Gene Expression Analysis of In Vitro Cocultures to Study Interactions between Breast Epithelium and Stroma
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The interactions between breast epithelium and stroma are fundamental to normal tissue homeostasis and for tumor initiation and progression. Gene expression studies of in vitro coculture models demonstrate that in vitro models have relevance for tumor progression in vivo. For example, stromal gene expression has been shown to vary in association with tumor subtype in vivo, and analogous in vitro cocultures recapitulate subtype‐specific biological interactions. Cocultures can be used to study cancer cell interactions with specific stromal components (e.g., immune cells, fibroblasts, endothelium) and different representative cell lines (e.g., cancer‐associated versus normal‐associated fibroblasts versus established, immortalized fibroblasts) can help elucidate the role of stromal variation in tumor phenotypes. Gene expression data can also be combined with cell‐based assays to identify cellular phenotypes associated with gene expression changes. Coculture systems are manipulable systems that can yield important insights about cell‐cell interactions and the cellular phenotypes that occur as tumor and stroma co‐evolve.
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In indirect co-culture, signaling pathways between different cell types such as cancer cells and fibroblasts can be better studied.
“In the latter, signaling pathways between the different types of cells such as cancer cells and fibroblasts can be better studied [51].”
From Microfluidic modelling of the tumor microenvironment for anti-cancer drug development (2019) · cites this paper as [51]
Section 2.1 describes indirect transwell cocultures used to examine gene-expression responses between breast cancer cells and fibroblasts, including changes in a signaling pathway. It does not establish that signaling pathways are generally better studied in indirect than in direct coculture; it notes that direct contact can produce distinct profiles, although separating the cells requires additional steps. Page numbers were not provided in our copy. (LLM, conf=0.78)
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Cites
Hallmarks of Cancer: The Next Generation
Hanahan, D., & Weinberg, R. A. (2011) · Cell · doi:10.1016/j.cell.2011.02.013 · Cited by 66,590 · see citing works
Tumors: Wounds That Do Not Heal
Flier, J. S., Underhill, L. H., & Dvorak, H. F. (1986) · New England Journal of Medicine · doi:10.1056/nejm198612253152606 · Cited by 4,391 · see citing works
Tensional homeostasis and the malignant phenotype
Paszek, M. J., Zahir, N., Johnson, K. R., Lakins, J. N., Rozenberg, G. I., Gefen, A., Reinhart-King, C. A., Margulies, S. S., Dembo, M., Boettiger, D., et al. (2005) · Cancer Cell · doi:10.1016/j.ccr.2005.08.010 · Cited by 3,941 · see citing works
Microenvironmental regulation of metastasis
Joyce, J. A., & Pollard, J. W. (2009) · Nature Reviews Cancer · doi:10.1038/nrc2618 · Cited by 3,684 · see citing works
Slaughter, D. P., Southwick, H. W., & Smejkal, W. (1953) · Cancer · doi:10.1002/1097-0142(195309)6:5 · Cited by 3,558 · see citing works
A collection of breast cancer cell lines for the study of functionally distinct cancer subtypes
Neve, R. M., Chin, K., Fridlyand, J., Yeh, J., Baehner, F. L., Fevr, T., Clark, L., Bayani, N., Coppé, J., Tong, F. K., et al. (2006) · Cancer Cell · doi:10.1016/j.ccr.2006.10.008 · Cited by 3,191 · see citing works
Friends or foes — bipolar effects of the tumour stroma in cancer
Mueller, M. M., & Fusenig, N. E. (2004) · Nature reviews. Cancer · doi:10.1038/nrc1477 · Cited by 1,757 · see citing works
Stromal gene expression predicts clinical outcome in breast cancer
