The surface area of the placenta and hypertension in the offspring in later life
Open accessAbstract
Hypertension is more common among people who had low birthweight. Birthweight depends on the mothers body size and on the growth of the placenta. We studied a group of 2003 subjects, of whom 644 were being treated for hypertension. They were born during 1934-44 in a hospital that kept detailed records of maternal and placental size. Hypertension was associated with reduced placental weight and surface area. These associations were strongest in the offspring of mothers with below average height or low socioeconomic status. In people whose mothers had below average height (160 cm) the prevalence of hypertension fell from 38% if the placental area was 200 cm(2) or less to 21% if the area was more than 320 cm(2) (p=0.0007). In the offspring of tall, middle class mothers, who were likely to have been the best nourished, hypertension was predicted by large placental weight in relation to birthweight. The odds ratio rose from 1.0 if the ratio of placental weight to birthweight was 0.17 or less to 1.9 (95% confidence interval 0.8 to 5.0) if the ratio was more than 0.21 (p for trend =0.03). We conclude that the effects of placental area on hypertension depend on the mothers nutritional state. Poor maternal nutrition may compound the adverse effects of small placental size. In better-nourished mothers the placental surface may expand to compensate for fetal undernutrition. Growth along the minor axis of the surface may be more nutritionally sensitive than growth along the major axis.
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The associations between placental measures and hypertension were strongest among mothers whose stature was below average height (160 cm) or who were of low socioeconomic status.
“When taking maternal characteristics into consideration, the associations were strongest among mothers whose stature was below average height (160cm), or who were of low socioeconomic status (Figure 8).”
From Placental Origins of Chronic Disease (2016) · cites this paper as [39]
Among 644 hypertensive subjects in the Helsinki Birth Cohort, treatment for hypertension was associated with low placental weight and surface area.
“Among the 644 hypertensive subjects, treatment for hypertension was associated with low placental weight and surface area (39).”
From Placental Origins of Chronic Disease (2016) · cites this paper as [39]
Among shorter women, the prevalence of hypertension fell from 38% if the placental area was 200 cm2 or less to 21% if the area exceeded 320 cm2 (p = 0.0007).
“Among these shorter women, the prevalence of hypertension fell from 38% if the placental area was 200 cm 2 or less, to 21% if the area exceeded 320 cm 2 (p=0.0007).”
From Placental Origins of Chronic Disease (2016) · cites this paper as [39]
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Fetal and placental size and risk of hypertension in adult life.
Barker, D. J., Bull, A. R., Osmond, C., & Simmonds, S. J. (1990) · BMJ · doi:10.1136/bmj.301.6746.259 · Cited by 1,728 · see citing works
Self-citationTrajectories of growth among children who have coronary events as adults
Barker, D. J. P., Osmond, C., Forsén, T. J., Kajantie, E., & Eriksson, J. G. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa044160 · Cited by 1,517 · see citing works
Self-citationNephron Number in Patients with Primary Hypertension
Keller, G., Zimmer, G., Mall, G., Ritz, E., & Amann, K. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa020549 · Cited by 1,102 · see citing works
The nutritional basis of the fetal origins of adult disease
Harding, J. E. (2001) · International Journal of Epidemiology · doi:10.1093/ije/30.1.15 · Cited by 561 · see citing works
Jansson, T., & Powell, T. L. (2007) · Clinical Science · doi:10.1042/cs20060339 · Cited by 542 · see citing works
Fetal and Childhood Growth and Hypertension in Adult Life
Eriksson, J., Forsén, T., Tuomilehto, J., Osmond, C., & Barker, D. (2000) · Hypertension · doi:10.1161/01.hyp.36.5.790 · Cited by 483 · see citing works
Self-citationMother's weight in pregnancy and coronary heart disease in a cohort of finnish men: follow up study
Forsén, T., Eriksson, J. G., Tuomilehto, J. O., Teramo, K., Osmond, C., & Barker, D. J. P. (1997) · BMJ · doi:10.1136/bmj.315.7112.837 · Cited by 452 · see citing works
Self-citationAlexander, J. R., & Tanner, J. M. (1979) · Biometrics · doi:10.2307/2530274 · Cited by 395 · see citing works
Diet in pregnancy and the offspring's blood pressure 40 years later
Campbell, D. M., Hall, M. H., Barker, D. J. P., Cross, J. F., Shiell, A. W., & Godfrey, K. M. (1996) · BJOG An International Journal of Obstetrics & Gynaecology · doi:10.1111/j.1471-0528.1996.tb09718.x · Cited by 344 · see citing works
Self-citationThe effect of maternal anaemia and iron deficiency on the ratio of fetal weight to placental weight
Godfrey, K. M., Redman, C. W. G., Barker, D. J. P., & Osmond, C. (1991) · BJOG An International Journal of Obstetrics & Gynaecology · doi:10.1111/j.1471-0528.1991.tb13510.x · Cited by 301 · see citing works
Self-citationMechanisms of Disease: in utero programming in the pathogenesis of hypertension
Barker, D. J. P., Bagby, S. P., & Hanson, M. A. (2006) · Nature Reviews Nephrology · doi:10.1038/ncpneph0344 · Cited by 281 · see citing works
Self-citationChildhood Growth and Hypertension in Later Life
Eriksson, J. G., Forsén, T., Kajantie, E., Osmond, C., & Barker, D. J. P. (2007) · Hypertension · doi:10.1161/hypertensionaha.106.085597 · Cited by 204 · see citing works
Self-citationBirth weight and blood pressure: cross sectional and longitudinal relations in childhood
Whincup, P. H., Cook, D. G., Papacosta, O., & Walker, M. (1995) · BMJ · doi:10.1136/bmj.311.7008.773 · Cited by 166 · see citing works
Size at birth and blood pressure: cross sectional study in 8-11 year old children
Taylor, S. J., Whincup, P. H., Cook, D. G., Papacosta, O., & Walker, M. (1997) · BMJ · doi:10.1136/bmj.314.7079.475 · Cited by 143 · see citing works
Fetal and placental size and risk of hypertension in adult life
Barker, D. J. P., Bull, A. R., Osmond, C., & Simmonds, S. (1991) · International Journal of Gynecology & Obstetrics · doi:10.1016/0020-7292(91)90104-d · Cited by 128 · see citing works
Self-citationPlacental weight, birth measurements, and blood pressure at age 8 years.
