Examining brain-cognition effects of ginkgo biloba extract: Brain activation in the left temporal and left prefrontal cortex in an object working memory task
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Ginkgo Biloba extract (GBE) is increasingly used to alleviate symptoms of age related cognitive impairment, with preclinical evidence pointing to a pro-cholinergic effect. While a number of behavioral studies have reported improvements to working memory (WM) associated with GBE, electrophysiological studies of GBE have typically been limited to recordings during a resting state. The current study investigated the chronic effects of GBE on steady state visually evoked potential (SSVEP) topography in nineteen healthy middle-aged (50-61 year old) male participants whilst completing an object WM task. A randomized double-blind crossover design was employed in which participants were allocated to receive 14 days GBE and 14 days placebo in random order. For both groups, SSVEP was recorded from 64 scalp electrode sites during the completion of an object WM task both pre- and 14 days post-treatment. GBE was found to improve behavioural performance on the WM task. GBE was also found to increase the SSVEP amplitude at occipital and frontal sites and increase SSVEP latency at left temporal and left frontal sites during the hold component of the WM task. These SSVEP changes associated with GBE may represent more efficient processing during WM task completion.
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Ginkgo biloba leaf extract has been prominently utilized for its ability to enhance memory and deter age-related impairments.
“The leaf extract of G. biloba has been prominently utilized for its ability to enhance memory and deter age-related impairments [113].”
From The Multifaceted Role of Neuroprotective Plants in Alzheimer’s Disease Treatment (2022) · cites this paper as [113]
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Adverse Reactions to Ginkgo biloba Medicinal Products Released in European Countries
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- Authors
- Silberstein, R. B., Pipingas, A., Song, J., Camfield, D. A., Nathan, P. J., & Stough, C.
- Affiliations
- Swinburne University of Technology (AU)
- GlaxoSmithKline (United Kingdom) (GB)
- Corresponding author
- Stough, C.
- Venue
- Evidence-based Complementary and Alternative Medicine
- Publisher
- Wiley
- Published
- 2011-01
- Volume
- 2011
- Issue
- 1
- Pages
- 164139-164139
- ISSN
- 1741-427X (ISSN-L)
- 1741-4288
- PMC
- PMC3166615
- OpenAlex
- W2094014404
- Cited by
- 36
- References
- 80
- Citations by year
- 2026: 2 · 2025: 1 · 2023: 3 · 2022: 5 · 2021: 2 · 2020: 4 · 2019: 3 · 2018: 3 · 2017: 1 · 2016: 2 · 2015: 2 · 2014: 4 · 2012: 3
- FWCI
- 6.83
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- Evidence-based Complementary and Alternative Medicine (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Apollo (University of Cambridge) (submittedVersion, cc-by)
- Research Online (University of Wollongong) (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- DMU Open Research Archive (De Montfort University) (submittedVersion)
- Figshare (submittedVersion)
- Swinburne figshare (Swinburne University of Technology) (submittedVersion, cc-by)
- Apollo
- Funders
- Blackmores Pty Ltd
- Topics
- Health Sciences › Medicine › Complementary and alternative medicine › Ginkgo biloba and Cashew Applications
- Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Cognitive Abilities and Testing
- Keywords
- Ginkgo biloba extract, working memory, steady-state visual evoked potentials, left temporal cortex, left prefrontal cortex, age-related cognitive impairment, cognitive enhancement
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