Finak, G., Bertos, N., Pepin, F., Sadekova, S., Souleimanova, M., Zhao, H., Chen, H., Ömeroğlu, G., Meterissian, S. H., Ömeroğlu, A., et al. (2008) · Nature Medicine · doi:10.1038/nm1764 · Cited by 1,687 · see citing works
Bissell, M. J., & Hines, W. C. (2011) · Nature Medicine · doi:10.1038/nm.2328 · Cited by 1,516 · see citing works
DeNardo, D. G., Barreto, J., Andreu, P., Vásquez, L. J., Tawfik, D., Kolhatkar, N. S., & Coussens, L. M. (2009) · Cancer Cell · doi:10.1016/j.ccr.2009.06.018 · Cited by 1,340 · see citing works
Molecular characterization of the tumor microenvironment in breast cancer
Allinen, M., Beroukhim, R., Cai, L., Brennan, C., Lahti-Domenici, J., Huang, H., Porter, D., Hu, M., Chin, L., Richardson, A., et al. (2004) · Cancer Cell · doi:10.1016/j.ccr.2004.06.010 · Cited by 1,299 · see citing works
Miller, L. D., Smeds, J., George, J., Vega, V. B., Vergara, L. A., Ploner, A., Yudi Pawitan, Y., Hall, P. N., Klaar, S., Liu, E. T., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0506230102 · Cited by 1,269 · see citing works
Cancer-associated adipocytes exhibit an activated phenotype and contribute to breast cancer invasion
Dirat, B., Bochet, L., Dabek, M., Daviaud, D., Dauvillier, S., Majed, B., Wang, Y. Y., Meulle, A., Salles, B., Le Gonidec, S., et al. (2011) · Cancer Research · doi:10.1158/0008-5472.can-10-3323 · Cited by 1,134 · see citing works
Chang, H. Y., Nuyten, D. S. A., Sneddon, J. B., Hastie, T., Tibshirani, R., Sørlie, T., Dai, H., He, Y. D., van't Veer, L. J., Bartelink, H., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0409462102 · Cited by 981 · see citing works
Chang, H. Y., Sneddon, J. B., Alizadeh, A. A., Sood, R., West, R. B., Montgomery, K. D., Chi, J., van de Rijn, M., Botstein, D., & Brown, P. O. (2004) · PLoS Biology · doi:10.1371/journal.pbio.0020007 · Cited by 952 · see citing works
Stromal Effects on Mammary Gland Development and Breast Cancer
Wiseman, B. S., & Werb, Z. (2002) · Science · doi:10.1126/science.1067431 · Cited by 926 · see citing works
The tumour microenvironment as a target for chemoprevention
Albini, A., & Sporn, M. B. (2007) · Nature reviews. Cancer · doi:10.1038/nrc2067 · Cited by 823 · see citing works
Gene expression profiling of the tumor microenvironment during breast cancer progression
Ma, X., Dahiya, S. M., Richardson, E., Erlander, M. G., & Sgroi, D. C. (2009) · Breast Cancer Research · doi:10.1186/bcr2222 · Cited by 618 · see citing works
Breast cancer stem cells are regulated by mesenchymal stem cells through cytokine networks
Liu, S., Ginestier, C., Ou, S. J., Clouthier, S. G., Patel, S. H., Monville, F., Korkaya, H., Heath, A., Dutcher, J., Kleer, C. G., et al. (2011) · Cancer Research · doi:10.1158/0008-5472.can-10-0538 · Cited by 611 · see citing works
Barcellos‐Hoff, M. H., & Ravani, S. A. (2000) · PubMed · Cited by 536 · see citing works
Schedin, P. S., & Keely, P. J. (2010) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a003228 · Cited by 523 · see citing works
Regulation of In Situ to Invasive Breast Carcinoma Transition
Hu, M., Yao, J., Carroll, D. K., Weremowicz, S., Chen, H., Carrasco, D. R., Richardson, A. L., Violette, S. M., Nikolskaya, T., Nikolsky, Y., et al. (2008) · Cancer Cell · doi:10.1016/j.ccr.2008.03.007 · Cited by 497 · see citing works
The Tension Mounts: Mechanics Meets Morphogenesis and Malignancy
Paszek, M. J., & Weaver, V. M. (2004) · Journal of Mammary Gland Biology and Neoplasia · doi:10.1007/s10911-004-1404-x · Cited by 468 · see citing works
Lim, P. K., Bliss, S. A., Patel, S. A., Taborga, M., Dave, M. A., Gregory, L. A., Greco, S. J., Bryan, M., Patel, P. S., & Rameshwar, P. (2011) · Cancer Research · doi:10.1158/0008-5472.can-10-2372 · Cited by 417 · see citing works
