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Cited by 133Alzheimer's disease research and treatmentsNeuroscience and Neuropharmacology ResearchDementia and Cognitive Impairment Research

Spines, plasticity, and cognition in Alzheimer's model mice

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Spires-Jones, Tara, Knafo, Shira·2012·Neural Plasticity
DOI 10.1155/2012/319836PMC PMC3238410
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Abstract

The pathological hallmarks of Alzheimer's disease (AD)—widespread synaptic and neuronal loss and the pathological accumulation of amyloid-beta peptide (A β) in senile plaques, as well as hyperphosphorylated tau in neurofibrillary tangles—have been known for many decades, but the links between AD pathology and dementia and effective therapeutic strategies remain elusive. Transgenic mice have been developed based on rare familial forms of AD and frontotemporal dementia, allowing investigators to test in detail the structural, functional, and behavioral consequences of AD-associated pathology. Here, we review work on transgenic AD models that investigate the degeneration of dendritic spine structure, synaptic function, and cognition. Together, these data support a model of AD pathogenesis in which soluble A β initiates synaptic dysfunction and loss, as well as pathological changes in tau, which contribute to both synaptic and neuronal loss. These changes in synapse structure and function as well as frank synapse and neuronal loss contribute to the neural system dysfunction which causes cognitive deficits. Understanding the underpinnings of dementia in AD will be essential to develop and evaluate therapeutic approaches for this widespread and devastating disease.

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  1. [2]Goedert M Spillantini MG A century of Alzheimer’s disease Science 2006 314 5800 777 781 17082447
  2. [3]Harris KM Structure, development, and plasticity of dendritic spines Current Opinion in Neurobiology 1999 9 3 343 348 10395574
  3. [4]Terry RD Masliah E Salmon DP Physical basis of cognitive alterations in Alzheimer’s disease: synapse loss is the major correlate of cognitive impairment Annals of Neurology 1991 30 4 572 580 1789684
  4. [5]DeKosky ST Scheff SW Styren SD Structural correlates of cognition in dementia: quantification and assessment of synapse change Neurodegeneration 1996 5 4 417 421 9117556
  5. [7]Spires TL Hyman BT Neuronal structure is altered by amyloid plaques Reviews in the Neurosciences 2004 15 4 267 278 15526551
  6. [8]Selkoe DJ Amyloid β-protein and the genetics of Alzheimer’s disease Journal of Biological Chemistry 1996 271 31 18295 18298 8756120
  7. [9]Hutton M Molecular genetics of chromosome 17 tauopathies Annals of the New York Academy of Sciences 2000 920 63 73 11193178
  8. [11]Spires TL Hyman BT Transgenic models of Alzheimer’s disease: learning from animals NeuroRx 2005 2 3 423 437 16389306 PMC1144486
  9. [12]Games D Adams D Alessandrini R Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein Nature 1995 373 6514 523 527 7845465
  10. [13]Knafo S Alonso-Nanclares L Gonzalez-Soriano J Widespread changes in dendritic spines in a model of Alzheimer’s Disease Cerebral Cortex 2009 19 3 586 592 18632740
  11. [14]Merino-Serrais P Knafo S Alonso-Nanclares L Fernaud-Espinosa I DeFelipe J Layer-specific alterations to CA1 dendritic spines in a mouse model of Alzheimer’s disease Hippocampus 2011 21 10 1037 1044 20848609
