzoglou, I., Bezirtzoglou, E., & Stavropoulou, E. (2025) · Frontiers in Gastroenterology · doi:10.3389/fgstr.2024.1534431 · Cited by 8 · see citing works
Zhang, Y., Han, S., Xiao, X., Zheng, L., Chen, Y., Zhang, Z., Gao, X., Zhou, S., Yu, K., Huang, L., et al. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1146861 · Cited by 9 · see citing works
Ju, C., Chen, Y., Yang, L., Huang, Y., & Liu, J. (2023) · Journal of Cancer · doi:10.7150/jca.90149 · Cited by 8 · see citing works
Weng, J., Zhu, Y., Wen, A., & Qin, L. (2023) · Food Bioscience · doi:10.1016/j.fbio.2023.103520 · Cited by 8 · see citing works
PRMT7 in cancer: Structure, effects, and therapeutic potentials
Yang, G., Liu, Y., Chen, R.-Y., Shi, J., Li, C.-Y., Wang, R., Lu, J., Yu, B., Zhang, L., Yu, B., et al. (2024) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2024.117103 · Cited by 8 · see citing works
Research progress on the correlation between intestinal flora and colorectal cancer
Wang, X., Zhang, Q., Xu, R., Li, X., & Hong, Z. (2024) · Frontiers in Oncology · doi:10.3389/fonc.2024.1416806 · Cited by 7 · see citing works
Sui, D., Song, Y., & Deng, Y. (2025) · Journal of Nanobiotechnology · doi:10.1186/s12951-025-03179-3 · Cited by 7 · see citing works
An, Y., Song, H., Qiu, H., Jiang, J., & Shi, J. (2025) · Cancer Medicine · doi:10.1002/cam4.70975 · Cited by 7 · see citing works
Periodontitis relates to benign prostatic hyperplasia via the gut microbiota and fecal metabolome
Guo, X., Yang, J., Wu, L., Fang, C., Gu, J., Li, F., Liu, H.-S., Li, L., & Wang, S.-Y. (2023) · Frontiers in Microbiology · doi:10.3389/fmicb.2023.1280628 · Cited by 7 · see citing works
Weng, C., Jin, R., Jin, X., Yang, Z., He, C., Zhang, Q., Xu, J., & Lv, B. (2024) · Drug Design Development and Therapy · doi:10.2147/dddt.s482340 · Cited by 7 · see citing works
Dolapchiev, L. I., Gonzales, K. A., Graham, L. C., Gagea, M., Stevenson, H. L., Kwan, S., & Beretta, L. (2024) · Journal of Hepatocellular Carcinoma · doi:10.2147/jhc.s485532 · Cited by 6 · see citing works
Tokarczyk, G., Bieńkiewicz, G., Biernacka, P., Przybylska, S., Sawicki, W., & Tabaszewska, M. (2025) · Molecules · doi:10.3390/molecules30051139 · Cited by 6 · see citing works
- Authors
- Tong, Y., Gao, H., Qi, Q., Liu, X., Li, J., Gao, J., Li, P., Wang, Y., Du, L., & Wang, C.
- Affiliations
- Shandong University (CN)
- Corresponding author
- Du, Lutao
- Wang, Chuanxin
- Venue
- Theranostics
- Publisher
- Ivyspring International Publisher
- Published
- 2021
- Volume
- 11
- Issue
- 12
- Pages
- 5889-5910
- ISSN
- 1838-7640 (ISSN-L)
- PMC
- PMC8058730
- OpenAlex
- W3153184525
- Cited by
- 205
- References
- 260
- Citations by year
- 2026: 31 · 2025: 60 · 2024: 56 · 2023: 42 · 2022: 13 · 2021: 3
- FWCI
- 9.03
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Theranostics (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Lipids, and Metabolism
- Keywords
- high-fat diet, gut microbiota, gastrointestinal cancer, diet and cancer, inflammation, tumor immune microenvironment, cancer risk factors
- MeSH terms
- Gastrointestinal Microbiome, Animals, Gastrointestinal Neoplasms, Humans, Inflammation, Tumor Microenvironment, Diet, High-Fat
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review