Hagemann, T. (2004) · Carcinogenesis · doi:10.1093/carcin/bgh146 · Cited by 373 · see citing works
Weigelt, B., Lo, A. T., Park, C. C., Gray, J. W., & Bissell, M. J. (2009) · Breast Cancer Research and Treatment · doi:10.1007/s10549-009-0502-2 · Cited by 336 · see citing works
Martin, F. T., Dwyer, R. M., Kelly, J., Khan, S., Murphy, J. M., Curran, C., Miller, N., Hennessy, E., Dockery, P., Barry, F. P., et al. (2010) · Breast Cancer Research and Treatment · doi:10.1007/s10549-010-0734-1 · Cited by 290 · see citing works
EGFR associated expression profiles vary with breast tumor subtype
Hoadley, K. A., Weigman, V., Fan, C., Sawyer, L., He, X., Troester, M. A., Sartor, C. I., Rieger-House, T., Bernard, P. S., Carey, L., et al. (2007) · BMC Genomics · doi:10.1186/1471-2164-8-258 · Cited by 278 · see citing works
Self-citationUnraveling the microenvironmental influences on the normal mammary gland and breast cancer
Weigelt, B., & Bissell, M. J. (2008) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2008.03.013 · Cited by 274 · see citing works
An intraductal human-in-mouse transplantation model mimics the subtypes of ductal carcinoma in situ
Behbod, F., Kittrell, F. S., LaMarca, H. L., Edwards, D., Kerbawy, S., Heestand, J., Young, E., Mukhopadhyay, P., Yeh, H., Allred, D. C., et al. (2009) · Breast Cancer Research · doi:10.1186/bcr2358 · Cited by 269 · see citing works
Microglia promote colonization of brain tissue by breast cancer cells in a Wnt‐dependent way
Pukrop, T., Dehghani, F., Chuang, H., Lohaus, R., Bayanga, K., Heermann, S., Regen, T., van Rossum, D., Klemm, F., Schulz, M., et al. (2010) · Glia · doi:10.1002/glia.21022 · Cited by 230 · see citing works
Compressing drug development timelines in oncology using phase '0' trials
Kummar, S., Kinders, R. J., Rubinstein, L., Parchment, R. E., Murgo, A. J., Collins, J. M., Pickeral, O. K., Low, J. A., Steinberg, S. M., Gutierrez, M. E., et al. (2007) · Nature reviews. Cancer · doi:10.1038/nrc2066 · Cited by 214 · see citing works
The Macrophage Colony-Stimulating Factor 1 Response Signature in Breast Carcinoma
Beck, A. H., Espinosa, Í., Edris, B., Li, R., Montgomery, K. D., Zhu, S., Varma, S., Marinelli, R. J., van de Rijn, M., & West, R. B. (2009) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-08-1283 · Cited by 210 · see citing works
Cell-Type-Specific Responses to Chemotherapeutics in Breast Cancer
Troester, M. A., Hoadley, K. A., Sørlie, T., Herbert, B., Børresen‐Dale, A., Lønning, P. E., Shay, J. W., Kaufmann, W. K., & Perou, C. M. (2004) · Cancer Research · doi:10.1158/0008-5472.can-04-0107 · Cited by 179 · see citing works
Self-citationKlopp, A. H., Lacerda, L., Gupta, A., Debeb, B. G., Solley, T. N., Li, L., Spaeth, E. L., Xu, W., Zhang, X., Lewis, M. T., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0012180 · Cited by 174 · see citing works
Gene expression patterns associated with p53 status in breast cancer
Troester, M. A., Herschkowitz, J. I., Oh, D. S., He, X., Hoadley, K. A., Barbier, C., & Perou, C. M. (2006) · BMC Cancer · doi:10.1186/1471-2407-6-276 · Cited by 168 · see citing works
Self-citationTyan, S., Kuo, W., Huang, C.-K., Pan, C.-C., Shew, J., Chang, K., Lee, E. Y.-H. P., & Lee, W. (2011) · PLoS ONE · doi:10.1371/journal.pone.0015313 · Cited by 167 · see citing works
Mammary ECM composition and function are altered by reproductive state
Schedin, P. S., Mitrenga, T., McDaniel, S. M., & Kaeck, M. R. (2004) · Molecular Carcinogenesis · doi:10.1002/mc.20058 · Cited by 151 · see citing works
Reconstruction of human mammary tissues in a mouse model
Proia, D. A., & Kuperwasser, C. (2006) · Nature Protocols · doi:10.1038/nprot.2006.31 · Cited by 144 · see citing works