  12. [15]Knafo S Venero C Merino-Serrais P Morphological alterations to neurons of the amygdala and impaired fear conditioning in a transgenic mouse model of Alzheimer’s disease Journal of Pathology 2009 219 1 41 51 19449368
  13. [16]Brion JP Ando K Heraud C Leroy K Modulation of tau pathology in tau transgenic models Biochemical Society Transactions 2010 38 4 996 1000 20658992
  14. [17]Gotz J Deters N Doldissen A A decade of tau transgenic animal models and beyond Brain Pathology 2007 17 1 91 103 17493043 PMC8095624
  15. [18]Hyman BT Amyloid-dependent and amyloid-independent stages of Alzheimer disease Archives of Neurology 2011 68 8 1062 1064 21482918
  16. [19]Lanz TA Carter DB Merchant KM Dendritic spine loss in the hippocampus of young PDAPP and Tg2576 mice and its prevention by the ApoE2 genotype Neurobiology of Disease 2003 13 3 246 253 12901839
  17. [20]Moolman DL Vitolo OV Vonsattel JPG Shelanski ML Dendrite and dendritic spine alterations in Alzheimer models Journal of Neurocytology 2004 33 3 377 387 15475691
  18. [22]Tsai J Grutzendler J Duff K Gan WB Fibrillar amyloid deposition leads to local synaptic abnormalities and breakage of neuronal branches Nature Neuroscience 2004 7 11 1181 1183 15475950
  19. [23]Alpár A Ueberham U Brückner MK Seeger G Arendt T Gärtner U Different dendrite and dendritic spine alterations in basal and apical arbors in mutant human amyloid precursor protein transgenic mice Brain Research 2006 1099 1 189 198 16781686
  20. [24]Rocher AB Kinson MS Luebke JI Significant structural but not physiological changes in cortical neurons of 12-month-old Tg2576 mice Neurobiology of Disease 2008 32 2 309 318 18721884 PMC2683422
  21. [25]Rocher AB Crimins JL Amatrudo JM Structural and functional changes in tau mutant mice neurons are not linked to the presence of NFTs Experimental Neurology 2010 223 2 385 393 19665462 PMC2864360
  22. [26]Holtmaat A Bonhoeffer T Chow DK Long-term, high-resolution imaging in the mouse neocortex through a chronic cranial window Nature Protocols 2009 4 8 1128 1144 19617885 PMC3072839
  23. [27]Holtmaat AJ Trachtenberg JT Wilbrecht L Transient and persistent dendritic spines in the neocortex in vivo Neuron 2005 45 2 279 291 15664179
  24. [28]Trachtenberg JT Chen BE Knott GW Long-term in vivo imaging of experience-dependent synaptic plasticity in adult cortex Nature 2002 420 6917 788 794 12490942
  25. [29]Feng G Mellor RH Bernstein M Imaging neuronal subsets in transgenic mice expressing multiple spectral variants of GFP Neuron 2000 28 1 41 51 11086982
  26. [30]Spires-Jones TL Mielke ML Rozkalne A Passive immunotherapy rapidly increases structural plasticity in a mouse model of Alzheimer disease Neurobiology of Disease 2009 33 2 213 220 19028582 PMC2672591
  27. [31]Lai Z Brady RO Gene transfer into the central nervous system in vivo using a recombinanat lentivirus vector Journal of Neuroscience Research 2002 67 3 363 371 11813241
  28. [32]Bacskai BJ Hickey GA Skoch J Four-dimensional multiphoton imaging of brain entry, amyloid binding, and clearance of an amyloid-β ligand in transgenic mice Proceedings of the National Academy of Sciences of the United States of America 2003 100 21 12462 12467 14517353 PMC218780
  29. [33]Bacskai BJ Kajdasz ST Christie RH Imaging of amyloid-β deposits in brains of living mice permits direct observation of clearance of plaques with immunotherapy Nature Medicine 2001 7 3 369 372 11231639
  30. [34]Christie R Kimchi E Kajdasz S Bacskai B Hyman BT Multiphoton microscopy and amyloid angiopathy Amyloid 2001 8 1 48 50 11676290
