The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.
DAMPening Inflammation by Modulating TLR Signalling
Open accessAbstract
Damage-associated molecular patterns (DAMPs) include endogenous intracellular molecules released by activated or necrotic cells and extracellular matrix (ECM) molecules that are upregulated upon injury or degraded following tissue damage. DAMPs are vital danger signals that alert our immune system to tissue damage upon both infectious and sterile insult. DAMP activation of Toll-like receptors (TLRs) induces inflammatory gene expression to mediate tissue repair. However, DAMPs have also been implicated in diseases where excessive inflammation plays a key role in pathogenesis, including rheumatoid arthritis (RA), cancer, and atherosclerosis. TLR activation by DAMPs may initiate positive feedback loops where increasing tissue damage perpetuates pro-inflammatory responses leading to chronic inflammation. Here we explore the current knowledge about distinct signalling cascades resulting from self TLR activation. We also discuss the involvement of endogenous TLR activators in disease and highlight how specifically targeting DAMPs may yield therapies that do not globally suppress the immune system.
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Cites
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Yang, Y., Li, S., Yang, Q., Shi, Y., Zheng, M., Liu, Y., Chen, F., Song, G., Xu, H., Wan, T., et al. (2014) · Cellular Physiology and Biochemistry · doi:10.1159/000358696 · Cited by 3,253
Immunopathogenesis of IBD: current state of the art
de Souza, H. S. P., & Fiocchi, C. (2016) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2015.186 · Cited by 1,551
The role of synovitis in osteoarthritis pathogenesis
Scanzello, C. R., & Goldring, S. R. (2012) · Bone · doi:10.1016/j.bone.2012.02.012 · Cited by 1,302
Acute chorioamnionitis and funisitis: definition, pathologic features, and clinical significance
Kim, C. J., Romero, R., Chaemsaithong, P., Chaiyasit, N., Yoon, B. H., & Kim, Y. M. (2015) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2015.08.040 · Cited by 910
Immunotherapeutic Implications of Il-6 Blockade for Cytokine Storm
Tanaka, T., Narazaki, M., & Kishimoto, T. (2016) · Immunotherapy · doi:10.2217/imt-2016-0020 · Cited by 708
Metadata
- Authors
- Piccinini, A. M., & Midwood, K. S.
- Venue
- Mediators of Inflammation
- Publisher
- Wiley
- Published
- 2010
- Volume
- 2010
- Pages
- 1-21
- ISSN
- 0962-9351 (ISSN-L)
- 1466-1861
- OpenAlex
- W1983419107
- Cited by
- 973
- References
- 25
- FWCI
- 21.78
- Type
- journal article
- Language
- en
- Open access
- gold
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