Noël, A., Pauw-Gillet, M. C. D., Purnell, G., Nusgens, B., LAPIERE, C. H. M., & Foidart, J. M. (1993) · British Journal of Cancer · doi:10.1038/bjc.1993.453 · Cited by 142 · see citing works
Mammary field cancerization: molecular evidence and clinical importance
Heaphy, C. M., Griffith, J. K., & Bisoffi, M. (2009) · Breast Cancer Research and Treatment · doi:10.1007/s10549-009-0504-0 · Cited by 136 · see citing works
Activation of Host Wound Responses in Breast Cancer Microenvironment
Troester, M. A., Lee, M. H., Carter, M. J., Fan, C., Cowan, D. W., Perez, E. R., Pirone, J. R., Perou, C. M., Jerry, D. J., & Schneider, S. S. (2009) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-09-1126 · Cited by 134 · see citing works
Self-citationGao, M., Kim, B. G., Kang, S., Choi, Y. P., Park, H., Kang, K. S., & Cho, N. H. (2010) · Journal of Cell Science · doi:10.1242/jcs.072900 · Cited by 132 · see citing works
Cichon, M. A., Degnim, A. C., Visscher, D. W., & Radisky, D. C. (2010) · Journal of Mammary Gland Biology and Neoplasia · doi:10.1007/s10911-010-9195-8 · Cited by 128 · see citing works
The dominance of the microenvironment in breast and ovarian cancer
Roskelley, C. D., & Bissell, M. J. (2002) · Seminars in Cancer Biology · doi:10.1006/scbi.2001.0417 · Cited by 126 · see citing works
Modeling Morphogenesis and Oncogenesis in Three-Dimensional Breast Epithelial Cultures
Hebner, C. M., Weaver, V. M., & Debnath, J. (2008) · Annual Review of Pathology Mechanisms of Disease · doi:10.1146/annurev.pathmechdis.3.121806.151526 · Cited by 122 · see citing works
Wang, X., Sun, L., Maffini, M. V., Soto, A., Sonnenschein, C., & Kaplan, D. L. (2010) · Biomaterials · doi:10.1016/j.biomaterials.2010.01.118 · Cited by 120 · see citing works
Trujillo, K. A., Heaphy, C. M., Mai, M., Vargas, K. M., Jones, A. C., Vo, P., Butler, K. S., Joste, N. E., Bisoffi, M., & Griffith, J. K. (2010) · International Journal of Cancer · doi:10.1002/ijc.25788 · Cited by 110 · see citing works
The fibromatosis signature defines a robust stromal response in breast carcinoma
Beck, A. H., Espinosa, Í., Gilks, C. B., van de Rijn, M., & West, R. B. (2008) · Laboratory Investigation · doi:10.1038/labinvest.2008.31 · Cited by 109 · see citing works
Interactions with Fibroblasts Are Distinct in Basal-Like and Luminal Breast Cancers
Camp, J. T., Elloumi, F., Romàn-Pèrez, E., Rein, J., Stewart, D. A., Harrell, J. C., Perou, C. M., & Troester, M. A. (2010) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-10-0372 · Cited by 109 · see citing works
Self-citationRhodes, L. V., Antoon, J. W., Muir, S. E., Elliott, S. G., Beckman, B. S., & Burow, M. E. (2010) · Molecular Cancer · doi:10.1186/1476-4598-9-295 · Cited by 101 · see citing works
Buess, M., Nuyten, D. S. A., Hastie, T. J., Nielsen, T. O., Pesich, R., & Brown, P. O. (2007) · Genome biology · doi:10.1186/gb-2007-8-9-r191 · Cited by 88 · see citing works
Bell, J. A., Reed, M. A., Consitt, L. A., Martin, O. J., Haynie, K. R., Hulver, M. W., Muoio, D. M., & Dohm, G. L. (2010) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2009-1596 · Cited by 87 · see citing works
Macrophages induce COX-2 expression in breast cancer cells: role of IL-1β autoamplification
Hou, Z., Falcone, D. J., Subbaramaiah, K., & Dannenberg, A. J. (2011) · Carcinogenesis · doi:10.1093/carcin/bgr027 · Cited by 80 · see citing works
CLIC4 mediates TGF-β1-induced fibroblast-to-myofibroblast transdifferentiation in ovarian cancer
Kong (2009) · Oncology Reports · doi:10.3892/or_00000469 · Cited by 78 · see citing works
NOX4-dependent ROS production by stromal mammary cells modulates epithelial MCF-7 cell migration
Tobar, N., Guerrero, J., Smith, P. C., & Martı́nez, J. (2010) · British Journal of Cancer · doi:10.1038/sj.bjc.6605847 · Cited by 70 · see citing works