  31. [35]Christie RH Bacskai BJ Zipfel WR Growth arrest of individual senile plaques in a model of Alzheimer’s disease observed by in vivo multiphoton microscopy Journal of Neuroscience 2001 21 3 858 864 11157072 PMC6762315
  32. [38]Meyer-Luehmann M Mielke M Spires-Jones TL A reporter of local dendritic translocation shows plaque-related loss of neural system function in APP-transgenic mice Journal of Neuroscience 2009 29 40 12636 12640 19812338 PMC2789808
  33. [39]Kuchibhotla KV Goldman ST Lattarulo CR Wu HY Hyman BT Bacskai BJ Aβ plaques lead to aberrant regulation of calcium homeostasis in vivo resulting in structural and functional disruption of neuronal networks Neuron 2008 59 2 214 225 18667150 PMC2578820
  34. [42]Hsieh H Boehm J Sato C AMPAR removal underlies Aβ-induced synaptic depression and dendritic spine loss Neuron 2006 52 5 831 843 17145504 PMC1850952
  35. [44]Wei W Nguyen LN Kessels HW Hagiwara H Sisodia S Malinow R Amyloid beta from axons and dendrites reduces local spine number and plasticity Nature Neuroscience 2010 13 2 190 196 20037574 PMC3310198
  36. [46]Lesné S Kotilinek L Ashe KH Plaque-bearing mice with reduced levels of oligomeric amyloid-β assemblies have intact memory function Neuroscience 2008 151 3 745 749 18155846 PMC2677385
  37. [47]Cleary JP Walsh DM Hofmeister JJ Natural oligomers of the amyloid-β protein specifically disrupt cognitive function Nature Neuroscience 2005 8 1 79 84 15608634
  38. [49]Brendza RP Bacskai BJ Cirrito JR Anti-Aβ antibody treatment promotes the rapid recovery of amyloid-associated neuritic dystrophy in PDAPP transgenic mice Journal of Clinical Investigation 2005 115 2 428 433 15668737 PMC544607
  39. [50]Buttini M Masliah E Barbour R β-amyloid immunotherapy prevents synaptic degeneration in a mouse model of Alzheimer’s disease Journal of Neuroscience 2005 25 40 9096 9101 16207868 PMC6725749
  40. [51]Dodart JC Bales KR Gannon KS Immunization reverses memory deficits without reducing brain Aβ burden in Alzheimer’s disease model Nature Neuroscience 2002 5 5 452 457 11941374
  41. [52]Games D Bard F Grajeda H Prevention and reduction of AD-type pathology in PDAPP mice immunized with Aβ 1–42 Annals of the New York Academy of Sciences 2000 920 274 284 11193164
  42. [53]Lombardo JA Stern EA McLellan ME Amyloid-β antibody treatment leads to rapid normalization of plaque-induced neuritic alterations Journal of Neuroscience 2003 23 34 10879 10883 14645482 PMC6740984
  43. [54]Micheva KD Busse B Weiler NC O’Rourke N Smith SJ Single-synapse analysis of a diverse synapse population: proteomic imaging methods and markers Neuron 2010 68 4 639 653 21092855 PMC2995697
  44. [55]Micheva KD Smith SJ Array tomography: a new tool for imaging the molecular architecture and ultrastructure of neural circuits Neuron 2007 55 1 25 36 17610815 PMC2080672
  45. [56]Koffie RM Meyer-Luehmann M Hashimoto T Oligomeric amyloid β associates with postsynaptic densities and correlates with excitatory synapse loss near senile plaques Proceedings of the National Academy of Sciences of the United States of America 2009 106 10 4012 4017 19228947 PMC2656196
  46. [58]Bastrikova N Gardner GA Reece JM Jeromin A Dudek SM Synapse elimination accompanies functional plasticity in hippocampal neurons Proceedings of the National Academy of Sciences of the United States of America 2008 105 8 3123 3127 18287055 PMC2268595
  47. [59]Yuste R Bonhoeffer T Morphological changes in dendritic spines associated with long-term synaptic plasticity Annual Review of Neuroscience 2001 24 1071 1089 11520928
