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Cited by 12

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JCM-16021, a Chinese Herbal Formula, Attenuated Visceral Hyperalgesia in TNBS-Induced Postinflammatory Irritable Bowel Syndrome through Reducing Colonic EC Cell Hyperplasia and Serotonin Availability in Rats

Qin, Hong-Yan, Xiao, Hai-Tao, Leung, Fung-Ping, Yang, Zhi-Jun, Wu, Justin C. Y., Sung, Joseph J. Y., Xu, Hong-Xi, Tong, Xu-Dong, Bian, Zhao-Xiang·2012·Evidence-Based Complementary and Alternative Medicine
DOI 10.1155/2012/239638
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Abstract

The present study aimed to investigate the analgesic effect of JCM-16021, a revised traditional Chinese herbal formula, on postinflammatory irritable bowel syndrome (PI-IBS) in rats. The trinitrobenzene sulfonic (TNBS) acid-induced PI-IBS model rats were orally administrated with different doses of JCM-16021 (1.2, 2.4, and 4.8 g/kg/d) for 14 consecutive days. The results showed that JCM-16021 treatment dose-dependently attenuated visceral hyperalgesia in PI-IBS rats. Further, the colonic enterochromaffin (EC) cell number, serotonin (5-HT) content, tryptophan hydroxylase expression, and mechanical-stimuli-induced 5-HT release were significantly ameliorated. Moreover, the decreased levels of mucosal cytokines in PI-IBS, especially the helper T-cell type 1- (T h 1-) related cytokine TNF-α, were also elevated after JCM-16021 treatment. These data demonstrate that the analgesic effect of JCM-16021 on TNBS-induced PI-IBS rats may be medicated via reducing colonic EC cell hyperplasia and 5-HT availability.

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Metadata

Authors
Qin, H.-Y., Xiao, H.-T., Leung, F.-P., Yang, Z.-J., Wu, J. C. Y., Sung, J. J. Y., Xu, H.-X., Tong, X.-D., & Bian, Z.-X.
Affiliations
  • School of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong, Hong Kong
  • Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong
  • Faculty of Chinese Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China
  • China Academy of Chinese Medicine, Beijing, China
Venue
Evidence-Based Complementary and Alternative Medicine
Publisher
Hindawi Limited
Published
2012
Volume
2012
Pages
1-12
ISSN
  • 1741-427X
  • 1741-4288
DOI
10.1155/2012/239638
Cited by
12
References
8
Language
en
Licence
creativecommons.org/licenses/by/3.0/ (unspecified)
Funders
Hong Kong Jockey Club institute of Chinese Medicine (JCICM-4-07)

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