Hattar, R., Maller, O., McDaniel, S. M., Hansen, K. C., Hedman, K., Lyons, T. R., Lucia, S. M., Wilson, R. S., & Schedin, P. S. (2009) · Breast Cancer Research · doi:10.1186/bcr2220 · Cited by 66 · see citing works
Lin, H.-J. L., Zuo, T., Lin, C., Kuo, C. T., Liyanarachchi, S., Sun, S., Shen, R. Z., Deatherage, D. E., Potter, D., Asamoto, L., et al. (2008) · Cancer Research · doi:10.1158/0008-5472.can-08-0288 · Cited by 63 · see citing works
Buess, M., Rajski, M., Vogel, B., Herrmann, R., & Rochlitz, C. F. (2009) · Neoplasia · doi:10.1593/neo.09670 · Cited by 61 · see citing works
Rozenchan, P. B., Carraro, D. M., Brentani, H., Mota, L. D. D. C., Bastos, E. P., Ferreira, E. N., Torres, C., Katayama, M. L. H., Roela, R. A., de Lyra, E. C., et al. (2009) · International Journal of Cancer · doi:10.1002/ijc.24646 · Cited by 61 · see citing works
Molecular analysis reveals heterogeneity of mouse mammary tumors conditionally mutant for Brca1
Wright, M. H., Robles, A., Herschkowitz, J. I., Hollingshead, M., Anver, M., Perou, C., & Varticovski, L. (2008) · Molecular Cancer · doi:10.1186/1476-4598-7-29 · Cited by 39 · see citing works
Fleming, J. M., Miller, T. C., Quiñones, M., Xiao, Z., Xu, X., Meyer, M. J., Ginsburg, E., Veenstra, T. D., & Vonderhaar, B. K. (2010) · BMC Medicine · doi:10.1186/1741-7015-8-27 · Cited by 37 · see citing works
Self-citationYe, Y., Qiu, T. H., Kavanaugh, C. J., & Green, J. E. (2004) · Breast Disease · doi:10.3233/bd-2004-19109 · Cited by 34 · see citing works
Integrating epithelial cancer, aging stroma and cellular senescence.
Krtolica, A., & Campisi, J. (2003) · PubMed · Cited by 34 · see citing works
Influence of stromal–epithelial interactions on breast cancer in vitro and in vivo
Potter, S., Dwyer, R. M., Hartmann, M. C., Khan, S., Boyle, M. P., Curran, C. E., & Kerin, M. J. (2011) · Breast Cancer Research and Treatment · doi:10.1007/s10549-011-1410-9 · Cited by 30 · see citing works
Genistein effects on stromal cells determines epithelial proliferation in endometrial co-cultures
Sampey, B. P., Lewis, T. D., Barbier, C., Makowski, L., & Kaufman, D. G. (2011) · Experimental and Molecular Pathology · doi:10.1016/j.yexmp.2011.01.006 · Cited by 27 · see citing works
Influence of the interaction between nodal fibroblast and breast cancer cells on gene expression
Santos, R. P. C., Benvenuti, T. T., Honda, S. T., Valle, P. R. D., Katayama, M. L. H., Brentani, H., Carraro, D. M., Rozenchan, P. B., Brentani, M. M., de Lyra, E. C., et al. (2010) · Tumor Biology · doi:10.1007/s13277-010-0108-7 · Cited by 27 · see citing works
Astrahantseff, K., & Morris, J. E. (1994) · In Vitro Cellular & Developmental Biology - Animal · doi:10.1007/bf02631300 · Cited by 23 · see citing works
Systems-Level Modeling of Cancer-Fibroblast Interaction
Wadlow, R. C., Wittner, B. S., Finley, S. A., Bergquist, H., Upadhyay, R., Finn, S. P., Loda, M. F., Mahmood, U., & Ramaswamy, S. (2009) · PLoS ONE · doi:10.1371/journal.pone.0006888 · Cited by 23 · see citing works
Benign mammary epithelial cells enhance the transformed phenotype of human breast cancer cells
Poczobutt, J. M., Tentler, J. J., Lu, X. J. D., Schedin, P. J., & Gutierrez‐Hartmann, A. (2010) · BMC Cancer · doi:10.1186/1471-2407-10-373 · Cited by 22 · see citing works
Luciani, M. G., Seok, J., Sayeed, A., Champion, S., Goodson, W. H., Jeffrey, S. S., Xiao, W., Mindrinos, M. N., Davis, R. W., & Dairkee, S. H. (2011) · PLoS ONE · doi:10.1371/journal.pone.0020016 · Cited by 14 · see citing works
Estrogen signaling in cancer microenvironment and prediction of response to hormonal therapy
Hayashi, S., & Yamaguchi, Y. (2008) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2008.03.013 · Cited by 11 · see citing works
Flagged first, then by citations
1 of the 73 references couldn’t be matched to a known paper.