  48. [60]Rozkalne A Hyman BT Spires-Jones TL Calcineurin inhibition with FK506 ameliorates dendritic spine density deficits in plaque-bearing Alzheimer model mice Neurobiology of Disease 2011 41 3 650 654 21134458 PMC3031746
  49. [61]Rozkalne A Spires-Jones TL Stern EA Hyman BT A single dose of passive immunotherapy has extended benefits on synapses and neurites in an Alzheimer’s disease mouse model Brain Research 2009 1280 178 185 19465012 PMC2709805
  50. [62]Wu H-Y Hudry E Hashimoto T Amyloid β induces the morphological neurodegenerative triad of spine loss, dendritic simplification, and neuritic dystrophies through calcineurin activation Journal of Neuroscience 2010 30 7 2636 2649 20164348 PMC2841957
  51. [65]de Calignon A Spires-Jones TL Pitstick R Carlson GA Hyman BT Tangle-bearing neurons survive despite disruption of membrane integrity in a mouse model of tauopathy Journal of Neuropathology and Experimental Neurology 2009 68 7 757 761 19535996 PMC2756569
  52. [66]Kopeikina KJ Carlson GA Pitstick R Tau accumulation causes mitochondrial distribution deficits in neurons in a mouse model of tauopathy and in human Alzheimer’s disease brain American Journal of Pathology 2011 179 4 2071 2082 21854751 PMC3181340
  53. [67]Spires-Jones TL de Calignon A Matsui T In vivo imaging reveals dissociation between caspase activation and acute neuronal death in tangle-bearing neurons Journal of Neuroscience 2008 28 4 862 867 18216194 PMC6670992
  54. [68]Spires-Jones TL Stoothoff WH de Calignon A Jones PB Hyman BT Tau pathophysiology in neurodegeneration: a tangled issue Trends in Neurosciences 2009 32 3 150 159 19162340
  55. [69]Hoover BR Reed MN Su J Tau mislocalization to dendritic spines mediates synaptic dysfunction independently of neurodegeneration Neuron 2010 68 6 1067 1081 21172610 PMC3026458
  56. [70]Ittner LM Ke YD Delerue F Dendritic function of tau mediates amyloid-β toxicity in alzheimer’s disease mouse models Cell 2010 142 3 387 397 20655099
  57. [71]Roberson ED Halabisky B Yoo JW Amyloid-β/fyn-induced synaptic, network, and cognitive impairments depend on tau levels in multiple mouse models of Alzheimer’s disease Journal of Neuroscience 2011 31 2 700 711 21228179 PMC3325794
  58. [74]D’Amelio M Cavallucci V Middei S Caspase-3 triggers early synaptic dysfunction in a mouse model of Alzheimer’s disease Nature Neuroscience 2011 14 1 69 79 21151119
  59. [75]Fitzjohn SM Morton RA Kuenzi F Age-related impairment of synaptic transmission but normal potentiation in transgenic mice that overexpress the human APP695SWE mutant form of amyloid precursor protein Journal of Neuroscience 2001 21 13 4691 4698 11425896 PMC6762352
  60. [76]Chapman PF White GL Jones MW Impaired synaptic plasticity and learning in aged amyloid precursor protein transgenic mice Nature Neuroscience 1999 2 3 271 276 10195221
  61. [77]Jung J An K Kwon OB Kim HS Kim J-H Pathway-specific alteration of synaptic plasticity in Tg2576 mice Molecules and Cells 2011 1 5 PMC3887667 21638202
  62. [78]Larson J Lynch G Games D Seubert P Alterations in synaptic transmission and long-term potentiation in hippocampal slices from young and aged PDAPP mice Brain Research 1999 840 1-2 23 35 10517949
  63. [80]Trinchese F Liu S Battaglia F Walter S Mathews PM Arancio O Progressive age-related development of Alzheimer-like pathology in APP/PS1 mice Annals of Neurology 2004 55 6 801 814 15174014
  64. [82]Kimura R Ohno M Impairments in remote memory stabilization precede hippocampal synaptic and cognitive failures in 5XFAD Alzheimer mouse model Neurobiology of Disease 2009 33 2 229 235 19026746 PMC2741400
