Cited by 206Gut microbiota and healthNutritional Studies and DietCancer, Lipids, and Metabolism

High fat diet, gut microbiome and gastrointestinal cancer

Open access
Tong, Yao, Gao, Huiru, Qi, Qiuchen, Liu, Xiaoyan, Li, Juan, Gao, Jie, Li, Peilong, Wang, Yunshan +2 more·2021·Theranostics

Abstract

Gastrointestinal cancer is currently one of the main causes of cancer death, with a large number of cases and a wide range of lesioned sites. A high fat diet, as a public health problem, has been shown to be correlated with various digestive system diseases and tumors, and can accelerate the occurrence of cancer due to inflammation and altered metabolism. The gut microbiome has been the focus of research in recent years, and associated with cell damage or tumor immune microenvironment changes via direct or extra-intestinal effects; this may facilitate the occurrence and development of gastrointestinal tumors. Based on research showing that both a high fat diet and gut microbes can promote the occurrence of gastrointestinal tumors, and that a high fat diet imbalances intestinal microbes, we propose that a high fat diet drives gastrointestinal tumors by changing the composition of intestinal microbes.

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  • Lack of a "healthy" microbiota is associated with many forms of disease, including metabolic diseases, gastrointestinal cancer, inflammatory bowel disease, renal disease, and neurodegenerative diseases associated with aging.

    “Lack of a “healthy” microbiota is associated with many forms of disease (19–24), such as metabolic diseases (obesity, type 2 diabetes), gastrointestinal cancer, inflammatory bowel disease, and renal disease, as well as neurodegenerative diseases (NDs) associated with aging, in which the activity and composition of the gut microbiota change during the life cycle.”

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  1. [229]Philip B Roland CL Daniluk J Liu Y Chatterjee D Gomez SB A high-fat diet activates oncogenic Kras and COX2 to induce development of pancreatic ductal adenocarcinoma in mice Gastroenterology 2013 145 1449 58 23958541 PMC3873752
  2. [230]Luo Y Yang Y Liu M Wang D Wang F Bi Y Oncogenic KRAS Reduces Expression of FGF21 in Acinar Cells to Promote Pancreatic Tumorigenesis in Mice on a High-Fat Diet Gastroenterology 2019 157 1413 28.e11 31352001 PMC6815712
  3. [231]Qin CJ Zhao LH Zhou X Zhang HL Wen W Tang L Inhibition of dipeptidyl peptidase IV prevents high fat diet-induced liver cancer angiogenesis by downregulating chemokine ligand 2 Cancer Lett 2018 420 26 37 29409972
  4. [232]Niku M Pajari AM Sarantaus L Päivärinta E Storvik M Heiman-Lindh A Western diet enhances intestinal tumorigenesis in Min/+ mice, associating with mucosal metabolic and inflammatory stress and loss of Apc heterozygosity J Nutr Biochem 2017 39 126 33 27833053
  5. [234]He Z Gharaibeh RZ Newsome RC Pope JL Dougherty MW Tomkovich S Campylobacter jejuni promotes colorectal tumorigenesis through the action of cytolethal distending toxin Gut 2019 68 289 300 30377189 PMC6352414

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Authors
Tong, Y., Gao, H., Qi, Q., Liu, X., Li, J., Gao, J., Li, P., Wang, Y., Du, L., & Wang, C.
Affiliations
Shandong University (CN)
Corresponding author
  • Du, Lutao
  • Wang, Chuanxin
Venue
Theranostics
Published
2021
Volume
11
Issue
12
Pages
5889-5910
ISSN
1838-7640 (ISSN-L)
OpenAlex
W3153184525
Cited by
205
References
260
Citations by year
2026: 31 · 2025: 60 · 2024: 56 · 2023: 42 · 2022: 13 · 2021: 3
FWCI
9.03
Type
journal article
Language
en
Open access
Licence
cc-by
Locations
  • Theranostics (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Lipids, and Metabolism
Keywords
high-fat diet, gut microbiota, gastrointestinal cancer, diet and cancer, inflammation, tumor immune microenvironment, cancer risk factors
MeSH terms
Gastrointestinal Microbiome, Animals, Gastrointestinal Neoplasms, Humans, Inflammation, Tumor Microenvironment, Diet, High-Fat

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