Research works printed but not linked: 1
- [56]Young B Lowe JS Stevens A Heath J Wheather’s functional Histology. A Text and Colour Atlas 2006 5th edition Churchill livingstone, Pa, USA Elsevier
Cited by
Sorted by citations
Microfluidic modelling of the tumor microenvironment for anti-cancer drug development
Shang, M., Soon, R. H., Lim, C. T., Khoo, B. L., & Han, J. (2019) · Lab on a Chip · doi:10.1039/c8lc00970h · Cited by 227 · see citing works
Marusyk, A., Tabassum, D. P., Janiszewska, M., Place, A. E., Trinh, A. C., Rozhok, A. I., Pyne, S., Guerriero, J. L., Shu, S., Ekram, M. B., et al. (2016) · Cancer Research · doi:10.1158/0008-5472.can-16-1457 · Cited by 126 · see citing works
Busch, S., Acar, A., Magnusson, Y., Gregersson, P., Rydén, L., & Landberg, G. (2013) · Oncogene · doi:10.1038/onc.2013.527 · Cited by 117 · see citing works
Ramamonjisoa, N., & Ackerstaff, E. (2017) · Frontiers in Oncology · doi:10.3389/fonc.2017.00003 · Cited by 93 · see citing works
Peng, Q., Zhao, L., Hou, Y., Sun, Y., Wang, L., Luo, H., Peng, H., & Liu, M. (2013) · PLoS ONE · doi:10.1371/journal.pone.0060321 · Cited by 89 · see citing works
Mature breast adipocytes promote breast cancer cell motility
Carter, J. C., & Church, F. (2012) · Experimental and Molecular Pathology · doi:10.1016/j.yexmp.2012.03.005 · Cited by 77 · see citing works
Folgueira, M. A. A. K., Maistro, S., Katayama, M. L. H., Roela, R. A., Mundim, F. G. L., Nanogaki, S., de Bock, G. H., & Brentani, M. M. (2013) · Bioscience Reports · doi:10.1042/bsr20130060 · Cited by 70 · see citing works
Esendagli, D. R., Esendağlı, G., Yılmaz, G., & Güç, D. (2014) · Molecular Biology Reports · doi:10.1007/s11033-014-3144-3 · Cited by 60 · see citing works
Reaves, D. K., Ginsburg, E., Bang, J. J., & Fleming, J. M. (2015) · Endocrine Related Cancer · doi:10.1530/erc-14-0411 · Cited by 58 · see citing works
Self-citationShen, K., Luk, S. O., Hicks, D. F., Elman, J. S., Bohr, S., Iwamoto, Y., Murray, R. M., Peña, K. C., Wang, F., Şeker, E., et al. (2014) · Nature Communications · doi:10.1038/ncomms6662 · Cited by 56 · see citing works
Fibroblasts as Turned Agents in Cancer Progression
Wieder, R. (2023) · Cancers · doi:10.3390/cancers15072014 · Cited by 54 · see citing works
Berg, E. L., Hsu, Y.-C., & Lee, J. A. (2014) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2014.01.013 · Cited by 53 · see citing works
Zhang, S. (2013) · WormBook · doi:10.1895/wormbook.1.157.1 · Cited by 46 · see citing works
Sundaram, S., Freemerman, A. J., Johnson, A., Milner, J. J., McNaughton, K. K., Galanko, J. A., Bendt, K. M., Darr, D. B., Perou, C. M., Troester, M. A., et al. (2013) · Breast Cancer Research and Treatment · doi:10.1007/s10549-013-2741-5 · Cited by 43 · see citing works
Self-citationWeight Loss Reversed Obesity-Induced HGF/c-Met Pathway and Basal-Like Breast Cancer Progression
Sundaram, S., Le, T., Essaid, L., Freemerman, A. J., Huang, M., Galanko, J. A., McNaughton, K. K., Bendt, K. M., Darr, D. B., Troester, M. A., et al. (2014) · Frontiers in Oncology · doi:10.3389/fonc.2014.00175 · Cited by 41 · see citing works
Self-citationPaper-based Transwell assays: an inexpensive alternative to study cellular invasion