  65. [83]Kimura R Devi L Ohno M Partial reduction of BACE1 improves synaptic plasticity, recent and remote memories in Alzheimer’s disease transgenic mice Journal of Neurochemistry 2010 113 1 248 261 20089133 PMC2921968
  66. [84]Selkoe DJ Alzheimer’s disease is a synaptic failure Science 2002 298 5594 789 791 12399581
  67. [85]Tanzi RE The synaptic Aβ hypothesis of Alzheimer disease Nature Neuroscience 2005 8 8 977 979 16047022
  68. [87]Middei S Roberto A Berretta N Learning discloses abnormal structural and functional plasticity at hippocampal synapses in the APP23 mouse model of Alzheimer’s disease Learning and Memory 2010 17 5 236 240 20404004
  69. [88]Perez-Cruz C Nolte MW van Gaalen MM Reduced spine density in specific regions of CA1 pyramidal neurons in two transgenic mouse models of Alzheimer’s disease Journal of Neuroscience 2011 31 10 3926 3934 21389247 PMC6622797
  70. [89]Smith DL Pozueta J Gong B Arancio O Shelanski M Reversal of long-term dendritic spine alterations in Alzheimer disease models Proceedings of the National Academy of Sciences of the United States of America 2009 106 39 16877 16882 19805389 PMC2743726
  71. [90]Trinchese F Fa’ M Liu S Inhibition of calpains improves memory and synaptic transmission in a mouse model of Alzheimer disease Journal of Clinical Investigation 2008 118 8 2796 2807 18596919 PMC2441853
  72. [92]Moechars D Dewachter I Lorent K Early phenotypic changes in transgenic mice that overexpress different mutants of amyloid precursor protein in brain Journal of Biological Chemistry 1999 274 10 6483 6492 10037741
  73. [94]Selkoe DJ Soluble oligomers of the amyloid β-protein impair synaptic plasticity and behavior Behavioural Brain Research 2008 192 1 106 113 18359102 PMC2601528
  74. [95]Goussakov I Miller MB Stutzmann GE NMDA-mediated Ca2+ influx drives aberrant ryanodine receptor activation in dendrites of young Alzheimer’s disease mice Journal of Neuroscience 2010 30 36 12128 12137 20826675 PMC2944253
  75. [96]Li Z Jo J Jia JM Caspase-3 activation via mitochondria is required for long-term depression and AMPA receptor internalization Cell 2010 141 5 859 871 20510932 PMC2909748
  76. [97]Squire LR Memory and the hippocampus: a synthesis from findings with rats, monkeys, and humans Psychological Review 1992 99 2 195 231 1594723
  77. [98]King DL Arendash GW Behavioral characterization of the Tg2576 transgenic model of Alzheimer’s disease through 19 months Physiology and Behavior 2002 75 5 627 642 12020728
  78. [99]King DL Arendash GW Crawford F Sterk T Menendez J Mullan MJ Progressive and gender-dependent cognitive impairment in the APP(SW) transgenic mouse model for Alzheimer’s disease Behavioural Brain Research 1999 103 2 145 162 10513583
  79. [100]Hsiao K Chapman P Nilsen S Correlative memory deficits, Aβ elevation, and amyloid plaques in transgenic mice Science 1996 274 5284 99 103 8810256
  80. [101]Morgan D Diamond DM Gottschall PE A β peptide vaccination prevents memory loss in an animal model of Alzheimer’s disease Nature 2000 408 6815 982 985 11140686
  81. [104]Pompl PN Mullan MJ Bjugstad K Arendash GW Adaptation of the circular platform spatial memory task for mice: use in detecting cognitive impairment in the APP(sw) transgenic mouse model for Alzheimer’s disease Journal of Neuroscience Methods 1999 87 1 87 95 10065997
  82. [105]Minkeviciene R Ihalainen J Malm T Age-related decrease in stimulated glutamate release and vesicular glutamate transporters in APP/PS1 transgenic and wild-type mice Journal of Neurochemistry 2008 105 3 584 594 18042177
