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Characterization and In Vitro Skin Permeation of Meloxicam-Loaded Liposomes versus Transfersomes
Open accessAbstract
The goal of this study was to develop and evaluate the potential use of liposome and transfersome vesicles in the transdermal drug delivery of meloxicam (MX). MX-loaded vesicles were prepared and evaluated for particle size, zeta potential, entrapment efficiency (%EE), loading efficiency, stability, and in vitro skin permeation. The vesicles were spherical in structure, 90 to 140 nm in size, and negatively charged ( to mV). The %EE of MX in the vesicles ranged from 40 to 70%. Transfersomes provided a significantly higher skin permeation of MX compared to liposomes. Fourier Transform Infrared Spectroscopy (FT-IR) and Differential Scanning Calorimetry (DSC) analysis indicated that the application of transfersomes significantly disrupted the stratum corneum lipid. Our research suggests that MX-loaded transfersomes can be potentially used as a transdermal drug delivery system.
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Cited by
Transfersomes: A Promising Nanoencapsulation Technique for Transdermal Drug Delivery
Opatha, S. A. T., Titapiwatanakun, V., & Chutoprapat, R. (2020) · Pharmaceutics · doi:10.3390/pharmaceutics12090855 · Cited by 537
Ghasemiyeh, P., & Mohammadi-Samani, S. (2020) · Drug Design, Development and Therapy · doi:10.2147/dddt.s264648 · Cited by 346
Lipid-based nanovesicles for nanomedicine
Grimaldi, N., Andrade, F., Segovia, N., Ferrer-Tasies, L., Sala, S., Veciana, J., & Ventosa, N. (2016) · Chemical Society Reviews · doi:10.1039/c6cs00409a · Cited by 309
Avadhani, K. S., Manikkath, J., Tiwari, M., Chandrasekhar, M., Godavarthi, A., Vidya, S. M., Hariharapura, R. C., Kalthur, G., Udupa, N., & Mutalik, S. (2017) · Drug Delivery · doi:10.1080/10717544.2016.1228718 · Cited by 308
Tretinoin-loaded liposomal formulations: from lab to comparative clinical study in acne patients
Rahman, S. A., Abdelmalak, N. S., Badawi, A., Elbayoumy, T., Sabry, N., & El Ramly, A. (2016) · Drug Delivery · doi:10.3109/10717544.2015.1041578 · Cited by 64
Metadata
- Authors
- Duangjit, S., Opanasopit, P., Rojanarata, T., & Ngawhirunpat, T.
- Venue
- Journal of Drug Delivery
- Publisher
- Hindawi Limited
- Published
- 2011-11-07
- Volume
- 2011
- Pages
- 1-9
- ISSN
- 2090-3014 (ISSN-L)
- 2090-3022
- OpenAlex
- W2041912496
- Cited by
- 189
- References
- 0
- FWCI
- 4.93
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Duangjit, S., Opanasopit, P., Rojanarata, T., & Ngawhirunpat, T. (2011). Characterization and In Vitro Skin Permeation of Meloxicam-Loaded Liposomes versus Transfersomes. Journal of Drug Delivery. https://doi.org/10.1155/2011/418316
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