Kenney, R. M., Loeser, A., Whitman, N. A., & Lockett, M. R. (2018) · The Analyst · doi:10.1039/c8an01157e · Cited by 41 · see citing works
Holton, S. E., Bergamaschi, A., Katzenellenbogen, B. S., & Bhargava, R. (2014) · PLoS ONE · doi:10.1371/journal.pone.0096878 · Cited by 38 · see citing works
Mathot, P., Grandin, M., Devailly, G., Souazé, F., Cahais, V., Morán, S., Campone, M., Herceg, Z., Esteller, M., Juin, P. P., et al. (2017) · Oncogenesis · doi:10.1038/oncsis.2017.88 · Cited by 38 · see citing works
Functional tissue units and their primary tissue motifs in multi-scale physiology
de Bono, B., Grenon, P., Baldock, R., & Hunter, P. J. (2013) · Journal of Biomedical Semantics · doi:10.1186/2041-1480-4-22 · Cited by 37 · see citing works
Khabbazi, S., Nassar, Z. D., Goumon, Y., & Parat, M. (2016) · Scientific Reports · doi:10.1038/srep31572 · Cited by 32 · see citing works
Yoo, J. H., Kim, T. H., Park, S. U., Char, K., Kim, S. H., Chung, J. J., & Jung, Y. (2020) · Advanced Functional Materials · doi:10.1002/adfm.202008172 · Cited by 26 · see citing works
Ueno, T., Utsumi, J., Toi, M., & Shimizu, K. (2015) · BioMed Research International · doi:10.1155/2015/960840 · Cited by 25 · see citing works
Cozzo, A. J., Sundaram, S., Zattra, O., Qin, Y., Freemerman, A. J., Essaid, L., Darr, D. B., Montgomery, S. A., McNaughton, K. K., Ezzell, J. A., et al. (2016) · SpringerPlus · doi:10.1186/s40064-016-1920-3 · Cited by 23 · see citing works
Self-citationRozenchan, P. B., Pasini, F. S., Roela, R. A., Katayama, M. L. H., Mundim, F. G. L., Brentani, H., de Lyra, E. C., & Brentani, M. M. (2015) · Tumor Biology · doi:10.1007/s13277-015-3727-1 · Cited by 18 · see citing works
Prognostic and functional role of subtype‐specific tumor–stroma interaction in breast cancer
Merlino, G., Miodini, P., Callari, M., D’Aiuto, F., Cappelletti, V., & Daidone, M. G. (2017) · Molecular Oncology · doi:10.1002/1878-0261.12107 · Cited by 10 · see citing works
Zheng, M., Wang, J., Ling, L., Xue, D., Wang, S., & Zhao, Y. (2016) · Oncology Letters · doi:10.3892/ol.2016.5310 · Cited by 9 · see citing works
Lau, H. S. H., Tan, V. K. M., Tan, B. K. T., Sim, Y., Quist, J., Thike, A. A., Tan, P. H., Pervaiz, S., Grigoriadis, A. E., & Sabapathy, K. (2023) · npj Breast Cancer · doi:10.1038/s41523-023-00590-7 · Cited by 8 · see citing works
Assessment of Breast Cancer Stem Cell Activity Using a Spheroid Formation Assay
Nandi, A., & Chakrabarti, R. (2022) · Methods in molecular biology · doi:10.1007/978-1-0716-1979-7_33 · Cited by 8 · see citing works
Stem cell and cancer stem cell games on the ECM field
Kamble, S. C., & Bapat, S. A. (2013) · Journal of Cancer Stem Cell Research · doi:10.14343/jcscr.2013.1e1002 · Cited by 5 · see citing works
Gene expression profiling of tumor stroma interactions in retinoblastoma
Raguraman, R., Parameswaran, S., Kanwar, J. R., Vasudevan, M., Chitipothu, S., Kanwar, R. K., & Krishnakumar, S. (2020) · Experimental Eye Research · doi:10.1016/j.exer.2020.108067 · Cited by 5 · see citing works
Brasch, M. E., Peña, A. N., & Henderson, J. H. (2021) · Medical & Biological Engineering & Computing · doi:10.1007/s11517-021-02418-7 · Cited by 3 · see citing works