  83. [106]Malm TM Iivonen H Goldsteins G Pyrrolidine dithiocarbamate activates Akt and improves spatial learning in APP/PS1 mice without affecting Î2-amyloid burden Journal of Neuroscience 2007 27 14 3712 3721 17409235 PMC6672417
  84. [109]Perez-Cruz C Nolte MW van Gaalen MM Reduced spine density in specific regions of CA1 pyramidal neurons in two transgenic mouse models of Alzheimer’s disease Journal of Neuroscience 2011 31 10 3926 3934 21389247 PMC6622797
  85. [110]Chen G Chen KS Knox J A learning deficit related to age and β-amyloid plaques in a mouse model of Alzheimer’s disease Nature 2000 408 6815 975 979 11140684
  86. [111]Westerman MA Cooper-Blacketer D Mariash A The relationship between AÎ2 and memory in the Tg2576 mouse model of Alzheimer’s disease Journal of Neuroscience 2002 22 5 1858 1867 11880515 PMC6758862
  87. [112]Corcoran KA Lu Y Scott Turner R Maren S Overexpression of hAPPswe impairs rewarded alternation and contextual fear conditioning in a transgenic mouse model of Alzheimer’s disease Learning and Memory 2002 9 5 243 252 12359834 PMC187133
  88. [113]Imbimbo BP Giardino L Sivilia S CHF5074, a novel γ-secretase modulator, restores hippocampal neurogenesis potential and reverses contextual memory deficit in a transgenic mouse model of Alzheimer’s disease Journal of Alzheimer’s Disease 2010 20 1 159 173 20164581
  89. [114]Comery TA Martone RL Aschmies S Acute Î3-secretase inhibition improves contextual fear conditioning in the Tg2576 mouse model of Alzheimer’s disease Journal of Neuroscience 2005 25 39 8898 8902 16192379 PMC6725598
  90. [115]Jacobsen JS Wu CC Redwine JM Early-onset behavioral and synaptic deficits in a mouse model of Alzheimer’s disease Proceedings of the National Academy of Sciences of the United States of America 2006 103 13 5161 5166 16549764 PMC1405622
  91. [116]Riddell DR Zhou H Comery TA The LXR agonist TO901317 selectively lowers hippocampal Aβ42 and improves memory in the Tg2576 mouse model of Alzheimer’s disease Molecular and Cellular Neuroscience 2007 34 4 621 628 17336088
  92. [118]Jacobsen JS Wu CC Redwine JM Early-onset behavioral and synaptic deficits in a mouse model of Alzheimer’s disease Proceedings of the National Academy of Sciences of the United States of America 2006 103 13 5161 5166 16549764 PMC1405622
  93. [119]Barnes P Good M Impaired pavlovian cued fear conditioning in Tg2576 mice expressing a human mutant amyloid precursor protein gene Behavioural Brain Research 2005 157 1 107 117 15617777
  94. [120]Tabuchi M Yamaguchi T Iizuka S Imamura S Ikarashi Y Kase Y Ameliorative effects of yokukansan, a traditional Japanese medicine, on learning and non-cognitive disturbances in the Tg2576 mouse model of Alzheimer’s disease Journal of Ethnopharmacology 2009 122 1 157 162 19146938
  95. [121]Thakker DR Weatherspoon MR Harrison J Intracerebroventricular amyloid-Î2 antibodies reduce cerebral amyloid angiopathy and associated micro-hemorrhages in aged Tg2576 mice Proceedings of the National Academy of Sciences of the United States of America 2009 106 11 4501 4506 19246392 PMC2647980
  96. [123]Filali M Lalonde R Rivest S Subchronic memantine administration on spatial learning, exploratory activity, and nest-building in an APP/PS1 mouse model of Alzheimer’s disease Neuropharmacology 2011 60 6 930 936 21281652
  97. [124]Arendash GW King DL Gordon MN Progressive, age-related behavioral impairments in transgenic mice carrying both mutant amyloid precursor protein and presenilin-1 transgenes Brain Research 2001 891 1-2 42 53 11164808