Moore, V., Miller, A., BOULTON, T. J. C., COCKINGTON, R. A., Craig, I. H., Magarey, A., & Robinson, J. S. (1996) · Archives of Disease in Childhood · doi:10.1136/adc.74.6.538 · Cited by 127 · see citing works
Pesonen, A., Räikkönen, K., Heinonen, K., Kajantie, E., Forsén, T., & Eriksson, J. G. (2007) · American Journal of Epidemiology · doi:10.1093/aje/kwm254 · Cited by 118 · see citing works
Self-citationMcCrabb, G. J., Egan, A. R., & Hosking, B. J. (1991) · British Journal Of Nutrition · doi:10.1079/bjn19910077 · Cited by 116 · see citing works
Congenital oligonephropathy: an inborn cause of adult hypertension and progressive renal injury?
Bm, B., & Chertow, G. M. (1993) · PubMed · Cited by 115 · see citing works
Maternal undernutrition during mid-pregnancy in sheep: variable effects on placental growth
McCrabb, G. J., Egan, A. R., & Hosking, B. J. (1992) · The Journal of Agricultural Science · doi:10.1017/s002185960006809x · Cited by 114 · see citing works
The human placenta becomes haemochorial at the 13th week of pregnancy
Foidart, J., Hustin, J., Dubois, M., & Schaaps, J. P. (1992) · The International Journal of Developmental Biology · doi:10.1387/ijdb.1445791 · Cited by 103 · see citing works
Burkhardt, T., Schäffer, L., Schneider, C., Zimmermann, R., & Kurmanavičius, J. (2005) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/j.ejogrb.2005.10.032 · Cited by 103 · see citing works
Changes in the placenta and in the rat embryo caused by the demethylating agent 5-azacytidine
Vlahović, M., Bulić‐Jakuš, F., Juric-Lekic, G., et al. (1999) · The International Journal of Developmental Biology · doi:10.1387/ijdb.10707910 · Cited by 55 · see citing works
An activating mutation in the PDGF receptor-beta causes abnormal morphology in the mouse placenta
Looman, C., Sun, T., Yu, Y., et al. (2007) · The International Journal of Developmental Biology · doi:10.1387/ijdb.072301cl · Cited by 22 · see citing works
Met signaling mutants as tools for developmental studies
Ponzetto, C., Panté, G., Prunotto, C., Ieraci, A., & Maina, F. (2000) · The International Journal of Developmental Biology · doi:10.1387/ijdb.11061428 · Cited by 19 · see citing works
Liang, L. Y., Kanduri, C., Pilartz, M., et al. (2000) · The International Journal of Developmental Biology · doi:10.1387/ijdb.11128572 · Cited by 13 · see citing works
Nutritional basis for the fetal origins of adult disease.
Harding, J. (2004) · CABI Publishing eBooks · doi:10.1079/9780851998213.0021 · Cited by 8 · see citing works
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- Authors
- Barker, D. J. P., Thornburg, K. L., Osmond, C., Kajantie, E., & Eriksson, J. G.
- Affiliations
- Southampton General Hospital (GB)
- Oregon Health & Science University (US)
- Helsinki University Hospital (FI)
- University of Helsinki (FI)
- Corresponding author
- Barker, David J.P.
- Venue
- The International Journal of Developmental Biology
- Publisher
- EHU Press
- Published
- 2010
- Volume
- 54
- Issue
- 2-3
- Pages
- 525-530
- ISSN
- 0214-6282 (ISSN-L)
- PMC
- PMC3923649
- OpenAlex
- W2079364354
- Cited by
- 212
- References
- 27
- Citations by year
- 2026: 5 · 2025: 3 · 2024: 7 · 2023: 9 · 2022: 12 · 2021: 13 · 2020: 12 · 2019: 11 · 2018: 14 · 2017: 5 · 2016: 11 · 2015: 21 · 2014: 12 · 2013: 17 · 2012: 21
- FWCI
- 17.47
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The International Journal of Developmental Biology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- ePrints Soton (University of Southampton) (submittedVersion)
- STM:n Hallinnonalan avoin julkaisuarkisto (Julkari) (submittedVersion)
- Funders
- Foundation for Cardiovascular Research
- Finska Läkaresällskapet
- British Heart Foundation
- Academy of Finland
- Sydäntutkimussäätiö
- Suomalainen Lääkäriseura Duodecim
- Diabetestutkimussäätiö
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (P01HD034430)
- Topics
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
- Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
- Keywords
- placental surface area, placental weight, hypertension, low birth weight, maternal height, maternal socioeconomic status, maternal nutrition, fetal malnutrition, placental development, birth cohort
- MeSH terms
- Adult, Body Height, Female, Humans, Hypertension, Infant, Low Birth Weight, Infant, Newborn, Male, Maternal-Fetal Exchange, Organ Size, Placenta, Pregnancy, Prenatal Exposure Delayed Effects, Socioeconomic Factors, Odds Ratio, Prenatal Nutritional Physiological Phenomena
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