Cited by 36Ginkgo biloba and Cashew ApplicationsMedicinal Plants and NeuroprotectionCognitive Abilities and Testing

Examining brain-cognition effects of ginkgo biloba extract: Brain activation in the left temporal and left prefrontal cortex in an object working memory task

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Silberstein, R. B., Pipingas, A., Song, J., Camfield, D. A., Nathan, P. J., Stough, C.·2011·Evidence-based Complementary and Alternative Medicine

Abstract

Ginkgo Biloba extract (GBE) is increasingly used to alleviate symptoms of age related cognitive impairment, with preclinical evidence pointing to a pro-cholinergic effect. While a number of behavioral studies have reported improvements to working memory (WM) associated with GBE, electrophysiological studies of GBE have typically been limited to recordings during a resting state. The current study investigated the chronic effects of GBE on steady state visually evoked potential (SSVEP) topography in nineteen healthy middle-aged (50-61 year old) male participants whilst completing an object WM task. A randomized double-blind crossover design was employed in which participants were allocated to receive 14 days GBE and 14 days placebo in random order. For both groups, SSVEP was recorded from 64 scalp electrode sites during the completion of an object WM task both pre- and 14 days post-treatment. GBE was found to improve behavioural performance on the WM task. GBE was also found to increase the SSVEP amplitude at occipital and frontal sites and increase SSVEP latency at left temporal and left frontal sites during the hold component of the WM task. These SSVEP changes associated with GBE may represent more efficient processing during WM task completion.

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  1. [13]Rigney U Kimber S Hindmarch I The effects of acute doses of standardized Ginkgo biloba extract on memory and psychomotor performance in volunteers Phytotherapy Research 1999 13 5 408 415 10441781
  2. [59]Harner RN Samson-Dollfus D Topographic analysis of multichannel EEG data Statistics and Topography in Quantitative EEG 1988 New York, NY, USA Elsevier 49 61

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Authors
Silberstein, R. B., Pipingas, A., Song, J., Camfield, D. A., Nathan, P. J., & Stough, C.
Affiliations
  • Swinburne University of Technology (AU)
  • GlaxoSmithKline (United Kingdom) (GB)
Corresponding author
Stough, C.
Venue
Evidence-based Complementary and Alternative Medicine
Publisher
Wiley
Published
2011-01
Volume
2011
Issue
1
Pages
164139-164139
ISSN
  • 1741-427X (ISSN-L)
  • 1741-4288
OpenAlex
W2094014404
Cited by
36
References
80
Citations by year
2026: 2 · 2025: 1 · 2023: 3 · 2022: 5 · 2021: 2 · 2020: 4 · 2019: 3 · 2018: 3 · 2017: 1 · 2016: 2 · 2015: 2 · 2014: 4 · 2012: 3
FWCI
6.83
Type
journal article
Language
en
Open access
Locations
  • Evidence-based Complementary and Alternative Medicine (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Apollo (University of Cambridge) (submittedVersion, cc-by)
  • Research Online (University of Wollongong) (submittedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • DMU Open Research Archive (De Montfort University) (submittedVersion)
  • Figshare (submittedVersion)
  • Swinburne figshare (Swinburne University of Technology) (submittedVersion, cc-by)
  • Apollo
Funders
Blackmores Pty Ltd
Topics
  • Health Sciences › Medicine › Complementary and alternative medicine › Ginkgo biloba and Cashew Applications
  • Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Cognitive Abilities and Testing
Keywords
Ginkgo biloba extract, working memory, steady-state visual evoked potentials, left temporal cortex, left prefrontal cortex, age-related cognitive impairment, cognitive enhancement

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