Dittrich, T., & Wenlian Qiao Peter, W. (2015) · Journal of Bone Marrow Research · doi:10.4172/2329-8820.1000160 · Cited by 2 · see citing works
Wang, M., & Qu, G. (2024) · Reproductive Sciences · doi:10.1007/s43032-024-01681-x · Cited by 1 · see citing works
Angres, B., & Wurst, H. (2017) · doi:10.1002/9781118851647.ch9 · Cited by 1 · see citing works
Abolins-Thompson, H. (2022) · doi:10.26686/wgtn.20153567 · Cited by 1 · see citing works
Influência do microambiente no prognóstico do câncer da mama
Makdissi, F. B. A. (2014) · doi:10.11606/t.5.2014.tde-01042014-112230
Influência do microambiente no prognóstico do câncer de mama
Azevedo, M. A., Folgueira, M. A. A. K., & Paulo, S. (2013)
Control of sex myoblast migration in C. elegans
Zhang, S. (2013) · VTechWorks (Virginia Tech)
Cozzo, A. J. (2019) · Carolina Digital Repository (University of North Carolina at Chapel Hill) · doi:10.17615/4jep-ge68
Triple-negative breast cancer microenvironments: Molecular and histologic portraits
Fuller, A. M. (2020) · Carolina Digital Repository (University of North Carolina at Chapel Hill) · doi:10.17615/nxrb-pb78
Functional association of Micrornas with molecular subtypes of breast cancer
Arif, K. T. (2021) · Queensland University of Technology · doi:10.5204/thesis.eprints.213110
- Authors
- Casbas-Hernandez, P., Fleming, J. M., & Troester, M. A.
- Affiliations
- North Carolina Central University (US)
- University of North Carolina at Chapel Hill (US)
- Corresponding author
- Troester, Melissa A.
- Venue
- BioMed Research International
- Publisher
- Wiley
- Published
- 2011-01
- Volume
- 2011
- Issue
- 1
- Pages
- 520987-520987
- ISSN
- 1110-7243 (ISSN-L)
- 2314-6133
- 2314-6141
- PMC
- PMC3238808
- OpenAlex
- W2106443904
- Cited by
- 43
- References
- 73
- Citations by year
- 2024: 1 · 2023: 2 · 2022: 2 · 2021: 2 · 2020: 3 · 2019: 2 · 2018: 1 · 2017: 4 · 2016: 4 · 2015: 4 · 2014: 6 · 2013: 10 · 2012: 2
- FWCI
- 0.53
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- BioMed Research International (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Carolina Digital Repository (University of North Carolina at Chapel Hill) (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- UNC Libraries
- Funders
- National Cancer Institute (1R01CA138255-03, 5P50CA058233, 5P30ES10126-11)
- UNC Breast SPORE (1R01CA138255-03, 5P50CA058233, 5P30ES10126-11)
- UNC Center for Environmental Health and Susceptibility (1R01CA138255-03, 5P50CA058233, 5P30ES10126-11)
- HHMI Translational Research Grant (1R01CA138255-03, 5P50CA058233, 5P30ES10126-11)
- Topics
- Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Breast Cancer Treatment Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular Mechanics and Interactions
- Keywords
- gene expression, tumor progression, cancer-associated fibroblasts, tumor microenvironment, breast cancer subtypes, tumor-immune cell interactions, tumor phenotype
- MeSH terms
- Breast, Breast Neoplasms, Cell Communication, Endothelium, Epithelial Cells, Epithelium, Female, Fibroblasts, Humans, Phenotype, Gene Expression Regulation, Neoplastic, Stromal Cells, Coculture Techniques, Cell Culture Techniques, Gene Expression Profiling, Models, Animal, Tumor Microenvironment
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