  98. [125]Trinchese F Liu S Battaglia F Walter S Mathews PM Arancio O Progressive age-related development of Alzheimer-like pathology in APP/PS1 mice Annals of Neurology 2004 55 6 801 814 15174014
  99. [126]Yu Y He J Zhang Y Increased hippocampal neurogenesis in the progressive stage of Alzheimer’s disease phenotype in an APP/PS1 double transgenic mouse model Hippocampus 2009 19 12 1247 1253 19309037
  100. [127]Scullion GA Kendalla DA Marsdena CA Sunterc D Pardona M-C Chronic treatment with the α 2-adrenoceptor antagonist fluparoxan prevents age-related deficits in spatial working memory in APP × PS1 transgenic mice without altering β-amyloid plaque load or astrocytosis Neuropharmacology 2011 60 2-3 223 234 20850464
  101. [128]Puoliväli J Wang J Heikkinen T Hippocampal Aβ 42 levels correlate with spatial memory deficit in APP and PS1 double transgenic mice Neurobiology of Disease 2002 9 3 339 347 11950278
  102. [129]Wirths O Breyhan H Schäfer S Roth C Bayer TA Deficits in working memory and motor performance in the APP/PS1ki mouse model for Alzheimer’s disease Neurobiology of Aging 2008 29 6 891 901 17215062
  103. [130]Cotel M-C Jawhar S Christensen DZ Bayer TA Wirths O Environmental enrichment fails to rescue working memory deficits, neuron loss, and neurogenesis in APP/PS1KI mice Neurobiol Aging 2012 33 1 96 107 20359774
  104. [131]Pardon MC Sarmad S Rattray I Repeated novel cage exposure-induced improvement of early Alzheimer’s-like cognitive and amyloid changes in TASTPM mice is unrelated to changes in brain endocannabinoids levels Neurobiology of Aging 2009 30 7 1099 1113 18023506
  105. [132]Rattray I Scullion GA Soulby A Kendall DA Pardon MC The occurrence of a deficit in contextual fear extinction in adult amyloid-over-expressing TASTPM mice is independent of the strength of conditioning but can be prevented by mild novel cage stress Behavioural Brain Research 2009 200 1 83 90 19162086
  106. [133]Rattray I Pitiot A Lowe J Novel cage stress alters remote contextual fear extinction and regional T{2} magnetic resonance relaxation times in TASTPM mice overexpressing amyloid Journal of Alzheimer’s Disease 2010 20 4 1049 1068 20413887
  107. [135]Liu L Ikonen S Heikkinen T Tapiola T van Groen T Tanila H The effects of long-term treatment with metrifonate, a cholinesterase inhibitor, on cholinergic activity, amyloid pathology, and cognitive function in APP and PS1 doubly transgenic mice Experimental Neurology 2002 173 2 196 204 11822883
  108. [136]Carroll JC Rosario ER Chang L Progesterone and estrogen regulate Alzheimer-like neuropathology in female 3xTg-AD mice Journal of Neuroscience 2007 27 48 13357 13365 18045930 PMC6673397
  109. [137]Guan H Liu Y Daily A Peripherally expressed neprilysin reduces brain amyloid burden: a novel approach for treating Alzheimer’s disease Journal of Neuroscience Research 2009 87 6 1462 1473 19021293 PMC2832596
  110. [138]McKee AC Carreras I Hossain L Ibuprofen reduces Aβ, hyperphosphorylated tau and memory deficits in Alzheimer mice Brain Research 2008 1207 225 236 18374906 PMC2587244
  111. [139]Caccamo A Oddo S Billings LM M1 receptors play a central role in modulating AD-like pathology in transgenic mice Neuron 2006 49 5 671 682 16504943
  112. [140]Caccamo A Maldonado MA Bokov AF Majumder S Oddo S CBP gene transfer increases BDNF levels and ameliorates learning and memory deficits in a mouse model of Alzheimer’s disease Proceedings of the National Academy of Sciences of the United States of America 2010 107 52 22687 22692 21149712 PMC3012497
