The Prominent Role of Neutrophils during the Initial Phase of Infection by Leishmania Parasites
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Neutrophils are rapidly and massively recruited to the site of Leishmania inoculation, where they phagocytose the parasites, some of which are able to survive within these first host cells. Neutrophils can thus provide a transient safe shelter for the parasites, prior to their entry into macrophages where they will replicate. In addition, neutrophils release and synthesize rapidly several factors including cytokines and chemokines. The mechanism involved in their rapid recruitment to the site of parasite inoculation, as well as the putative consequences of their massive presence on the microenvironment of the focus of infection will be discussed in the context of the development of the Leishmania-specific immune response.
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Neutrophils phagocytose and kill 80-90% of invading Leishmania parasites.
“Neutrophils phagocytose and kill 80–90% of the invading Leishmania parasites [285,286].”
From Functions of ROS in Macrophages and Antimicrobial Immunity (2021) · cites this paper as [286]
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Functions of ROS in Macrophages and Antimicrobial Immunity
Herb, M., & Schramm, M. (2021) · Antioxidants · doi:10.3390/antiox10020313 · Cited by 633 · see citing works
- Authors
- Charmoy, M., Auderset, F., Allenbach, C., & Tacchini-Cottier, F.
- Affiliations
- World Health Organization (CH)
- WHO Immunology Research and Training Center, Department of Biochemistry, University of Lausanne, 1066 Epalinges, Switzerland
- Venue
- Journal of Biomedicine and Biotechnology
- Publisher
- Wiley
- Published
- 2010
- Volume
- 2010
- Pages
- 1-8
- ISSN
- 1110-7243 (ISSN-L)
- 1110-7251
- PMC
- PMC2768872
- OpenAlex
- W1990509955
- Cited by
- 80
- References
- 44
- Citations by year
- 2026: 2 · 2024: 3 · 2023: 4 · 2022: 4 · 2021: 7 · 2020: 4 · 2019: 6 · 2018: 2 · 2017: 5 · 2016: 6 · 2015: 3 · 2014: 6 · 2013: 7 · 2012: 11
- FWCI
- 0.95
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- BioMed Research International (publishedVersion, cc-by)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Funders
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (320000-116197)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Research on Leishmaniasis Studies
- Health Sciences › Medicine › Infectious Diseases › Leprosy Research and Treatment
- Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Keywords
- neutrophils, Leishmania, leishmaniasis, neutrophil recruitment, phagocytosis, macrophages, cytokines, chemokines, host-parasite interactions, innate immune response
- MeSH terms
- Animals, Humans, Immune System, Leishmania, Leishmaniasis, Macrophages, Mice, Inbred BALB C, Mice, Inbred C57BL, Models, Biological, Neutrophils, Psychodidae, Species Specificity, Cytokines, Chemokines, Mice
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