Functional Brain Activity Changes after 4 Weeks Supplementation with a Multi-Vitamin/Mineral Combination: A Randomized, Double-Blind, Placebo-Controlled Trial Exploring Functional Magnetic Resonance Imaging and Steady-State Visual Evoked Potentials during Working Memory
Open accessAbstract
This study explored the neurocognitive effects of four weeks daily supplementation with a multivitamin and mineral combination (MVM) in healthy adults (aged 18-40 years). Using a randomized, double-blind, placebo-controlled design, participants underwent assessments of brain activity using functional Magnetic Resonance Imaging (fMRI; n=32, 16 females) and Steady-State Visual Evoked Potential recordings (SSVEP; n=39, 20 females) during working memory and continuous performance tasks at baseline and following four weeks of active MVM treatment or placebo. There were several treatment-related effects suggestive of changes in functional brain activity associated with MVM administration. SSVEP data showed latency reductions across centro-parietal regions during the encoding period of a spatial working memory task following four weeks of active MVM treatment. Complementary results were observed with the fMRI data, in which a subset of those completing fMRI assessment after SSVEP assessment (n=16) demonstrated increased BOLD response during completion of the Rapid Visual Information Processing task (RVIP) within regions of interest including bilateral parietal lobes. No treatment-related changes in fMRI data were observed in those who had not first undergone SSVEP assessment, suggesting these results may be most evident under conditions of fatigue. Performance on the working memory and continuous performance tasks did not significantly differ between treatment groups at follow-up. In addition, within the fatigued fMRI sample, increased RVIP BOLD response was correlated with the change in number of target detections as part of the RVIP task. This study provides preliminary evidence of changes in functional brain activity during working memory associated with four weeks of daily treatment with a multivitamin and mineral combination in healthy adults, using two distinct but complementary measures of functional brain activity.
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During working memory tasks, the centro-parietal regions showed higher activity after multiple supplementation, especially when subjects were investigated in a situation of mental fatigue.
“During working memory tasks, the centro-parietal regions showed higher activity after multiple supplementation, especially when subjects were investigated in a situation of mental fatigue [221].”
From Vitamins and Minerals for Energy, Fatigue and Cognition: A Narrative Review of the Biochemical and Clinical Evidence (2020) · cites this paper as [221]
Preliminary findings suggest that the same 4-week multiple micronutrient supplementation could induce changes in brain function, using hemodynamic and electrophysiological assessments.
“the same authors also reported preliminary findings suggesting that this same 4-week multiple micronutrient supplementation could induce changes in brain function, using both hemodynamic and electrophysiological assessments.”
From Vitamins and Minerals for Energy, Fatigue and Cognition: A Narrative Review of the Biochemical and Clinical Evidence (2020) · cites this paper as [221]
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Self-citation
- Authors
- White, D. J., Cox, K. H. M., Hughes, M. E., Pipingas, A., Peters, R., & Scholey, A. B.
- Affiliations
- Swinburne University of Technology (AU)
- Corresponding author
- White, David J.
- Scholey, Andrew B.
- ORCID
- Venue
- Frontiers in Aging Neuroscience
- Publisher
- Frontiers Media SA
- Published
- 2016-12-02
- Volume
- 8
- Pages
- 288-288
- ISSN
- 1663-4365 (ISSN-L)
- PMC
- PMC5133263
- OpenAlex
- W2560639215
- Cited by
- 8
- References
- 48
- Citations by year
- 2025: 2 · 2021: 1 · 2020: 2 · 2019: 2 · 2017: 1
- FWCI
- 0.99
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Frontiers in Aging Neuroscience (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Figshare (submittedVersion, cc-by)
- Minerva Access (University of Melbourne) (submittedVersion, cc-by)
- Swinburne figshare (Swinburne University of Technology) (submittedVersion, cc-by)
- Swinburne figshare (Swinburne University of Technology) (cc-by)
- Funders
- Bayer
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutrition and Health Studies
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Cognitive Abilities and Testing
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Keywords
- working memory, steady-state visual evoked potentials, functional brain activity, BOLD signal, parietal lobe, fatigue, continuous performance test, rapid visual information processing, healthy young adults, cognitive performance
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