  113. [141]Rosario ER Carroll JC Oddo S LaFerla FM Pike CJ Androgens regulate the development of neuropathology in a triple transgenic mouse model of Alzheimer’s disease The Journal of Neuroscience 2006 26 51 13384 13389 17182789 PMC6674990
  114. [142]Matsuoka Y Jouroukhin Y Gray AJ A neuronal microtubule-interacting agent, NAPVSIPQ, reduces tau pathology and enhances cognitive function in a mouse model of Alzheimer’s disease Journal of Pharmacology and Experimental Therapeutics 2008 325 1 146 153 18199809
  115. [143]Oddo S Vasilevko V Caccamo A Kitazawa M Cribbs DH LaFerla FM Reduction of soluble AÎ2 and tau, but not soluble AÎ2 alone, ameliorates cognitive decline in transgenic mice with plaques and tangles Journal of Biological Chemistry 2006 281 51 39413 39423 17056594
  116. [144]Ohno M Chang L Tseng W Temporal memory deficits in Alzheimer’s mouse models: rescue by genetic deletion of BACE1 European Journal of Neuroscience 2006 23 1 251 260 16420434
  117. [145]Devi L Ohno M Genetic reductions of β-site amyloid precursor protein-cleaving enzyme 1 and amyloid-β ameliorate impairment of conditioned taste aversion memory in 5XFAD Alzheimer’s disease model mice European Journal of Neuroscience 2010 31 1 110 118 20092558 PMC2887274
  118. [146]Ohno M Cole SL Yasvoina M BACE1 gene deletion prevents neuron loss and memory deficits in 5XFAD APP/PS1 transgenic mice Neurobiology of Disease 2007 26 1 134 145 17258906 PMC1876698
  119. [147]Santacruz K Lewis J Spires T Tau suppression in a neurodegenerative mouse model improves memory function Science 2005 309 5733 476 481 16020737 PMC1574647
  120. [148]Sydow A van der Jeugd A Zheng F Tau-induced defects in synaptic plasticity, learning, and memory are reversible in transgenic mice after switching off the toxic tau mutant Journal of Neuroscience 2011 31 7 2511 2525 21325519 PMC6623704

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Authors
Spires-Jones, T., & Knafo, S.
Affiliations
  • Massachusetts General Hospital, Harvard Medical School, 114 16th Street, Charlestown, MA 02129, USA
  • Consejo Superior de Investigaciones Científicas (ES)
Corresponding author
Knafo, Shira
ORCID
Knafo, Shira
Venue
Neural Plasticity
Publisher
Hindawi Limited
Published
2012
Volume
2012
Pages
1-10
ISSN
  • 1687-5443 (ISSN-L)
  • 2090-5904
DOI
10.1155/2012/319836
PMC
PMC3238410
OpenAlex
W1974073785
Cited by
133
References
27
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FWCI
1.47
Type
journal article
Language
en
Open access
Licence
Locations
  • Neural Plasticity (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Edinburgh Research Explorer (University of Edinburgh) (submittedVersion, cc-by)
  • DIGITAL.CSIC (Spanish National Research Council (CSIC)) (submittedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
Funders
National Institute on Aging (R00AG033670)
Topics
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Keywords
Alzheimer's disease, transgenic mouse model, dendritic spines, synaptic plasticity, synaptic dysfunction, amyloid-beta, tau hyperphosphorylation, neurofibrillary tangles, amyloid plaques, cognitive impairment, neuronal loss, dementia pathogenesis
MeSH terms
Alzheimer Disease, Animals, Cognition, Disease Models, Animal, Humans, Mice, Transgenic, Neuronal Plasticity, Synapses, Amyloid beta-Peptides, Amyloid beta-Protein Precursor, tau Proteins, Dendritic Spines, Mice, Plaque, Amyloid

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