The DOI matches its Crossref record; 17 of the 17 references it cites were found in a registry or an index.
PPAR and Oxidative Stress: Con() Catenating NRF2 and FOXO
Open accessAbstract
Peroxisome-proliferator activator receptor γ(PPAR γ) is a nuclear receptor of central importance in energy homeostasis and inflammation. Recent experimental pieces of evidence demonstrate that PPAR γ is implicated in the oxidative stress response, an imbalance between antithetic prooxidation and antioxidation forces that may lead the cell to apoptotic or necrotic death. In this delicate and intricate game of equilibrium, PPAR γ stands out as a central player devoted to the quenching and containment of the damage and to foster cell survival. However, PPAR γ does not act alone: indeed the nuclear receptor is at the point of interconnection of various pathways, such as the nuclear factor erythroid 2-related factor 2 (NRF2), Wnt/β-catenin, and forkhead box proteins O (FOXO) pathways. Here we reviewed the role of PPAR γ in response to oxidative stress and its interaction with other signaling pathways implicated in this process, an interaction that emerged as a potential new therapeutic target for several oxidative-related diseases.
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Forkhead transcription factor FOXO3a protects quiescent cells from oxidative stress
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Background
Cited by
Are Reactive Oxygen Species Always Detrimental to Pathogens?
Paiva, C. N., & Bozza, M. T. (2014) · Antioxidants & Redox Signaling · doi:10.1089/ars.2013.5447 · Cited by 564
The inflammatory response in sepsis
Bosmann, M., & Ward, P. A. (2013) · Trends in Immunology · doi:10.1016/j.it.2012.09.004 · Cited by 558
ROS and Brain Diseases: The Good, the Bad, and the Ugly
Popa-Wagner, A., Mitran, S., Sivanesan, S., Chang, E., & Buga, A.-M. (2013) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2013/963520 · Cited by 427
Yoon, Y.-S., Kim, S.-Y., Kim, M.-J., Lim, J.-H., Cho, M.-S., & Kang, J. L. (2015) · Mucosal Immunology · doi:10.1038/mi.2014.130 · Cited by 145
Stress-induced blood brain barrier disruption: Molecular mechanisms and signaling pathways
Welcome, M. O., & Mastorakis, N. E. (2020) · Pharmacological Research · doi:10.1016/j.phrs.2020.104769 · Cited by 139
Metadata
- Authors
- Polvani, S., Tarocchi, M., & Galli, A.
- Venue
- PPAR Research
- Publisher
- Wiley
- Published
- 2012
- Volume
- 2012
- Pages
- 1-15
- ISSN
- 1687-4757 (ISSN-L)
- 1687-4765
- OpenAlex
- W1992800757
- Cited by
- 245
- References
- 17
- FWCI
- 3.72
- Type
- journal article
- Language
- en
- Open access
- gold
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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