The DOI matches its Crossref record; 123 of the 123 references it cites were found in a registry or an index.
Cancer Cachexia: Mechanisms and Clinical Implications
Open accessAbstract
Cachexia is a multifactorial process of skeletal muscle and adipose tissue atrophy resulting in progressive weight loss. It is associated with poor quality of life, poor physical function, and poor prognosis in cancer patients. It involves multiple pathways: procachectic and proinflammatory signals from tumour cells, systemic inflammation in the host, and widespread metabolic changes (increased resting energy expenditure and alterations in metabolism of protein, fat, and carbohydrate). Whether it is primarily driven by the tumour or as a result of the host response to the tumour has yet to be fully elucidated. Cachexia is compounded by anorexia and the relationship between these two entities has not been clarified fully. Inconsistencies in the definition of cachexia have limited the epidemiological characterisation of the condition and there has been slow progress in identifying therapeutic agents and trialling them in the clinical setting. Understanding the complex interplay of tumour and host factors will uncover new therapeutic targets.
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Cited by
Cancer cachexia—pathophysiology and management
Suzuki, H., Asakawa, A., Amitani, H., Nakamura, N., & Inui, A. (2013) · Journal of Gastroenterology · doi:10.1007/s00535-013-0787-0 · Cited by 268
Judge, S. M., Wu, C.-L., Beharry, A. W., Roberts, B. M., Ferreira, L. F., Kandarian, S. C., & Judge, A. R. (2014) · BMC Cancer · doi:10.1186/1471-2407-14-997 · Cited by 111
Mueller, T. C., Bachmann, J., Prokopchuk, O., Friess, H., & Martignoni, M. E. (2016) · BMC Cancer · doi:10.1186/s12885-016-2121-8 · Cited by 95
Chen, M.-C., Hsu, W.-L., Hwang, P.-A., Chen, Y.-L., & Chou, T.-C. (2016) · Oncotarget · doi:10.18632/oncotarget.9958 · Cited by 69
Nishie, K., Yamamoto, S., Nagata, C., Koizumi, T., & Hanaoka, M. (2017) · Lung Cancer · doi:10.1016/j.lungcan.2017.07.023 · Cited by 52
Metadata
- Authors
- Donohoe, C. L., Ryan, A. M., & Reynolds, J. V.
- Venue
- Gastroenterology Research and Practice
- Publisher
- Hindawi Limited
- Published
- 2011
- Volume
- 2011
- Pages
- 1-13
- ISSN
- 1687-6121 (ISSN-L)
- 1687-630X
- OpenAlex
- W2028849454
- Cited by
- 273
- References
- 123
- FWCI
- 8.47
- Type
- journal article
- Language
- en
- Open access
- gold
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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