The DOI matches its Crossref record; 23 of the 23 references it cites were found in a registry or an index.
Alterations of GABAergic Signaling in Autism Spectrum Disorders
Open accessAbstract
Autism spectrum disorders (ASDs) comprise a heterogeneous group of pathological conditions, mainly of genetic origin, characterized by stereotyped behavior, marked impairment in verbal and nonverbal communication, social skills, and cognition. Interestingly, in a small number of cases, ASDs are associated with single mutations in genes encoding for neuroligin-neurexin families. These are adhesion molecules which, by regulating transsynaptic signaling, contribute to maintain a proper excitatory/inhibitory (E/I) balance at the network level. Furthermore, GABA, the main inhibitory neurotransmitter in adult life, at late embryonic/early postnatal stages has been shown to depolarize and excite targeted cell through an outwardly directed flux of chloride. The depolarizing action of GABA and associated calcium influx regulate a variety of developmental processes from cell migration and differentiation to synapse formation. Here, we summarize recent data concerning the functional role of GABA in building up and refining neuronal circuits early in development and the molecular mechanisms regulating the E/I balance. A dysfunction of the GABAergic signaling early in development leads to a severe E/I unbalance in neuronal circuits, a condition that may account for some of the behavioral deficits observed in ASD patients.
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Model of autism: increased ratio of excitation/inhibition in key neural systems
Rubenstein, J. L. R., & Merzenich, M. M. (2003) · Genes, Brain and Behavior · doi:10.1034/j.1601-183x.2003.00037.x · Cited by 2,768
Critical period plasticity in local cortical circuits
Hensch, T. K. (2005) · Nature Reviews Neuroscience · doi:10.1038/nrn1787 · Cited by 2,323
Advances in autism genetics: on the threshold of a new neurobiology
Abrahams, B. S., & Geschwind, D. H. (2008) · Nature Reviews Genetics · doi:10.1038/nrg2346 · Cited by 1,866
Mutations of the X-linked genes encoding neuroligins NLGN3 and NLGN4 are associated with autism
Study, P. A. R. I. S., Jamain, S., Quach, H., Betancur, C., Råstam, M., Colineaux, C., Gillberg, I. C., Soderstrom, H., Giros, B., Leboyer, M., et al. (2003) · Nature Genetics · doi:10.1038/ng1136 · Cited by 1,851
Neuroligins and neurexins link synaptic function to cognitive disease
Südhof, T. C. (2008) · Nature · doi:10.1038/nature07456 · Cited by 1,849
Durand, C. M., Betancur, C., Boeckers, T. M., Bockmann, J., Chaste, P., Fauchereau, F., Nygren, G., Rastam, M., Gillberg, I. C., Anckarsäter, H., et al. (2007) · Nature Genetics · doi:10.1038/ng1933 · Cited by 1,602
Deficiency of methyl-CpG binding protein-2 in CNS neurons results in a Rett-like phenotype in mice
Chen, R. Z., Akbarian, S., Tudor, M., & Jaenisch, R. (2001) · Nature Genetics · doi:10.1038/85906 · Cited by 1,275
Dysfunction in GABA signalling mediates autism-like stereotypies and Rett syndrome phenotypes
Chao, H.-T., Chen, H., Samaco, R. C., Xue, M., Chahrour, M., Yoo, J., Neul, J. L., Gong, S., Lu, H.-C., Heintz, N., et al. (2010) · Nature · doi:10.1038/nature09582 · Cited by 1,168
Channelrhodopsin-2-assisted circuit mapping of long-range callosal projections
Petreanu, L., Huber, D., Sobczyk, A., & Svoboda, K. (2007) · Nature Neuroscience · doi:10.1038/nn1891 · Cited by 930
Minicolumnar pathology in autism
Casanova, M. F., Buxhoeveden, D. P., Switala, A. E., & Roy, E. (2002) · Neurology · doi:10.1212/wnl.58.3.428 · Cited by 846 · cited 1×
“Interestingly, analysis of postmortem tissues from ASDs patients has revealed alterations in the number of mini columns, in the horizontal spacing separating cell columns, and in their internal structure [22].”
Background
Cited by
Brain hyperconnectivity in children with autism and its links to social deficits
Supekar, K., Uddin, L. Q., Khouzam, A., Phillips, J., Gaillard, W. D., Kenworthy, L. E., Yerys, B. E., Vaidya, C. J., & Menon, V. (2013) · Cell Reports · doi:10.1016/j.celrep.2013.10.001 · Cited by 538
A Scoping Review of Health Disparities in Autism Spectrum Disorder
Bishop-Fitzpatrick, L., & Kind, A. J. H. (2017) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-017-3251-9 · Cited by 351
Cerliani, L., Mennes, M., Thomas, R. M., Di Martino, A., Thioux, M., & Keysers, C. (2015) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2015.0101 · Cited by 339
A randomised controlled trial of bumetanide in the treatment of autism in children
Lemonnier, E., Degrez, C., Phelep, M., Tyzio, R., Josse, F., Grandgeorge, M., Hadjikhani, N., & Ben-Ari, Y. (2012) · Translational Psychiatry · doi:10.1038/tp.2012.124 · Cited by 322
Gaetz, W., Bloy, L., Wang, D. J., Port, R. G., Blaskey, L., Levy, S. E., & Roberts, T. P. L. (2014) · NeuroImage · doi:10.1016/j.neuroimage.2013.05.068 · Cited by 267
Metadata
- Authors
- Pizzarelli, R., & Cherubini, E.
- Venue
- Neural Plasticity
- Publisher
- Wiley
- Published
- 2011
- Volume
- 2011
- Pages
- 1-12
- ISSN
- 1687-5443 (ISSN-L)
- 2090-5904
- OpenAlex
- W2127590260
- Cited by
- 321
- References
- 23
- FWCI
- 7.86
- Type
- journal article
- Language
- en
- Open access
- gold
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