Brain hyperconnectivity in children with autism and its links to social deficits
Open accessAbstract
Autism spectrum disorder (ASD), a neurodevelopmental disorder affecting nearly 1 in 88 children, is thought to result from aberrant brain connectivity. Remarkably, there have been no systematic attempts to characterize whole-brain connectivity in children with ASD. Here, we use neuroimaging to show that there are more instances of greater functional connectivity in the brains of children with ASD in comparison to those of typically developing children. Hyperconnectivity in ASD was observed at the whole-brain and subsystems levels, across long- and short-range connections, and was associated with higher levels of fluctuations in regional brain signals. Brain hyperconnectivity predicted symptom severity in ASD, such that children with greater functional connectivity exhibited more severe social deficits. We replicated these findings in two additional independent cohorts, demonstrating again that at earlier ages, the brain of children with ASD is largely functionally hyperconnected in ways that contribute to social dysfunction. Our findings provide unique insights into brain mechanisms underlying childhood autism.
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- Authors
- Supekar, K., Uddin, L. Q., Khouzam, A., Phillips, J., Gaillard, W. D., Kenworthy, L. E., Yerys, B. E., Vaidya, C. J., & Menon, V.
- Affiliations
- Stanford Medicine (US)
- Children's National (US)
- Children's Hospital of Philadelphia (US)
- Corresponding author
- Supekar, Kaustubh
- Menon, Vinod
- ORCID
- Venue
- Cell Reports
- Publisher
- Elsevier BV
- Published
- 2013-11
- Volume
- 5
- Issue
- 3
- Pages
- 738-747
- ISSN
- 2211-1247 (ISSN-L)
- PMC
- PMC3894787
- OpenAlex
- W2116476161
- Cited by
- 538
- References
- 98
- Citations by year
- 2026: 34 · 2025: 40 · 2024: 32 · 2023: 38 · 2022: 41 · 2021: 44 · 2020: 41 · 2019: 40 · 2018: 54 · 2017: 53 · 2016: 54 · 2015: 43 · 2014: 22 · 2013: 2
- FWCI
- 22.12
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Cell Reports (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Georgetown University
- National Institute of Mental Health (MH084164, K01MH092288, R01MH084164, R01MH084961, MH084961, K23MH086111)
- National Institute on Deafness and Other Communication Disorders (R21DC011095, DC0111095)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (P30HD40677, HD047520, P30HD040677, HD059205, R01HD047520, R01HD059205)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Keywords
- autism spectrum disorder, functional connectivity, children, social dysfunction, symptom severity, neurodevelopmental disorders
- MeSH terms
- Adolescent, Brain, Brain Mapping, Child, Child Development Disorders, Pervasive, Female, Humans, Magnetic Resonance Imaging, Male, Cohort Studies
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